Tang Lab

Tang_photo

Moon-shong Tang Ph.D.

Professor, Department of Environmental Medicine and Pathology and Medicine (Pulmy&CCM Div)

Contact Info:

Address: 57 Old Forge Road, Tuxedo, NY 10987
Phone: 845-731-3585
Email: Moon-Shong.Tang@nyumc.org

 

 

Key Interests

Chromatin structure, epigenetic mechanisms, histone variants, gene expression, carcinogenesis

Biographic Details:

Graduate Education: Graduate Education: BS, National Taiwan University; MS and PhD, University of Texas at Dallas.

Postdoctoral Training: Roswell Park Cancer Institute; Stanford University and Washington University

Academic Appointments:

1982-1999: Assistant professor to professor, M.D. Anderson Cancer Center, University of Texas System
1999-Present: Professor, New York University School of Medicine

Major Responsibilities: Research and Teaching

Major Honors:

  1. 1997 Texas Twenty 1997 (Selected by Texas Monthly)
  2. The top ten advances of 1996 by Harvard Health Letter from Harvard University Medical School (Denissenko, M.F., Pao, A., Tang*, M.-s., and Pfeifer*, G.P.  Preferential formation of  benzo[a]pyrene adduct at lung cancer mutation hotspots in p53.Science, 274:430-432, 1996)
  3. Outstanding award from American Hakka Association 1997

 

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Research Interests:

1. The role of tobacco smoke in lung carcinogenesis and bladder carcinogenesis.

2. Aflatoxin B1 and alcohol in hepatocarcinogenesis.

3. Melanin effect on UVA and UVB induced melanomagenesis.

4. The role of p53 and p63 in DNA repair and bladder cancer.

5. Development of biomarkers for lung and bladder cancer early detection.

 

Selected Publications:

  1. Denissenko MF, Pao A., Tang M-s, and Pfeifer GP. Preferential formation of benzo[a]pyrene adduct at lung cancer mutation hotspots in p53. Science 1996;274:430-432.
  2. Denissenko MF, Chen JX, Tang M-s, and Pfeifer GP. Cytosine methylation determines hotspots of DNA damage in the human p53 gene. Proc Natl Acad Sci USA 1997;94:3893-3898. PMCID: PMC20538
  3. Chen JX, Zheng Y, West M, and Tang M-s. Carcinogenesis preferentially bind at methylated CpG in the p43 mutational hot spots. Cancer Res 1998;58:2070-2075.
  4. Denissenko M, Pao A, Pfeifer G and Tang M-s. Slow repair of preferentially formed benzo(a)pyrene diol epoxide DNA adducts at the mutational hotspots in the human  p53 gene. Oncogene1998;16:1241-1249.
  5. Feng Z, Hu W, Chen JX, Pao A, Li H, Rom W, Hung M-C, and Tang M-s. Preferential DNA damage and poor repair determineras gene mutational hotspot in human cancer. J Natl Cancer Inst 2002:94:1527-1536.
  6. Feng Z, Hu W, and Tang M-s. Preferential carcinogen-DNA adduct formation at codon 12 and 14 in the human K-ras gene and their possible mechanisms. Biochemistry 2003;42:10012-10023.
  7. Feng Z, Hu W, and Tang M-s.  Trans-4-hydroxy-2-nonenal inhibits nucleotide excision repair in human cells: a possible mechanism for lipid peroxidation-induced carcinogenesis.  Proc Natl Acad Sci USA 2004;101:8598-8602. PMCID: PMC423240.
  8. Feng Z, Hu W, Hu Y, and Tang M-sAcrolein Is A Major Cigarette-Related Lung Cancer Agent. Preferential Binding at p53 Mutational Hotspots and inhibition of DNA Repair. Proc Natl Acad Sci USA 2006;103;15404-15409. PMCID: PMC1592536
  9. Wang, H L, Lu, ML, Tang, M-s, van Houten, B, Ross, JBA, Weinfeld, M, Le, XC. DNA wrapping is required for DNA damage recognition in the Escherichia coli DNA nucleotide excision repair pathway.  Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 12849–12854. PMCID: PMC2700148
  10. Wang, H-s, Choi, B, and Tang, M-s. Melanocytes are deficient in repair of oxidative DNA damage and UV-induced photoproducts. Proc. Natl. Acad. Sci. U.S.A. 2010107, 180-185. PMCID: PMC2901481
  11. Weng MW, Zheng Y, Jasti VP, Champeil E, Tomasz M, Wang Y, Basu AK, Tang M-s. Repair of mitomycin C mono- and interstrand cross-linked DNA adducts by UvrABC: a new model. Nucleic Acids Res. 2010, 38, 6976-84. PMCID: PMC2978355.
  12. Tang M-s, Wang, H-s, Hu Y, Chen WS, Akao M, Feng Z, Hu W. Acrolein induced DNA damage, mutagenicity and effect on DNA repair. Mole Nut and Food Res 2011, 55,1291-300.
  13. Arakawa H, Weng MW, Chen WC, Tang M-sChromium (VI) induces both bulky DNA adducts and oxidative DNA damage at adenines and guanines in the p53 gene of human lung cells. Carcinogenesis. 2012 Jul 12
  14. Wang HT, Hu Y, Tong D, Huang J, Gu L, Wu XR, Chung FL, Li GM, Tang M-sEffect of carcinogenic acrolein on DNA repair and mutagenic susceptibility. J Biol Chem. 2012, 287, 12379-86.
  15. Wang HT, Weng M-w, Chen W-c, Yobin M, Pan J, Chung F-L, Wu X-R, Rom W, Tang M-s.   Effect of CpG Methylation at Different Sequence Context on Acrolein- and BPDE-DNA Binding and Mutagenesis Carcinogenesis, 2012 (In press)

See All Publications

Lab Members:

Mao-wen Weng, PhD, Senior Research Scientist
Hyun-Wook Lee, PhD, Associate Research Scientist
Hsiang Tsui (Mandy) Wang, PhD, Assistant Research Scientist
Martha Huang, BA, Lab Manager

Alumni:

Zhaohui Feng, MB, PhD, Assistant Professor, UMDNJ
Wenwei Hu, MB, PhD, Assistant Professor, UMDNJ
Yu Hu, MB, PhD, Professor, Hongzhou Normal University
Yi Zheng, PhD, Senior Scientist, Harvard University
Qiao Hung, MS, Scientist, University of Pennsylvania