Akiko Koide, PhD

My research is focused on creating proteins with novel functions for therapy and basic science applications. I have made important contribution to the development of technologies that have made it possible to create synthetic binding proteins from inert protein scaffolds. I am an expert of designing and constructing large combinatorial libraries in the phage- and yeast-display systems. Using these technologies, I have developed potent and selective binding proteins, both antibody and non-antibody molecules, against diverse targets. These novel molecules have enabled numerous collaborative investigations in which we elucidated structures and molecular mechanisms of biomedically important proteins and revealed novel approaches to controlling them.

My colleagues and I are further advancing our protein engineering technologies with a particular emphasis on developing therapeutic strategies against currently “undruggable” cancer drivers.