Jin Lab

Jin_photo

Chunyuan Jin, M.D., D.Phil.

Assistant Professor, Department of Environmental Medicine and Biochemistry and Molecular Pharmacology

Contact Info:

Address: 57 Old Forge Road, Rm 274A, Tuxedo, NY 10987
Phone: 845-731-3602
Email: Chunyuan.Jin@nyumc.org

 

 

Key Interests

Chromatin structure, epigenetic mechanisms, histone variants, gene expression, carcinogenesis

Biographic Details:

Graduate Education:
1997 M.Sc from China Medical University 
2002 PhD from University of Tokyo

Postdoctoral Training: 2003-2008 National Institutes of Health

Academic Appointments:
2008-2010 Research Fellow, National Institutes of Health
2010-Present Assistant Professor, Department of Environmental Medicine & Biochemistry and Molecular Pharmacology

Major Honors: 2007 The Fellows Award for Research Excellence, National Institutes of Health

Research Interests:

In eukaryotic cells, DNA is packaged into a DNA-protein complex called chromatin. The fundamental subunit of chromatin is the nucleosome core particle, which consists of 147 base pairs of DNA wrapped around a histone octamer. Chromatin structure regulates the access of regulatory factors to the genomic DNA and thus exerts a profound control over most DNA-templated processes such as transcription, DNA repair and replication. Elucidating the interaction between chromatin structure and these nuclear processes is critical for understanding of development and human disease. Chromatin structure can be altered by several epigenetic mechanisms including DNA methylation, post-translational histone modifications, and the assembly of variant histones into chromatin. Our research focuses on how epigenetic mechanisms, in particular the incorporation of histone variants into nucleosome, modulate chromatin structure and gene expression. Another focus in our laboratory involves understanding the mechanisms of both assembly/disassembly and replication of nucleosomes containing histone variant(s). We are also interested in the mechanisms by which environmental factors influence epigenetic profiles of normal cells and contribute to carcinogenesis.

Selected Publications:

 

Regulation of Chromatin Assembly and Cell Transformation by Formaldehyde Exposure in Human Cells.
Chen D, Fang Lei, Mei S, Li H, Xu Xia, Des Marais TL, Lu Kun, Liu X, Jin C*.
Environmental Health Perspectives. 2017 (In press).

Mechanisms Underlying Acrolein-Mediated Inhibition of Chromatin Assembly.
Fang L, Chen D, Yu C, Li H, Brocato J, Huang L, Jin C*.
Molecular and Cellular Biology. 2016, 36(23):2995-3008.

Hexavalent Chromium (Cr(VI)) Down-regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1
Chen D, Kluz T, Fang L, Zhang X, Sun H, Jin C*, Costa M. 
PLoS One 2016, 11, e0157317.

A Potential New Mechanism of Arsenic Carcinogenesis: Depletion of Stem-Loop Binding Protein and Increase in Polyadenylated Canonical Histone H3.1 mRNA
Brocato J, Chen D, Liu J, Fang L, Jin C*, Costa M. 
Biol Trace Elem Res 2015, 166:72-81.

Environmental-stress-induced Chromatin Regulation and its Heritability
Fang L, Wuptra K, Chen D, Li H, Huang SK, Jin C*, Yokoyama KK. 
J Carcinog Mutagen 2014, 5.

Arsenic Induces Polyadenylation of Canonical Histone mRNA by Down-regulating Stem-Loop-binding Protein Gene Expression
Brocato J, Fang L, Chervona Y, Chen D, Kiok K, Sun H, Tseng HC, Xu D, Shamy M, Jin C*, Costa M. 
J Biol Chem 2014, 289:31751-31764.

Cigarette smoke component acrolein modulates chromatin assembly by inhibiting histone acetylation
Chen D, Fang L, Li H, Tang MS, Jin C*
J Biol Chem 2013, 288:21678-21687.

H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regions
Jin C, Zang C, Wei G, Cui K, Peng W, Zhao K, Felsenfeld G. 
Nat Genet 2009, 41:941-945.

Nucleosome stability mediated by histone variants H3.3 and H2A.Z.
Jin C, Felsenfeld G. 
Genes Dev 2007, 21:1519-1529.

Regulation of histone acetylation and nucleosome assembly by transcription factor JDP2
Jin C, Kato K, Chimura T, Yamasaki T, Nakade K, Murata T, Li H, Pan J, Zhao M, Sun K, et al. 
Nat Struct Mol Biol 2006, 13:331-338.

Distribution of histone H3.3 in hematopoietic cell lineages
Jin C, Felsenfeld G. 
Proc Natl Acad Sci U S A 2006, 103:574-579.

See All Publications

Lab Members:

Current Members:

Danqi Chen, PhD Candidate
Xia Xu, PhD, Visiting Scholar

 

Past Members:

Lei Fang, PhD, Associate Professor, Nanjing University
Jianli Liu, PhD, Associate Professor, Liaoning University