Chen Lab


Lung-Chi Chen, Ph.D.

Professor, Department of Environmental Medicine

Contact Info:

Address:  57 Old Forge Road, Tuxedo, NY 10987
Phone: 845-731-3560



Key Interests

Nanoparticle Toxicity and functional utilization, The role of health disparity in air pollution-induced cardiopulmonary diseases, Gene-environment interactions in environmentally induced diseases, Effects of particulate air pollution in the pathogenesis of atherosclerosis, Mechanisms of air pollution induced asthma, Pollutant-induced alterations in biological response modifiers and associated membrane receptors, Signal transduction pathways associated with oxidative stress

Biographic Details:

Graduate Education: 1983 — Ph.D. in Environmental Health Science from New York University, NY, NY

Research Interests:

Dr. Chen is an internationally recognized expert on inhalation toxicology and has extensive experience in the measurement of cardiopulmonary effects of inhaled pollutants. He is also an expert in the generation and characterization of exposure atmospheres, and in the performance of toxicology studies using all routes of exposure, primarily those involving pulmonary exposure. He has served on a number of national and international committees and study sections in his areas of expertise. Dr. Chen is the author of over 120 research papers and book chapters dealing with the mechanisms underlying the adverse cardiopulmonary effects resulting from inhalation exposure to occupational and environmental air pollutants. His research approach is to systematically dissect the role that physico-chemical properties of these pollutants play in the exposure, uptake at sites of deposition in the respiratory tract and translocation to the heart, as well as in the development, progression, and resolution of cardiopulmonary diseases.

Selected Publications:

Pulmonary T cell activation in response to chronic particulate air pollution. Deiuliis, Jeffrey A; Kampfrath, Thomas; Zhong, Jixin; Oghumu, Steve; Maiseyeu, Andrei; Chen, Lung Chi; Sun, Qinghua; Satoskar, Abhay R; Rajagopalan, Sanjay. 2012 Feb;302(4):L399-L409, American journal of physiology. Lung cellular & molecular physiology. — id: 157749, year: 2012, vol: 302, page: L399, stat: Journal Article,

Comparison of WTC Dust Size on Macrophage Inflammatory Cytokine Release In vivo and In vitro. Weiden, Michael D; Naveed, Bushra; Kwon, Sophia; Segal, Leopoldo N; Cho, Soo Jung; Tsukiji, Jun; Kulkarni, Rohan; Comfort, Ashley L; Kasturiarachchi, Kusali J; Prophete, Colette; Cohen, Mitchell D; Chen, Lung-Chi; Rom, William N; Prezant, David J; Nolan, Anna. 2012 ;7(7):e40016-e40016 e40016, PLoS ONE. — id: 174082, year: 2012, vol: 7, page: e40016, stat: Journal Article, 

Association of systemic inflammation with marked changes in particulate air pollution in Beijing in 2008. Xu, Xiaohua; Deng, Furong; Guo, Xinbiao; Lv, Peng; Zhong, Mianhua; Liu, Cuiqing; Wang, Aixia; Tzan, Kevin; Jiang, Silis Y; Lippmann, Morton; Rajagopalan, Sanjay; Qu, Qingshan; Chen, Lung-Chi; Sun, Qinghua. 2012 Jul;212(2):147-156, Toxicology letters. — id: 173080, year: 2012, vol: 212, page: 147, stat: Journal Article,

Particulate matter neurotoxicity in culture is size-dependent. Gillespie, P; Tajuba, J; Lippmann, M; Chen, LC; Veronesi, B. 2011 Oct;:88-98, Neurotoxicology. — id: 159353, year: 2011, vol: , page: 88, stat: Journal Article,

Pulmonary toxicity of inhaled nanoscale and fine zinc oxide particles: Mass and surface area as an exposure metric. Ho M.; Wu K.-Y.; Chein H.-M.; Chen L.-C.; Cheng T.-J. 2011 ;23(14):947-956, Inhalation toxicology. — id: 146270, year: 2011, vol: 23, page: 947, stat: Journal Article,

Chronic fine particulate matter exposure induces systemic vascular dysfunction via NADPH oxidase and TLR4 pathways. Kampfrath, Thomas; Maiseyeu, Andrei; Ying, Zhekang; Shah, Zubair; Deiuliis, Jeffrey A; Xu, Xiaohua; Kherada, Nisharahmed; Brook, Robert D; Reddy, Kongara M; Padture, Nitin P; Parthasarathy, Sampath; Chen, Lung Chi; Moffatt-Bruce, Susan; Sun, Qinghua; Morawietz, Henning; Rajagopalan, Sanjay. 2011 Mar 18;108(6):716-726, Circulation research. — id: 134217, year: 2011, vol: 108, page: 716, stat: Journal Article,

See All Publications