Gordon Lab

<

Terry Gordon, Ph.D.

Professor, Department of Environmental Medicine

Contact Info:

Address: 57 Old Forge Road, Tuxedo, NY 10987
Phone: 845-731-3536
Email: Terry.Gordon@nyumc.org

 

 

Key Interests

genetic susceptibility, environmental and occupational agents, inhalation toxicology, pulmonary disease

Biographic Details:

Graduate Education:
1975-1977 — M.S. (Toxicology), University of Michigan
1978-1981 — Ph.D. (Toxicology), MIT

Postdoctoral Training: 1983-1985 — UCSF

Research Interests:

Genetic Susceptibility: Our research program utilizes both human and animal experimental models to study the genetic susceptibility underlying the adverse pulmonary and cardiac effects of environmental and occupational air pollutants. We perform these studies in collaboration with several investigators at NYU School of Medicine and other academic centers. One primary focus of ongoing studies is to examine the cellular, molecular, and humoral interactions which lead to pollutant-induced pulmonary injury. The most important aim of my susceptibility work examines the contribution of genetic susceptibility to the adverse effects of inhaled pollutants. We examine the role of genetic host factors in murine models of disease using both classic mouse genetic and computational genomics approaches. Ongoing genetic studies examine the relative contribution of ozone, age, beryllium, hyperbaric oxygen, and nanoparticles to adverse effects. Our overall goal is to examine not only the pathways involved in the progression of pulmonary disease but also the role of endogenous mediators in the development of tolerance associated with chronic exposure to environmental and occupational agents.

Particulate Matter: Ambient PM produces significant adverse cardiopulmonary effects. Our lab examines the role of coarse, fine, and ultrafine PM both in vitro and in vivo. Over the last few years, we have collected ambient PM in several cities in the U.S., Germany, and China (the latter both during and after the 2008 Olympics). Ongoing studies focus on the differential toxicity of PM on the basis of particle size, season, composition, and urban/rural location.

Exposure Assessment: Understanding the exposures to ambient and workplace particles and gases is critical to improving environmental health. Recent studies in the Gordon lab have monitored the exposure of human volunteers to ambient particulate matter (along major roadways), e-cigarette aerosols, and hookah water pipe smoke (in NYC hookah bars).

Selected Publications:

Thoracic and respirable particle definitions for human health risk assessment. Brown JS, Gordon T, Price O, Asgharian B. Part Fibre Toxicol. 2013 Apr 10;10:12. PMID:23575443

Black carbon and particulate matter (PM2.5) concentrations in New York City's subway stations. Vilcassim MJ, Thurston GD, Peltier RE, Gordon T. Environ Sci Technol. 2014 Nov 19. PMID:25409007

The changing face of tobacco use among United States youth. Lauterstein D, Hoshino R, Gordon T, Watkins BX, Weitzman M, Zelikoff J. Curr Drug Abuse Rev. 2014;7(1):29-43. PMID:25323124

Air quality in New York City hookah bars. Tob Control. Zhou S, Weitzman M, Vilcassim R, Wilson J, Legrand N, Saunders E, Travers M, Chen LC, Peltier R, Gordon T. 2014 Sep 16. PMID:25232045

The effect of particle size, location and season on the toxicity of urban and rural particulate matter. Mirowsky J, Hickey C, Horton L, Blaustein M, Galdanes K, Peltier RE, Chillrud S, Chen LC, Ross J, Nadas A, Lippmann M, Gordon T. Inhal Toxicol. 25:747-57, 2013

See All Publications