Agnel Sfeir

Agnel Sfeir, PhD

Skirball Institute

Assistant Professor, Department of Cell Biology

Keywords
cancer, developmental genetics, genome integrity, metabolism, stem cell biology
Summary

The linearity of chromosomes creates two major problems for eukaryotic cells: the end replication problem and the end protection problem. The former stems from the inherent inability of the replication machinery to fully duplicate linear templates. The latter refers to the propensity of linear chromosome ends to be recognized as DNA double stranded breaks. To surmount both problems, cells use telomeres, the specific nucleoprotein complexes that are essential to ensure genomic stability and promote cellular survival. In mammalian cells, telomeres consist of long tracts of repetitive DNA sequences (TTAGGG) that are bound by a specialized six-subunit protein complex termed shelterin. Telomeres are replenished by telomerase, a reverse transcriptase that is active in the germ line and during early embryonic development. Normal human somatic cells lack the activity of telomerase and gradually loose telomeric repeats during progressive division cycles until they ultimately undergo cellular senescence. Our lab is mainly interested in understanding the basic mechanism that leads to telomere length resetting. In particular, we rely on nuclear reprograming as a platform to identify factors that regulate telomere length. A second area of interest to us is to understand how telomere dynamics impact stem cell function and leads to tumorigenesis, using the mouse as a model organism.

Phone

646-501-6742

Academic office

540-562 First Avenue

Fourth Floor

New York, NY 10016

Lab Website
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Assistant Professor, Department of Cell Biology

PhD from Southwestern University

Phillips, Aaron F; Millet, Armel R; Tigano, Marco; Dubois, Sonia M; Crimmins, Hannah; Babin, Loelia; Charpentier, Marine; Piganeau, Marion; Brunet, Erika; Sfeir, Agnel

Molecular cell. 2017 Jan 19; 65(3):527-538.e6

Kent, Tatiana; Mateos-Gomez, Pedro A; Sfeir, Agnel; Pomerantz, Richard T

eLife. 2016 Jun 17; 5:?-?

Pinzaru, Alexandra M; Hom, Robert A; Beal, Angela; Phillips, Aaron F; Ni, Eric; Cardozo, Timothy; Nair, Nidhi; Choi, Jaehyuk; Wuttke, Deborah S; Sfeir, Agnel; Denchi, Eros Lazzerini

Cell reports. 2016 Jun 07; 15(10):2170-2184

Lazzerini-Denchi, Eros; Sfeir, Agnel

Nature reviews. Molecular cell biology. 2016 Jun; 17(6):364-378

The role of mammalian polymerase theta in DNA repair [Meeting Abstract]

Sfeir, A

FASEB journal. 2016 Apr; 30(no):

Tong, Adrian S; Stern, J Lewis; Sfeir, Agnel; Kartawinata, Melissa; de Lange, Titia; Zhu, Xu-Dong; Bryan, Tracy M

Cell reports. 2015 Nov 24; 13(8):1633-1646

Sfeir, Agnel; Symington, Lorraine S

Trends in biochemical sciences. 2015 Nov; 40(11):701-714

Mateos-Gomez, Pedro A; Gong, Fade; Nair, Nidhi; Miller, Kyle M; Lazzerini-Denchi, Eros; Sfeir, Agnel

Nature. 2015 Feb 12; 518(7538):254-257

A Molecular Repair Tool’s Glitch May Help Halt Breast Cancer