Zelikoff Lab

Zelikoff_photo

Judith Zelikoff, Ph.D.

Professor
Department of Environmental Medicine

Contact Info::

Address: 57 Old Forge Road, Tuxedo, NY 10987
Phone: 845-731-3528
Email:

 

Key Interests

immunotoxicity, immunotoxicology, inhaled pollutants, macrophage activation

Biographic Details

Graduate Education: 1982 — Dr. Zelikoff received her Ph.D. degree from the Medical School of the University of Medicine and Dentistry New Jersey

Research Interests

Major research interests in this laboratory are twofold: The first examines the immunotoxicity and underlying mechanisms associated with inhaled indoor/outdoor pollutants such as woodsmoke, ozone, metals, and respirable particulate matter. Recent toxicological studies in our laboratory demonstrated that inhalation of smoke generated from the burning of a commonly used wood for home heating dramatically compromises pulmonary resistance against infectious bacterial agents. Alterations in host immunocompetence appear to be due, at least in part, to smoke-induced changes in the production of reactive oxygen/nitrogen species. We are also investigating effects on macrophage activation, cytokine biochemistry, and surface receptor expression as possible mechanisms responsible for the observed effects on bacterial resistance. Our results help explain the epidemiological evidence that suggests an increased incidence, duration, and severity of infectious respiratory diseases in children living in homes heated with woodburning devices.

The primary goal of our second research objective is developing alternative animal models for immunotoxicological studies. This work reflects the increasing social and political pressure to use nonmammalian models for predicting human health risks and to develop markers for assessing the biological effects of environmental stress. Studies using nonspecific, humoral, and cell-mediated aspects of the fish immune response, i.e., lymphoproliferation, cytokine activity, antibody formation, and free-radical production, have demonstrated its applicability for use as an alternative system to predict the immunotoxic effects of environmental contaminants and, possibly, for estimating human health risks.Selected Publications:

Selected Publications

Cadmium associated with inhaled cadmium oxide nanoparticles impacts fetal and neonatal development and growth. Blum, Jason L; Xiong, Judy Q; Hoffman, Carol; Zelikoff, Judith T. 2012 Apr;126(2):478-486, Toxicological sciences. — id: 162025, year: 2012, vol: 126, page: 478, stat: Journal Article,

Toxicology of smokeless tobacco: implications for immune, reproductive, and cardiovascular systems. Willis, Daniel; Popovech, Mary; Gany, Francesca; Zelikoff, Judith. 2012 Jul;15(5):317-331, Journal of toxicology & environmental health. Pt. B. Critical reviews. — id: 174399, year: 2012, vol: 15, page: 317, stat: Journal Article,

Maternal allergy acts synergistically with cigarette smoke exposure during pregnancy to induce hepatic fibrosis in adult male offspring. Allina, Jorge; Grabowski, Jacquelin; Doherty-Lyons, Shannon; Fiel, M Isabel; Jackson, Christine E; Zelikoff, Judith T; Odin, Joseph A. 2011 Oct;8(4):258-264, Journal of immunotoxicology. — id: 140522, year: 2011, vol: 8, page: 258, stat: Journal Article,

Exposure of pregnant mice to cadmium oxide (CdO) nanoparticles (NP) poses a risk to the developing offspring. Blum, J L; Hoffman, C; Xiong, J Q; Zelikoff, J T. 2010 November 2010;83(1):-, Biology of reproduction. — id: 174159, year: 2010, vol: 83, page: , stat: Journal Article,

Exposure of Pregnant Mice to Cadmium Oxide (CdO) Nanopartides (NP) Poses a Risk to the Developing Offspring. Blum, Jason L.; Hoffman, Carol; Xiong, Judy Q.; Zelikoff, Judith T.. 2010 NOV 23 ;122(21):115-115, Biology of reproduction. — id: 120559, year: 2010, vol: 122, page: 115, stat: Journal Article,

Effects of metal compounds with distinct physicochemical properties on iron homeostasis and antibacterial activity in the lungs: chromium and vanadium. Cohen, Mitchell D; Sisco, Maureen; Prophete, Colette; Yoshida, Kotaro; Chen, Lung-chi; Zelikoff, Judith T; Smee, Jason; Holder, Alvin A; Stonehuerner, Jacqueline; Crans, Debbie C; Ghio, Andrew J. 2010 Feb;22(2):169-178, Inhalation toxicology. — id: 105696, year: 2010, vol: 22, page: 169, stat: Journal Article,

See All Publications