Alexander A. Serganov

Alexander A. Serganov

Associate Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
biophysics, genome integrity, pharmacology, RNA biology
Summary

We are a biochemical and structural biology laboratory focused on fundamental cellular activities involving RNA molecules.

RNA plays a multifaceted role in all living organisms. In addition to conveying genetic instructions for protein synthesis, RNA participates in other important biological processes as a component of cellular machineries and a modulator of gene expression. The major impact of RNA molecules on the control of gene expression has been highlighted by recent discoveries of small regulatory RNAs, long non-coding RNAs, and regulatory RNA elements in the non-coding regions of mRNAs. Despite their simple composition, RNA molecules can fold into intricate three-dimensional structures that expand the utility of RNA beyond that of the information carrier. Both RNA sequences and spatial structures are key for interactions with partners and assembly of functional complexes controlling gene expression.

We use a combination of biophysical methods, biochemical techniques, and structural approaches, including X-ray crystallography and cryo-electron microscopy, to elucidate molecular mechanisms of fundamental cellular processes associated with biosynthesis of mRNA, metabolism of RNA, and RNA-mediated gene expression control.

Phone

212-263-4446

Academic office

550 First Avenue, Medical Science Bldg.

3, 393

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Associate Professor, Department of Biochemistry and Molecular Pharmacology

Grad Advisor for Molecular Biophysics Training Pgm

Luciano, Daniel J; Vasilyev, Nikita; Richards, Jamie; Serganov, Alexander; Belasco, Joel G

Molecular cell. 2017 Jun 29; 67(1):44-54.e6

Vasilyev, Nikita; Serganov, Alexander

Methods in molecular biology. 2016; 1320:11-20

Peselis, Alla; Gao, Ang; Serganov, Alexander

Methods in molecular biology. 2016; 1320:21-36

Ren, Aiming; Xue, Yi; Peselis, Alla; Serganov, Alexander; Al-Hashimi, Hashim M; Patel, Dinshaw J

Cell reports. 2015 Dec 01; 13(9):1800-1813

Peselis, Alla; Gao, Ang; Serganov, Alexander

Biochimie. 2015 Oct; 117:100-109

Vasilyev, Nikita; Polonskaia, Anna; Darnell, Jennifer C; Darnell, Robert B; Patel, Dinshaw J; Serganov, Alexander

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Sep 29; 112(39):E5391-E5400

Miao, Zhichao; Adamiak, Ryszard W; Blanchet, Marc-Frederick; Boniecki, Michal; Bujnicki, Janusz M; Chen, Shi-Jie; Cheng, Clarence; Chojnowski, Grzegorz; Chou, Fang-Chieh; Cordero, Pablo; Cruz, Jose Almeida; Ferre-D'Amare, Adrian R; Das, Rhiju; Ding, Feng; Dokholyan, Nikolay V; Dunin-Horkawicz, Stanislaw; Kladwang, Wipapat; Krokhotin, Andrey; Lach, Grzegorz; Magnus, Marcin; Major, Francois; Mann, Thomas H; Masquida, Benoit; Matelska, Dorota; Meyer, Melanie; Peselis, Alla; Popenda, Mariusz; Purzycka, Katarzyna J; Serganov, Alexander; Stasiewicz, Juliusz; Szachniuk, Marta; Tandon, Arpit; Tian, Siqi; Wang, Jian; Xiao, Yi; Xu, Xiaojun; Zhang, Jinwei; Zhao, Peinan; Zok, Tomasz; Westhof, Eric

RNA. 2015 Jun; 21(6):1066-1084

Vasilyev, Nikita; Serganov, Alexander

Journal of biological chemistry. 2015 Apr 10; 290(15):9487-9499