Immunology Journal Club

Papers

Date Presenter Lab Paper Link
November 14, 2017 Jason Hall Littman    
November 14, 2017 James Muller Dustin    
November 7, 2017 Maria Pokrovskii Littman Mass E, Jacome-Galarza CE, Blank T, Lazarov T, Durham BH, Ozkaya N, Pastore A, Schwabenland M, Chung YR, Rosenblum MK, Prinz M, Abdel-Wahab O, Geissmann F. A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease. Nature. 2017 Sep 21;549(7672):389-393 Mass
November 7, 2017 Sean Saunders Maria Lafaille Mayer CT, Gazumyan A, Kara EE, Gitlin AD, Golijanin J, Viant C, Pai J, Oliveira TY, Wang Q, Escolano A, Medina-Ramirez M, Sanders RW, Nussenzweig MC. The microanatomic segregation of selection by apoptosis in the germinal center. Science. 2017 Oct 13;358(6360). pii: eaao2602 Mayer
October 31, 2017 Varsha Raghavan Littman Hoytema van Konijnenburg DP, Reis BS, Pedicord VA, Farache J, Victora GD, Mucida D. Intestinal Epithelial and Intraepithelial T Cell Crosstalk Mediates a Dynamic Response to Infection. Cell. 2017 Nov 2;171(4):783-794.e13 Hoytema van Konijnenburg
October 31, 2017 Hernandez Moura Silva Lafaille Atarashi K, Suda W, Luo C, Kawaguchi T, Motoo I, Narushima S, Kiguchi Y, Yasuma K, Watanabe E, Tanoue T, Thaiss CA, Sato M, Toyooka K, Said HS, Yamagami H, Rice SA, Gevers D, Johnson RC, Segre JA, Chen K, Kolls JK, Elinav E, Morita H, Xavier RJ, Hattori M, Honda K. Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation. Science. 2017 Oct 20;358(6361):359-365 Atarashi
October 17, 2017 Tariq Najar Littman Dang EV, McDonald JG, Russell DW, Cyster JG. Oxysterol Restraint of Cholesterol Synthesis Prevents AIM2 Inflammasome Activation. Cell. 2017 Oct 7. pii: S0092-8674(17)31123-6. doi: 10.1016/j.cell.2017.09.029. [Epub ahead of print] PubMed PMID: 29033131. Dang
October 17, 2017 Jhimmy Talbot Littman Isoda T, Moore AJ, He Z, Chandra V, Aida M, Denholtz M, Piet van Hamburg J, Fisch KM, Chang AN, Fahl SP, Wiest DL, Murre C. Non-coding Transcription Instructs Chromatin Folding and Compartmentalization to Dictate Enhancer-Promoter Communication and T Cell Fate. Cell. 2017 Sep 21;171(1):103-119.e18 Isoda
October 3, 2017 Mo Xu Littman Bunker JJ, Erickson SA, Flynn TM, Henry C, Koval JC, Meisel M, Jabri B, Antonopoulos DA, Wilson PC, Bendelac A (2017) Natural polyreactive IgA antibodies coat the intestinal microbiota. Science. 28 Sep 2017: DOI: 10.1126/science.aan6619 Bunker
October 3, 2017 Michelle Krogsgaard Krogsgaard Li L, Guo X, Shi X, Li C, Wu W, Yan C, Wang H, Li H, Xu C. Ionic CD3-Lck interaction regulates the initiation of T-cell receptor signaling. Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5891-E5899 Li
September 26, 2017 Priya Issuree Littman Geller LT, Barzily-Rokni M, Danino T, Jonas OH, Shental N, Nejman D, Gavert N, Zwang Y, Cooper ZA, Shee K, Thaiss CA, Reuben A, Livny J, Avraham R, Frederick DT, Ligorio M, Chatman K, Johnston SE, Mosher CM, Brandis A, Fuks G, Gurbatri C, Gopalakrishnan V, Kim M, Hurd MW, Katz M, Fleming J, Maitra A, Smith DA, Skalak M, Bu J, Michaud M, Trauger SA, Barshack I, Golan T, Sandbank J, Flaherty KT, Mandinova A, Garrett WS, Thayer SP, Ferrone CR, Huttenhower C, Bhatia SN, Gevers D, Wargo JA, Golub TR, Straussman R. Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine. Science. 2017 Sep 15; 357(6356): 1156-1160 Geller
September 26, 2017 Susan Schwab Schwab Tassetto M, Kunitomi M, Andino R. Circulating Immune Cells Mediate a Systemic RNAi-Based Adaptive Antiviral Response in Drosophila. Cell. 2017 Apr 6;169(2):314-325.e13 Tassetto
September 19, 2017 Oriana Perez Reizis Ribas A, Dummer R, Puzanov I, VanderWalde A, Andtbacka RHI, Michielin O, Olszanski AJ, Malvehy J, Cebon J, Fernandez E, Kirkwood JM, Gajewski TF, Chen L, Gorski KS, Anderson AA, Diede SJ, Lassman ME, Gansert J, Hodi FS, Long GV. Oncolytic Virotherapy Promotes Intratumoral T Cell Infiltration and Improves Anti-PD-1 Immunotherapy. Cell. 2017 Sep 7;170(6):1109-1119 Ribas
September 12, 2017 Doua Azzouz Silverman Magri G, Comerma L, Pybus M, Sintes J, Lligé D, Segura-Garzón D, Bascones S, Yeste A, Grasset EK, Gutzeit C, Uzzan M, Ramanujam M, van Zelm MC, Albero-González R, Vazquez I, Iglesias M, Serrano S, Márquez L, Mercade E, Mehandru S, Cerutti A. Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals. Immunity. 2017 Jul 18;47(1):118-134.e8 Magri
September 12, 2017 Charles Ng Littman Cardoso V, Chesné J, Ribeiro H, García-Cassani B, Carvalho T, Bouchery T, Shah K, Barbosa-Morais NL, Harris N, Veiga-Fernandes H. Neuronal regulation of type 2 innate lymphoid cells via neuromedin U. Nature. 2017 Sep 6. doi: 10.1038/nature23469. [Epub ahead of print] PubMed PMID: 28869974. Cardoso
September 5, 2017 Margaret Warren Reizis Baratin M, Simon L, Jorquera A, Ghigo C, Dembele D, Nowak J, Gentek R, Wienert S, Klauschen F, Malissen B, Dalod M, Bajénoff M. T Cell Zone Resident Macrophages Silently Dispose of Apoptotic Cells in the Lymph Node. Immunity. 2017 Aug 15;47(2):349-362.e5. doi: 10.1016/j.immuni.2017.07.019. Epub 2017 Aug 8. PubMed PMID: 28801233. Baratin
September 5, 2017 Katharine Lu Yang Koralov Burr ML, Sparbier CE, Chan YC, Williamson JC, Woods K, Beavis PA, Lam EYN, Henderson MA, Bell CC, Stolzenburg S, Gilan O, Bloor S, Noori T, Morgens DW, Bassik MC, Neeson PJ, Behren A, Darcy PK, Dawson SJ, Voskoboinik I, Trapani JA, Cebon J, Lehner PJ, Dawson MA. CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity. Nature. 2017 Aug 16. doi: 10.1038/nature23643. [Epub ahead of print] PubMed PMID: 28813417. Burr
August 29, 2017 Yu Matsuzawa Cadwell Zhang D, Chia C, Jiao X, Jin W, Kasagi S, Wu R, Konkel JE, Nakatsukasa H, Zanvit P, Goldberg N, Chen Q, Sun L, Chen ZJ, Chen W. D-mannose induces regulatory T cells and suppresses immunopathology. Nat Med. 2017 Sep;23(9):1036-1045 Zhang
August 29, 2017 Axel Concepcion Feske Patel SJ, Sanjana NE, Kishton RJ, Eidizadeh A, Vodnala SK, Cam M, Gartner JJ, Jia L, Steinberg SM, Yamamoto TN, Merchant AS, Mehta GU, Chichura A, Shalem O, Tran E, Eil R, Sukumar M, Guijarro EP, Day CP, Robbins P, Feldman S, Merlino G, Zhang F, Restifo NP. Identification of essential genes for cancer immunotherapy. Nature. 2017 Aug 31;548(7669):537-542 Patel
August 22, 2017 Ioanna Tiniakou Reizis Kwong B, Rua R, Gao Y, Flickinger J Jr, Wang Y, Kruhlak MJ, Zhu J, Vivier E, McGavern DB, Lazarevic V. T-bet-dependent NKp46(+) innate lymphoid cells regulate the onset of T(H)17-induced neuroinflammation. Nat Immunol. 2017 Aug 14. doi: 10.1038/ni.3816. [Epub ahead of print] PubMed PMID: 28805812. Kwong
August 22, 2017 Hao Xu Littman Li D, Meng L, Xu T, Su Y, Liu X, Zhang Z, Wang X. RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system. Elife. 2017 Aug 15;6. pii: e27692. doi: 10.7554/eLife.27692 Li
August 15, 2017 Jessica Neil Cadwell Cervantes-Barragan L, Chai JN, Tianero MD, DiLuccia B, Ahern PP, Merriman J, Cortez VS, Caparon MG, Donia MS, Gilfillan S, Cella M, Gordon JI, Hsieh CS, Colonna M. Lactobacillus reuteri induces gut intraepithelial CD4(+)CD8αα(+) T cells. Science. 2017 Aug 3. pii: eaah5825. doi: 10.1126/science.aah5825 Cervantes-Barragan
August 15, 2017 Brian Norris Ernst Galani IE, Triantafyllia V, Eleminiadou EE, Koltsida O, Stavropoulos A, Manioudaki M, Thanos D, Doyle SE, Kotenko SV, Thanopoulou K, Andreakos E. Interferon-λ Mediates Non-redundant Front-Line Antiviral Protection against Influenza Virus Infection without Compromising Host Fitness. Immunity. 2017 May 16;46(5):875-890.e6 Galani
August 8, 2017 Boris Reizis Reizis Takizawa H, Fritsch K, Kovtonyuk LV, Saito Y, Yakkala C, Jacobs K, Ahuja AK, Lopes M, Hausmann A, Hardt WD, Gomariz Á, Nombela-Arrieta C, Manz MG. Pathogen-Induced TLR4-TRIF Innate Immune Signaling in Hematopoietic Stem Cells Promotes Proliferation but Reduces Competitive Fitness. Cell Stem Cell. 2017 Jul 19. pii: S1934-5909(17)30239-4 Takizawa
August 8, 2017 Matt Keller Cadwell Steed AL, Christophi GP, Kaiko GE, Sun L, Goodwin VM, Jain U, Esaulova E, Artyomov MN, Morales DJ, Holtzman MJ, Boon ACM, Lenschow DJ, Stappenbeck TS. The microbial metabolite desaminotyrosine protects from influenza through type I interferon. Science. 2017 Aug 4;357(6350):498-502 Steed
August 1, 2017 Ulrike Kaufmann Feske Rauber S, Luber M, Weber S, Maul L, Soare A, Wohlfahrt T, Lin NY, Dietel K, Bozec A, Herrmann M, Kaplan MH, Weigmann B, Zaiss MM, Fearon U, Veale DJ, Cañete JD, Distler O, Rivellese F, Pitzalis C, Neurath MF, McKenzie ANJ, Wirtz S, Schett G, Distler JHW, Ramming A. Resolution of inflammation by interleukin-9-producing type 2 innate lymphoid cells. Nat Med. 2017 Jul 17. doi: 10.1038/nm.4373. [Epub ahead of print] PubMed PMID: 28714991. Rauber
August 1, 2017 Hannah Fehlner-Peach Littman Mariño E, Richards JL, McLeod KH, Stanley D, Yap YA, Knight J, McKenzie C, Kranich J, Oliveira AC, Rossello FJ, Krishnamurthy B, Nefzger CM, Macia L, Thorburn A, Baxter AG, Morahan G, Wong LH, Polo JM, Moore RJ, Lockett TJ, Clarke JM, Topping DL, Harrison LC, Mackay CR. Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes. Nat Immunol. 2017 May;18(5):552-562. Mariño
July 25, 2017 Juan Lafaille Lafaille Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA. Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen. Immunity. 2017 Jul 18;47(1):107-117.e8. Leonard
July 18, 2017 Duane Moogk Krogsgaard Ott PA, Hu Z, Keskin DB, Shukla SA, Sun J, Bozym DJ, Zhang W, Luoma A, Giobbie-Hurder A, Peter L, Chen C, Olive O, Carter TA, Li S, Lieb DJ, Eisenhaure T, Gjini E, Stevens J, Lane WJ, Javeri I, Nellaiappan K, Salazar AM, Daley H, Seaman M, Buchbinder EI, Yoon CH, Harden M, Lennon N, Gabriel S, Rodig SJ, Barouch DH, Aster JC, Getz G, Wucherpfennig K, Neuberg D, Ritz J, Lander ES, Fritsch EF, Hacohen N, Wu CJ. An immunogenic personal neoantigen vaccine for patients with melanoma. Nature. 2017 Jul 13;547(7662):217-221 Ott
July 18, 2017 Patricia Martin Cadwell St Leger AJ, Desai JV, Drummond RA, Kugadas A, Almaghrabi F, Silver P, Raychaudhuri K, Gadjeva M, Iwakura Y, Lionakis MS, Caspi RR. An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells. Immunity. 2017 Jul 18;47(1):148-158.e5 St Leger
July 11, 2017 Sascha Kahlfuss Feske Laffont S, Blanquart E, Savignac M, Cénac C, Laverny G, Metzger D, Girard JP, Belz GT, Pelletier L, Seillet C, Guéry JC. Androgen signaling negatively controls group 2 innate lymphoid cells. J Exp Med. 2017 Jun 5;214(6):1581-1592 Laffont
July 11, 2017 Audrey Baeyens Schwab Zhu S, Ding S, Wang P, Wei Z, Pan W, Palm NW, Yang Y, Yu H, Li HB, Wang G, Lei X, de Zoete MR, Zhao J, Zheng Y, Chen H, Zhao Y, Jurado KA, Feng N, Shan L, Kluger Y, Lu J, Abraham C, Fikrig E, Greenberg HB, Flavell RA. Nlrp9b inflammasome restricts rotavirus infection in intestinal epithelial cells. Nature. 2017 Jun 29;546(7660):667-670 Zhu
June 20, 2017 Joel Ernst Ernst Moguche AO, Musvosvi M, Penn-Nicholson A, Plumlee CR, Mearns H, Geldenhuys H, Smit E, Abrahams D, Rozot V, Dintwe O, Hoff ST, Kromann I, Ruhwald M, Bang P, Larson RP, Shafiani S, Ma S, Sherman DR, Sette A, Lindestam Arlehamn CS, McKinney DM, Maecker H, Hanekom WA, Hatherill M, Andersen P, Scriba TJ, Urdahl KB. Antigen Availability Shapes T Cell Differentiation and Function during Tuberculosis. Cell Host Microbe. 2017 Jun 14;21(6):695-706.e5. Moguche
June 20, 2017 Martin Vaeth Feske Shan Q, Zeng Z, Xing S, Li F, Hartwig SM, Gullicksrud JA, Kurup SP, Van Braeckel-Budimir N, Su Y, Martin MD, Varga SM, Taniuchi I, Harty JT, Peng W, Badovinac VP, Xue HH. The transcription factor Runx3 guards cytotoxic CD8(+) effector T cells against deviation towards follicular helper T cell lineage. Nat Immunol. 2017 Jun 12. doi: 10.1038/ni.3773. [Epub ahead of print] PubMed PMID:28604718. Shan
June 13, 2017 Raquel Arifa Lafaille Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA. Interferon-γ Drives T(reg) Fragility to Promote Anti-tumor Immunity. Cell. 2017 Jun 1;169(6):1130-1141.e11 Overacre-Delgoffe
June 6, 2017 Lin Wu Littman Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation. Cell. 2017 Jun 1;169(6):1119-1129.e11. doi: 10.1016/j.cell.2017.05.002. Epub 2017 May 25. PubMed PMID: 28552347. Ali
June 6, 2017 Ali Rashidfarrokhi Reizis Ip WKE, Hoshi N, Shouval DS, Snapper S, Medzhitov R. Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages. Science. 2017 May 5;356(6337):513-519. doi: 10.1126/science.aal3535. PubMed PMID: 28473584. Ip
May 30, 2017 June-Yong Lee Littman Minutti CM, Jackson-Jones LH, García-Fojeda B, Knipper JA, Sutherland TE, Logan N, Rinqvist E, Guillamat-Prats R, Ferenbach DA, Artigas A, Stamme C, Chroneos ZC, Zaiss DM, Casals C, Allen JE. Local amplifiers of IL-4Rα-mediated macrophage activation promote repair in lung and liver. Science. 2017 May 11. pii: eaaj2067. doi: 10.1126/science.aaj2067. [Epub ahead of print] PubMed PMID:28495878. Minutti
May 30, 2017 Eugene Rudensky Cadwell Morales AJ, Carrero JA, Hung PJ, Tubbs AT, Andrews JM, Edelson BT, Calderon B, Innes CL, Paules RS, Payton JE, Sleckman BP. A type I IFN-dependent DNA damage response regulates the genetic program and inflammasome activation in macrophages. Elife. 2017 Mar 31;6. pii: e24655. doi: 10.7554/eLife.24655. PubMed PMID: 28362262; PubMed Central PMCID: PMC5409825. Morales
May 23, 2017 Maria Pokrovskii Littman

Lis R, Karrasch CC, Poulos MG, Kunar B, Redmond D, Duran JGB, Badwe CR, Schachterle W, Ginsberg M, Xiang J, Tabrizi AR, Shido K, Rosenwaks Z, Elemento O, Speck NA, Butler JM, Scandura JM, Rafii S. Conversion of adult endothelium to immunocompetent haematopoietic stem cells. Nature. 2017 May 17. doi: 10.1038/nature22326. [Epub ahead of print] PubMed PMID: 28514438.

Sugimura R, Jha DK, Han A, Soria-Valles C, da Rocha EL, Lu YF, Goettel JA, Serrao E, Rowe RG, Malleshaiah M, Wong I, Sousa P, Zhu TN, Ditadi A, Keller G, Engelman AN, Snapper SB, Doulatov S, Daley GQ. Haematopoietic stem and progenitor cells from human pluripotent stem cells. Nature. 2017 May 17. doi: 10.1038/nature22370. [Epub ahead of print] PubMed PMID: 28514439.

Lis

Sugimura

May 23, 2017 Ludovic Desvignes Ernst Wolf Y, Boura-Halfon S, Cortese N, Haimon Z, Sar Shalom H, Kuperman Y, Kalchenko V, Brandis A, David E, Segal-Hayoun Y, Chappell-Maor L, Yaron A, Jung S. Brown-adipose-tissue macrophages control tissue innervation and homeostatic energy expenditure. Nat Immunol. 2017 Jun;18(6):665-674. doi: 10.1038/ni.3746. Epub 2017 May 1. PubMed PMID: 28459435. Wolf
May 2, 2017 James Muller Dustin Lu P, Shih C, Qi H. Ephrin B1-mediated repulsion and signaling control germinal center T cell territoriality and function. Science. 2017 Apr 13. pii: eaai9264. doi: 10.1126/science.aai9264. [Epub ahead of print] PubMed PMID: 28408722. Lu
May 2, 2017 Maria Lafaille M. Lafaille Van Dyken SJ, Liang HE, Naikawadi RP, Woodruff PG, Wolters PJ, Erle DJ, Locksley RM. Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease. Cell. 2017 Apr 20;169(3):497-509.e13. doi: 10.1016/j.cell.2017.03.044. PubMed PMID: 28431248. Van Dyken
April 25, 2017 Adam Pelzek Silverman Turner JS, Marthi M, Benet ZL, Grigorova I. Transiently antigen-primed B cells return to naive-like state in absence of T-cell help. Nat Commun. 2017 Apr 21;8:15072 Turner
April 18, 2017 Varsha Raghavan Littman Moor K, Diard M, Sellin ME, Felmy B, Wotzka SY, Toska A, Bakkeren E, Arnoldini M, Bansept F, Co AD, Völler T, Minola A, Fernandez-Rodriguez B, Agatic G, Barbieri S, Piccoli L, Casiraghi C, Corti D, Lanzavecchia A, Regoes RR, Loverdo C, Stocker R, Brumley DR, Hardt WD, Slack E. High-avidity IgA protects the intestine by enchaining growing bacteria. Nature. 2017 Apr 12. doi: 10.1038/nature22058. [Epub ahead of print] PubMed PMID: 28405025 Moor
April 18, 2017 Sean Saunders M. Lafaille Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Hervé PL, Dériaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eléouët JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissières P, Lo-Man R. Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity. Immunity. 2017 Feb 21;46(2):301-314 Zhivaki
April 11, 2017 Jhimmy Talbot Littman Bouziat R, Hinterleitner R, Brown JJ, Stencel-Baerenwald JE, Ikizler M, Mayassi T, Meisel M, Kim SM, Discepolo V, Pruijssers AJ, Ernest JD, Iskarpatyoti JA, Costes LM, Lawrence I, Palanski BA, Varma M, Zurenski MA, Khomandiak S, McAllister N, Aravamudhan P, Boehme KW, Hu F, Samsom JN, Reinecker HC, Kupfer SS, Guandalini S, Semrad CE, Abadie V, Khosla C, Barreiro LB, Xavier RJ, Ng A, Dermody TS, Jabri B. Reovirus infection triggers inflammatory responses to dietary antigens and development of celiac disease. Science. 2017 Apr 7;356(6333):44-50 Bouziat
April 11, 2017 Hernandez Moura Silva Lafaille Shan B, Wang X, Wu Y, Xu C, Xia Z, Dai J, Shao M, Zhao F, He S, Yang L, Zhang M, Nan F, Li J, Liu J, Liu J, Jia W, Qiu Y, Song B, Han JJ, Rui L, Duan SZ, Liu Y. The metabolic ER stress sensor IRE1α suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nat Immunol. 2017 Mar 27. doi: 10.1038/ni.3709. [Epub ahead of print] PubMed PMID: 28346409. Shan
April 4, 2017 Mo Xu Littman Taylor MJ, Husain K, Gartner ZJ, Mayor S, Vale RD. A DNA-Based T Cell Receptor Reveals a Role for Receptor Clustering in Ligand Discrimination. Cell. 2017 Mar 23;169(1):108-119.e20. doi: 10.1016/j.cell.2017.03.006. PubMed PMID: 28340336. Taylor
April 4, 2017 P'ng Loke Loke Piccolo V, Curina A, Genua M, Ghisletti S, Simonatto M, Sabò A, Amati B, Ostuni R, Natoli G. Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk. Nat Immunol. 2017 Mar 13. doi: 10.1038/ni.3710. [Epub ahead of print] PubMed PMID: 28288101. Piccolo
March 28, 2017 Priya Issuree Littman Choi S, Warzecha C, Zvezdova E, Lee J, Argenty J, Lesourne R, Aravind L, Love PE. THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1. Nat Immunol. 2017 Apr;18(4):433-441 Choi
March 28, 2017 Ken Cadwell Cadwell Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 2017 Mar 9;168(6):1135-1148.e12 Yissachar
March 21, 2017 Charles Ng Littman Kamphorst AO, Wieland A, Nasti T, Yang S, Zhang R, Barber DL, Konieczny BT, Daugherty CZ, Koenig L, Yu K, Sica GL, Sharpe AH, Freeman GJ, Blazar BR, Turka LA, Owonikoko TK, Pillai R, Ramalingam SS, Araki K, Ahmed R. Rescue of exhausted CD8 T cells by PD-1-targeted therapies is CD28-dependent. Science. 2017 Mar 9. pii: eaaf0683. doi: 10.1126/science.aaf0683. [Epub ahead of print] PubMed PMID:28280249. Kamphorst
March 14, 2017 Doua Azzouz Silverman Geva-Zatorsky N, Sefik E, Kua L, Pasman L, Tan TG, Ortiz-Lopez A, Yanortsang TB, Yang L, Jupp R, Mathis D, Benoist C, Kasper DL. Mining the Human Gut Microbiota for Immunomodulatory Organisms. Cell. 2017 Feb 23;168(5):928-943 Geva-Zatorsky
March 14, 2017 Susan Schwab Schwab Pan Y, Tian T, Park CO, Lofftus SY, Mei S, Liu X, Luo C, O'Malley JT, Gehad A, Teague JE, Divito SJ, Fuhlbrigge R, Puigserver P, Krueger JG, Hotamisligil GS, Clark RA, Kupper TS. Survival of tissue-resident memory T cells requires exogenous lipid uptake and metabolism. Nature. 2017 Feb 20. doi: 10.1038/nature21379. [Epub ahead of print] PubMed PMID: 28219080. Pan
March 7, 2017 Katharine Yang Koralov Spath S, Komuczki J, Hermann M, Pelczar P, Mair F, Schreiner B, Becher B. Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System. Immunity. 2017 Feb 21;46(2):245-260 Spath
March 7, 2017 Margaret Warren Reizis Sakamoto K, Kim Y-G, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, Núñez G. 2017. IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections. Science Immunology. 03 Feb 2017. Vo. 2, Issue 8. DOI: 10.1126/sciimmunol.aai8371 Sakamoto
February 28, 2017 Yu Matsuzawa Cadwell Karki R, Man SM, Malireddi RK, Kesavardhana S, Zhu Q, Burton AR, Sharma BR, Qi X, Pelletier S, Vogel P, Rosenstiel P, Kanneganti TD. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016 Dec 12. doi: 10.1038/nature20597. [Epub ahead of print] PubMed PMID: 27951586. Karki
February 21, 2017 Ioanna Tiniakou Reizis Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, Patel R, Gautier EL, Hugues S, Longhi MP, Henry JY, Quezada SA, Lauvau G, Lennon-Duménil AM, Gutiérrez-Martínez E, Bessis A, Gomez-Perdiguero E, Jacome-Galarza CE, Garner H, Geissmann F, Golub R, Nussenzweig MC, Guermonprez P. The Heterogeneity of Ly6C(hi) Monocytes Controls Their Differentiation into iNOS(+) Macrophages or Monocyte-Derived Dendritic Cells. Immunity. 2016 Dec 20;45(6):1205-1218 Menezes
February 21, 2017 Mick Ménager Littman

Chen J, Ganguly A, Mucsi AD, Meng J, Yan J, Detampel P, Munro F, Zhang Z, Wu M, Hari A, Stenner MD, Zheng W, Kubes P, Xia T, Amrein MW, Qi H, Shi Y. Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy. J Exp Med. 2017 Feb;214(2):327-338

Yan J, Liu B, Shi Y, Qi H. Class II MHC-independent suppressive adhesion of dendritic cells by regulatory T cells in vivo. J Exp Med. 2017 Feb;214(2):319-326

Chen

Yan

February 14, 2017 Vanja Sisirak Reizis Brewitz A, Eickhoff S, Dähling S, Quast T, Bedoui S, Kroczek RA, Kurts C, Garbi N, Barchet W, Iannacone M, Klauschen F, Kolanus W, Kaisho T, Colonna M, Germain RN, Kastenmüller W. CD8+ T Cells Orchestrate pDC-XCR1+ Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming. Immunity In Press Corrected Proof DOI: http://dx.doi.org/10.1016/j.immuni.2017.01.003 Brewitz
February 14, 2017 Axel Concepcion Feske Rao DA, Gurish MF, Marshall JL, Slowikowski K, Fonseka CY, Liu Y, Donlin LT, Henderson LA, Wei K, Mizoguchi F, Teslovich NC, Weinblatt ME, Massarotti EM, Coblyn JS, Helfgott SM, Lee YC, Todd DJ, Bykerk VP, Goodman SM, Pernis AB, Ivashkiv LB, Karlson EW, Nigrovic PA, Filer A, Buckley CD, Lederer JA, Raychaudhuri S, Brenner MB. Pathologically expanded peripheral T helper cell subset drives B cells in rheumatoid arthritis. Nature. 2017 Feb 1;542(7639):110-114 Rao
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May 24, 2016 Hernandez Moura Silva Lafaille Chu H, Khosravi A, Kusumawardhani IP, Kwon AH, Vasconcelos AC, Cunha LD, Mayer AE, Shen Y, Wu WL, Kambal A, Targan SR, Xavier RJ, Ernst PB, Green DR, McGovern DP, Virgin HW, Mazmanian SK. Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease. Science. 2016 May 27;352(6289):1116-20 Chu
May 17, 2016 Adam Pelzek Silverman Zeng MY, Cisalpino D, Varadarajan S, Hellman J, Warren HS, Cascalho M, Inohara N, Núñez G. Gut Microbiota-Induced Immunoglobulin G Controls Systemic Infection by Symbiotic Bacteria and Pathogens. Immunity. 2016 Mar 15;44(3):647-58 Zeng
May 17, 2016 Varsha Raghavan Littman Vatanen T, Kostic AD, d'Hennezel E, Siljander H, Franzosa EA, Yassour M, Kolde R, Vlamakis H, Arthur TD, Hämäläinen AM, Peet A, Tillmann V, Uibo R, Mokurov S, Dorshakova N, Ilonen J, Virtanen SM, Szabo SJ, Porter JA, Lähdesmäki H, Huttenhower C, Gevers D, Cullen TW, Knip M; DIABIMMUNE Study Group, Xavier RJ. Variation in Microbiome LPS Immunogenicity Contributes to Autoimmunity in Humans. Cell. 2016 May 5;165(4):842-53 Vatanen
May 10, 2016 Jhimmy Talbot Littman Koch MA, Reiner GL, Lugo KA, Kreuk LS, Stanbery AG, Ansaldo E, Seher TD, Ludington WB, Barton GM. Maternal IgG and IgA Antibodies Dampen Mucosal T Helper Cell Responses in Early Life. Cell. 2016 May 5;165(4):827-41 Koch
May 3, 2016 James Muller Dustin Verbist KC, Guy CS, Milasta S, Liedmann S, Kamiński MM, Wang R, Green DR. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature. 2016 Apr 21;532(7599):389-93 Verbist
May 3, 2016 Ken Cadwell Cadwell Beura LK, Hamilton SE, Bi K, Schenkel JM, Odumade OA, Casey KA, Thompson EA, Fraser KA, Rosato PC, Filali-Mouhim A, Sekaly RP, Jenkins MK, Vezys V, Haining WN, Jameson SC, Masopust D. Normalizing the environment recapitulates adult human immune traits in laboratory mice. Nature. 2016 Apr 20. doi: 10.1038/nature17655. [Epub ahead of print] PubMed PMID: 27096360. Beura
April 19, 2016 Priya Issuree Littman Wang J, Kubes P. A Reservoir of Mature Cavity Macrophages that Can Rapidly Invade Visceral Organs to Affect Tissue Repair. Cell. 2016 Apr 6. pii: S0092-8674(16)30265-3. doi: 10.1016/j.cell.2016.03.009. [Epub ahead of print] PubMed PMID: 27062926. Wang
April 19, 2016 Mo Xu Littman Fourgeaud L, Través PG, Tufail Y, Leal-Bailey H, Lew ED, Burrola PG, Callaway P, Zagórska A, Rothlin CV, Nimmerjahn A, Lemke G. TAM receptors regulate multiple features of microglial physiology. Nature. 2016 Apr 14;532(7598):240-4 Fourgeaud
April 12, 2016 Katharine Yang Koralov Yang W, Bai Y, Xiong Y, Zhang J, Chen S, Zheng X, Meng X, Li L, Wang J, Xu C, Yan C, Wang L, Chang CC, Chang TY, Zhang T, Zhou P, Song BL, Liu W, Sun SC, Liu X, Li BL, Xu C (2016) Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism. Nature. 531(7596):651-5 Yang
April 12, 2016 Charles Ng Littman Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E, Silva-Santos B. TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets. Nat Immunol. 2016 Apr 4. doi: 10.1038/ni.3424. [Epub ahead of print] PubMed PMID: 27043412. Muñoz-Ruiz
April 5, 2016 Doua Azzouz Silverman Ruane D, Chorny A, Lee H, Faith J, Pandey G, Shan M, Simchoni N, Rahman A, Garg A, Weinstein EG, Oropallo M, Gaylord M, Ungaro R, Cunningham-Rundles C, Alexandropoulos K, Mucida D, Merad M, Cerutti A, Mehandru S. (2016) Microbiota regulate the ability of lung dendritic cells to induce IgA class-switch recombination and generate protective gastrointestinal immune responses. J Exp Med. 213(1):53-73. Ruane
April 5, 2016 Sang-Won Kim Littman Esterházy D, Loschko J, London M, Jove V, Oliveira TY, Mucida D. Classical dendritic cells are required for dietary antigen-mediated induction of peripheral T(reg) cells and tolerance. Nat Immunol. 2016 Mar 28. doi: 10.1038/ni.3408. [Epub ahead of print] PubMed PMID: 27019226. Esterházy
March 29, 2016 Vickie Fang Schwab Ma C, Kesarwala AH, Eggert T, Medina-Echeverz J, Kleiner DE, Jin P, Stroncek DF, Terabe M, Kapoor V, ElGindi M, Han M, Thornton AM, Zhang H, Egger M, Luo J, Felsher DW, McVicar DW, Weber A, Heikenwalder M, Greten TF. (2016) NAFLD causes selective CD4(+) T lymphocyte loss and promotes hepatocarcinogenesis. Nature. 531(7593):253-7 Ma
March 29, 2016 Jessica Neil Cadwell C. Nakahashi-Oda, K. G. S. Udayanga, Y. Nakamura, Y. Nakazawa, N. Totsuka, H. Miki, S. Iino, S. Tahara-Hanaoka, S.-i. Honda, K. Shibuya and A. Shibuya. Apoptotic epithelial cells control the abundance of Treg cells at barrier surfaces. Nat Immunol. 2016. 17(4): 441-450. Nakahashi-Oda
March 22, 2016 Mick Ménager Littman Basu R, Whitlock BM, Husson J, Le Floc'h A, Jin W, Oyler-Yaniv A, Dotiwala F, Giannone G, Hivroz C, Biais N, Lieberman J, Kam LC, Huse M. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing. Cell. 2016 Feb 24. pii: S0092-8674(16)00061-1. doi: 10.1016/j.cell.2016.01.021. [Epub ahead of print] PubMed PMID: 26924577. Basu
March 22, 2016 Duane Moogk Krogsgaard Gros A, Parkhurst MR, Tran E, Pasetto A, Robbins PF, Ilyas S, Prickett TD, Gartner JJ, Crystal JS, Roberts IM, Trebska-McGowan K, Wunderlich JR, Yang JC, Rosenberg SA. Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients. Nat Med. 2016 Feb 22. doi: 10.1038/nm.4051. [Epub ahead of print] PubMed PMID: 26901407. Gros
March 15, 2016 Yu Matsuzawa Cadwell Zhong Z, Umemura A, Sanchez-Lopez E, Liang S, Shalapour S, Wong J, He F, Boassa D, Perkins G, Ali SR, McGeough MD, Ellisman MH, Seki E, Gustafsson AB, Hoffman HM, Diaz-Meco MT, Moscat J, Karin M. NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria. Cell. 2016 Feb 25;164(5):896-910. doi: 10.1016/j.cell.2015.12.057. PubMed PMID: 26919428; PubMed Central PMCID: PMC4769378. Zhong
March 15, 2016 Hao Xu Littman Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF. Transient inhibition of ROR-γt therapeutically limits intestinal inflammation by reducing T(H)17 cells and preserving group 3 innate lymphoid cells. Nat Med. 2016 Feb 15. doi: 10.1038/nm.4046. [Epub ahead of print] PubMed PMID: 26878233. Withers
March 8, 2016 Matthew Keller Cadwell Kabat AM, Harrison OJ, Riffelmacher T, Moghaddam AE, Pearson CF, Laing A, Abeler-Dörner L, Forman SP, Grencis RK, Sattentau Q, Simon AK, Pott J, Maloy KJ. The autophagy gene Atg16l1 differentially regulates Treg and TH2 cells to control intestinal inflammation. Elife. 2016 Feb 24;5. pii: e12444. doi: 10.7554/eLife.12444. [Epub ahead of print] PubMed PMID: 26910010. Kabat
March 1, 2016 Hannah Fehlner-Peach Littman Kim KS, Hong SW, Han D, Yi J, Jung J, Yang BG, Lee JY, Lee M, Surh CD. Dietary antigens limit mucosal immunity by inducing regulatory T cells in the small intestine. Science. 2016 Feb 19;351(6275):858-63 Kim
March 1, 2016 Brian Norris Ernst Tas JM, Mesin L, Pasqual G, Targ S, Jacobsen JT, Mano YM, Chen CS, Weill JC, Reynaud CA, Browne EP, Meyer-Hermann M, Victora GD. Visualizing antibody affinity maturation in germinal centers. Science. 2016 Feb 18. pii: aad3439. [Epub ahead of print] PubMed PMID: 26912368. Tas
February 23, 2016 Juan Lafaille Lafaille Park Y, Jin HS, Lopez J, Lee J, Liao L, Elly C, Liu YC. SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex. Nat Immunol. 2016 Mar;17(3):286-96 Park
February 23, 2016 Kirsten Wiens Ernst Long JS, Giotis ES, Moncorgé O, Frise R, Mistry B, James J, Morisson M, Iqbal M, Vignal A, Skinner MA, Barclay WS. Species difference in ANP32A underlies influenza A virus polymerase host restriction. Nature. 2016 Jan 7;529(7584):101-4 Long
February 16, 2016 Patricia Martin Cadwell Howitt MR, Lavoie S, Michaud M, Blum AM, Tran SV, Weinstock JV, Gallini CA, Redding K, Margolskee RF, Osborne LC, Artis D, Garrett WS. Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science. 2016 Feb 4. pii: aaf1648. [Epub ahead of print] PubMed PMID: 26847546. Howitt
February 16, 2016 Teruyuki Sano Littman Pillay S, Meyer NL, Puschnik AS, Davulcu O, Diep J, Ishikawa Y, Jae LT, Wosen JE, Nagamine CM, Chapman MS, Carette JE. An essential receptor for adeno-associated virus infection. Nature. 2016 Jan 27. doi: 10.1038/nature16465. [Epub ahead of print] PubMed PMID: 26814968. Pillay
February 9, 2016 Joel Ernst Ernst Tan J, Pieper K, Piccoli L, Abdi A, Foglierini M, Geiger R, Tully CM, Jarrossay D, Ndungu FM, Wambua J, Bejon P, Fregni CS, Fernandez-Rodriguez B, Barbieri S, Bianchi S, Marsh K, Thathy V, Corti D, Sallusto F, Bull P, Lanzavecchia A. A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens. Nature. 2016 Jan 7; 529 (7584): 105-9 Tan
February 9, 2016 Ulrike Kaufmann Feske Luo CT, Liao W, Dadi S, Toure A, Li MO. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016 Jan 28; 529 (7587): 532-6 Luo
February 2, 2016 Audrey Baeyens Schwab Kiermaier E, Moussion C, Veldkamp CT, Gerardy-Schahn R, de Vries I, Williams LG, Chaffee GR, Phillips AJ, Freiberger F, Imre R, Taleski D, Payne RJ, Braun A, Förster R, Mechtler K, Mühlenhoff M, Volkman BF, Sixt M. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science. 2016 Jan 8;351(6269):186-90 Kiermaier
January 26, 2016 Wendy Huang Littman York AG, Williams KJ, Argus JP, Zhou QD, Brar G, Vergnes L, Gray EE, Zhen A, Wu NC, Yamada DH, Cunningham CR, Tarling EJ, Wilks MQ, Casero D, Gray DH, Yu AK, Wang ES, Brooks DG, Sun R, Kitchen SG, Wu TT, Reue K, Stetson DB, Bensinger SJ. Limiting Cholesterol Biosynthetic Flux Spontaneously Engages Type I IFN Signaling. Cell. 2015 Dec 17;163(7):1716-29 York
January 26, 2016 Martin Vaeth Feske Jain R, Chen Y, Kanno Y, Joyce-Shaikh B, Vahedi G, Hirahara K, Blumenschein WM, Sukumar S, Haines CJ, Sadekova S, McClanahan TK, McGeachy MJ, O'Shea JJ, Cua DJ. Interleukin-23-Induced Transcription Factor Blimp-1 Promotes Pathogenicity of T Helper 17 Cells. Immunity. 2016 Jan 19;44(1):131-42 Jain
January 19, 2016 Lin Wu Littman von Moltke J, Ji M, Liang HE, Locksley RM. Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit. Nature. 2016 Jan 14;529(7585):221-5 von Moltke
January 19, 2016 Maryaline Coffre Koralov Weisel FJ, Zuccarino-Catania GV, Chikina M, Shlomchik MJ. A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells. Immunity. 2016 Jan 19;44(1):116-30 Weisel
January 12, 2016 Ludovic Desvignes Ernst Mujal AM, Gilden JK, Gérard A, Kinoshita M, Krummel MF. A septin requirement differentiates autonomous and contact-facilitated T cell proliferation. Nat Immunol. 2015 Dec 21. doi: 10.1038/ni.3330. [Epub ahead of print] Mujal
January 12, 2016 Mate Maus Feske Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, Tonc E, Schreiber RD, Pearce EJ, Pearce EL. Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression. Cell. 2015 Sep 10;162(6):1229-41 Chang
January 5, 2016 Maria Pokrovskii Littman Lindemans CA, Calafiore M, Mertelsmann AM, O'Connor MH, Dudakov JA, Jenq RR, Velardi E, Young LF, Smith OM, Lawrence G, Ivanov JA, Fu YY, Takashima S, Hua G, Martin ML, O'Rourke KP, Lo YH, Mokry M, Romera-Hernandez M, Cupedo T, Dow LE, Nieuwenhuis EE, Shroyer NF, Liu C, Kolesnick R, van den Brink MR, Hanash AM. Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration. Nature. 2015 Dec 24;528(7583):560-4 Lindemans
December 22, 2015 Ken Cadwell Cadwell Kimmey JM, Huynh JP, Weiss LA, Park S, Kambal A, Debnath J, Virgin HW, Stallings CL. Unique role for ATG5 in neutrophil-mediated immunopathology during M. tuberculosis infection. Nature. 2015 Dec 24;528(7583):565-9 Kimmey
December 22, 2015 Hernandez Moura Silva Lafaille Pikor NB, Astarita JL, Summers-Deluca L, Galicia G, Qu J, Ward LA, Armstrong S, Dominguez CX, Malhotra D, Heiden B, Kay R, Castanov V, Touil H, Boon L, O'Connor P, Bar-Or A, Prat A, Ramaglia V, Ludwin S, Turley SJ, Gommerman JL. Integration of Th17- and Lymphotoxin-Derived Signals Initiates Meningeal-Resident Stromal Cell Remodeling to Propagate Neuroinflammation. Immunity. 2015 Dec 15;43(6):1160-73 Pikor
December 15, 2015 Varsha Raghavan Littman Levy M, Thaiss CA, Zeevi D, Dohnalová L, Zilberman-Schapira G, Mahdi JA, David E, Savidor A, Korem T, Herzig Y, Pevsner-Fischer M, Shapiro H, Christ A, Harmelin A, Halpern Z, Latz E, Flavell RA, Amit I, Segal E, Elinav E. Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling. Cell. 2015 Dec 3;163(6):1428-43 Levy
December 15, 2015 Jhimmy Talbot Littman Feng Y, van der Veeken J, Shugay M, Putintseva EV, Osmanbeyoglu HU, Dikiy S, Hoyos BE, Moltedo B, Hemmers S, Treuting P, Leslie CS, Chudakov DM, Rudensky AY. A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. Nature. 2015 Dec 3;528(7580):132-6 Feng
December 8, 2015 Adam Pelzek Silverman Legoux FP, Lim JB, Cauley AW, Dikiy S, Ertelt J, Mariani TJ, Sparwasser T, Way SS, Moon JJ. CD4(+) T Cell Tolerance to Tissue-Restricted Self Antigens Is Mediated by Antigen-Specific Regulatory T Cells Rather Than Deletion. Immunity. 2015 Nov 17;43(5):896-908 Legoux
December 8, 2015 Aswin Natarajan Krogsgaard Lee MS, Glassman CR, Deshpande NR, Badgandi HB, Parrish HL, Uttamapinant C, Stawski PS, Ting AY, Kuhns MS. A Mechanical Switch Couples T Cell Receptor Triggering to the Cytoplasmic Juxtamembrane Regions of CD3ζζ. Immunity. 2015 Aug 18;43(2):227-39 Lee
December 1, 2015 Shika Ramanan Cadwell Gasteiger G, Fan X, Dikiy S, Lee SY, Rudensky AY. Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs. Science. 2015 Nov 20;350(6263):981-5 Gasteiger
December 1, 2015 June-Yong Lee Littman Scharschmidt TC, Vasquez KS, Truong HA, Gearty SV, Pauli ML, Nosbaum A, Gratz IK, Otto M, Moon JJ, Liese J, Abbas AK, Fischbach MA, Rosenblum MD. A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes. Immunity. 2015 Nov 17;43(5):1011-21 Scharschmidt
November 24, 2015 James Muller Dustin    
November 24, 2015 Jason Hall Littman Wang C, Yosef N, Gaublomme J, Wu C, Lee Y, Clish CB, Kaminski J, Xiao S, Zu Horste GM, Pawlak M, Kishi Y, Joller N, Karwacz K, Zhu C, Ordovas-Montanes M, Madi A, Wortman I, Miyazaki T, Sobel RA, Park H, Regev A, Kuchroo VK (2015) CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity. Cell. Published online November 18 ahead of print. pii: S0092-8674(15)01424-5 Wang
November 17, 2015 Mo Xu Littman Takaba H, Morishita Y, Tomofuji Y, Danks L, Nitta T, Komatsu N, Kodama T, Takayanagi H (2015) Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. Cell 163(4):975-87 Takaba
November 17, 2015 Stefan Feske Feske Parnas O, Jovanovic M, Eisenhaure TM, Herbst RH, Dixit A, Ye CJ, Przybylski D, Platt RJ, Tirosh I, Sanjana NE, Shalem O, Satija R, Raychowdhury R, Mertins P, Carr SA, Zhang F, Hacohen N, Regev A (2015) A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks. Cell 162(3):675-86 Parnas
November 10, 2015 Charles Ng Littman Peng D, Kryczek I, Nagarsheth N, Zhao L, Wei S, Wang W, Sun Y, Zhao E, Vatan L, Szeliga W, Kotarski J, Tarkowski R, Dou Y, Cho K, Hensley-Alford S, Munkarah A, Liu R, Zou W (2015) Epigenetic silencing of T(H)1-type chemokines shapes tumour immunity and immunotherapy. Nature 527:249-253. Peng
November 10, 2015 Priya Issuree Littman Vétizou M, Pitt JM, Daillère R, Lepage P, Waldschmitt N, Flament C, Rusakiewicz S, Routy B, Roberti MP, Duong CP, Poirier-Colame V, Roux A, Becharef S, Formenti S, Golden E, Cording S, Eberl G, Schlitzer A, Ginhoux F, Mani S, Yamazaki T, Jacquelot N, Enot DP, Bérard M, Nigou J, Opolon P, Eggermont A, Woerther PL, Chachaty E, Chaput N, Robert C, Mateus C, Kroemer G, Raoult D, Boneca IG, Carbonnel F, Chamaillard M, Zitvogel L (2015) Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science. Published online November 5 ahead of print. Vétizou
November 3, 2015 Sang-Won Kim Littman Hoshino, A., Costa-Silva, B., Shen, T.-L., Rodrigues, G., Hashimoto, A., Tesic Mark, M., Molina, H., Kohsaka, S., Di Giannatale, A., Ceder, S., Singh, S., Williams, C., Soplop, N., Uryu, K., Pharmer, L., King, T., Bojmar, L., Davies, A. E., Ararso, Y., Zhang, T., Zhang, H., Hernandez, J., Weiss, J. M., Dumont-Cole, V. D., Kramer, K., Wexler, L. H., Narendran, A., Schwartz, G. K., Healey, J. H., Sandstrom, P., Jørgen Labori, K., Kure, E. H., Grandgenett, P. M., Hollingsworth, M. A., de Sousa, M., Kaur, S., Jain, M., Mallya, K., Batra, S. K., Jarnagin, W. R., Brady, M. S., Fodstad, O., Muller, V., Pantel, K., Minn, A. J., Bissell, M. J., Garcia, B. A., Kang, Y., Rajasekhar, V. K., Ghajar, C. M., Matei, I., Peinado, H., Bromberg, J. & Lyden, D. Tumour exosome integrins determine organotropic metastasis. Nature advance online publication, (2015). Hoshino
November 3, 2015 Colette O'Shaughnessy Ernst Mou, Z., Li, J., Boussoffara, T., Kishi, H., Hamana, H., Ezzati, P., Hu, C., Yi, W., Liu, D., Khadem, F., Okwor, I., Jia, P., Shitaoka, K., Wang, S., Ndao, M., Petersen, C., Chen, J., Rafati, S., Louzir, H., Muraguchi, A., Wilkins, J. A. & Uzonna, J. E. Identification of broadly conserved cross-species protective Leishmania antigen and its responding CD4+ T cells. Science Translational Medicine 7, 310ra167-310ra167, doi:10.1126/scitranslmed.aac5477 (2015). Mou
October 27, 2015 Takuya Uehata Littman Fonseca DM, Hand TW, Han SJ, Gerner MY, Glatman Zaretsky A, Byrd AL, Harrison OJ, Ortiz AM, Quinones M, Trinchieri G, Brenchley JM, Brodsky IE, Germain RN, Randolph GJ, Belkaid Y (2015) Microbiota-Dependent Sequelae of Acute Infection Compromise Tissue-Specific Immunity. Cell 163(2):354-66 Fonseca
October 27, 2015 Doua Azzouz Silverman Fransen F, Zagato E, Mazzini E, Fosso B, Manzari C, El Aidy S, Chiavelli A, D'Erchia AM, Sethi MK, Pabst O, Marzano M, Moretti S, Romani L, Penna G, Pesole G, Rescigno M (2015) BALB/c and C57BL/6 Mice Differ in Polyreactive IgA Abundance, which Impacts the Generation of Antigen-Specific IgA and Microbiota Diversity. Immunity 43(3):527-40 Fransen
October 6, 2015 Duane Moogk Krogsgaard Klammt C, Novotná L, Li DT, Wolf M, Blount A, Zhang K, Fitchett JR, Lillemeier BF (2015) T cell receptor dwell times control the kinase activity of Zap70. Nat Immunol. 16(9):961-9 Klammt
October 6, 2015 Martin Vaeth Feske Sekiya T, Kondo T, Shichita T, Morita R, Ichinose H, Yoshimura A (2015) Suppression of Th2 and Tfh immune reactions by Nr4a receptors in mature T reg cells. J Exp Med. 212(10):1623-40 Sekiya
September 29, 2015 Vickie Fang Schwab Lim K, Hyun YM, Lambert-Emo K, Capece T, Bae S, Miller R, Topham DJ, Kim M (2015) Neutrophil trails guide influenza-specific CD8⁺ T cells in the airways. Science 349(6252):aaa4352 Lim
September 29, 2015 Hao Xu Littman

Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM (2015) Caspase-11 cleaves gasdermin D for non-canonical inflammasome signaling. Nature. Published online September 16 ahead of print.

Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, Zhuang Y, Cai T, Wang F, Shao F (2015) Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. Published online September 16 ahead of print.

Kayagaki

Shi

September 22, 2015 Kirsten Wiens Ernst Schuberth-Wagner C, Ludwig J, Bruder AK, Herzner AM, Zillinger T, Goldeck M, Schmidt T, Schmid-Burgk JL, Kerber R, Wolter S, Stümpel JP, Roth A, Bartok E, Drosten C, Coch C, Hornung V, Barchet W, Kümmerer BM, Hartmann G, Schlee M (2015) A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2'O-Methylated Self RNA. Immunity 43(1):41-51 Schuberth-Wagner
September 22, 2015 Hannah Fehlner-Peach Littman Sefik E, Geva-Zatorsky N, Oh S, Konnikova L, Zemmour D, McGuire AM, Burzyn D, Ortiz-Lopez A, Lobera M, Yang J, Ghosh S, Earl A, Snapper SB, Jupp R, Kasper D, Mathis D, Benoist C (2015) Individual intestinal symbionts induce a distinct population of RORγ⁺ regulatory T cells. Science 349(6251):993-7 Sefik
September 15, 2015 Brian Norris Ernst Eickhoff S, Brewitz A, Gerner MY, Klauschen F, Komander K, Hemmi H, Garbi N, Kaisho T, Germain RN, Kastenmüller W (2015) Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions. Cell 162(6):1322-37 Eickhoff
September 15, 2015 Ulrike Kaufmann Feske Horai R, Zárate-Bladés CR, Dillenburg-Pilla P, Chen J, Kielczewski JL, Silver PB, Jittayasothorn Y, Chan CC, Yamane H, Honda K, Caspi RR (2015) Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity 43(2):343-53 Horai
September 8, 2015 Juan Lafaille Lafaille Griffith AV, Venables T, Shi J, Farr A, van Remmen H, Szweda L, Fallahi M, Rabinovitch P, Petrie HT (2015) Metabolic Damage and Premature Thymus Aging Caused by Stromal Catalase Deficiency. Cell Reports 12(7):1071-9 Griffith
September 8, 2015 Audrey Baeyens Schwab Yang Q, Li F, Harly C, Xing S, Ye L, Xia X, Wang H, Wang X, Yu S, Zhou X, Cam M, Xue HH, Bhandoola A (2015) TCF-1 upregulation identifies early innate lymphoid progenitors in the bone marrow. Nature Immunology. Published online August 17 ahead of print. Yang
September 1, 2015 Mick Ménager Littman Zhang Q, Pan Y, Yan R, Zeng B, Wang H, Zhang X, Li W, Wei H, Liu Z (2015) Commensal bacteria direct selective cargo sorting to promote symbiosis. Nature Immunology 16(9):918-26 Zhang
August 25, 2015 Maryaline Coffre Koralov Coquet JM, Schuijs MJ, Smyth MJ, Deswarte K, Beyaert R, Braun H, Boon L, Karlsson Hedestam GB, Nutt SL, Hammad H, Lambrecht BN (2015) Interleukin-21-Producing CD4(+) T Cells Promote Type 2 Immunity to House Dust Mites. Immunity 43(2):318-30 Coquet
August 25, 2015 Wendy Huang Littman Lévy J, Cacheux W, Bara MA, L'Hermitte A, Lepage P, Fraudeau M, Trentesaux C, Lemarchand J, Durand A, Crain AM, Marchiol C, Renault G, Dumont F, Letourneur F, Delacre M, Schmitt A, Terris B, Perret C, Chamaillard M, Couty JP, Romagnolo B (2015) Intestinal inhibition of Atg7 prevents tumour initiation through a microbiome-influenced immune response and suppresses tumour growth. Nature Cell Biology 17(8):1062-73 Lévy
August 18, 2015 P'ng Loke Loke Qu K, Zaba LC, Giresi PG, Li R, Longmire M, Kim YH, Greenleaf WJ, Chang HY (2015) Individuality and variation of personal regulomes in primary human T cells. Cell Systems 1(1):51-61 Qu
August 18, 2015 Amandine Crequer Erlebacher Barreira da Silva R, Laird ME, Yatim N, Fiette L, Ingersoll MA, Albert ML (2015) Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy. Nature Immunology 16(8):850-8 Barreira_da_Silva
August 11, 2015 Teruyuki Sano Littman Man SM, Zhu Q, Zhu L, Liu Z, Karki R, Malik A, Sharma D, Li L, Malireddi RK, Gurung P, Neale G, Olsen SR, Carter RA, McGoldrick DJ, Wu G, Finkelstein D, Vogel P, Gilbertson RJ, Kanneganti TD (2015) Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer. Cell 162(1):45-58 Man
August 11, 2015 Mate Maus Feske Bénézech C, Luu NT, Walker JA, Kruglov AA, Loo Y, Nakamura K, Zhang Y, Nayar S, Jones LH, Flores-Langarica A, McIntosh A, Marshall J, Barone F, Besra G, Miles K, Allen JE, Gray M, Kollias G, Cunningham AF, Withers DR, Toellner KM, Jones ND, Veldhoen M, Nedospasov SA, McKenzie AN, Caamaño JH (2015) Inflammation-induced formation of fat-associated lymphoid clusters. Nature Immunology 16(8):819-28 Bénézech
August 4, 2015 Lin Wu Littman Meller S, Di Domizio J, Voo KS, Friedrich HC, Chamilos G, Ganguly D, Conrad C, Gregorio J, Le Roy D, Roger T, Ladbury JE, Homey B, Watowich S, Modlin RL, Kontoyiannis DP, Liu YJ, Arold ST, Gilliet M (2015) T(H)17 cells promote microbial killing and innate immune sensing of DNA via interleukin 26. Nature Immunology. Published online July 13 ahead of print. Meller
August 4, 2015 Ludovic Desvignes Ernst Matteo Gentili, Joanna Kowal, Mercedes Tkach, Takeshi Satoh, Xavier Lahaye, Cécile Conrad, Marilyn Boyron, Bérangère Lombard, Sylvère Durand, Guido Kroemer, Damarys Loew, Marc Dalod, Clotilde Théry, and Nicolas Manel (2015) Transmission of innate immune signaling by packaging of cGAMP in viral particles. Science. Published online 30 July 2015 ahead of print. Gentili
July 28, 2015 Maria Pokrovskii Littman Okada S, Markle JG, Deenick EK, Mele F, Averbuch D, Lagos M, Alzahrani M, Al-Muhsen S, Halwani R, Ma CS, Wong N, Soudais C, Henderson LA, Marzouqa H, Shamma J, Gonzalez M, Martinez-Barricarte R, Okada C, Avery DT, Latorre D, Deswarte C, Jabot-Hanin F, Torrado E, Fountain J, Belkadi A, Itan Y, Boisson B, Migaud M, Arlehamn CS, Sette A, Breton S, McCluskey J, Rossjohn J, de Villartay JP, Moshous D, Hambleton S, Latour S, Arkwright PD, Picard C, Lantz O, Engelhard D, Kobayashi M, Abel L, Cooper AM, Notarangelo LD, Boisson-Dupuis S, Puel A, Sallusto F, Bustamante J, Tangye SG, Casanova JL (2015) Impairment of immunity to Candida and Mycobacterium in humans with bi-allelic RORC mutations. Science. Published online July 9 ahead of print. Okada
July 28, 2015 Hernandez Moura Silva Lafaille Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G (2015) The microbiota regulates type 2 immunity through RORγt+ T cells. Science. Published online July 9 ahead of print. Ohnmacht
July 21, 2015 Shika Ramanan Cadwell Bruchard M, Rebé C, Derangère V, Togbé D, Ryffel B, Boidot R, Humblin E, Hamman A, Chalmin F, Berger H, Chevriaux A, Limagne E, Apetoh L, Végran F, Ghiringhelli F (2015) The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nature Immunology 16(8):859-70 Bruchard
July 14, 2015 Amy Sun Koralov Oftedal BE, Hellesen A, Erichsen MM, Bratland E, Vardi A, Perheentupa J, Kemp EH, Fiskerstrand T, Viken MK, Weetman AP, Fleishman SJ, Banka S, Newman WG, Sewell WA, Sozaeva LS, Zayats T, Haugarvoll K, Orlova EM, Haavik J, Johansson S, Knappskog PM, Løvås K, Wolff AS, Abramson J, Husebye ES (2015) Dominant Mutations in the Autoimmune Regulator AIRE Are Associated with Common Organ-Specific Autoimmune Diseases. Immunity 42(6):1185-96 Oftedal
July 14, 2015 Ken Cadwell Cadwell Furman D, Jojic V, Sharma S, Shen-Orr SS, Angel CJ, Onengut-Gumuscu S, Kidd BA, Maecker HT, Concannon P, Dekker CL, Thomas PG, Davis MM (2015) Cytomegalovirus infection enhances the immune response to influenza. Sci Transl Med. 7(281):281ra43 Furman
July 7, 2015 Priya Issuree Littman Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ (2015) Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. Published online June 24 ahead of print. Talbot
July 7, 2015 Michelle Krogsgaard Krogsgaard Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL (2015) Pre-TCR ligand binding impacts thymocyte development before αβTCR expression. Proc Natl Acad Sci U S A. Published online June 8 ahead of print. Mallis
June 30, 2015 Jason Hall Littman Cubillos-Ruiz JR, Silberman PC, Rutkowski MR, Chopra S, Perales-Puchalt A, Song M, Zhang S, Bettigole SE, Gupta D, Holcomb K, Ellenson LH, Caputo T, Lee AH, Conejo-Garcia JR, Glimcher LH (2015) ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis. Cell 161(7):1527-38 Cubillos-Ruiz
June 30, 2015 Dan Littman Littman Stary G, Olive A, Radovic-Moreno AF, Gondek D, Alvarez D, Basto PA, Perro M, Vrbanac VD, Tager AM, Shi J, Yethon JA, Farokhzad OC, Langer R, Starnbach MN, von Andrian UH. (2015) A mucosal vaccine against Chlamydia trachomatis generates two waves of protective memory T cells. Science 348(6241):aaa8205. Stary
June 23, 2015 Richard Copin Ernst Askenase MH, Han SJ, Byrd AL, Morais da Fonseca D, Bouladoux N, Wilhelm C, Konkel JE, Hand TW, Lacerda-Queiroz N, Su XZ, Trinchieri G, Grainger JR, Belkaid Y (2015) Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection. Immunity 42(6):1130-42 Askenase
June 23, 2015 June-Yong Lee Littman Yamano T, Nedjic J, Hinterberger M, Steinert M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L (2015) Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction. Immunity 42(6):1048-61 Yamano
June 16, 2015 Mo Xu Littman Tussiwand R, Everts B, Grajales-Reyes GE, Kretzer NM, Iwata A, Bagaitkar J, Wu X, Wong R, Anderson DA, Murphy TL, Pearce EJ, Murphy KM (2015) Klf4 expression in conventional dendritic cells is required for T helper 2 cell responses. Immunity 42(5):916-28 Tussiwand
June 16, 2015 Susan Schwab Schwab Louveau A, Smirnov I, Keyes TJ, Eccles JD, Rouhani SJ, Peske JD, Derecki NC, Castle D, Mandell JW, Lee KS, Harris TH, Kipnis J (2015) Structural and functional features of central nervous system lymphatic vessels. Nature. Published online June 1 ahead of print. Louveau
June 9, 2015 Patricia Grace Ernst Mitra S, Ring AM, Amarnath S, Spangler JB, Li P, Ju W, Fischer S, Oh J, Spolski R, Weiskopf K, Kohrt H, Foley JE, Rajagopalan S, Long EO, Fowler DH, Waldmann TA, Garcia KC, Leonard WJ (2015) Interleukin-2 activity can be fine tuned with engineered receptor signaling clamps. Immunity 42(5):826-38 Mitra
June 9, 2015 Adam Pelzek Silverman Butt D, Chan TD, Bourne K, Hermes JR, Nguyen A, Statham A, O'Reilly LA, Strasser A, Price S, Schofield P, Christ D, Basten A, Ma CS, Tangye SG, Phan TG, Rao VK, Brink R (2015) FAS Inactivation Releases Unconventional Germinal Center B Cells that Escape Antigen Control and Drive IgE and Autoantibody Production. Immunity 42(5):890-902 Butt
June 2, 2015 Elisabeth Kernbauer Cadwell Chimen M, McGettrick HM, Apta B, Kuravi SJ, Yates CM, Kennedy A, Odedra A, Alassiri M, Harrison M, Martin A, Barone F, Nayar S, Hitchcock JR, Cunningham AF, Raza K, Filer A, Copland DA, Dick AD, Robinson J, Kalia N, Walker LS, Buckley CD, Nash GB, Narendran P, Rainger GE (2015) Homeostatic regulation of T cell trafficking by a B cell-derived peptide is impaired in autoimmune and chronic inflammatory disease. Nature Medicine 21(5):467-75 Chimen
June 2, 2015 Sang-Won Kim Littman Worthington JJ, Kelly A, Smedley C, Bauché D, Campbell S, Marie JC, Travis MA (2015) Integrin αvβ8-Mediated TGF-β Activation by Effector Regulatory T Cells Is Essential for Suppression of T-Cell-Mediated Inflammation. Immunity 42(5):903-915 Worthington
May 26, 2015 James Muller Dustin Weist BM, Kurd N, Boussier J, Chan SW, Robey EA (2015) Thymic regulatory T cell niche size is dictated by limiting IL-2 from antigen-bearing dendritic cells and feedback competition. Nature Immunology 16(6):635-41 Weist
May 19, 2015 Colette O'Shaughnessy Ernst Boyle MJ, Reiling L, Feng G, Langer C, Osier FH, Aspeling-Jones H, Cheng YS, Stubbs J, Tetteh KK, Conway DJ, McCarthy JS, Muller I, Marsh K, Anders RF, Beeson JG (2015) Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria. Immunity 42(3):580-90 Boyle
May 19, 2015 Takuya Uehata Littman Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G (2015) Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury. Immunity 42(4):744-55 Seo
May 12, 2015 Doua Azzouz Silverman Cao AT, Yao S, Gong B, Nurieva RI, Elson CO, Cong Y. Interleukin (IL)-21 promotes intestinal IgA response to microbiota. Mucosal Immunol. 2015 Jan 14. doi: 10.1038/mi.2014.134. [Epub ahead of print] PubMed PMID: 25586558. Cao
May 12, 2015 Charles Ng Littman Gagliani N, Vesely MC, Iseppon A, Brockmann L, Xu H, Palm NW, de Zoete MR, Licona-Limón P, Paiva RS, Ching T, Weaver C, Zi X, Pan X, Fan R, Garmire LX, Cotton MJ, Drier Y, Bernstein B, Geginat J, Stockinger B, Esplugues E, Huber S, Flavell RA. Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation. Nature. 2015 Apr 29. doi: 10.1038/nature14452. [Epub ahead of print] PubMed PMID: 25924064. Gagliani
May 5, 2015 Adam Blaisdell Erlebacher Carmi Y, Spitzer MH, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG (2015) Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity. Nature. Published online April 29 ahead of print. Carmi
May 5, 2015 Martin Vaeth Feske Ramirez-Ortiz ZG, Prasad A, Griffith JW, Pendergraft WF 3rd, Cowley GS, Root DE, Tai M, Luster AD, El Khoury J, Hacohen N, Means TK (2015) The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity. Nature Immunology 16(5):495-504 Ramirez-Ortiz
April 28, 2015 Duane Moogk Krogsgaard Twyman-Saint Victor C, Rech AJ, Maity A, Rengan R, Pauken KE, Stelekati E, Benci JL, Xu B, Dada H, Odorizzi PM, Herati RS, Mansfield KD, Patsch D, Amaravadi RK, Schuchter LM, Ishwaran H, Mick R, Pryma DA, Xu X, Feldman MD, Gangadhar TC, Hahn SM, Wherry EJ, Vonderheide RH, Minn AJ (2015) Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer. Nature 520(7547):373-7 Twyman-Saint Victor
April 28, 2015 Vickie Fang Schwab Deng W, Gowen BG, Zhang L, Wang L, Lau S, Iannello A, Xu J, Rovis TL, Xiong N, Raulet DH (2015) Antitumor immunity. A shed NKG2D ligand that promotes natural killer cell activation and tumor rejection. Science 348(6230):136-9 Deng
April 21, 2015 Hannah Fehlner-Peach Littman Moon C, Baldridge MT, Wallace MA, Burnham CA, Virgin HW, Stappenbeck TS (2015) Vertically transmitted faecal IgA levels determine extra-chromosomal phenotypic variation. Nature. Published online February 16 ahead of print. Moon
April 21, 2015 Smita Srivastava Ernst Okoye I, Wang L, Pallmer K, Richter K, Ichimura T, Haas R, Crouse J, Choi O, Heathcote D, Lovo E, Mauro C, Abdi R, Oxenius A, Rutschmann S, Ashton-Rickardt PG (2015) The protein LEM promotes CD8+ T cell immunity through effects on mitochondrial respiration. Science. Published online April 16 ahead of print. Okoye
April 14, 2015 Stefan Feske Feske Blagih J, Coulombe F, Vincent EE, Dupuy F, Galicia-Vázquez G, Yurchenko E, Raissi TC, van der Windt GJ, Viollet B, Pearce EL, Pelletier J, Piccirillo CA, Krawczyk CM, Divangahi M, Jones RG (2015) The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity 42(1):41-54 Blagih
April 14, 2015 Kirsten Wiens Ernst Jovanovic M, Rooney MS, Mertins P, Przybylski D, Chevrier N, Satija R, Rodriguez EH, Fields AP, Schwartz S, Raychowdhury R, Mumbach MR, Eisenhaure T, Rabani M, Gennert D, Lu D, Delorey T, Weissman JS, Carr SA, Hacohen N, Regev A. (2015) Immunogenetics. Dynamic profiling of the protein life cycle in response to pathogens. Science 347(6226):1259038 Jovanovic
April 7, 2015 Katie Maurer Cadwell Noval Rivas M, Burton OT, Wise P, Charbonnier LM, Georgiev P, Oettgen HC, Rachid R, Chatila TA (2015) Regulatory T Cell Reprogramming toward a Th2-Cell-like Lineage Impairs Oral Tolerance and Promotes Food Allergy. Immunity. 42(3):512-23 Noval Rivas
March 31, 2015 Brian Norris Ernst Hickman HD, Reynoso GV, Ngudiankama BF, Cush SS, Gibbs J, Bennink JR, Yewdell JW (2015) CXCR3 Chemokine Receptor Enables Local CD8(+) T Cell Migration for the Destruction of Virus-Infected Cells. Immunity 42(3):524-37 Hickman
March 24, 2015 Juan Lafaille Lafaille Yang S, Fujikado N, Kolodin D, Benoist C, Mathis D (2015) Regulatory T cells generated early in life play a distinct role in maintaining self-tolerance. Science. Published online March 19 ahead of print. Yang
March 24, 2015 Ulrike Kaufmann Feske Brown CC, Esterhazy D, Sarde A, London M, Pullabhatla V, Osma-Garcia I, Al-Bader R, Ortiz C, Elgueta R, Arno M, de Rinaldis E, Mucida D, Lord GM, Noelle RJ (2015) Retinoic Acid is essential for Th1 cell lineage stability and prevents transition to a th17 cell program. Immunity 42(3):499-511 Brown
March 17, 2015 Audrey Baeyens Schwab Gunawan M, Venkatesan N, Loh JT, Wong JF, Berger H, Neo WH, Li LY, Win MK, Yau YH, Guo T, See PC, Yamazaki S, Chin KC, Gingras AR, Shochat SG, Ng LG, Sze SK, Ginhoux F, Su IH (2015) The methyltransferase Ezh2 controls cell adhesion and migration through direct methylation of the extranuclear regulatory protein talin. Nature Immunology. Published online March 9 ahead of print. Gunawan
March 10, 2015 Mick Ménager Littman Xia P, Wang S, Ye B, Du Y, Huang G, Zhu P, Fan Z (2015) Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection. Nature Immunology. Published online March 2 ahead of print. Xia
March 10, 2015 Joel Ernst Ernst Chou S, Daugherty MD, Peterson SB, Biboy J, Yang Y, Jutras BL, Fritz-Laylin LK, Ferrin MA, Harding BN, Jacobs-Wagner C, Yang XF, Vollmer W, Malik HS, Mougous JD (2015) Transferred interbacterial antagonism genes augment eukaryotic innate immune function. Nature 518(7537):98-101 Chou
March 3, 2015 Maryaline Coffre Koralov DuPage M, Chopra G, Quiros J, Rosenthal WL, Morar MM, Holohan D, Zhang R, Turka L, Marson A, Bluestone JA (2015) The chromatin-modifying enzyme ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity 42(2):227-38 DuPage
March 3, 2015 Wendy Huang Littman Bonavita E, Gentile S, Rubino M, Maina V, Papait R, Kunderfranco P, Greco C, Feruglio F, Molgora M, Laface I, Tartari S, Doni A, Pasqualini F, Barbati E, Basso G, Galdiero MR, Nebuloni M, Roncalli M, Colombo P, Laghi L, Lambris JD, Jaillon S, Garlanda C, Mantovani A (2015) PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer. Cell 160(4):700-14 Bonavita
February 24, 2015 Mei San Tang Loke Mancino A, Termanini A, Barozzi I, Ghisletti S, Ostuni R, Prosperini E, Ozato K, Natoli G (2015) A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages. Genes and Development 29(4):394-408 Mancino
February 24, 2015 Amandine Crequer Erlebacher Basu R, Whitley SK, Bhaumik S, Zindl CL, Schoeb TR, Benveniste EN, Pear WS, Hatton RD, Weaver CT (2015) IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nature Immunology 16(3):286-95 Basu
February 17, 2015 Teruyuki Sano Littman Satoh-Takayama N, Serafini N, Verrier T, Rekiki A, Renauld JC, Frankel G, Di Santo JP (2014) The chemokine receptor CXCR6 controls the functional topography of interleukin-22 producing intestinal innate lymphoid cells. Immunity 41(5):776-88 Satoh-Takayama
February 17, 2015 Mate Maus Feske Kwak HJ, Liu P, Bajrami B, Xu Y, Park SY, Nombela-Arrieta C, Mondal S, Sun Y, Zhu H, Chai L, Silberstein LE, Cheng T, Luo HR (2015) Myeloid cell-derived reactive oxygen species externally regulate the proliferation of myeloid progenitors in emergency granulopoiesis. Immunity 42(1):159-71 Kwak
February 10, 2015 Lin Wu Littman Vasanthakumar A, Moro K, Xin A, Liao Y, Gloury R, Kawamoto S, Fagarasan S, Mielke LA, Afshar-Sterle S, Masters SL, Nakae S, Saito H, Wentworth JM, Li P, Liao W, Leonard WJ, Smyth GK, Shi W, Nutt SL, Koyasu S, Kallies A (2015) The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue-resident regulatory T cells. Nature Immunology. Published online January 19 ahead of print. Vasanthakumar
February 10, 2015 Ludovic Desvignes Ernst Nelson RW, Beisang D, Tubo NJ, Dileepan T, Wiesner DL, Nielsen K, Wüthrich M, Klein BS, Kotov DI, Spanier JA, Fife BT, Moon JJ, Jenkins MK (2014) T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity 42:95-107 Nelson
February 3, 2015 Maria Pokrovskii Littman Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA (2014) Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA. Cell 159(7):1563-77 Rongvaux
February 3, 2015 Sergei Koralov Koralov Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Gölz G, Rosenberger K, Kammertöns T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp F, Kipnis J (2015) MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. Journal of Clinical Investigation. Published online January 20 ahead of print. Walsh
January 20, 2015 Priya Issuree Littman Reniere ML, Whiteley AT, Hamilton KL, John SM, Lauer P, Brennan RG, Portnoy DA (2015) Glutathione activates virulence gene expression of an intracellular pathogen. Nature 517(7533):170-3 Reniere
January 20, 2015 Shika Ramanana Cadwell Baldridge MT, Nice TJ, McCune BT, Yokoyama CC, Kambal A, Wheadon M, Diamond MS, Ivanova Y, Artyomov M, Virgin HW (2014) Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection. Science. Published online November 27 ahead of print. Baldridge
January 13, 2015 Mo Xu Littman Yu F, Sharma S, Edwards J, Feigenbaum L, Zhu J (2014) Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance. Nature Immunology. Published online December 15 ahead of print. Yu
January 13, 2015 Richard Copin Ernst Zhang LJ, Guerrero-Juarez CF, Hata T, Bapat SP, Ramos R, Plikus MV, Gallo RL (2015) Dermal adipocytes protect against invasive Staphylococcus aureus skin infection. Science 347(6217):67-71 Zhang
January 6, 2015 Jason Hall Littman Brestoff JR, Kim BS, Saenz SA, Stine RR, Monticelli LA, Sonnenberg GF, Thome JJ, Farber DL, Lutfy K, Seale P, Artis D (2014) Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity. Nature. Published online December 22 ahead of print. Brestoff
January 6, 2015 Amy Sun Koralov Lee SY, Coffey F, Fahl SP, Peri S, Rhodes M, Cai KQ, Carleton M, Hedrick SM, Fehling HJ, Zúñiga-Pflücker JC, Kappes DJ, Wiest DL (2014) Noncanonical mode of ERK action controls alternative αβ and γδ T cell lineage fates. Immunity 41(6):934-46 Lee
December 16, 2014 Patricia Grace Ernst Yang H, Qiu Q, Gao B, Kong S, Lin Z, Fang D (2014) Hrd1-mediated BLIMP-1 ubiquitination promotes dendritic cell MHCII expression for CD4 T cell priming during inflammation. Journal of Experimental Medicine 211(12):2467-79 Yang
December 16, 2014 Ken Cadwell Cadwell Sun L, Miyoshi H, Origanti S, Nice TJ, Barger AC, Manieri NA, Fogel LA, French AR, Piwnica-Worms D, Piwnica-Worms H, Virgin HW, Lenschow DJ, Stappenbeck TS (2014) Type I Interferons Link Viral Infection to Enhanced Epithelial Turnover and Repair. Cell Host Microbe. Published online December 3 ahead of print. Sun
December 9, 2014 Adam Pelzek Silverman Yilmaz B, Portugal S, Tran T M, Gozzelino R, Ramos S, Gomes J, Regalado A, Cowan PJ, d’Apice AJF, Chong AS, Doumbo OK, Traore B, Crompton PD, Silveira H, Soares MP (2014) Gut microbiota elicits a protective immune response against malaria transmission. Cell 159(6):1277-89 Yilmaz
December 9, 2014 Elisabeth Kernbauer Cadwell Woo S, Fuertes MB, Corrales L, Spranger S, Furdyna MJ, Leung MYK, Duggan R, Wang Y, Barber GN, Fitzgerald KA, Alegre M, Gajewski TF (2014) STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors. Immunity 41(5):830-42 Woo
December 2, 2014 Sang-Won Kim Littman

Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD (2014) Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens. Nature 515(7528):577-81

Yadav M, Jhunjhunwala S, Phung QT, Lupardus P, Tanguay J, Bumbaca S, Franci C, Cheung TK, Fritsche J, Weinschenk T, Modrusan Z, Mellman I, Lill JR, Delamarre L (2014) Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing. Nature 515(7528):572-6

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Yadav

December 2, 2014 Doua Azzouz Silverman Eilertsen G, Nossent JC (2014) APRIL levels strongly correlate with IL-17 in systemic lupus erythematosus. Lupus 23(13):1383-91 Eilertsen
November 25, 2014 Takuya Uehata Littman Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I, Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V (2014) Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation. Nature Immunology 15(11):1079-89 Jeltsch
November 25, 2014 Adam Blaisdell Erlebacher Di Mitri D, Toso A, Chen JJ, Sarti M, Pinton S, Jost TR, D'Antuono R, Montani E, Garcia-Escudero R, Guccini I, Da Silva-Alvarez S, Collado M, Eisenberger M, Zhang Z, Catapano C, Grassi F, Alimonti A (2014) Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer. Nature 515(7525):134-7 Di Mitri
November 18, 2014 Charles Ng Littman Jones MK, Watanabe M, Zhu S, Graves CL, Keyes LR, Grau KR, Gonzalez-Hernandez MB, Iovine NM, Wobus CE, Vinjé J, Tibbetts SA, Wallet SM, Karst SM (2014) Enteric bacteria promote human and mouse norovirus infection of B cells. Science 346(6210):755-9 Jones
November 18, 2014 Kirsten Wiens Ernst Suzuki M, Danilchanka O, Mekalanos JJ (2014) Vibrio cholerae T3SS effector VopE modulates mitochondrial dynamics and innate immune signaling by targeting Miro GTPases. Cell Host and Microbe 16(5):581-91 Suzuki
November 11, 2014 Vickie Fang Schwab Astarita JL, Cremasco V, Fu J, Darnell MC, Peck JR, Nieves-Bonilla JM, Song K, Kondo Y, Woodruff MC, Gogineni A, Onder L, Ludewig B, Weimer RM, Carroll MC, Mooney DJ, Xia L, Turley SJ (2014) The CLEC-2-podoplanin axis controls the contractility of fibroblastic reticular cells and lymph node microarchitecture. Nature Immunology. Published online October 27 ahead of print. Astarita
November 11, 2014 Duane Moogk Krogsgaard Stepanek O, Prabhakar AS, Osswald C, King CG, Bulek A, Naeher D, Beaufils-Hugot M, Abanto ML, Galati V, Hausmann B, Lang R, Cole DK, Huseby ES, Sewell AK, Chakraborty AK, Palmer E (2014) Coreceptor scanning by the T cell receptor provides a mechanism for T cell tolerance. Cell 159:333-45 Stepanek
November 4, 2014 Colette O'Shaughnessy Ernst Branzk N, Lubojemska A, Hardison SE, Wang Q, Gutierrez MG, Brown GD, Papayannopoulos V (2014) Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nature Immunology 15(11):1017-25 Branzk
November 4, 2014 Dan Littman Littman Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali DA, Kappler JW, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S (2014) Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease. Science 346(6207):363-8 Ito
October 28, 2014 Hannah Fehlner-Peach Littman Pickard JM, Maurice CF, Kinnebrew MA, Abt MC, Schenten D, Golovkina TV, Bogatyrev SR, Ismagilov RF, Pamer EG, Turnbaugh PJ, Chervonsky AV. Rapid fucosylation of intestinal epithelium sustains host-commensal symbiosis in sickness. Nature. Published online October 1 ahead of print. Pickard
October 21, 2014 Smita Srivastava Ernst Laidlaw BJ, Zhang N, Marshall HD, Staron MM, Guan T, Hu Y, Cauley LS, Craft J, Kaech SM (2014) CD4+ T cell help guides formation of CD103+ lung-resident memory CD8+ T cells during influenza viral infection. Immunity 41:633-45 Laidlaw
October 21, 2014 Martin Vaeth Feske Levine AG, Arvey A, Jin W, Rudensky AY (2014) Continuous requirement for the TCR in regulatory T cell function. Nature Immunology. Published online September 28 ahead of print. Levine
October 7, 2014 Katie Maurer Cadwell Odendall C, Dixit E, Stavru F, Bierne H, Franz KM, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC (2014) Diverse intracellular pathogens activate type III interferon expression from peroxisomes. Nature Immunology 15:717-26 Odendall
October 7, 2014 Brian Norris Ernst St John AL, Ang WX, Huang MN, Kunder CA, Chan EW, Gunn MD, Abraham SN (2014) S1P-dependent trafficking of intracellular Yersinia pestis through lymph nodes establishes buboes and systemic infection. Immunity 41:440-50 St John
September 30, 2014 Susan Schwab Schwab Cremasco V, Woodruff MC, Onder L, Cupovic J, Nieves-Bonilla JM, Schildberg FA, Chang J, Cremasco F, Harvey CJ, Wucherpfennig K, Ludewig B, Carroll MC, Turley SJ (2014) B cell homeostasis and follicle confines are governed by fibroblastic reticular cells. Nature Immunology 15:973-81 Cremasco
September 30, 2014 Ulrike Kaufmann Feske Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BM, Löhning M, Belkaid Y, Fallon PG, Powrie F (2014) The alarmin IL-33 promotes regulatory T-cell function in the intestine. Nature 513:564-568 Schiering
September 23, 2014 Amanda Marchiando Cadwell Takahashi N, Vereecke L, Bertrand MJ, Duprez L, Berger SB, Divert T, Gonçalves A, Sze M, Gilbert B, Kourula S, Goossens V, Lefebvre S, Günther C, Becker C, Bertin J, Gough PJ, Declercq W, van Loo G, Vandenabeele P (2014) RIPK1 ensures intestinal homeostasis by protecting the epithelium against apoptosis. Nature 513:95-9 Takahashi
September 23, 2014 Mick Ménager Littman Oh JZ, Ravindran R, Chassaing B, Carvalho FA, Maddur MS, Bower M, Hakimpour P, Gill KP, Nakaya HI, Yarovinsky F, Sartor RB, Gewirtz AT, Pulendran B (2014) TLR5-mediated sensing of gut microbiota is necessary for antibody responses to seasonal influenza vaccination. Immunity 41:478-92 Oh
September 16, 2014 Juan Lafaille Lafaille Perry JS, Lio CW, Kau AL, Nutsch K, Yang Z, Gordon JI, Murphy KM, Hsieh CS (2014) Distinct contributions of Aire and antigen-presenting-cell subsets to the generation of self-tolerance in the thymus. Immunity 41:1-13 Perry
September 16, 2014 Maryaline Coffre Koralov Burton BR, Britton GJ, Fang H, Verhagen J, Smithers B, Sabatos-Peyton CA, Carney LJ, Gough J, Strobel S, Wraith DC (2014) Sequential transcriptional changes dictate safe and effective antigen-specific immunotherapy. Nature Communications 5:4741 Burton
September 9, 2014 Wendy Huang Littman Palm NW, de Zoete MR, Cullen TW, Barry NA, Stefanowski J, Hao L, Degnan PH, Hu J, Peter I, Zhang W, Ruggiero E, Cho JH, Goodman AL, Flavell RA (2014) Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease. Cell 158:1000-10 Palm
September 9, 2014 Joel Ernst Ernst Ballesteros-Tato A, León B, Lee BO, Lund FE, Randall TD (2014) Epitope-specific regulation of memory programming by differential duration of antigen presentation to influenza-specific CD8+ T cells. Immunity 41:127-40 Ballesteros-Tato
September 2, 2014 Teruyuki Sano Littman Bain CC, Bravo-Blas A, Scott CL, Gomez Perdiguero E, Geissmann F, Henri S, Malissen B, Osborne LC, Artis D, Mowat AM (2014) Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nature Immunology. Published online August 24 ahead of print. Bain
September 2, 2014 Amandine Crequer Erlebacher Schenkel JM, Fraser KA, Beura LK, Pauken KE, Vezys V, Masopust D (2014) Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Science. Published online August 28 ahead of print. Schenkel
August 26, 2014 Michelle Krogsgaard Krogsgaard Han A, Glanville J, Hansmann L, Davis MM (2014) Linking T-cell receptor sequence to functional phenotype at the single-cell level. Nature Biotechnology 32:684-92 Han
August 19, 2014 Mate Maus Feske Watanabe M, Moon KD, Vacchio MS, Hathcock KS, Hodes RJ (2014) Downmodulation of tumor suppressor p53 by T cell receptor signaling is critical for antigen-specific CD4+ T cell responses. Immunity 40:681-91 Watanabe
August 12, 2014 Stefan Feske Feske O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL (2014) Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity 41:75-88 O'Sullivan
August 12, 2014 Ludovic Desvignes Ernst van Panhuys N, Klauschen F, Germain RN (2014) T-cell-receptor-dependent signal intensity dominantly controls CD4+ T cell polarization in vivo. Immunity 41:63-74 van Panhuys
August 5, 2014 Lin Wu Littman Yang B, Treweek JB, Kulkarni RP, Deverman BE, Chen CK, Lubeck E, Shah S, Cai L, Gradinaru V (2014) Single-cell phenotyping within transparent intact tissue through whole-body clearing. Cell. Published online July 31 ahead of print. Yang
August 5, 2014 Shika Ramanan Cadwell Osborne, L. C., L. A. Monticelli, T. J. Nice, T. E. Sutherland, M. C. Siracusa, M. R. Hepworth, V. T. Tomov, D. Kobuley, S. V. Tran, K. Bittinger, A. G. Bailey, A. L. Laughlin, J.-L. Boucher, E. J. Wherry, F. D. Bushman, J. E. Allen, H. W. Virgin and D. Artis (2014) Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation. Science 345(6196): 578-582 Osborne
July 29, 2014 Carl Weidinger Feske Motz GT, Santoro SP, Wang LP, Garrabrant T, Lastra RR, Hagemann IS, Lal P, Feldman MD, Benencia F, Coukos G (2014) Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors. Nature Medicine 20:607-15 Motz
July 29, 2014 Randy Longman Littman Muller PA, Koscsó B, Rajani GM, Stevanovic K, Berres ML, Hashimoto D, Mortha A, Leboeuf M, Li XM, Mucida D, Stanley ER, Dahan S, Margolis KG, Gershon MD, Merad M, Bogunovic M (2014) Crosstalk between muscularis macrophages and enteric neurons regulates gastrointestinal motility. Cell 158:300-13 Muller
July 22, 2014 Sergei Koralov Koralov Okoye IS, Coomes SM, Pelly VS, Czieso S, Papayannopoulos V, Tolmachova T, Seabra MC, Wilson MS (2014) MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells. Immunity 41:89-103 Okoye
July 22, 2014 James Muller Dustin Mahmud SA, Manlove LS, Schmitz HM, Xing Y, Wang Y, Owen DL, Schenkel JM, Boomer JS, Green JM, Yagita H, Chi H, Hogquist KA, Farrar MA (2014) Costimulation via the tumor-necrosis factor receptor superfamily couples TCR signal strength to the thymic differentiation of regulatory T cells. Nature Immunology 15:473-81 Mahmud
July 15, 2014 Priya Issuree Littman Marchant DJ, Bellac CL, Moraes TJ, Wadsworth SJ, Dufour A, Butler GS, Bilawchuk LM, Hendry RG, Robertson AG, Cheung CT, Ng J, Ang L, Luo Z, Heilbron K, Norris MJ, Duan W, Bucyk T, Karpov A, Devel L, Georgiadis D, Hegele RG, Luo H, Granville DJ, Dive V, McManus BM, Overall CM (2014) A new transcriptional role for matrix metalloproteinase-12 in antiviral immunity. Nature Medicine 20:493-502 Marchant
July 15, 2014 Maria Pokrovskii Littman Reese TA, Wakeman BS, Choi HS, Hufford MM, Huang SC, Zhang X, Buck MD, Jezewski A, Kambal A, Liu CY, Goel G, Murray PJ, Xavier RJ, Kaplan MH, Renne R, Speck SH, Artyomov MN, Pearce EJ, Virgin HW (2014) Helminth infection reactivates latent γ-herpesvirus via cytokine competition at a viral promoter. Science. Published online June 26 ahead of print. Reese
July 8, 2014 Mo Xu Littman Xu H, Yang J, Gao W, Li L, Li P, Zhang L, Gong YN, Peng X, Xi JJ, Chen S, Wang F, Shao F (2014) Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature. Published online June 11 ahead of print. Xu
July 1, 2014 Laura Fogli Koralov Gollwitzer ES, Saglani S, Trompette A, Yadava K, Sherburn R, McCoy KD, Nicod LP, Lloyd CM, Marsland BJ (2014) Lung microbiota promotes tolerance to allergens in neonates via PD-L1. Nature Medicine 20:642-7 Gollwitzer
July 1, 2014 Richard Copin Ernst Soudja SM, Chandrabos C, Yakob E, Veenstra M, Palliser D, Lauvau G (2014) Memory-T-cell-derived interferon-γ instructs potent innate cell activation for protective immunity. Immunity 40:974-88 Soudja
June 24, 2014 Jason Hall Littman Bessede A, Gargaro M, Pallotta MT, Matino D, Servillo G, Brunacci C, Bicciato S, Mazza EM, Macchiarulo A, Vacca C, Iannitti R, Tissi L, Volpi C, Belladonna ML, Orabona C, Bianchi R, Lanz TV, Platten M, Della Fazia MA, Piobbico D, Zelante T, Funakoshi H, Nakamura T, Gilot D, Denison MS, Guillemin GJ, DuHadaway JB, Prendergast GC, Metz R, Geffard M, Boon L, Pirro M, Iorio A, Veyret B, Romani L, Grohmann U, Fallarino F, Puccetti P (2014) Aryl hydrocarbon receptor control of a disease tolerance defence pathway. Nature. Published online June 15 ahead of print. Bessede
June 24, 2014 Smita Srivastava Ernst Goo L, Chohan V, Nduati R, Overbaugh J (2014) Early development of broadly neutralizing antibodies in HIV-1-infected infants. Nature Medicine 20:655-8 Goo
June 17, 2014 Adam Blaisdell Erlebacher Affara NI, Ruffell B, Medler TR, Gunderson AJ, Johansson M, Bornstein S, Bergsland E, Steinhoff M, Li Y, Gong Q, Ma Y, Wiesen JF, Wong MH, Kulesz-Martin M, Irving B, Coussens LM (2014) B cells regulate macrophage phenotype and response to chemotherapy in squamous carcinomas. Cancer Cell. Published online June 4 ahead of print. Affara
June 17, 2014 Elisabeth Kernbauer Cadwell

Zigmond E, Bernshtein B, Friedlander G, Walker CR, Yona S, Kim KW, Brenner O, Krauthgamer R, Varol C, Müller W, Jung S (2014) Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis. Immunity 40:720-33

Shouval DS, Biswas A, Goettel JA, McCann K, Conaway E, Redhu NS, Mascanfroni ID, Al Adham Z, Lavoie S, Ibourk M, Nguyen DD, Samsom JN, Escher JC, Somech R, Weiss B, Beier R, Conklin LS, Ebens CL, Santos FG, Ferreira AR, Sherlock M, Bhan AK, Müller W, Mora JR, Quintana FJ, Klein C, Muise AM, Horwitz BH, Snapper SB (2014) Interleukin-10 receptor signaling in innate immune cells regulates mucosal immune tolerance and anti-inflammatory macrophage function. Immunity 40:706-19

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June 10, 2014 Sang-Won Kim Littman

Rao RR, Long JZ, White JP, Svensson KJ, Lou J, Lokurkar I, Jedrychowski MP, Ruas JL, Wrann CD, Lo JC, Camera DM, Lachey J, Gygi S, Seehra J, Hawley JA, Spiegelman BM (2014) Meteorin-like is a hormone that regulates immune-adipose interactions to increase beige fat thermogenesis. Cell 157:1279-91

Qiu Y, Nguyen KD, Odegaard JI, Cui X, Tian X, Locksley RM, Palmiter RD, Chawla A (2014) Eosinophils and type 2 cytokine signaling in macrophages orchestrate development of functional beige fat. Cell 157:1292-308

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June 10, 2014 Ken Cadwell Cadwell Meunier E, Dick MS, Dreier RF, Schürmann N, Kenzelmann Broz D, Warming S, Roose-Girma M, Bumann D, Kayagaki N, Takeda K, Yamamoto M, Broz P (2014) Caspase-11 activation requires lysis of pathogen-containing vacuoles by IFN-induced GTPases. Nature 509:366-70 Meunier
June 3, 2014 Patty Grace Ernst Stelekati E, Shin H, Doering TA, Dolfi DV, Ziegler CG, Beiting DP, Dawson L, Liboon J, Wolski D, Ali MA, Katsikis PD, Shen H, Roos DS, Haining WN, Lauer GM, Wherry EJ (2014) Bystander chronic infection negatively impacts development of CD8+ T cell memory. Immunity 40:801-13 Stelekati
June 3, 2014 Martin Vaeth Feske Wang H, Geng J, Wen X, Bi E, Kossenkov AV, Wolf AI, Tas J, Choi YS, Takata H, Day TJ, Chang LY, Sprout SL, Becker EK, Willen J, Tian L, Wang X, Xiao C, Jiang P, Crotty S, Victora GD, Showe LC, Tucker HO, Erikson J, Hu H (2014) The transcription factor Foxp1 is a critical negative regulator of the differentiation of follicular helper T cells. Nature Immunology. Published online May 25 ahead of print. Wang
May 27, 2014 Wendy Huang Littman M. L. Balmer, E. Slack, A. de Gottardi, M. A. Lawson, S. Hapfelmeier, L. Miele, A. Grieco, H. Van Vlierberghe, R. Fahrner, N. Patuto, C. Bernsmeier, F. Ronchi, M. Wyss, D. Stroka, N. Dickgreber, M. H. Heim, K. D. McCoy, A. J. Macpherson, The Liver May Act as a Firewall Mediating Mutualism Between the Host and Its Gut Commensal Microbiota. Sci. Transl. Med. 6, 237ra66 (2014) Balmer
May 27, 2014 Susan Schwab Schwab Ulvmar MH, Werth K, Braun A, Kelay P, Hub E, Eller K, Chan L, Lucas B, Novitzky-Basso I, Nakamura K, Rülicke T, Nibbs RJ, Worbs T, Förster R, Rot A. The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes. Nature Immunology. Published online May 11 ahead of print. Ulvmar
May 20, 2014 Benny Yang Littman Tran E, Turcotte S, Gros A, Robbins PF, Lu YC, Dudley ME, Wunderlich JR, Somerville RP, Hogan K, Hinrichs CS, Parkhurst MR, Yang JC, Rosenberg SA (2014) Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer. Science 344:641-5 Tran
May 20, 2014 Brian Norris Ernst Stock AT, Smith JM, Carbone FR (2014) Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection. Journal of Experimental Medicine 211:751-9 Stock
May 13, 2014 Ulrike Kaufmann Feske Lin CC, Bradstreet TR, Schwarzkopf EA, Sim J, Carrero JA, Chou C, Cook LE, Egawa T, Taneja R, Murphy TL, Russell JH, Edelson BT (2014) Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation. Nature Communications 5:3551 Lin
May 6, 2014 Amanda Marchiando Cadwell Chu VT, Beller A, Rausch S, Strandmark J, Zänker M, Arbach O, Kruglov A, Berek C (2014) Eosinophils promote generation and maintenance of immunoglobulin-A-expressing plasma cells and contribute to gut immune homeostasis. Immunity 40:582-93 Chu
May 6, 2014 Mick Ménager Littman Roth S, Rottach A, Lotz-Havla AS, Laux V, Muschaweckh A, Gersting SW, Muntau AC, Hopfner KP, Jin L, Vanness K, Petrini JH, Drexler I, Leonhardt H, Ruland J (2014) Rad50-CARD9 interactions link cytosolic DNA sensing to IL-1β production. Nature Immunology. Published online April 28 ahead of print. Roth
April 29, 2014 Katie Maurer Cadwell Coulombe F, Jaworska J, Verway M, Tzelepis F, Massoud A, Gillard J, Wong G, Kobinger G, Xing Z, Couture C, Joubert P, Fritz JH, Powell WS, Divangahi M (2014) Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages. Immunity 40:554-68 Coulombe
April 29, 2014 Amandine Crequer Erlebacher Fan X, Quezada SA, Sepulveda MA, Sharma P, Allison JP (2014) Engagement of the ICOS pathway markedly enhances efficacy of CTLA-4 blockade in cancer immunotherapy. Journal of Experimental Medicine 211:715-25 Fan
April 22, 2014 Juan Lafaille Lafaille Constantinides MG, McDonald BD, Verhoef PA, Bendelac A (2014) A committed precursor to innate lymphoid cells. Nature 508:397-401 Constantinides
April 22, 2014 Teruyuki Sano Littman O'Donnell H, Pham OH, Li LX, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ, McSorley SJ (2014) Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells. Immunity 40:213-24 O'Donnell
April 15, 2014 Joel Ernst Ernst Ravindran R, Khan N, Nakaya HI, Li S, Loebbermann J, Maddur MS, Park Y, Jones DP, Chappert P, Davoust J, Weiss DS, Virgin HW, Ron D, Pulendran B (2014) Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation. Science 343:313-7 Ravindran
April 8, 2014 Gregg Silverman Silverman Li F, Smith P, Ravetch JV (2014) Inhibitory Fcγ receptor is required for the maintenance of tolerance through distinct mechanisms. Journal of Immunology 192:3021-8 Li
April 8, 2014 Mate Maus Feske Afshar-Sterle S, Zotos D, Bernard NJ, Scherger AK, Rödling L, Alsop AE, Walker J, Masson F, Belz GT, Corcoran LM, O'Reilly LA, Strasser A, Smyth MJ, Johnstone R, Tarlinton DM, Nutt SL, Kallies A (2014) Fas ligand-mediated immune surveillance by T cells is essential for the control of spontaneous B cell lymphomas. Nature Medicine 20:283-90 Afshar-Sterle
March 25, 2014 P'ng Loke Loke Mortha A, Chudnovskiy A, Hashimoto D, Bogunovic M, Spencer SP, Belkaid Y, Merad M (2014) Microbiota-dependent crosstalk between macrophages and ILC3 promotes intestinal homeostasis. Science. Published March 13 online ahead of print. Mortha
March 18, 2014 Vanessa Hubbard Cadwell Murthy A, Li Y, Peng I, Reichelt M, Katakam AK, Noubade R, Roose-Girma M, DeVoss J, Diehl L, Graham RR, van Lookeren Campagne M (2014) A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3. Nature 506:456-62 Murthy
March 11, 2014 Ludovic Desvignes Ernst Lee MN, Ye C, Villani AC, Raj T, Li W, Eisenhaure TM, Imboywa SH, Chipendo PI, Ran FA, Slowikowski K, Ward LD, Raddassi K, McCabe C, Lee MH, Frohlich IY, Hafler DA, Kellis M, Raychaudhuri S, Zhang F, Stranger BE, Benoist CO, De Jager PL, Regev A, Hacohen N (2014) Common genetic variants modulate pathogen-sensing responses in human dendritic cells. Science 343:1246980 Lee
March 11, 2014 Fabio Santori Littman Paolino M, Choidas A, Wallner S, Pranjic B, Uribesalgo I, Loeser S, Jamieson AM, Langdon WY, Ikeda F, Fededa JP, Cronin SJ, Nitsch R, Schultz-Fademrecht C, Eickhoff J, Menninger S, Unger A, Torka R, Gruber T, Hinterleitner R, Baier G, Wolf D, Ullrich A, Klebl BM, Penninger JM (2014) The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells. Nature. Published online February 19 ahead of print. Paolino
March 4, 2014 Carl Weidinger Feske Kim HY, Lee HJ, Chang YJ, Pichavant M, Shore SA, Fitzgerald KA, Iwakura Y, Israel E, Bolger K, Faul J, DeKruyff RH, Umetsu DT (2014) Interleukin-17-producing innate lymphoid cells and the NLRP3 inflammasome facilitate obesity-associated airway hyperreactivity. Nature Medicine 20:54-61 Kim
March 4, 2014 Shika Ramanan Cadwell Wlodarska M, Thaiss CA, Nowarski R, Henao-Mejia J, Zhang JP, Brown EM, Frankel G, Levy M, Katz MN, Philbrick WM, Elinav E, Finlay BB, Flavell RA (2014) NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156:1045-59 Wlodarska
February 25, 2014 Lin Wu Littman Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek AB, Lee YK, Weaver CT, Yagi R, Lazarevic V (2014) The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-g-producing T helper 17 cells. Immunity. Published online February 11 ahead of print. Wang
February 25, 2014 Stefan Feske Feske

Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelsen TS, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F (2014) Genome-scale CRISPR-Cas9 knockout screening in human cells. Science 343:84-7

Wang T, Wei JJ, Sabatini DM, Lander ES (2014) Genetic screens in human cells using the CRISPR-Cas9 system. Science 343:80-4

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February 11, 2014 Randy Longman Littman Spencer SP, Wilhelm C, Yang Q, Hall JA, Bouladoux N, Boyd A, Nutman TB, Urban JF Jr, Wang J, Ramalingam TR, Bhandoola A, Wynn TA, Belkaid Y (2014) Adaptation of innate lymphoid cells to a micronutrient deficiency promotes type 2 barrier immunity. Science 343:432-7 Spencer
February 11, 2014 James Muller Dustin Choudhuri K, Llodra J, Roth EW, Tsai J, Gordo S, Wucherpfennig KW, Kam LC, Stokes DL, Dustin ML (2014) Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse. Nature. Published online February 2 ahead of print. Choudhuri
February 4, 2014 Maria Pokrovskii Littman Zhou P, Shaffer DR, Alvarez Arias DA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW (2014) In vivo discovery of immunotherapy targets in the tumour microenvironment. Nature. Published online January 29 ahead of print. Zhou
February 4, 2014 Richard Copin Ernst Arora P, Baena A, Yu KO, Saini NK, Kharkwal SS, Goldberg MF, Kunnath-Velayudhan S, Carreno LJ, Venkataswamy MM, Kim J, Lazar-Molnar E, Lauvau G, Chang YT, Liu Z, Bittman R, Al-Shamkhani A, Cox LR, Jervis PJ, Veerapen N, Besra GS, Porcelli SA (2014) A single subset of dendritic cells controls the cytokine bias of natural killer T cell responses to diverse glycolipid antigens. Immunity 40:105-16 Arora
January 28, 2014 Maryaline Coffre Koralov De Nardo D, Labzin LI, Kono H, Seki R, Schmidt SV, Beyer M, Xu D, Zimmer S, Lahrmann C, Schildberg FA, Vogelhuber J, Kraut M, Ulas T, Kerksiek A, Krebs W, Bode N, Grebe A, Fitzgerald ML, Hernandez NJ, Williams BR, Knolle P, Kneilling M, Rocken M, Lutjohann D, Wright SD, Schultze JL, Latz E (2014) High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3. Nature Immunology 15:152-60 DeNardo
January 28, 2014 Michelle Krogsgaard Krogsgaard Tan YX, Manz BN, Freedman TS, Zhang C, Shokat KM, Weiss A (2014) Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling. Nature Immunology 15:186-94 Tan
January 21, 2014 Mo Xu Littman Honda T, Egen JG, Lammermann T, Kastenmuller W, Torabi-Parizi P, Germain RN (2014) Tuning of antigen sensitivity by T cell receptor-dependent negative feedback controls T cell effector function in inflamed tissues. Immunity. Published online January 14 ahead of print. Honda
January 21, 2014 Sergei Koralov Koralov Molnarfi N, Schulze-Topphoff U, Weber MS, Patarroyo JC, Prod'homme T, Varrin-Doyer M, Shetty A, Linington C, Slavin AJ, Hidalgo J, Jenne DE, Wekerle H, Sobel RA, Bernard CC, Shlomchik MJ, Zamvil SS (2013) MHC class II-dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies. Journal of Experimental Medicine 210:2921-37 Molnarfi
January 14, 2014 Jason Hall Littman Wencker M, Turchinovich G, Di Marco Barros R, Deban L, Jandke A, Cope A, Hayday AC (2014) Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness. Nature Immunology 15:80-7 Wencker
January 14, 2014 Elisabeth Kernbauer Cadwell Helaine S, Cheverton AM, Watson KG, Faure LM, Matthews SA, Holden DW (2014) Internalization of Salmonella by macrophages induces formation of nonreplicating persisters. Science 343:204-8 Helaine
January 7, 2014 Ken Cadwell Cadwell Gur C, Coppenhagen-Glazer S, Rosenberg S, Yamin R, Enk J, Glasner A, Bar-On Y, Fleissig O, Naor R, Abed J, Mevorach D, Granot Z, Bachrach G, Mandelboim O (2013) Natural killer cell-mediated host defense against uropathogenic E. coli is counteracted by bacterial hemolysinA-dependent killing of NK cells. Cell Host Microbe 14:664-74. Gur
January 7, 2014 Smita Srivastava Ernst Doitsh G, Galloway NL, Geng X, Yang Z, Monroe KM, Zepeda O, Hunt PW, Hatano H, Sowinski S, Munoz-Arias I, Greene WC (2013) Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. Nature. Published online December 19 ahead of print. Doitsh
December 17, 2013 Adam Blaisdell Erlebacher Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, Codelli JA, Chow J, Reisman SE, Petrosino JF, Patterson PH, Mazmanian SK (2013) Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell. Published online December 3 ahead of print. Hsiao
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December 10, 2013 Patricia Grace Ernst Palm NW, Rosenstein RK, Yu S, Schenten DD, Florsheim E, Medzhitov R (2013) Bee venom phospholipase A2 induces a primary type 2 response that is dependent on the receptor ST2 and confers protective immunity. Immunity 39:976-85 Palm
December 10, 2013 Sang-Won Kim Littman

Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, Nakanishi Y, Uetake C, Kato K, Kato T, Takahashi M, Fukuda NN, Murakami S, Miyauchi E, Hino S, Atarashi K, Onawa S, Fujimura Y, Lockett T, Clarke JM, Topping DL, Tomita M, Hori S, Ohara O, Morita T, Koseki H, Kikuchi J, Honda K, Hase K, Ohno H (2013) Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. Published online November 13 ahead of print.

Arpaia N, Campbell C, Fan X, Dikiy S, van der Veeken J, Deroos P, Liu H, Cross JR, Pfeffer K, Coffer PJ, Rudensky AY (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. Published online November 13 ahead of print.

Furusawa

Arpaia

December 3, 2013 Martin Vaeth Feske Jin HS, Park Y, Elly C, Liu YC (2013) Itch expression by Treg cells controls Th2 inflammatory responses. Journal of Clinical Investigation 123:4923-34 Jin
December 3, 2013 Wendy Huang Littman Ivanov SS, Roy CR (2013) Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR. Nature Immunology 14:1219-28 Ivanov
November 26, 2013 Brian Norris Ernst Slutter B, Pewe LL, Kaech SM, Harty JT (2013) Lung airway-surveilling CXCR3hi memory CD8+ T cells are critical for protection against influenza A virus. Immunity 39:939-48 Slutter
November 26, 2013 Laura Fogli Koralov Obata-Ninomiya K, Ishiwata K, Tsutsui H, Nei Y, Yoshikawa S, Kawano Y, Minegishi Y, Ohta N, Watanabe N, Kanuka H, Karasuyama H (2013) The skin is an important bulwark of acquired immunity against intestinal helminths. Journal of Experimental Medicine 210:2583-95 Obata-Ninomiya
November 19, 2013 Amanda Marchiando Cadwell Yu X, Rollins D, Ruhn KA, Stubblefield JJ, Green CB, Kashiwada M, Rothman PB, Takahashi JS, Hooper LV (2013) TH17 cell differentiation is regulated by the circadian clock. Science 342:727-30  
November 19, 2013 Benny Yang Littman Shan M, Gentile M, Yeiser JR, Walland AC, Bornstein VU, Chen K, He B, Cassis L, Bigas A, Cols M, Comerma L, Huang B, Blander JM, Xiong H, Mayer L, Berin C, Augenlicht LH, Velcich A, Cerutti A (2013) Mucus enhances gut homeostasis and oral tolerance by delivering immunoregulatory signals. Science 342:447-53  
November 12, 2013 Katie Maurer Cadwell Albacker LA, Chaudhary V, Chang YJ, Kim HY, Chuang YT, Pichavant M, Dekruyff RH, Savage PB, Umetsu DT (2013) Invariant natural killer T cells recognize a fungal glycosphingolipid that can induce airway hyperreactivity. Nature Medicine 19:1297-304  
November 12, 2013 Mick Ménager Littman Konno H, Konno K, Barber GN (2013) Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155:688-98  
November 5, 2013 Joel Ernst Ernst Horowitz A, Strauss-Albee DM, Leipold M, Kubo J, Nemat-Gorgani N, Dogan OC, Dekker CL, Mackey S, Maecker H, Swan GE, Davis MM, Norman PJ, Guethlein LA, Desai M, Parham P, Blish CA (2013) Genetic and environmental determinants of human NK cell diversity revealed by mass cytometry. Science Translational Medicine 5:208ra145  
November 5, 2013 Gregg Silverman Silverman Wesemann DR, Portuguese AJ, Meyers RM, Gallagher MP, Cluff-Jones K, Magee JM, Panchakshari RA, Rodig SJ, Kepler TB, Alt FW (2013) Microbial colonization influences early B-lineage development in the gut lamina propria. Nature 501:112-5  
October 29, 2013 Joshua Ziel Littman Spooner CJ, Lesch J, Yan D, Khan AA, Abbas A, Ramirez-Carrozzi V, Zhou M, Soriano R, Eastham-Anderson J, Diehl L, Lee WP, Modrusan Z, Pappu R, Xu M, Devoss J, Singh H (2013) Specification of type 2 innate lymphocytes by the transcriptional determinant Gfi1. Nature Immunology. Published online October 20 ahead of print.  
October 22, 2013 Amandine Crequer Erlebacher Pyonteck SM, Akkari L, Schuhmacher AJ, Bowman RL, Sevenich L, Quail DF, Olson OC, Quick ML, Huse JT, Teijeiro V, Setty M, Leslie CS, Oei Y, Pedraza A, Zhang J, Brennan CW, Sutton JC, Holland EC, Daniel D, Joyce JA (2013) CSF-1R inhibition alters macrophage polarization and blocks glioma progression. Nature Medicine 19:1264-72  
October 22, 2013 Mate Maus Feske Gubser PM, Bantug GR, Razik L, Fischer M, Dimeloe S, Hoenger G, Durovic B, Jauch A, Hess C (2013) Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch. Nature Immunology 14:1064-72  
October 8, 2013 P'ng Loke Loke Ridaura VK, Faith JJ, Rey FE, Cheng J, Duncan AE, Kau AL, Griffin NW, Lombard V, Henrissat B, Bain JR, Muehlbauer MJ, Ilkayeva O, Semenkovich CF, Funai K, Hayashi DK, Lyle BJ, Martini MC, Ursell LK, Clemente JC, Van Treuren W, Walters WA, Knight R, Newgard CB, Heath AC, Gordon JI (2013) Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 341:1241214  
October 8, 2013 Teruyuki Sano Littman Ohyagi H, Onai N, Sato T, Yotsumoto S, Liu J, Akiba H, Yagita H, Atarashi K, Honda K, Roers A, Müller W, Kurabayashi K, Hosoi-Amaike M, Takahashi N, Hirokawa M, Matsushima K, Sawada K, Ohteki T (2013) Monocyte-derived dendritic cells perform hemophagocytosis to fine-tune excessive immune responses. Immunity 39:584-98  
October 1, 2013 Fabio Santori Littman Manzanillo PS, Ayres JS, Watson RO, Collins AC, Souza G, Rae CS, Schneider DS, Nakamura K, Shiloh MU, Cox JS (2013) The ubiquitin ligase parkin mediates resistance to intracellular pathogens. Nature 501:512-6  
October 1, 2013 Vanessa Hubbard Cadwell Yang Z, Fujii H, Mohan SV, Goronzy JJ, Weyand CM (2013) Phosphofructokinase deficiency impairs ATP generation, autophagy, and redox balance in rheumatoid arthritis T cells. Journal of Experimental Medicine 210:2119-34  
September 24, 2013 Ludovic Desvignes Ernst Gardner JM, Metzger TC, McMahon EJ, Au-Yeung BB, Krawisz AK, Lu W, Price JD, Johannes KP, Satpathy AT, Murphy KM, Tarbell KV, Weiss A, Anderson MS (2013) Extrathymic Aire-expressing cells are a distinct bone marrow-derived population that induce functional inactivation of CD4+ T cells. Immunity 39:560-72  
September 17, 2013 James Muller Dustin Delgoffe GM, Woo SR, Turnis ME, Gravano DM, Guy C, Overacre AE, Bettini ML, Vogel P, Finkelstein D, Bonnevier J, Workman CJ, Vignali DA (2013) Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature. Published online August 4 ahead of print.  
September 17, 2013 Juan Lafaille Lafaille Nussbaum JC, Van Dyken SJ, Moltke J, Cheng LE, Mohapatra A, Molofsky AB, Thornton EE, Krummel MF, Chawla A, Liang H, Locksley RM (2013) Type 2 innate lymphoid cells control eosinophil homeostasis. Nature. Published online September 15 ahead of print.  
September 3, 2013 Vivek Mayya Dustin

Gerlach C, Rohr JC, Perie L, van Rooij N, van Heijst JW, Velds A, Urbanus J, Naik SH, Jacobs H, Beltman JB, de Boer RJ, Schumacher TN (2013) Heterogeneous differentiation patterns of individual CD8+ T cells. Science 340:635-9

Tubo NJ, Pagan AJ, Taylor JJ, Nelson RW, Linehan JL, Ertelt JM, Huseby ES, Way SS, Jenkins MK (2013) Single naive CD4+ T cells from a diverse repertoire produce different effector cell types during infection. Cell 153:785-96

 
September 3, 2013 Randy Longman Littman Lee SM, Donaldson GP, Mikulski Z, Boyajian S, Ley K, Mazmanian SK (2013) Bacterial colonization factors control specificity and stability of the gut microbiota. Nature. Published online August 18 ahead of print.  
August 27, 2013 Shika Ramanan Cadwell Kostic AD, Chun E, Robertson L, Glickman JN, Gallini CA, Michaud M, Clancy TE, Chung DC, Lochhead P, Hold GL, El-Omar EM, Brenner D, Fuchs CS, Meyerson M, Garrett WS (2013) Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. Cell Host Microbe 14:207-15  
August 27, 2013 Gretchen Diehl Littman Grainger JR, Wohlfert EA, Fuss IJ, Bouladoux N, Askenase MH, Legrand F, Koo LY, Brenchley JM, Fraser ID, Belkaid Y (2013) Inflammatory monocytes regulate pathologic responses to commensals during acute gastrointestinal infection. Nature Medicine 19:713-21  
August 20, 2013 Maryaline Coffre Koralov Vossenkamper A, Blair PA, Safinia N, Fraser LD, Das L, Sanders TJ, Stagg AJ, Sanderson JD, Taylor K, Chang F, Choong LM, D'Cruz DP, Macdonald TT, Lombardi G, Spencer J (2013) A role for gut-associated lymphoid tissue in shaping the human B cell repertoire. Journal of Experimental Medicine. Published online August 12 ahead of print.  
August 20, 2013 Mo Xu Littman Schraml BU, van Blijswijk J, Zelenay S, Whitney PG, Filby A, Acton SE, Rogers NC, Moncaut N, Carvajal JJ, Reis e Sousa C (2013) Genetic tracing via DNGR-1 expression history defines dendritic cells as a hematopoietic lineage. Cell 154:843-58  
August 13, 2013 Jason Hall Littman Smith PM, Howitt MR, Panikov N, Michaud M, Gallini CA, Bohlooly-Y M, Glickman JN, Garrett WS (2013) The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science 341:569-73  
August 13, 2013 Elisabeth Kernbauer Cadwell Satpathy AT, Briseno CG, Lee JS, Ng D, Manieri NA, Kc W, Wu X, Thomas SR, Lee WL, Turkoz M, McDonald KG, Meredith MM, Song C, Guidos CJ, Newberry RD, Ouyang W, Murphy TL, Stappenbeck TS, Gommerman JL, Nussenzweig MC, Colonna M, Kopan R, Murphy KM (2013) Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Nature Immunology. Published online August 4 ahead of print.  
August 6, 2013 Ken Cadwell Cadwell Hashimoto D, Chow A, Noizat C, Teo P, Beasley MB, Leboeuf M, Becker CD, See P, Price J, Lucas D, Greter M, Mortha A, Boyer SW, Forsberg EC, Tanaka M, van Rooijen N, Garcia-Sastre A, Stanley ER, Ginhoux F, Frenette PS, Merad M (2013) Tissue-resident macrophages self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Immunity 38:792-804  
August 6, 2013 Richard Copin Ernst Myles IA, Fontecilla NM, Valdez PA, Vithayathil PJ, Naik S, Belkaid Y, Ouyang W, Datta SK (2013) Signaling via the IL-20 receptor inhibits cutaneous production of IL-1beta and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus. Nature Immunology 14:804-11  
July 30, 2013 Smita Srivastava Ernst Olson JA, McDonald-Hyman C, Jameson SC, Hamilton SE (2013) Effector-like CD8+ T cells in the memory population mediate potent protective immunity. Immunity 38:1250-60  
July 30, 2013 Lin Wu Littman Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H (2013) mTORC1 couples immune signals and metabolic programming to establish Treg-cell function. Nature 499:485-90  
July 23, 2013 Stefan Feske Feske Chaigne-Delalande B, Li FY, O'Connor GM, Lukacs MJ, Jiang P, Zheng L, Shatzer A, Biancalana M, Pittaluga S, Matthews HF, Jancel TJ, Bleesing JJ, Marsh RA, Kuijpers TW, Nichols KE, Lucas CL, Nagpal S, Mehmet H, Su HC, Cohen JI, Uzel G, Lenardo MJ (2013) Mg2+ regulates cytotoxic functions of NK and CD8 T cells in chronic EBV infection through NKG2D. Science 341:186-91  
July 23, 2013 Susan Schwab Schwab Schenkel JM, Fraser KA, Vezys V, Masopust D (2013) Sensing and alarm function of resident memory CD8+ T cells. Nature Immunology 14:509-13  
July 16, 2013 Sang-Won Kim Littman Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M, Honda K (2013) Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature. Published online July 10 ahead of print.  
July 16, 2013 Adam Blaisdell Erlebacher Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N (2013) Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499:97-101  
July 9, 2013 Patricia Grace Ernst Shafiani S, Dinh C, Ertelt JM, Moguche AO, Siddiqui I, Smigiel KS, Sharma P, Campbell DJ, Way SS, Urdahl KB (2013) Pathogen-specific Treg cells expand early during Mycobacterium tuberculosis infection but are later eliminated in response to interleukin-12. Immunity 38:1261-70  
July 9, 2013 Carl Weidinger Feske Roychoudhuri R, Hirahara K, Mousavi K, Clever D, Klebanoff CA, Bonelli M, Sciume G, Zare H, Vahedi G, Dema B, Yu Z, Liu H, Takahashi H, Rao M, Muranski P, Crompton JG, Punkosdy G, Bedognetti D, Wang E, Hoffmann V, Rivera J, Marincola FM, Nakamura A, Sartorelli V, Kanno Y, Gattinoni L, Muto A, Igarashi K, O'Shea JJ, Restifo NP (2013) BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis. Nature 498:506-10  
July 2, 2013 Wendy Huang Littman Kawashima T, Kosaka A, Yan H, Guo Z, Uchiyama R, Fukui R, Kaneko D, Kumagai Y, You DJ, Carreras J, Uematsu S, Jang MH, Takeuchi O, Kaisho T, Akira S, Miyake K, Tsutsui H, Saito T, Nishimura I, Tsuji NM (2013) Double-stranded RNA of intestinal commensal but not pathogenic bacteria triggers production of protective interferon-β. Immunity. Published online June 19 ahead of print.  
July 2, 2013 Laura Fogli Koralov Yang XO, Zhang H, Kim BS, Niu X, Peng J, Chen Y, Kerketta R, Lee YH, Chang SH, Corry DB, Wang D, Watowich SS, Dong C (2013) The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation. Nature Immunology 14:732-40  
June 25, 2013 Benny Yang Littman Shalek AK, Satija R, Adiconis X, Gertner RS, Gaublomme JT, Raychowdhury R, Schwartz S, Yosef N, Malboeuf C, Lu D, Trombetta JJ, Gennert D, Gnirke A, Goren A, Hacohen N, Levin JZ, Park H, Regev A (2013) Single-cell transcriptomics reveals bimodality in expression and splicing in immune cells. Nature 498:236-40  
June 25, 2013 Amanda Marchiando Cadwell Barr JJ, Auro R, Furlan M, Whiteson KL, Erb ML, Pogliano J, Stotland A, Wolkowicz R, Cutting AS, Doran KS, Salamon P, Youle M, Rohwer F (2013) Bacteriophage adhering to mucus provide a non-host-derived immunity. Proceedings of the National Academy of Sciences of the United States of America 110:10771-6  
June 18, 2013 Mo Xu Littman Shu J, Wu C, Wu Y, Li Z, Shao S, Zhao W, Tang X, Yang H, Shen L, Zuo X, Yang W, Shi Y, Chi X, Zhang H, Gao G, Shu Y, Yuan K, He W, Tang C, Zhao Y, Deng H (2013) Induction of pluripotency in mouse somatic cells with lineage specifiers. Cell 153:963-75  
June 18, 2013 Joshua Ziel Littman Persson EK, Uronen-Hansson H, Semmrich M, Rivollier A, Hagerbrand K, Marsal J, Gudjonsson S, Hakansson U, Reizis B, Kotarsky K, Agace WW (2013) IRF4 transcription-factor-dependent CD103+CD11b+ dendritic cells drive mucosal T delper 17 cell differentiation. Immunity 38:958-69  
June 11, 2013 Michelle Krogsgaard Krogsgaard Mandl JN, Monteiro JP, Vrisekoop N, Germain RN (2013) T cell-positive selection uses self-ligand binding strength to optimize repertoire recognition of foreign antigens. Immunity 38:263-74  
June 11, 2013 Willy Ramos-Perez Schwab Lammermann T, Afonso PV, Angermann BR, Wang JM, Kastenmuller W, Parent CA, Germain RN (2013) Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature. Published online May 26 ahead of print.  
June 4, 2013 Mate Maus Feske Sinclair LV, Rolf J, Emslie E, Shi YB, Taylor PM, Cantrell DA (2013) Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nature Immunology 14:500-8  
June 4, 2013 Maria Ciofani Littman Hepworth MR, Monticelli LA, Fung TC, Ziegler CG, Grunberg S, Sinha R, Mantegazza AR, Ma HL, Crawford A, Angelosanto JM, Wherry EJ, Koni PA, Bushman FD, Elson CO, Eberl G, Artis D, Sonnenberg GF (2013) Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria. Nature. Published online May 22 ahead of print.  
May 28, 2013 Teruyuki Sano Littman Sokolovska A, Becker CE, Ip WK, Rathinam VA, Brudner M, Paquette N, Tanne A, Vanaja SK, Moore KJ, Fitzgerald KA, Lacy-Hulbert A, Stuart LM (2013) Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function. Nature Immunology 14:543-53  
May 21, 2013 Elisabeth Kernbauer Cadwell Dudda JC, Salaun B, Ji Y, Palmer DC, Monnot GC, Merck E, Boudousquie C, Utzschneider DT, Escobar TM, Perret R, Muljo SA, Hebeisen M, Rufer N, Zehn D, Donda A, Restifo NP, Held W, Gattinoni L, Romero P (2013) MicroRNA-155 is required for effector CD8+ T cell responses to virus infection and cancer. Immunity 38:742-53  
May 21, 2013 Fabio Santori Littman Mukherji A, Kobiita A, Ye T, Chambon P (2013) Homeostasis in intestinal epithelium is orchestrated by the circadian clock and microbiota cues transduced by TLRs. Cell 153:812-27  
May 14, 2013 Gretchen Diehl Littman Cebula A, Seweryn M, Rempala GA, Pabla SS, McIndoe RA, Denning TL, Bry L, Kraj P, Kisielow P, Ignatowicz L (2013) Thymus-derived regulatory T cells contribute to tolerance to commensal microbiota. Nature 497:258-62  
May 14, 2013 Jarrod Johnson Littman Shirey KA, Lai W, Scott AJ, Lipsky M, Mistry P, Pletneva LM, Karp CL, McAlees J, Gioannini TL, Weiss J, Chen WH, Ernst RK, Rossignol DP, Gusovsky F, Blanco JC, Vogel SN (2013) The TLR4 antagonist Eritoran protects mice from lethal influenza infection. Nature. Published online May 1 ahead of print.  
May 7, 2013 P'ng Loke Loke Heredia JE, Mukundan L, Chen FM, Mueller AA, Deo RC, Locksley RM, Rando TA, Chawla A (2013) Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration. Cell 153:376-88  
April 30, 2013 Vivek Mayya Dustin Pace L, Tempez A, Arnold-Schrauf C, Lemaitre F, Bousso P, Fetler L, Sparwasser T, Amigorena S (2012) Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. Science 338:532-6  
April 30, 2013 Ludovic Desvignes Ernst Roca FJ, Ramakrishnan L (2013) TNF dually mediates resistance and susceptibility to mycobacteria via mitochondrial reactive oxygen species. Cell 153:521-34  
April 23, 2013 Randy Longman Littman Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. (2013) Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496:238-42  
April 16, 2013 Jun Huh Littman Chung K, Wallace J, Kim SY, Kalyanasundaram S, Andalman AS, Davidson TJ, Mirzabekov JJ, Zalocusky KA, Mattis J, Denisin AK, Pak S, Bernstein H, Ramakrishnan C, Grosenick L, Gradinaru V, Deisseroth K (2013) Structural and molecular interrogation of intact biological systems. Nature. Published online April 10 ahead of print.  
April 16, 2013 Shika Ramanan Cadwell Lupfer C, Thomas PG, Anand PK, Vogel P, Milasta S, Martinez J, Huang G, Green M, Kundu M, Chi H, Xavier RJ, Green DR, Lamkanfi M, Dinarello CA, Doherty PC, Kanneganti TD (2013) Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nature Immunology. Published online March 24 ahead of print.  
April 9, 2013 Joel Ernst Ernst Ladell K, Hashimoto M, Iglesias MC, Wilmann PG, McLaren JE, Gras S, Chikata T, Kuse N, Fastenackels S, Gostick E, Bridgeman JS, Venturi V, Arkoub ZA, Agut H, van Bockel DJ, Almeida JR, Douek DC, Meyer L, Venet A, Takiguchi M, Rossjohn J, Price DA, Appay V (2013) A molecular basis for the control of preimmune escape variants by HIV-specific CD8+ T cells. Immunity 38:425-36  
April 9, 2013 Juan Lafaille Lafaille Hirota K, Turner JE, Villa M, Duarte JH, Demengeot J, Steinmetz OM, Stockinger B (2013) Plasticity of TH17 cells in Peyer's patches is responsible for the induction of T cell-dependent IgA responses. Nature Immunology 14:372-9  
April 2, 2013 Mac Sellars Littman Malchow S, Leventhal DS, Nishi S, Fischer BI, Shen L, Paner GP, Amit AS, Kang C, Geddes JE, Allison JP, Socci ND, Savage PA (2013) Aire-dependent thymic development of tumor-associated regulatory T cells. Science 339:1219-24  
March 26, 2013 Mick Ménager Littman McEwan WA, Tam JC, Watkinson RE, Bidgood SR, Mallery DL, James LC (2013) Intracellular antibody-bound pathogens stimulate immune signaling via the Fc receptor TRIM21. Nature Immunology 14:327-36  
March 19, 2013 Jason Hall Littman Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK (2013) Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature. Published online March 6 ahead of print.  
March 19, 2013 Mike Dustin Dustin Guy CS, Vignali KM, Temirov J, Bettini ML, Overacre AE, Smeltzer M, Zhang H, Huppa JB, Tsai YH, Lobry C, Xie J, Dempsey PJ, Crawford HC, Aifantis I, Davis MM, Vignali DA (2013) Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nature Immunology 14:262-70  
March 12, 2013 Maryaline Coffre Koralov Huang C, Hatzi K, Melnick A (2013) Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms. Nature Immunology. Published online March 3 ahead of print.  
March 12, 2013 Smita Srivastava Ernst Su LF, Kidd BA, Han A, Kotzin JJ, Davis MM (2013) Virus-specific CD4+ memory-phenotype T cells are abundant in unexposed adults. Immunity 38:373-83  
March 5, 2013 PJ Stewart-Hutchinson Dustin Mattarollo SR, Steegh K, Li M, Duret H, Foong Ngiow S, Smyth MJ (2013) Transient Foxp3+ regulatory T-cell depletion enhances therapeutic anticancer vaccination targeting the immune-stimulatory properties of NKT cells. Immunology and Cell Biology 91:105-14  
March 5, 2013 Richard Copin Ernst Aachoui Y, Leaf IA, Hagar JA, Fontana MF, Campos CG, Zak DE, Tan MH, Cotter PA, Vance RE, Aderem A, Miao EA (2013) Caspase-11 protects against bacteria that escape the vacuole. Science 339:975-8  
February 26, 2013 Adam Blaisdell Erlebacher Grivennikov SI, Wang K, Mucida D, Stewart CA, Schnabl B, Jauch D, Taniguchi K, Yu GY, Osterreicher CH, Hung KE, Datz C, Feng Y, Fearon ER, Oukka M, Tessarollo L, Coppola V, Yarovinsky F, Cheroutre H, Eckmann L, Trinchieri G, Karin M (2012) Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature 491:254-8  
February 26, 2013 Sang-Won Kim Littman Greenbaum A, Hsu YMS, Day RB, Schuettpelz LG, Christopher MJ, Borgerding JN, Nagasawa T, Link DC (2013) CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature. Published online February 24 ahead of print.  
February 19, 2013 David Blair Dustin Marangoni F, Murooka TT, Manzo T, Kim EY, Carrizosa E, Elpek NM, Mempel TR (2013) The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells. Immunity 38:237-249  
February 19, 2013 Patricia Grace Ernst Strainic MG, Shevach EM, An F, Lin F, Medof ME (2013) Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells. Nature Immunology 14:162-171  
February 12, 2013 Vanessa Hubbard Cadwell Chang SY, Song JH, Guleng B, Cotoner CA, Arihiro S, Zhao Y, Chiang HS, O'Keeffe M, Liao G, Karp CL, Kweon MN, Sharpe AH, Bhan A, Terhorst C, Reinecker HC (2013) Circulatory antigen processing by mucosal dendritic cells controls CD8(+) T cell activation. Immunity 38:153-65  
February 12, 2013 Mate Maus Feske Patra AK, Avots A, Zahedi RP, Schüler T, Sickmann A, Bommhardt U, Serfling E (2012) An alternative NFAT-activation pathway mediated by IL-7 is critical for early thymocyte development. Nature Immunology 14:127-35  
February 5, 2013 Laura Fogli Koralov Juncadella IJ, Kadl A, Sharma AK, Shim YM, Hochreiter-Hufford A, Borish L, Ravichandran KS (2013) Apoptotic cell clearance by bronchial epithelial cells critically influences airway inflammation. Nature 493:547-51  
February 5, 2013 Susan Schwab Schwab Kastenmüller W, Brandes M, Wang Z, Herz J, Egen JG, Germain RN (2013) Peripheral prepositioning and local CXCL9 chemokine-mediated guidance orchestrate rapid memory CD8(+) T cell responses in the lymph node. Immunity. Published online January 22 ahead of print.  
January 29, 2013 Wendy Huang Littman Raetz M, Hwang SH, Wilhelm CL, Kirkland D, Benson A, Sturge CR, Mirpuri J, Vaishnava S, Hou B, Defranco AL, Gilpin CJ, Hooper LV, Yarovinsky F (2013) Parasite-induced T(H)1 cells and intestinal dysbiosis cooperate in IFN-γ-dependent elimination of Paneth cells. Nature Immunology 14:136-42  
January 29, 2013 Willy Ramos‑Perez Schwab Arnon TI, Horton RM, Grigorova IL, Cyster JG (2012) Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress. Nature. Published online December 23 ahead of print.  
January 22, 2013 Carl Weidinger Feske Cortez-Retamozo V, Etzrodt M, Newton A, Ryan R, Pucci F, Sio SW, Kuswanto W, Rauch PJ, Chudnovskiy A, Iwamoto Y, Kohler R, Marinelli B, Gorbatov R, Wojtkiewicz G, Panizzi P, Mino-Kenudson M, Forghani R, Figueiredo JL, Chen JW, Xavier R, Swirski FK, Nahrendorf M, Weissleder R, Pittet MJ (2013) Angiotensin II drives the production of tumor-promoting macrophages. Immunity. Published online January 17 ahead of print.  
January 22, 2013 Amanda Marchiando Cadwell Han MS, Jung DY, Morel C, Lakhani SA, Kim JK, Flavell RA, Davis RJ (2013) JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation. Science 339:218-22  
January 15, 2013 Stefan Feske Feske Shi X, Bi Y, Yang W, Guo X, Jiang Y, Wan C, Li L, Bai Y, Guo J, Wang Y, Chen X, Wu B, Sun H, Liu W, Wang J, Xu C (2013) Ca2+ regulates T-cell receptor activation by modulating the charge property of lipids. Nature 493:111-5  
January 8, 2013 Benny Yang Littman Wu J, Sun L, Chen X, Du F, Shi H, Chen C, Chen ZJ (2012) Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science. Published online December 20 ahead of print.  
December 18, 2012 Ken Cadwell Cadwell Henault J, Martinez J, Riggs JM, Tian J, Mehta P, Clarke L, Sasai M, Latz E, Brinkmann MM, Iwasaki A, Coyle AJ, Kolbeck R, Green DR, Sanjuan MA (2012) Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes. Immunity. Published online December 5 ahead of print.  
December 11, 2012 Maria Ciofani Littman Lee J, Sayed N, Hunter A, Au KF, Wong WH, Mocarski ES, Pera RR, Yakubov E, Cooke JP (2012) Activation of innate immunity is required for efficient nuclear reprogramming. Cell 151:547-58  
December 11, 2012 Joshua Ziel Littman Basu R, O'Quinn DB, Silberger DJ, Schoeb TR, Fouser L, Ouyang W, Hatton RD, Weaver CT (2012) Th22 cells are an important source of IL-22 for host protection against enteropathogenic bacteria. Immunity. Published online November 28 ahead of print.  
November 20, 2012 Melissa Fernandez Bhardwaj Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ (2012) Novel role of PKR in inflammasome activation and HMGB1 release. Nature 488:670-4  
November 20, 2012 David Fooksman Dustin Singh NJ, Bando JK, Schwartz RH (2012) Subsets of nonclonal neighboring CD4+ T cells specifically regulate the frequency of individual antigen-reactive T cells. Immunity 37:735-46  
October 16, 2012 Ludovic Desvignes Ernst Benezech C, Mader E, Desanti G, Khan M, Nakamura K, White A, Ware CF, Anderson G, Caamano JH (2012) Lymphotoxin-b receptor signaling through NF-kB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells. Immunity 37:721-34  
October 16, 2012 Fabio Santori Littman Rowe JH, Ertelt JM, Xin L, Way SS (2012) Pregnancy imprints regulatory memory that sustains anergy to fetal antigen. Nature 490:102-6  
October 2, 2012 Jonathan Weiss Lafaille Hall AO, Beiting DP, Tato C, John B, Oldenhove G, Lombana CG, Pritchard GH, Silver JS, Bouladoux N, Stumhofer JS, Harris TH, Grainger J, Wojno ED, Wagage S, Roos DS, Scott P, Turka LA, Cherry S, Reiner SL, Cua D, Belkaid Y, Elloso MM, Hunter CA (2012) The cytokines interleukin 27 and interferon-g promote distinct Treg cell populations required to limit infection-induced pathology. Immunity 37:511-23  
October 2, 2012 Inês Silva Bhardwaj Rangachari M, Zhu C, Sakuishi K, Xiao S, Karman J, Chen A, Angin M, Wakeham A, Greenfield EA, Sobel RA, Okada H, McKinnon PJ, Mak TW, Addo MM, Anderson AC, Kuchroo VK (2012) Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion. Nature Medicine 18:1394-1400  
September 25, 2012 Shika Ramanan Cadwell Upadhyay V, Poroyko V, Kim TJ, Devkota S, Fu S, Liu D, Tumanov AV, Koroleva EP, Deng L, Nagler C, Chang EB, Tang H, Fu YX (2012) Lymphotoxin regulates commensal responses to enable diet-induced obesity. Nature Immunology 13:947-53  
September 25, 2012 Jarrod Johnson Littman Litvak V, Ratushny AV, Lampano AE, Schmitz F, Huang AC, Raman A, Rust AG, Bergthaler A, Aitchison JD, Aderem A (2012) A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses. Nature. Published online September 16 ahead of print.  
September 18, 2012 Davor Frleta Bhardwaj Dühren-von Minden M, Übelhart R, Schneider D, Wossning T, Bach MP, Buchner M, Hofmann D, Surova E, Follo M, Köhler F, Wardemann H, Zirlik K, Veelken H, Jumaa H (2012) Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling. Nature 489:309-12  
September 18, 2012 Gretchen Diehl Littman von Moltke J, Trinidad NJ, Moayeri M, Kintzer AF, Wang SB, van Rooijen N, Brown CR, Krantz BA, Leppla SH, Gronert K, Vance RE (2012) Rapid induction of inflammatory lipid mediators by the inflammasome in vivo. Nature. Published online August 19 ahead of print.  
September 11, 2012 P'ng Loke Loke Hand TW, Dos Santos LM, Bouladoux N, Molloy MJ, Pagán AJ, Pepper M, Maynard CL, Elson CO 3rd, Belkaid Y (2012) Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses. Science. Published online August 23 ahead of print.  
September 11, 2012 Randy Longman Littman Arthur JC, Perez-Chanona E, Mühlbauer M, Tomkovich S, Uronis JM, Fan TJ, Campbell BJ, Abujamel T, Dogan B, Rogers AB, Rhodes JM, Stintzi A, Simpson KW, Hansen JJ, Keku TO, Fodor AA, Jobin C (2012) Intestinal inflammation targets cancer-inducing activity of the microbiota. Science. Published online August 16 ahead of print.  
August 28, 2012 Olivier Manches Bhardwaj Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, Casanova JL (2012) Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency. Science. Published online August 2 ahead of print.  
August 28, 2012 Vivek Mayya Dustin Wei P, Wong WW, Park JS, Corcoran EE, Peisajovich SG, Onuffer JJ, Weiss A, Lim WA (2012) Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells. Nature 488:384-8  
August 21, 2012 Patrick Shaw Feske Chiba S, Baghdadi M, Akiba H, Yoshiyama H, Kinoshita I, Dosaka-Akita H, Fujioka Y, Ohba Y, Gorman JV, Colgan JD, Hirashima M, Uede T, Takaoka A, Yagita H, Jinushi M (2012) Tumor-infiltrating DCs suppress nucleic acid-mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1. Nature Immunology. Published online July 29 ahead of print.  
August 21, 2012 Gregg Silverman Silverman Barr TA, Shen P, Brown S, Lampropoulou V, Roch T, Lawrie S, Fan B, O'Connor RA, Anderton SM, Bar-Or A, Fillatreau S, Gray D (2012) B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells. Journal of Experimental Medicine 209:1001-10  
August 14, 2012 Jun Huh Littman Schepers AG, Snippert HJ, Stange DE, van den Born M, van Es JH, van de Wetering M, Clevers H (2012) Lineage tracing reveals Lgr5+ stem cell activity in mouse intestinal adenomas. Science 337:730-5  
August 14, 2012 Smita Srivastava Ernst Scheiermann C, Kunisaki Y, Lucas D, Chow A, Jang JE, Zhang D, Hashimoto D, Merad M, Frenette PS (2012) Adrenergic nerves govern circadian leukocyte recruitment to tissues. Immunity. Published online August 1 ahead of print.  
August 7, 2012 Mac Sellars Littman Hashimoto T, Perlot T, Rehman A, Trichereau J, Ishiguro H, Paolino M, Sigl V, Hanada T, Hanada R, Lipinski S, Wild B, Camargo SM, Singer D, Richter A, Kuba K, Fukamizu A, Schreiber S, Clevers H, Verrey F, Rosenstiel P, Penninger JM (2012) ACE2 links amino acid malnutrition to microbial ecology and intestinal inflammation. Nature 487:477-81  
August 7, 2012 Juan Lafaille Lafaille Haas JD, Ravens S, Düber S, Sandrock I, Oberdörfer L, Kashani E, Chennupati V, Föhse L, Naumann R, Weiss S, Krueger A, Förster R, Prinz I (2012) Development of interleukin-17-producing γδ T cells is restricted to a functional embryonic wave. Immunity 37:48-59  
July 31, 2012 Michelle Krogsgaard Krogsgaard Stadinski BD, Trenh P, Smith RL, Bautista B, Huseby PG, Li G, Stern LJ, Huseby ES (2011) A role for differential variable gene pairing in creating T cell receptors specific for unique major histocompatibility ligands. Immunity 35:694-704  
July 31, 2012 Mick Ménager Littman Holm CK, Jensen SB, Jakobsen MR, Cheshenko N, Horan KA, Moeller HB, Gonzalez-Dosal R, Rasmussen SB, Christensen MH, Yarovinsky TO, Rixon FJ, Herold BC, Fitzgerald KA, Paludan SR (2012) Virus-cell fusion as a trigger of innate immunity dependent on the adaptor STING. Nature Immunology 13:737-43  
July 24, 2012 Mike Dustin Dustin James JR, Vale RD (2012) Biophysical mechanism of T-cell receptor triggering in a reconstituted system. Nature 487:64-9  
July 24, 2012 Jason Hall Littman Shui JW, Larange A, Kim G, Vela JL, Zahner S, Cheroutre H, Kronenberg M (2012) HVEM signalling at mucosal barriers provides host defence against pathogenic bacteria. Nature. Published online July 15 ahead of print.  
July 17, 2012 Dan Littman Littman Devkota S, Wang Y, Musch MW, Leone V, Fehlner-Peach H, Nadimpalli A, Antonopoulos DA, Jabri B, Chang EB (2012) Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice. Nature 487:104-8  
July 17, 2012 Michael Gobert Lafaille Purwar R, Schlapbach C, Xiao S, Kang HS, Elyaman W, Jiang X, Jetten AM, Khoury SJ, Fuhlbrigge RC, Kuchroo VK, Clark RA, Kupper TS (2012) Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nature Medicine. Published online July 8 ahead of print.  
July 10, 2012 PJ Stewart-Hutchinson Dustin Wang CJ, Kenefeck R, Wardzinski L, Attridge K, Manzotti C, Schmidt EM, Qureshi OS, Sansom DM, Walker LS (2012) Cell-extrinsic immune regulation by CTLA-4 expressed on conventional T cells. Journal of Immunology. Published online June 29 ahead of print.  
July 10, 2012 Jaya Vas Silverman Joo H, Coquery C, Xue Y, Gayet I, Dillon SR, Punaro M, Zurawski G, Banchereau J, Pascual V, Oh S (2012) Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation. Journal of Experimental Medicine 209:1335-48  
June 26, 2012 Adam Blaisdell Erlebacher Allen IC, Wilson JE, Schneider M, Lich JD, Roberts RA, Arthur JC, Woodford RM, Davis BK, Uronis JM, Herfarth HH, Jobin C, Rogers AB, Ting JP (2012) NLRP12 suppresses colon inflammation and tumorigenesis through the negative regulation of noncanonical NF-κB signaling. Immunity 36:742-54  
June 26, 2012 Richard Copin Ernst Cole C, Thomas S, Filak H, Henson PM, Lenz LL (2012) Nitric oxide increases susceptibility of Toll-like receptor-activated macrophages to spreading Listeria monocytogenes. Immunity 36:807-20  
June 19, 2012 Sergei Koralov Koralov Yang Z, Sullivan BM, Allen CD (2012) Fluorescent in vivo detection reveals that IgE+ B cells are restrained by an intrinsic cell rate predisposition. Immunity 36:857-72  
June 19, 2012 Sang-Won Kim Littman Kamada N, Kim YG, Sham HP, Vallance BA, Puente JL, Martens EC, Núñez G (2012) Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science 336:1325-9  
June 12, 2012 David Blair Dustin Sonnenberg GF, Monticelli LA, Alenghat T, Fung TC, Hutnick NA, Kunisawa J, Shibata N, Grunberg S, Sinha R, Zahm AM, Tardif MR, Sathaliyawala T, Kubota M, Farber DL, Collman RG, Shaked A, Fouser LA, Weiner DB, Tessier PA, Friedman JR, Kiyono H, Bushman FD, Chang KM, Artis D (2012) Innate lymphoid cells promote anatomical containment of lymphoid-resident commensal bacteria. Science 336:1321-5  
June 12, 2012 Patricia Grace Ernst Xu S, Liu X, Bao Y, Zhu X, Han C, Zhang P, Zhang X, Li W, Cao X (2012) Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway. Nature Immunology 13:551-9  
June 5, 2012 Vanessa Hubbard Cadwell Negishi H, Yanai H, Nakajima A, Koshiba R, Atarashi K, Matsuda A, Matsuki K, Miki S, Doi T, Aderem A, Nishio J, Smale ST, Honda K, Taniguchi T (2012) Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses. Nature Immunology. Published online May 20 ahead of print.  
June 5, 2012 Mate Maus Feske Pobezinsky LA, Angelov GS, Tai X, Jeurling S, Van Laethem F, Feigenbaum L, Park JH, Singer A (2012) Clonal deletion and the fate of autoreactive thymocytes that survive negative selection. Nature Immunology 13:569-78  
May 29, 2012 Maryaline Coffre Koralov Wang NS, McHeyzer-Williams LJ, Okitsu SL, Burris TP, Reiner SL, McHeyzer-Williams MG (2012) Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα. Nature Immunology 13:604-11  
May 29, 2012 Joel Ernst Ernst Sanderson NS, Puntel M, Kroeger KM, Bondale NS, Swerdlow M, Iranmanesh N, Yagita H, Ibrahim A, Castro MG, Lowenstein PR (2012) Cytotoxic immunological synapses do not restrict the action of interferon-γ to antigenic target cells. Proceedings of the National Academy of Sciences of the United States of America 109:7835-40  
May 22, 2012 Willy Ramos-Perez Schwab Cipolletta D, Feuerer M, Li A, Kamei N, Lee J, Shoelson SE, Benoist C, Mathis D (2012) PPAR-γ is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. Published online May 16 ahead of print.  
May 22, 2012 Carl Weidinger Feske Darce J, Rudra D, Li L, Nishio J, Cipolletta D, Rudensky AY, Mathis D, Benoist C (2012) An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetes. Immunity. Published online May 9 ahead of print.  
May 15, 2012 Wendy Huang Littman Takahashi H, Kanno T, Nakayamada S, Hirahara K, Sciumè G, Muljo SA, Kuchen S, Casellas R, Wei L, Kanno Y, O'Shea JJ (2012) TGF-β and retinoic acid induce the microRNA miR-10a, which targets Bcl-6 and constrains the plasticity of helper T cells. Nature Immunology. Published online April 29 ahead of print.  
May 15, 2012 Susan Schwab Schwab Jiang X, Clark RA, Liu L, Wagers AJ, Fuhlbrigge RC, Kupper TS (2012) Skin infection generates non-migratory memory CD8+ T(RM) cells providing global skin immunity. Nature 483:227-31  
May 8, 2012 Benny Yang Littman Eisenbarth SC, Williams A, Colegio OR, Meng H, Strowig T, Rongvaux A, Henao-Mejia J, Thaiss CA, Joly S, Gonzalez DG, Xu L, Zenewicz LA, Haberman AM, Elinav E, Kleinstein SH, Sutterwala FS, Flavell RA (2012) NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells. Nature 484:510-3  
May 8, 2012 Yelina Alvarez Hioe Zielinski CE, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, Monticelli S, Lanzavecchia A, Sallusto F (2012) Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β. Nature 484:514-8  
May 1, 2012 Shaukat Khan Bhardwaj Olszak T, An D, Zeissig S, Vera MP, Richter J, Franke A, Glickman JN, Siebert R, Baron RM, Kasper DL, Blumberg RS (2012) Microbial exposure during early life has persistent effects on natural killer T cell function. Science 336:489-93  
May 1, 2012 Amanda Marchiando Cadwell Franchi L, Kamada N, Nakamura Y, Burberry A, Kuffa P, Suzuki S, Shaw MH, Kim YG, Núñez G (2012) NLRC4-driven production of IL-1β discriminates between pathogenic and commensal bacteria and promotes host intestinal defense. Nature Immunology 13:449-56  
April 24, 2012 David Fooksman Dustin Facciotti F, Ramanjaneyulu GS, Lepore M, Sansano S, Cavallari M, Kistowska M, Forss-Petter S, Ni G, Colone A, Singhal A, Berger J, Xia C, Mori L, De Libero G (2012) Peroxisome-derived lipids are self antigens that stimulate invariant natural killer T cells in the thymus. Nature Immunology 13:474-80  
April 24, 2012 Joshua Ziel Littman Shifrin DA Jr, McConnell RE, Nambiar R, Higginbotham JN, Coffey RJ, Tyska MJ (2012) Enterocyte microvillus-derived vesicles detoxify bacterial products and regulate epithelial-microbial interactions. Current Biology 22:627-31  
April 17, 2012 Ken Cadwell Cadwell Hill DA, Siracusa MC, Abt MC, Kim BS, Kobuley D, Kubo M, Kambayashi T, LaRosa DF, Renner ED, Orange JS, Bushman FD, Artis D (2012) Commensal bacteria-derived signals regulate basophil hematopoiesis and allergic inflammation. Nature Medicine 18:538-46  
April 10, 2012 Melissa Fernandez Bhardwaj Gringhuis SI, Kaptein TM, Wevers BA, Theelen B, van der Vlist M, Boekhout T, Geijtenbeek TB (2012) Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Nature Immunology 13:246-54  
April 10, 2012 Maria Ciofani Littman Derecki NC, Cronk JC, Lu Z, Xu E, Abbott SB, Guyenet PG, Kipnis J (2012) Wild-type microglia arrest pathology in a mouse model of Rett syndrome. Nature 484:105-9  
April 3, 2012 Sudha Kumari Dustin Li P, Banjade S, Cheng HC, Kim S, Chen B, Guo L, Llaguno M, Hollingsworth JV, King DS, Banani SF, Russo PS, Jiang QX, Nixon BT, Rosen MK (2012) Phase transitions in the assembly of multivalent signalling proteins. Nature 483:336-40  
April 3, 2012 Fabio Santori Littman Matsushita H, Vesely MD, Koboldt DC, Rickert CG, Uppaluri R, Magrini VJ, Arthur CD, White JM, Chen YS, Shea LK, Hundal J, Wendl MC, Demeter R, Wylie T, Allison JP, Smyth MJ, Old LJ, Mardis ER, Schreiber RD (2012) Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature 482:400-4  
March 27, 2012 Jarrod Johnson Littman Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, García-Sastre A, Roeder RG, Tarakhovsky A (2012) Suppression of the antiviral response by an influenza histone mimic. Nature 483:428-33  
March 27, 2012 Shika Ramanan Cadwell McDole JR, Wheeler LW, McDonald KG, Wang B, Konjufca V, Knoop KA, Newberry RD, Miller MJ (2012) Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature 483:345-9  
March 20, 2012 Davor Frleta Bhardwaj Kirkland D, Benson A, Mirpuri J, Pifer R, Hou B, Defranco AL, Yarovinsky F (2012) B cell-intrinsic MyD88 signaling prevents the lethal dissemination of commensal bacteria during colonic damage. Immunity 36:228-38  
March 20, 2012 Jonathan Weiss Lafaille Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, Hori S (2012) Plasticity of foxp3+ T cells reflects promiscuous foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 36:262-75  
March 13, 2012 Ludovic Desvignes Ernst Moseman EA, Iannacone M, Bosurgi L, Tonti E, Chevrier N, Tumanov A, Fu YX, Hacohen N, von Andrian UH (2012) B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. Immunity. Published online March 1 ahead of print.  
March 13, 2012 Randy Longman Littman Dudakov JA, Hanash AM, Jenq RR, Young LF, Ghosh A, Singer NV, West ML, Smith OM, Holland AM, Tsai JJ, Boyd RL, van den Brink MR (2012) Interleukin-22 drives endogenous thymic regeneration in mice. Science. Published online March 1 ahead of print.  
March 6, 2012 P'ng Loke Loke Nguyen KD, Qiu Y, Cui X, Goh YP, Mwangi J, David T, Mukundan L, Brombacher F, Locksley RM, Chawla A (2011) Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis. Nature 480:104-8  
March 6, 2012 Inês Silva Bhardwaj Narni-Mancinelli E, Jaeger BN, Bernat C, Fenis A, Kung S, De Gassart A, Mahmood S, Gut M, Heath SC, Estellé J, Bertosio E, Vely F, Gastinel LN, Beutler B, Malissen B, Malissen M, Gut IG, Vivier E, Ugolini S (2012) Tuning of natural killer cell reactivity by NKp46 and Helios calibrates T cell responses. Science 335:344-8  
February 28, 2012 Olivier Manches Bhardwaj Bonilla WV, Fröhlich A, Senn K, Kallert S, Fernandez M, Johnson S, Kreutzfeldt M, Hegazy AN, Schrick C, Fallon PG, Klemenz R, Nakae S, Adler H, Merkler D, Löhning M, Pinschewer DD (2012) The alarmin interleukin-33 drives protective antiviral CD8+ T cell responses. Science 335:984-9  
February 28, 2012 Gretchen Diehl Littman Josefowicz SZ, Niec RE, Kim HY, Treuting P, Chinen T, Zheng Y, Umetsu DT, Rudensky AY (2012) Extrathymically generated regulatory T cells control mucosal TH2 inflammation. Nature 482:395-9  
February 21, 2012 Patrick Shaw Feske Silver AC, Arjona A, Walker WE and Fikrig E (2012) The circadian clock controls Toll-like Receptor 9-mediated innate and adaptive immunity. Immunity 36:1-11  
February 21, 2012 Vivek Mayya Dustin van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, Pearce EJ, Pearce EL (2012) Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 36:68-78  
February 14, 2012 Mac Sellars Littman Weber BN, Chi AW, Chavez A, Yashiro-Ohtani Y, Yang Q, Shestova O, Bhandoola A (2011) A critical role for TCF-1 in T-lineage specification and differentiation. Nature 476:63-8  
February 14, 2012 Smita Srivastava Ernst Tobin DM, Roca FJ, Oh SF, McFarland R, Vickery TW, Ray JP, Ko DC, Zou Y, Bang ND, Chau TT, Vary JC, Hawn TR, Dunstan SJ, Farrar JJ, Thwaites GE, King MC, Serhan CN, Ramakrishnan L (2012) Host genotype-specific therapies can optimize the inflammatory response to mycobacterial infections. Cell 148:434-46  
February 7, 2012 Jun Huh Littman Arima Y, Harada M, Kamimura D, Park JH, Kawano F, Yull FE, Kawamoto T, Iwakura Y, Betz UAK, Márquez G, Blackwell TS, Ohira Y, Hirano T, Murakami M (2012) Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier. Cell 148:447-57  
February 7, 2012 Michael Gobert Lafaille Michaud M, Martins I, Sukkurwala AQ, Adjemian S, Ma Y, Pellegatti P, Shen S, Kepp O, Scoazec M, Mignot G, Rello-Varona S, Tailler M, Menger L, Vacchelli E, Galluzzi L, Ghiringhelli F, di Virgilio F, Zitvogel L, Kroemer G (2011) Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice. Science 334:1573-7  
January 31, 2012 Gregg Silverman Silverman Miles K, Heaney J, Sibinska Z, Salter D, Savill J, Gray D, Gray M (2012) A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells. Proceedings of the National Academy of Sciences of the United States of America 109:887-92  
January 31, 2012 Catarina Sacristán Dustin Waggoner SN, Cornberg M, Selin LK, Welsh RM (2012) Natural killer cells act as rheostats modulating antiviral T cells. Nature 481:394-8  
January 24, 2012 Juan Lafaille Lafaille Fritz JH, Rojas OL, Simard N, McCarthy DD, Hapfelmeier S, Rubino S, Robertson SJ, Larijani M, Gosselin J, Ivanov II, Martin A, Casellas R, Philpott DJ, Girardin SE, McCoy KD, Macpherson AJ, Paige CJ, Gommerman JL (2012) Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut. Nature 481:199-203  
January 24, 2012 PJ Stewart-Hutchinson Dustin Shulman Z, Cohen SJ, Roediger B, Kalchenko V, Jain R, Grabovsky V, Klein E, Shinder V, Stoler-Barak L, Feigelson SW, Meshel T, Nurmi SM, Goldstein I, Hartley O, Gahmberg CG, Etzioni A, Weninger W, Ben-Baruch A, Alon R (2012) Transendothelial migration of lymphocytes mediated by intraendothelial vesicle stores rather than by extracellular chemokine depots. Nature Immunology 13:67-76  
January 17, 2012 Mike Dustin Dustin

Barnett BE, Ciocca ML, Goenka R, Barnett LG, Wu J, Laufer TM, Burkhardt JK, Cancro MP, Reiner SL (2011) Asymmetric B cell division in the germinal center reaction. Science. Published online December 15 ahead of print.

Duffy KR, Wellard CJ, Markham JF, Zhou JH, Holmberg R, Hawkins ED, Hasbold J, Dowling MR, Hodgkin PD (2012) Activation-induced B cell fates are selected by intracellular stochastic competition. Science. Published online January 5 ahead of print.

 
January 17, 2012 Mick Ménager Littman Honke N, Shaabani N, Cadeddu G, Sorg UR, Zhang DE, Trilling M, Klingel K, Sauter M, Kandolf R, Gailus N, van Rooijen N, Burkart C, Baldus SE, Grusdat M, Löhning M, Hengel H, Pfeffer K, Tanaka M, Häussinger D, Recher M, Lang PA, Lang KS (2011) Enforced viral replication activates adaptive immunity and is essential for the control of a cytopathic virus. Nature Immunology 13:51-7  
January 10, 2012 Sang-Won Kim Littman Rosenblum MD, Gratz IK, Paw JS, Lee K, Marshak-Rothstein A, Abbas AK (2011) Response to self antigen imprints regulatory memory in tissues. Nature 480:538-42  
January 10, 2012 Stefan Feske Feske Kiss EA, Vonarbourg C, Kopfmann S, Hobeika E, Finke D, Esser C, Diefenbach A (2011) Natural aryl hydrocarbon receptor ligands control organogenesis of intestinal lymphoid follicles. Science 334:1561-5  
December 20, 2011 Dan Littman Littman Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B, Kirkland JL, van Deursen JM (2011) Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature 479:232-6  
December 20, 2011 Daniela Anghelina Lafaille Shulzhenko N, Morgun A, Hsiao W, Battle M, Yao M, Gavrilova O, Orandle M, Mayer L, Macpherson AJ, McCoy KD, Fraser-Liggett C, Matzinger P (2011) Crosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut. Nature Medicine 17:1585-93  
December 13, 2011 Michelle Krogsgaard Krogsgaard Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC (2011) T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex. Immunity 35:681-93  
December 13, 2011 Richard Copin Ernst Moussion C, Girard JP (2011) Dendritic cells control lymphocyte entry to lymph nodes through high endothelial venules. Nature 479:542-6  
December 6, 2011 Jason Hall Littman Yoo SK, Starnes TW, Deng Q, Huttenlocher A (2011) Lyn is a redox sensor that mediates leukocyte wound attraction in vivo. Nature 480:109-12  
December 6, 2011 Adam Blaisdell Erlebacher Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L (2011) Senescence surveillance of pre-malignant hepatocytes limits liver cancer development. Nature 479:547-51  
November 29, 2011 Sergei Koralov Koralov Cai Y, Shen X, Ding C, Qi C, Li K, Li X, Jala VR, Zhang HG, Wang T, Zheng J, Yan J (2011) Pivotal role of dermal IL-17-producing γδ T cells in skin inflammation. Immunity 35:596-610  
November 29, 2011 David Blair Dustin Cui W, Liu Y, Weinstein JS, Craft J, Kaech SM (2011) An interleukin-21- interleukin-10-STAT3 pathway is critical for functional maturation of memory CD8+ T cells. Immunity 35:792-805  
November 22, 2011 Vanessa Hubbard Cadwell Yang K, Neale G, Green DR, He W, Chi H (2011) The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nature Immunology 12:888-97  
November 22, 2011 Patricia Grace Ernst Hershko AY, Suzuki R, Charles N, Alvarez-Errico D, Sargent JL, Laurence A, Rivera J (2011) Mast cell interleukin-2 production contributes to suppression of chronic allergic dermatitis. Immunity 35:562-71  
November 15, 2011 Duane Moogk Krogsgaard Schoenborn JR, Tan YX, Zhang C, Shokat KM, Weiss A (2011) Feedback circuits monitor and adjust basal Lck-dependent events in T cell receptor signaling. Science Signaling 4(190):ra59  
November 15, 2011 Mate Maus Feske Yuseff MI, Reversat A, Lankar D, Diaz J, Fanget I, Pierobon P, Randrian V, Larochette N, Vascotto F, Desdouets C, Jauffred B, Bellaiche Y, Gasman S, Darchen F, Desnos C, Lennon-Duménil AM (2011) Polarized secretion of lysosomes at the B cell synapse couples antigen extraction to processing and presentation. Immunity 35:361-74  
November 8, 2011 Maryaline Coffre Koralov Ma F, Xu S, Liu X, Zhang Q, Xu X, Liu M, Hua M, Li N, Yao H, Cao X (2011) The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ. Nature Immunology 12:861-9  
November 8, 2011 Willy Ramos‑Perez Schwab Arnon TI, Xu Y, Lo C, Pham T, An J, Coughlin S, Dorn GW, Cyster JG (2011) GRK2-dependent S1PR1 desensitization is required for lymphocytes to overcome their attraction to blood. Science 333:1898-903  
November 1, 2011 Carl Weidinger Feske Granot Z, Henke E, Comen EA, King TA, Norton L, Benezra R (2011) Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20:300-14  
November 1, 2011 Joel Ernst Ernst Burdette DL, Monroe KM, Sotelo-Troha K, Iwig JS, Eckert B, Hyodo M, Hayakawa Y, Vance RE (2011) STING is a direct innate immune sensor of cyclic di-GMP. Nature 478:515-8  
October 25, 2011 Susan Schwab Schwab Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H (2011) Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule. Nature Immunology 12:1086-95  
October 25, 2011 Wendy Huang Littman Li Y, Innocentin S, Withers DR, Roberts NA, Gallagher AR, Grigorieva EF, Wilhelm C, Veldhoen M (2011) Exogenous stimuli maintain intraepithelial lymphocytes via aryl hydrocarbon receptor activation. Cell. Published online October 11 ahead of print.  
October 11, 2011 Yelina Alvarez Hioe Elahi S, Dinges WL, Lejarcegui N, Laing KJ, Collier AC, Koelle DM, McElrath MJ, Horton H (2011) Protective HIV-specific CD8+ T cells evade Treg cell suppression. Nature Medicine 17:989-95  
October 11, 2011 David Fooksman Dustin Lukacs-Kornek V, Malhotra D, Fletcher AL, Acton SE, Elpek KG, Tayalia P, Collier AR, Turley SJ (2011) Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes. Nature Immunology. Published online September 18 ahead of print.  
October 4, 2011 Shaukat Khan Bhardwaj Ippagunta SK, Malireddi RK, Shaw PJ, Neale GA, Walle LV, Green DR, Fukui Y, Lamkanfi M, Kanneganti TD (2011) The inflammasome adaptor ASC regulates the function of adaptive immune cells by controlling Dock2-mediated Rac activation and actin polymerization. Nature Immunology 12:1010-6  
October 4, 2011 Benny Yang Littman Lathrop SK, Bloom SM, Rao SM, Nutsch K, Lio CW, Santacruz N, Peterson DA, Stappenbeck TS, Hsieh CS (2011) Peripheral education of the immune system by colonic commensal microbiota. Nature. Published online September 21 ahead of print.  
September 27, 2011 Jarrod Johnson Littman Li S, Wang L, Berman M, Kong YY, Dorf ME. Mapping a dynamic innate immunity protein interaction network regulating type I interferon production. Immunity 35:426-440  
September 27, 2011 Alexandra Zanin‑Zhorov Dustin Beavis PA, Gregory B, Green P, Cribbs AP, Kennedy A, Amjadi P, Palfreeman AC, Feldmann M, Brennan FM (2011) Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells. Proceedings of the National Academy of Sciences of the United States of America. Published online September 16 ahead of print.  
September 20, 2011 Anne Gallois Bhardwaj Alter G, Heckerman D, Schneidewind A, Fadda L, Kadie CM, Carlson JM, Oniangue-Ndza C, Martin M, Li B, Khakoo SI, Carrington M, Allen TM, Altfeld M (2011) HIV-1 adaptation to NK-cell-mediated immune pressure. Nature 476:96-100  
September 20, 2011 Ken Cadwell Cadwell Kim S, Lee S, Shin J, Kim Y, Evnouchidou I, Kim D, Kim YK, Kim YE, Ahn JH, Riddell SR, Stratikos E, Kim VN, Ahn K (2011) Human cytomegalovirus microRNA miR-US4-1 inhibits CD8+ T cell responses by targeting the aminopeptidase ERAP1. Nature Immunology. Published online September 4 ahead of print.  
September 13, 2011 Melissa Fernandez Bhardwaj Kofoed EM, Vance RE (2011) Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature. Published online August 28 ahead of print.  
September 13, 2011 Huizhong Xiong Lafaille Li F, Ravetch JV (2011) Inhibitory Fc&gamma receptor engagement drives adjuvant and anti-tumor activities of agonistic CD40 antibodies. Science 333:1030-4  
September 6, 2011 Sudha Kumari Dustin Li FY, Chaigne-Delalande B, Kanellopoulou C, Davis JC, Matthews HF, Douek DC, Cohen JI, Uzel G, Su HC, Lenardo MJ (2011) Second messenger role for Mg2+ revealed by human T-cell immunodeficiency. Nature 475:471-6  
September 6, 2011 Fabio Santori Littman Hannedouche S, Zhang J, Yi T, Shen W, Nguyen D, Pereira JP, Guerini D, Baumgarten BU, Roggo S, Wen B, Knochenmuss R, Noël S, Gessier F, Kelly LM, Vanek M, Laurent S, Preuss I, Miault C, Christen I, Karuna R, Li W, Koo DI, Suply T, Schmedt C, Peters EC, Falchetto R, Katopodis A, Spanka C, Roy MO, Detheux M, Chen YA, Schultz PG, Cho CY, Seuwen K, Cyster JG, Sailer AW (2011) Oxysterols direct immune cell migration via EBI2. Nature 475:524-7  
August 30, 2011 Beatrice Breart Schwab Gebhardt T, Whitney PG, Zaid A, Mackay LK, Brooks AG, Heath WR, Carbone FR, Mueller SN (2011) Different patterns of peripheral migration by memory CD4+ and CD8+ T cells. Nature. Published online August 14 ahead of print.  
August 30, 2011 Jonathan Weiss Lafaille Braun A, Worbs T, Moschovakis GL, Halle S, Hoffmann K, Bölter J, Münk A, Förster R (2011) Afferent lymph-derived T cells and DCs use different chemokine receptor CCR7-dependent routes for entry into the lymph node and intranodal migration. Nature Immunology 12:879-87  
August 23, 2011 Mac Sellars Littman Siracusa MC, Saenz SA, Hill DA, Kim BS, Headley MB, Doering TA, Wherry EJ, Jessup HK, Siegel LA, Kambayashi T, Dudek EC, Kubo M, Cianferoni A, Spergel JM, Ziegler SF, Comeau MR, Artis D (2011) TSLP promotes interleukin-3-independent basophil haematopoiesis and type 2 inflammation. Nature. Published online August 14 ahead of print.  
August 23, 2011 Davor Frleta Bhardwaj Kalos M, Levine BL, Porter DL, Katz S, Grupp SA, Bagg A, June CH (2011) T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia. Science Translational Medicine 3(95):95ra73  
August 16, 2011 Ludovic Desvignes Ernst Pallotta MT, Orabona C, Volpi C, Vacca C, Belladonna ML, Bianchi R, Servillo G, Brunacci C, Calvitti M, Bicciato S, Mazza EM, Boon L, Grassi F, Fioretti MC, Fallarino F, Puccetti P, Grohmann U (2011) Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells. Nature Immunology. Published online July 31 ahead of print.  
August 16, 2011 Randy Longman Littman Geddes K, Rubino SJ, Magalhaes JG, Streutker C, Le Bourhis L, Cho JH, Robertson SJ, Kim CJ, Kaul R, Philpott DJ, Girardin SE (2011) Identification of an innate T helper type 17 response to intestinal bacterial pathogens. Nature Medicine 17:837-44  
August 9, 2011 Amanda Marchiando Cadwell Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernández-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M (2011) FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature. Published online July 31 ahead of print.  
August 9, 2011 P'ng Loke Loke Jenkins SJ, Ruckerl D, Cook PC, Jones LH, Finkelman FD, van Rooijen N, MacDonald AS, Allen JE (2011) Local macrophage proliferation, rather than recruitment from the blood, is a signature of TH2 inflammation. Science. 332:1284-8  
August 2, 2011 Olivier Manches Bhardwaj Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, Chi H (2011) HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. Journal of Experimental Medicine 208:1367-76  
August 2, 2011 Gretchen Diehl Littman Geuking MB, Cahenzli J, Lawson MA, Ng DC, Slack E, Hapfelmeier S, McCoy KD, Macpherson AJ (2011) Intestinal bacterial colonization induces mutualistic regulatory T cell responses. Immunity 34:794-806  
July 26, 2011 Inês Silva Bhardwaj Thiery J, Keefe D, Boulant S, Boucrot E, Walch M, Martinvalet D, Goping IS, Bleackley RC, Kirchhausen T, Lieberman J (2011) Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells. Nature Immunology 12:770-7  
July 26, 2011 Manolis Gialitakis Littman Tun-Kyi A, Finn G, Greenwood A, Nowak M, Lee TH, Asara JM, Tsokos GC, Fitzgerald K, Israel E, Li X, Exley M, Nicholson LK, Lu KP (2011) Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity. Nature Immunology. Published online July 10 ahead of print.  
July 19, 2011 Patrick Shaw Feske van Gisbergen KPJM, Klarenbeek PL, Kragten NAM, Unger PPA, Nieuwenhuis MBB, Wensveen FM, ten Brinke A, Tak PP, Eldering E, Nolte MA, van Lier RAW (2011) The costimulatory molecule CD27 maintains clonally diverse CD8+ T cell responses of low antigen affinity to protect against viral variants. Immunity. Published online July 14 ahead of print.  
July 19, 2011 Vivek Mayya Dustin Feng X, Wang H, Takata H, Day TJ, Willen J, Hu H (2011) Transcription factor Foxp1 exerts essential cell-intrinsic regulation of the quiescence of naive T cells. Nature Immunology 12:544-50  
July 12, 2011 Sonia Jimenez‑Baranda Bhardwaj Settembre C, Di Malta C, Polito VA, Garcia Arencibia M, Vetrini F, Erdin S, Erdin SU, Huynh T, Medina D, Colella P, Sardiello M, Rubinsztein DC, Ballabio A (2011) TFEB links autophagy to lysosomal biogenesis. Science 332:1429-33  
July 12, 2011 Angelina Bilate Lafaille Haribhai D, Williams JB, Jia S, Nickerson D, Schmitt EG, Edwards B, Ziegelbauer J, Yassai M, Li SH, Relland LM, Wise PM, Chen A, Zheng YQ, Simpson PM, Gorski J, Salzman NH, Hessner MJ, Chatila TA, Williams CB (2011) A requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversity. Immunity. Published online June 29 ahead of print.  
July 5, 2011 Derya Unutmaz Unutmaz Paiardini M, Cervasi B, Reyes-Aviles E, Micci L, Ortiz AM, Chahroudi A, Vinton C, Gordon SN, Bosinger SE, Francella N, Hallberg PL, Cramer E, Schlub T, Chan ML, Riddick NE, Collman RG, Apetrei C, Pandrea I, Else J, Munch J, Kirchhoff F, Davenport MP, Brenchley JM, Silvestri G (2011) Low levels of SIV infection in sooty mangabey central memory CD4+ T cells are associated with limited CCR5 expression. Nature Medicine. Published online June 26 ahead of print.  
July 5, 2011 Michael Gobert Lafaille Fujisaki J, Wu J, Carlson AL, Silberstein L, Putheti P, Larocca R, Gao W, Saito TI, Lo Celso C, Tsuyuzaki H, Sato T, Côté D, Sykes M, Strom TB, Scadden DT, Lin CP (2011) In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature 474:216-9  
June 28, 2011 Catarina Sacristán Dustin Williamson DJ, Owen DM, Rossy J, Magenau A, Wehrmann M, Gooding JJ, Gaus K (2011) Pre-existing clusters of the adaptor Lat do not participate in early T cell signaling events. Nature Immunology 12:655-62  
June 28, 2011 Jun Huh Littman Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD (2011) A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature 474:506-10  
June 14, 2011 Gregg Silverman Silverman Griffin DO, Holodick NE, Rothstein TL (2011) Human B1 cells in umbilical cord and adult peripheral blood express the novel phenotype CD20+ CD27+ CD43+ CD70-. Journal of Experimental Medicine 208:67-80  
June 14, 2011 Mick Ménager Littman Pichlmair A, Lassnig C, Eberle CA, Górna MW, Baumann CL, Burkard TR, Bürckstümmer T, Stefanovic A, Krieger S, Bennett KL, Rülicke T, Weber F, Colinge J, Müller M, Superti-Furga G (2011) IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA. Nature Immunology 12:624-30  
June 7, 2011 Juan Lafaille Lafaille Ferreira A, Marguti I, Bechmann I, Jeney V, Chora Â, Palha NR, Rebelo S, Henri A, Beuzard Y, Soares MP (2011) Sickle hemoglobin confers tolerance to Plasmodium infection. Cell 145:398-409  
June 7, 2011 Sang-Won Kim Littman Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ, Peaper DR, Bertin J, Eisenbarth SC, Gordon JI, Flavell RA (2011) NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145:745-57  
May 31, 2011 Mike Dustin Dustin Jain A, Liu R, Ramani B, Arauz E, Ishitsuka Y, Ragunathan K, Park J, Chen J, Xiang YK, Ha T (2011) Probing cellular protein complexes using single-molecule pull-down. Nature 473:484-8  
May 31, 2011 Dan Littman Littman Round JL, Lee SM, Li J, Tran G, Jabri B, Chatila TA, Mazmanian SK (2011) The toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota. Science 332:974-7  
May 24, 2011 Daniela Anghelina Lafaille Codarri L, Gyülvészi G, Tosevski V, Hesske L, Fontana A, Magnenat L, Suter T, Becher B (2011) RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation. Nature Immunology 12:560-7  
May 17, 2011 Maria Ciofani Littman Bendall SC, Simonds EF, Qiu P, Amir el-AD, Krutzik PO, Finck R, Bruggner RV, Melamed R, Trejo A, Ornatsky OI, Balderas RS, Plevritis SK, Sachs K, Pe'er D, Tanner SD, Nolan GP (2011) Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum. Science 332:687-96  
May 17, 2011 Adam Blaisdell Erlebacher Flach TL, Ng G, Hari A, Desrosiers MD, Zhang P, Ward SM, Seamone ME, Vilaysane A, Mucsi AD, Fong Y, Prenner E, Ling CC, Tschopp J, Muruve DA, Amrein MW, Shi Y (2011) Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity. Nature Medicine 17:479-87  
May 10, 2011 Sergei Koralov Koralov Kulkarni S, Savan R, Qi Y, Gao X, Yuki Y, Bass SE, Martin MP, Hunt P, Deeks SG, Telenti A, Pereyra F, Goldstein D, Wolinsky S, Walker B, Young HA, Carrington M (2011) Differential microRNA regulation of HLA-C expression and its association with HIV control. Nature 472:495-8  
May 10, 2011 David Blair Dustin Chang JT, Ciocca ML, Kinjyo I, Palanivel VR, McClurkin CE, Dejong CS, Mooney EC, Kim JS, Steinel NC, Oliaro J, Yin CC, Florea BI, Overkleeft HS, Berg LJ, Russell SM, Koretzky GA, Jordan MS, Reiner SL (2011) Asymmetric proteasome segregation as a mechanism for unequal partitioning of the transcription factor T-bet during T lymphocyte division. Immunity 34:492-504  
May 3, 2011 Duane Moogk Krogsgaard Staton TL, Lazarevic V, Jones DC, Lanser AJ, Takagi T, Ishii S, Glimcher LH (2011) Dampening of death pathways by schnurri-2 is essential for T-cell development. Nature 472:105-9  
May 3, 2011 Stefan Feske Feske Schenk U, Frascoli M, Proietti M, Geffers R, Traggiai E, Buer J, Ricordi C, Westendorf AM, Grassi F (2011) ATP inhibits the generation and function of regulatory T cells through the activation of purinergic P2X receptors. Science Signaling 4:ra12  
April 26, 2011 Michelle Krogsgaard Krogsgaard Yin Y, Li Y, Kerzic MC, Martin R, Mariuzza RA (2011) Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection. The EMBO Journal 30:1137-48  
April 26, 2011 Willy Ramos-Perez Schwab Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, Bando JK, Chawla A, Locksley RM (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332:243-7  
April 19, 2011 Susan Schwab Schwab Qureshi OS, Zheng Y, Nakamura K, Attridge K, Manzotti C, Schmidt EM, Baker J, Jeffery LE, Kaur S, Briggs Z, Hou TZ, Futter CE, Anderson G, Walker LS, Sansom DM (2011) Trans-endocytosis of CD80 and CD86: a molecular basis for the cell extrinsic function of CTLA-4. Science. Published online April 7 ahead of print.  
April 19, 2011 Wendy Huang Littman Fukuda S, Toh H, Hase K, Oshima K, Nakanishi Y, Yoshimura K, Tobe T, Clarke JM, Topping DL, Suzuki T, Taylor TD, Itoh K, Kikuchi J, Morita H, Hattori M, Ohno H (2011) Bifidobacteria can protect from enteropathogenic infection through production of acetate. Nature 469:543-7  
April 12, 2011 Joel Ernst Ernst Paul P, van den Hoorn T, Jongsma ML, Bakker MJ, Hengeveld R, Janssen L, Cresswell P, Egan DA, van Ham M, Ten Brinke A, Ovaa H, Beijersbergen RL, Kuijl C, Neefjes J (2011) A genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. Cell. Published online March 30 ahead of print.  
April 12, 2011 Yelina Alvarez Hioe Wakim LM, Bevan MJ (2011) Cross-dressed dendritic cells drive memory CD8+ T-cell activation after viral infection. Nature 471:629-32  
April 5, 2011 Gerard Honig Littman Puneet P, McGrath MA, Tay HK, Al-Riyami L, Rzepecka J, Moochhala SM, Pervaiz S, Harnett MM, Harnett W, Melendez AJ (2011) The helminth product ES-62 protects against septic shock via Toll-like receptor 4-dependent autophagosomal degradation of the adaptor MyD88. Nature Immunology 12:344-51  
April 5, 2011 David Fooksman Dustin Adams KN, Takaki K, Connolly LE, Wiedenhoft H, Winglee K, Humbert O, Edelstein PH, Cosma CL, Ramakrishnan L (2011) Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism. Cell. Published online March 2 ahead of print.  
March 29, 2011 Benny Yang Littman Pandiyan P, Conti HR, Zheng L, Peterson AC, Mathern DR, Hernández-Santos N, Edgerton M, Gaffen SL, Lenardo MJ (2011) CD4+CD25+Foxp3+ regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. Immunity 34:422-34  
March 29, 2011 Huizhong Xiong Lafaille Tan W, Zhang W, Strasner A, Grivennikov S, Cheng JQ, Hoffman RM, Karin M (2011) Tumour-infiltrating regulatory T cells stimulate mammary cancer metastasis through RANKL-RANK signalling. Nature 470:548-53  
March 22, 2011 Jiyun Kim Dustin Burguillos MA, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, Cano J, Brundin P, Englund E, Venero JL, Joseph B (2011) Caspase signalling controls microglia activation and neurotoxicity. Nature. Published online March 9 ahead of print.  
March 22, 2011 Jarrod Johnson Littman Kasturi SP, Skountzou I, Albrecht RA, Koutsonanos D, Hua T, Nakaya HI, Ravindran R, Stewart S, Alam M, Kwissa M, Villinger F, Murthy N, Steel J, Jacob J, Hogan RJ, García-Sastre A, Compans R, Pulendran B (2011) Programming the magnitude and persistence of antibody responses with innate immunity. Nature 470:543-7  
March 15, 2011 Jonathan Weiss Lafaille Biton M, Levin A, Slyper M, Alkalay I, Horwitz E, Mor H, Kredo-Russo S, Avnit-Sagi T, Cojocaru G, Zreik F, Bentwich Z, Poy MN, Artis D, Walker MD, Hornstein E, Pikarsky E, Ben-Neriah Y (2011) Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk. Nature Immunology 12:239-46  
March 15, 2011 Ken Cadwell Cadwell Félix MA, Ashe A, Piffaretti J, Wu G, Nuez I, Bélicard T, Jiang Y, Zhao G, Franz CJ, Goldstein LD, Sanroman M, Miska EA, Wang D (2011) Natural and experimental infection of Caenorhabditis nematodes by novel viruses related to nodaviruses. PLoS Biology 9:e1000586  
March 8, 2011 Fabio Santori Littman Wang W, Barnaby JY, Tada Y, Li H, Tör M, Caldelari D, Lee DU, Fu XD, Dong X (2011) Timing of plant immune responses by a central circadian regulator. Nature 470:110-4  
March 8, 2011 Sudha Kumari Dustin Schroeder BO, Wu Z, Nuding S, Groscurth S, Marcinowski M, Beisner J, Buchner J, Schaller M, Stange EF, Wehkamp J (2011) Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1. Nature 469:419-23  
March 1, 2011 Ludovic Desvignes Ernst Kataru RP, Kim H, Jang C, Choi DK, Koh BI, Kim M, Gollamudi S, Kim YK, Lee SH, Koh GY (2011) T lymphocytes negatively regulate lymph node lymphatic vessel formation. Immunity 34:96-107  
March 1, 2011 Mac Sellars Littman DePaolo RW, Abadie V, Tang F, Fehlner-Peach H, Hall JA, Wang W, Marietta EV, Kasarda DD, Waldmann TA, Murray JA, Semrad C, Kupfer SS, Belkaid Y, Guandalini S, Jabri B (2011) Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. Published online February 9 ahead of print.