Alejandro Pironti

Alejandro Pironti, ScD

Assistant Professor, Department of Microbiology

Keywords
antimicrobial resistance, microbial virulence, computational genomics, bioinformatics, bacteriology, virology
Summary

My lab's research focuses on microbial genomics, antibiotic resistance, bacterial virulence, and the impact of the human microbiome on health.

We are particularly involved in the study of antimicrobial-resistant pathogens, a critical area of biomedical research given the global rise of antibiotic-resistant bacteria. Within NYU's Antimicrobial-Resistant Pathogens Program, we are working on cutting-edge genomic techniques to better understand and combat bacterial infections within nosocomial settings. We use computational tools to explore how bacterial pathogens develop resistance to drugs, aiming to improve both prevention and treatment strategies​.

A key component of my lab's work includes the analysis of bacterial virulence factors, such as those deployed by Staphylococcus aureus and Enterobacter hormaechei, two major human pathogens. We strive to identify and understand how virulence factors function and interact with the human immune system, particularly focusing on the mechanisms that make bacterial strains virulent or resistant to treatment.

In addition, my lab has explored the dynamics of the gut microbiome, including how changes in microbial composition during disease flares can influence conditions like lupus.

Academic office

430 East 29th Street, Alexandria – West Tower

5th floor

New York, NY 10016

Lab Website
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Director, Microbial Computational Genomics Core Laboratory

ScD from Saarland University

Broad Institute of MIT and Harvard, Infectious Disease and Microbiome Program

Lubkin, Ashira; Bernard-Raichon, Lucie; DuMont, Ashley L; Valero Jimenez, Ana Mayela; Putzel, Gregory G; Gago, Juan; Zwack, Erin E; Olusanya, Olufolakemi; Boguslawski, Kristina M; Dallari, Simone; Dyzenhaus, Sophie; Herrmann, Christin; Ilmain, Juliana K; Isom, Georgia L; Pawline, Miranda; Perault, Andrew I; Perelman, Sofya; Sause, William E; Shahi, Ifrah; St John, Amelia; Tierce, Rebecca; Zheng, Xuhui; Zhou, Chunyi; Noval, Maria G; O'Keeffe, Anna; Podkowik, Magda; Gonzales, Sandra; Inglima, Kenneth; Desvignes, Ludovic; Hochman, Sarah E; Stapleford, Kenneth A; Thorpe, Lorna E; Pironti, Alejandro; Shopsin, Bo; Cadwell, Ken; Dittmann, Meike; Torres, Victor J

MBio. 2024 Aug 14; 15(8):e0166724

Savin, Avital; Anderson, Exene E; Dyzenhaus, Sophie; Podkowik, Magdalena; Shopsin, Bo; Pironti, Alejandro; Torres, Victor J

Infection & immunity. 2024 Feb 13; 92(2):e0052623

Ilmain, Juliana K; Perelman, Sofya S; Panepinto, Maria C; Irnov, Irnov; Coudray, Nicolas; Samhadaneh, Nora; Pironti, Alejandro; Ueberheide, Beatrix; Ekiert, Damian C; Bhabha, Gira; Torres, Victor J

Journal of biological chemistry. 2023 Dec; 299(12):105321

Azzouz, Doua F; Chen, Ze; Izmirly, Peter M; Chen, Lea Ann; Li, Zhi; Zhang, Chongda; Mieles, David; Trujillo, Kate; Heguy, Adriana; Pironti, Alejandro; Putzel, Greg G; Schwudke, Dominik; Fenyo, David; Buyon, Jill P; Alekseyenko, Alexander V; Gisch, Nicolas; Silverman, Gregg J

Annals of the rheumatic diseases. 2023 Oct; 82(10):1315-1327

Jang, Kyung Ku; Heaney, Thomas; London, Mariya; Ding, Yi; Putzel, Gregory; Yeung, Frank; Ercelen, Defne; Chen, Ying-Han; Axelrad, Jordan; Gurunathan, Sakteesh; Zhou, Chaoting; Podkowik, Magdalena; Arguelles, Natalia; Srivastava, Anusha; Shopsin, Bo; Torres, Victor J; Keestra-Gounder, A Marijke; Pironti, Alejandro; Griffin, Matthew E; Hang, Howard C; Cadwell, Ken

Cell host & microbe. 2023 Sep 13; 31(9):1450-1468.e8

Zhu, Jiaqi; Abruzzo, Annie R; Wu, Cindy; Bee, Gavyn Chern Wei; Pironti, Alejandro; Putzel, Gregory; Aggarwal, Surya D; Eichner, Hannes; Weiser, Jeffrey N

PLoS pathogens. 2023 Aug; 19(8):e1011509

Limón, Gina; Samhadaneh, Nora M; Pironti, Alejandro; Darwin, K Heran

MBio. 2023 Jun 23; e0036323

St John, Amelia; Perault, Andrew I; Giacometti, Sabrina I; Sommerfield, Alexis G; DuMont, Ashley L; Lacey, Keenan A; Zheng, Xuhui; Sproch, Julia; Petzold, Chris; Dancel-Manning, Kristen; Gonzalez, Sandra; Annavajhala, Medini; Beckford, Colleen; Zeitouni, Nathalie; Liang, Feng-Xia; van Bakel, Harm; Shopsin, Bo; Uhlemann, Anne-Catrin; Pironti, Alejandro; Torres, Victor J

MBio. 2023 Feb 13; e0259022