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Alexander A. Serganov

Alexander A. Serganov

Associate Professor, Department of Biochemistry and Molecular Pharmacology

biophysics, genome integrity, pharmacology, RNA biology

We are a biochemical and structural biology laboratory focused on fundamental cellular activities involving RNA molecules.

RNA plays a multifaceted role in all living organisms. In addition to conveying genetic instructions for protein synthesis, RNA participates in other important biological processes as a component of cellular machineries and a modulator of gene expression. The major impact of RNA molecules on the control of gene expression has been highlighted by recent discoveries of small regulatory RNAs, long non-coding RNAs, and regulatory RNA elements in the non-coding regions of mRNAs. Despite their simple composition, RNA molecules can fold into intricate three-dimensional structures that expand the utility of RNA beyond that of the information carrier. Both RNA sequences and spatial structures are key for interactions with partners and assembly of functional complexes controlling gene expression.

We use a combination of biophysical methods, biochemical techniques, and structural approaches, including X-ray crystallography and cryo-electron microscopy, to elucidate molecular mechanisms of fundamental cellular processes associated with biosynthesis of mRNA, metabolism of RNA, and RNA-mediated gene expression control.



Academic office

550 First Avenue, Medical Science Bldg.

3, 393

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Grad Advisor for Molecular Biophysics Training Pgm

Vice Chair for Research, Department of Biochemistry & Molecular Pharmacology

Weaver, Jacob W; Proshkin, Sergey; Duan, Wenqian; Epshtein, Vitaly; Gowder, Manjunath; Bharati, Binod K; Afanaseva, Elena; Mironov, Alexander; Serganov, Alexander; Nudler, Evgeny

Nature structural & molecular biology. 2023 May; 30(5):600-607

Nuthanakanti, Ashok; Ariza-Mateos, Ascensión; Serganov, Alexander

Methods in molecular biology. 2023 Oct; 2568:213-232

Zeller, Meredith J; Favorov, Oleg; Li, Kelin; Nuthanakanti, Ashok; Hussein, Dina; Michaud, Auréliane; Lafontaine, Daniel A; Busan, Steven; Serganov, Alexander; Aubé, Jeffrey; Weeks, Kevin M

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2022 May 17; 119(20):e2122660119

Zeller, Meredith J; Nuthanakanti, Ashok; Li, Kelin; Aubé, Jeffrey; Serganov, Alexander; Weeks, Kevin M

ACS chemical biology. 2022 Feb 18; 17(2):438-448

Levenson-Palmer, Rose; Luciano, Daniel J; Vasilyev, Nikita; Nuthanakanti, Ashok; Serganov, Alexander; Belasco, Joel G

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2022 Feb 08; 119(6):

Kaushik, Abhishek; Nuthanakanti, Ashok; Serganov, Alexander

Nature chemical biology. 2022 Feb; 18(2):120-122

Ariza-Mateos, Ascensión; Nuthanakanti, Ashok; Serganov, Alexander

Biochemistry = Biokhimiya. 2021 Aug; 86(8):962-975

Shatalin, Konstantin; Nuthanakanti, Ashok; Kaushik, Abhishek; Shishov, Dmitry; Peselis, Alla; Shamovsky, Ilya; Pani, Bibhusita; Lechpammer, Mirna; Vasilyev, Nikita; Shatalina, Elena; Rebatchouk, Dmitri; Mironov, Alexander; Fedichev, Peter; Serganov, Alexander; Nudler, Evgeny

Science. 2021 06 11; 372(6547):1169-1175