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Amanda W. Lund

Amanda W. Lund, PhD

Associate Professor, Ronald O. Perelman Department of Dermatology

Associate Professor, Department of Pathology

Lymphatic Vessels, Cutaneous Immunity, Melanoma, T cell Trafficking, Lymph Nodes

The lymphatic vasculature is the critical interface between peripheral tissues and secondary lymphoid organs where adaptive immune responses are initiated. Though the immune response and the lymphatic vasculature are anatomically and functionally related, the contribution of these vessels to anti-tumor immunity remains underappreciated and unexplored. Our group tests the hypothesis that the lymphatic vasculature is an active regulator of cutaneous and tumor immunity both serving as the requisite route for immune priming and directly contributing to multiple mechanisms of immune resolution and tumor immune escape. We apply novel tools to track and quantify lymphatic biology in vivo, including three-dimensional and high-content imaging, in situ photoconversion, bulk and single-cell transcriptomics, and cell-specific proteomics strategies. By elucidating novel mechanisms of lymphatic vessel-mediated immune control, we are working towards the long-term goal of identifying novel targets and strategies to use the lymphatic vasculature to tune immune function to enhance cancer immunotherapy. 



Academic office

522 First Ave.

4th Floor, Lab 406; Office 410

New York, NY 10016

Lab Website
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Director, PhD Curriculum, Vilcek Institute

PhD from Rensselaer Polytechnic Institute

Ecole Polytechnique Federale de Lausanne, Laboratory of Lymphatic and Cancer Bioengineering

Lund, Amanda W

Journal of experimental medicine. 2023 Sep 04; 220(9):

Cristaldi, Vanessa; Lund, Amanda W

Cancer research. 2023 Aug 15; 83(16):2643-2644

Park, Ha-Ram; Shiva, Anahita; Cummings, Portia; Kim, Seoyeon; Kim, Sungsoo; Lee, Eunhyeong; Leong, Alessandra; Chowdhury, Subrata; Shawber, Carrie; Carvajal, Richard; Thurston, Gavin; An, Joon Yong; Lund, Amanda W; Yang, Hee Won; Kim, Minah

Cancer research. 2023 Jun 15; 83(12):1968-1983

Steele, Maria M; Jaiswal, Abhinav; Delclaux, Ines; Dryg, Ian D; Murugan, Dhaarini; Femel, Julia; Son, Sunny; du Bois, Haley; Hill, Cameron; Leachman, Sancy A; Chang, Young H; Coussens, Lisa M; Anandasabapathy, Niroshana; Lund, Amanda W

Nature immunology. 2023 Apr; 24(4):664-675

Werba, Gregor; Weissinger, Daniel; Kawaler, Emily A; Zhao, Ende; Kalfakakou, Despoina; Dhara, Surajit; Wang, Lidong; Lim, Heather B; Oh, Grace; Jing, Xiaohong; Beri, Nina; Khanna, Lauren; Gonda, Tamas; Oberstein, Paul; Hajdu, Cristina; Loomis, Cynthia; Heguy, Adriana; Sherman, Mara H; Lund, Amanda W; Welling, Theodore H; Dolgalev, Igor; Tsirigos, Aristotelis; Simeone, Diane M

Nature communications. 2023 Feb 13; 14(1):797

Blair, Tiffany C; Bambina, Shelly; Kramer, Gwen F; Dowdell, Alexa K; Alice, Alejandro F; Baird, Jason R; Lund, Amanda W; Piening, Brian D; Crittenden, Marka R; Gough, Michael J

Life science alliance. 2022 Sep; 5(9):

Ventre, Katherine S; Karakousi, Triantafyllia; Lund, Amanda W

Trends in cancer. 2022 Aug; 8(8):623-625

Barkley, Dalia; Moncada, Reuben; Pour, Maayan; Liberman, Deborah A; Dryg, Ian; Werba, Gregor; Wang, Wei; Baron, Maayan; Rao, Anjali; Xia, Bo; França, Gustavo S; Weil, Alejandro; Delair, Deborah F; Hajdu, Cristina; Lund, Amanda W; Osman, Iman; Yanai, Itai

Nature genetics. 2022 Aug; 54(8):1192-1201