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Research Associate 

The Basu Lab at the NYU Neuroscience Institute is looking to fill a Research Associate position. 

Position Summary:

The Basu lab  seeks highly motivated individuals with research experience in molecular and cellular approaches including but not limited to cell culture, immunohistochemistry, and animal handling.  Our research focuses on understanding the cellular and circuit mechanisms underlying spatial navigation, and long-term memory processing. How are sensory experiences and the external environment represented in the brain and how do our past experiences stored as long-term memories shape our ongoing sensory processing and future learning behavior? The lab uses state-of-the-art approaches including in vitro and in vivo electrophysiology and imaging combined with optogenetics and pharmacogenetics to monitor and change the activity of different types of neurons and circuits in the cortex and hippocampus. Model systems include mice- both in vitro and in vivo, and human tissue.  We aim to link pathophysiological deficits seen in humans to mouse models of neurological disorders such as Epilepsy and Alzheimer’s Disease. We believe in work life balance and diversity, equality and inclusion in STEM. Candidates with diverse including URM and LGBTQ backgrounds,  who aim to pursue a research career are encouraged to apply.

Job responsibilities:

  • Specific Research Activities:
  1. Coordinates with patients, neurosurgery and clinical pathology teams, to transfer live patient derived brain tissue from the hospital to the lab, as part of our Human Epilepsy project with the NYU Langone Health Comprehensive Epilepsy Center.
  2. Prepares cell culture reagents and generates organotypic slice cultures from resected human and mouse tissue for further experimentation.
  3. Runs stereotaxic surgeries,  viral injections and fiber optic implants for circuit mapping and optogenetic stimulation in mice during behavioral tasks. Performs post-hoc immunohistochemistry, fluorescence imaging and neuronal reconstructions.
  • General Research Activities:
  1. Designs and executes multiple experiments, independently and in collaboration with others.
  2. Records all experimental findings, analyzes and interprets experiments.
  3. Participates, presents and contributes to lab meetings, and research ideas.
  • Administrative/Lab Managerial Activities:
  1. Organizes, maintains, and oversees lab supplies, inventory, ordering, and lab management - financial and operational.
  2. Manages mouse colonies and tasks such as breeding, genotyping and weaning litters.
  3. Oversees adherence to regulatory protocols, including managing NYS DOH Controlled Substances, IRB, IACUC and IBC standards.
  • Communication/Interactions:Communicates clearly and discusses results, problems, troubleshooting with collaborators and lab members in a timely, organized manner. Actively seeks appropriate guidance and feedback for performance of duties and addressing issues. Interacts  well with and relates to all levels of the lab, institute and NYU Langone Med Center.

Minimum requirements:

College graduate with a B.S. /B.A. or higher (Masters) in Biomedical Sciences or Engineering. Effective oral and written communication skills required. Strong organizational abilities is a must.

Preferred qualifications:

Prior experience interacting in a research or clinical environment, working with research data. Familiarity with cell culture and animal handling preferred.

 

If interested, please contact Jayeeta Basu at Jayeeta.Basu@nyulangone.org, with your current CV, a short paragraph describing your research interests and contacts for two references.

Post-doctoral Researchers

We are looking for talented post-doctoral scholars, graduate and undergraduate students with strong interest in synaptic and circuit function to join our team.

We are particularly eager to recruit candidates who are motivated to incorporate as well as develop creative and novel experimental and analysis paradigms to study how behaviorally relevant activity shapes information processing in mnemonic circuits. There will be ample scope to further develop (but not limited to) the following approaches:

  • assays for learning behaviors in freely moving and head-fixed mice in virtual reality environments
  • optical, molecular and genetic tools to monitor and modulate neuronal activity
  • models of synaptic integrative properties, excitation-inhibition dynamics and neuronal ensemble coding

Interested candidates can send their resumes, a short statement of research interests and experience and contact information of 2-3 references in PDF format to jayeeta.basu@nyulangone.org.

Graduate Students

We are offering lab rotations. Whatever your background or research experience, if you are keen to learn patch clamp electrophysiology and/or two-photon imaging and explore how fundamental circuits control activity in the entorhinal cortex and hippocampus please email. Projects involving behavioral testing with optogenetic gain or loss of function approaches are also conceivable.