Alec C. Kimmelman

Alec C. Kimmelman, MD, PhD

Dean and Chief Executive Officer

Laura and Isaac Perlmutter Professor of Radiation Oncology, Department of Radiation Oncology

Positions

Laura and Isaac Perlmutter Professor of Radiation Oncology, Department of Radiation Oncology at NYU Grossman School of Medicine

Dean and Chief Executive Officer

Graduate Education

MD from Mount Sinai School of Medicine

PhD from Mount Sinai School of Medicine

Residency And Fellowship Training

Residency, Brigham and Women's Hospital (Harvard Medical School) NIH, Radiation Oncology

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Extracellular matrix sensing regulates intratumoral heterogeneity of autophagic flux

Assi, Mohamad; Wang, Ruohong; Kawaler, Emily A; Sohn, Albert S W; Zahidunnabi Dewan, M; Kalfakakou, Despoina; Encarnacion-Rosado, Joel; Kapner, Kevin S; Ganguly, Koelina; Paulo, Joao A; Simeone, Diane M; Aguirre, Andrew J; Banh, Robert S; Kimmelman, Alec C

Cell. 2026 Feb 16;

Clinical and translational results from a phase 1 trial of gemcitabine/nab-paclitaxel with nivolumab/ipilimumab or hydroxychloroquine/ipilimumab in untreated metastatic pancreatic adenocarcinoma

O'Reilly, Eileen M; Cabanski, Christopher R; Lyman, Jaclyn P; Wainberg, Zev A; Fisher, George A; Wolff, Robert A; Ko, Andrew H; O'Hara, Mark H; Spencer, Christine N; Yu, Jia Xin; Da Silva, Diane M; Padrón, Lacey J; Arnott, Jamie; Fairchild, Justin; Moore, Jonni S; Peng, Brandon; Hoos, William A; O'Donnell-Tormey, Jill; Boffo, Silvia; Dugan, Ute; Kimmelman, Alec C; Amaravadi, Ravi K; Vonderheide, Robert H

Journal for immunotherapy of cancer. 2026 Jan 30; 14(1):

IFNγ-dependent metabolic reprogramming restrains an immature, pro-metastatic lymphatic state in melanoma

Karakousi, Triantafyllia; Cristaldi, Vanessa; Lopes de Oliveira, Maria Luiza; Delclaux, Ines; Besson, Naomi R; Geraldo, Luiz Henrique; González-Robles, Tania J; McDonnough, Devyon R; Martinez-Krams, Daniel; da Silva, Gabrielle; Breazeale, Alec P; Encarnacion-Rosado, Joel; Pozniak, Joanna; Qiu, Shi; Illa Bochaca, Irineu; Kaiza, Medard E; Kim, Hye Mi; Bruno, Tullia C; Reizis, Boris; Moshiri, Ata S; Kimmelman, Alec C; Ruggles, Kelly V; Osman, Iman; Marine, Jean-Christophe; Chandel, Navdeep S; Lund, Amanda W

Cancer cell. 2026 Jan 22;

Serine tRNAs compete to regulate the mRNA translation of serine-sensitive codons

Costiniti, Veronica; Tran, Wyatt C; Babu, Nandhini Rajesh; Kanshin, Evgeny; Ueberheide, Beatrix; Kimmelman, Alec C; Banh, Robert S

Science advances. 2025 Nov 14; 11(46):eady4521

Author Correction: Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

Tintelnot, Joseph; Xu, Yang; Lesker, Till R; Schönlein, Martin; Konczalla, Leonie; Giannou, Anastasios D; Pelczar, Penelope; Kylies, Dominik; Puelles, Victor G; Bielecka, Agata A; Peschka, Manuela; Cortesi, Filippo; Riecken, Kristoffer; Jung, Maximilian; Amend, Lena; Bröring, Tobias S; Trajkovic-Arsic, Marija; Siveke, Jens T; Renné, Thomas; Zhang, Danmei; Boeck, Stefan; Strowig, Till; Uzunoglu, Faik G; Güngör, Cenap; Stein, Alexander; Izbicki, Jakob R; Bokemeyer, Carsten; Sinn, Marianne; Kimmelman, Alec C; Huber, Samuel; Gagliani, Nicola

Nature. 2025 May; 641(8065):E12-E13

Genetics and biology of pancreatic ductal adenocarcinoma

Ying, Haoqiang; Kimmelman, Alec C; Bardeesy, Nabeel; Kalluri, Raghu; Maitra, Anirban; DePinho, Ronald A

Genes & development. 2025 Jan 07; 39(1-2):36-63

Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma

Guinn, Samantha; Kinny-Köster, Benedict; Tandurella, Joseph A; Mitchell, Jacob T; Sidiropoulos, Dimitrios N; Loth, Melanie; Lyman, Melissa R; Pucsek, Alexandra B; Zabransky, Daniel J; Lee, Jae W; Kartalia, Emma; Ramani, Mili; Seppälä, Toni T; Cherry, Christopher; Suri, Reecha; Zlomke, Haley; Patel, Jignasha; He, Jin; Wolfgang, Christopher L; Yu, Jun; Zheng, Lei; Ryan, David P; Ting, David T; Kimmelman, Alec; Gupta, Anuj; Danilova, Ludmila; Elisseeff, Jennifer H; Wood, Laura D; Stein-O'Brien, Genevieve; Kagohara, Luciane T; Jaffee, Elizabeth M; Burkhart, Richard A; Fertig, Elana J; Zimmerman, Jacquelyn W

Cancer research. 2024 May 02; 84(9):1517-1533

The Role of Stroma in Cancer Metabolism

Kimmelman, Alec C; Sherman, Mara H

Cold Spring Harbor perspectives in medicine. 2024 May 02; 14(5):

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