Kathryn J. Moore, PhD

Professor; Departments of Medicine (Cardio Div) and Cell Biology

LAB WEBSITE:

Training Program in Cardiovascular Sciences

RESEARCH THEMES:
Cell Biology, Medicine

 

 

 

 

Contact Information

522 First Avenue
Smilow Research Center
Floor 7, Room 705
New York, NY 10016

Tel: 212-263-9259
Fax: 212-263-9115
Email: Kathryn.Moore@nyumc.org

MicroRNAs and Atherosclerosis

The overall interest of the Moore Laboratory is to understand (1) the role of the innate immune system in sterile inflammatory conditions and host defense, and (2) the role of microRNAs in regulating lipoprotein metabolism and atherosclerosis.

The innate immune system senses invading microorganisms and modified endogenous ligands by recognizing conserved molecular structures that are normally absent in the healthy host. It is becoming increasingly clear that pattern recognition receptors, expressed by myeloid cells, can cooperate to precisely regulate signaling pathways essential for the proper initiation of innate and acquired immunity.

The inappropriate activation of these receptors has also been linked to inflammatory syndromes, including atherosclerosis and Alzheimer's disease. MicroRNAs (miRNAs) represent an elegant mechanism of posttranscriptional control of gene expression that serves to fine-tune biological pathways.

Work from our group identified the miRNA miR-33, located with the sterol response element-binding protein (SREBP)-2 gene, as an important regulator of cellular cholesterol efflux, fatty acid I? oxidation, and high-density lipoprotein metabolism. Antagonism of this microRNA increases plasma HDL and reduces VLDL triglycerides. These findings have highlighted the important role that miRNAs play in lipoprotein metabolism and opened new avenues for the treatment of dyslipidemias.