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Alexander A. Serganov

Alexander A. Serganov

Associate Professor, Department of Biochemistry and Molecular Pharmacology

biophysics, genome integrity, pharmacology, RNA biology

We are a biochemical and structural biology laboratory focused on fundamental cellular activities involving RNA molecules.

RNA plays a multifaceted role in all living organisms. In addition to conveying genetic instructions for protein synthesis, RNA participates in other important biological processes as a component of cellular machineries and a modulator of gene expression. The major impact of RNA molecules on the control of gene expression has been highlighted by recent discoveries of small regulatory RNAs, long non-coding RNAs, and regulatory RNA elements in the non-coding regions of mRNAs. Despite their simple composition, RNA molecules can fold into intricate three-dimensional structures that expand the utility of RNA beyond that of the information carrier. Both RNA sequences and spatial structures are key for interactions with partners and assembly of functional complexes controlling gene expression.

We use a combination of biophysical methods, biochemical techniques, and structural approaches, including X-ray crystallography and cryo-electron microscopy, to elucidate molecular mechanisms of fundamental cellular processes associated with biosynthesis of mRNA, metabolism of RNA, and RNA-mediated gene expression control.



Academic office

550 First Avenue, Medical Science Bldg.

3, 393

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Grad Advisor for Molecular Biophysics Training Pgm

Shatalin, Konstantin; Nuthanakanti, Ashok; Kaushik, Abhishek; Shishov, Dmitry; Peselis, Alla; Shamovsky, Ilya; Pani, Bibhusita; Lechpammer, Mirna; Vasilyev, Nikita; Shatalina, Elena; Rebatchouk, Dmitri; Mironov, Alexander; Fedichev, Peter; Serganov, Alexander; Nudler, Evgeny

Science. 2021 06 11; 372(6547):1169-1175

Peselis, Alla; Serganov, Alexander

Methods in molecular biology. 2021 01; 2253:255-271

Gao, Ang; Vasilyev, Nikita; Kaushik, Abhishek; Duan, Wenqian; Serganov, Alexander

Nucleic acids research. 2020 Apr 17; 48(7):3776-3788

Weaver, Jacob W; Serganov, Alexander

Nature structural & molecular biology. 2019 Dec; 26(12):1081-1083

Zhu, Yalan; Gao, Ang; Zhan, Qi; Wang, Yong; Feng, Han; Liu, Songqing; Gao, Guangxia; Serganov, Alexander; Gao, Pu

Molecular cell. 2019 Apr 18; 74(2):296-309.e7

Vasilyev, Nikita; Gao, Ang; Serganov, Alexander

Wiley interdisciplinary reviews. RNA. 2018 Oct 01; e1509

Peselis, Alla; Serganov, Alexander

Nature chemical biology. 2018 Sep; 14(9):887-894

Gao, Ang; Vasilyev, Nikita; Luciano, Daniel J; Levenson-Palmer, Rose; Richards, Jamie; Marsiglia, William M; Traaseth, Nathaniel J; Belasco, Joel G; Serganov, Alexander

Nucleic acids research. 2018 Jul 27; 46(13):6841-6856