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Amanda W. Lund

Amanda W. Lund, PhD

Associate Professor, Ronald O. Perelman Department of Dermatology

Associate Professor, Department of Pathology

Keywords
Lymphatic Vessels, Cutaneous Immunity, Melanoma, T cell Trafficking, Lymph Nodes
Summary

The lymphatic vasculature is the critical interface between peripheral tissues and secondary lymphoid organs where adaptive immune responses are initiated. Though the immune response and the lymphatic vasculature are anatomically and functionally related, the contribution of these vessels to anti-tumor immunity remains underappreciated and unexplored. Our group tests the hypothesis that the lymphatic vasculature is an active regulator of cutaneous and tumor immunity both serving as the requisite route for immune priming and directly contributing to multiple mechanisms of immune resolution and tumor immune escape. We apply novel tools to track and quantify lymphatic biology in vivo, including three-dimensional and high-content imaging, in situ photoconversion, bulk and single-cell transcriptomics, and cell-specific proteomics strategies. By elucidating novel mechanisms of lymphatic vessel-mediated immune control, we are working towards the long-term goal of identifying novel targets and strategies to use the lymphatic vasculature to tune immune function to enhance cancer immunotherapy. 

Phone

347-266-7243

Academic office

522 First Ave.

4th Floor, Lab 406; Office 410

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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PhD from Rensselaer Polytechnic Institute

Ecole Polytechnique Federale de Lausanne, Laboratory of Lymphatic and Cancer Bioengineering

Yu, Wesley Y; Hill, Sheena T; Chan, E Ricky; Pink, John J; Cooper, Kevin; Leachman, Sancy; Lund, Amanda W; Kulkarni, Rajan; Bordeaux, Jeremy S

Journal of investigative dermatology. 2021 Jul; 141(7):1802-1809

Marin-Bejar, Oskar; Rogiers, Aljosja; Dewaele, Michael; Femel, Julia; Karras, Panagiotis; Pozniak, Joanna; Bervoets, Greet; Van Raemdonck, Nina; Pedri, Dennis; Swings, Toon; Demeulemeester, Jonas; Borght, Sara Vander; Lehnert, Stefan; Bosisio, Francesca; van den Oord, Joost J; Bempt, Isabelle Vanden; Lambrechts, Diether; Voet, Thierry; Bechter, Oliver; Rizos, Helen; Levesque, Mitchell P; Leucci, Eleonora; Lund, Amanda W; Rambow, Florian; Marine, Jean-Christophe

Cancer cell. 2021 Jun 07;

Patton, E Elizabeth; Mueller, Kristen L; Adams, David J; Anandasabapathy, Niroshana; Aplin, Andrew E; Bertolotto, Corine; Bosenberg, Marcus; Ceol, Craig J; Burd, Christin E; Chi, Ping; Herlyn, Meenhard; Holmen, Sheri L; Karreth, Florian A; Kaufman, Charles K; Khan, Shaheen; Kobold, Sebastian; Leucci, Eleonora; Levy, Carmit; Lombard, David B; Lund, Amanda W; Marie, Kerrie L; Marine, Jean-Christophe; Marais, Richard; McMahon, Martin; Robles-Espinoza, Carla Daniela; Ronai, Ze'ev A; Samuels, Yardena; Soengas, Maria S; Villanueva, Jessie; Weeraratna, Ashani T; White, Richard M; Yeh, Iwei; Zhu, Jiyue; Zon, Leonard I; Hurlbert, Marc S; Merlino, Glenn

Cancer cell. 2021 May 10; 39(5):610-631

Wilson, John T; Lund, Amanda W

Science advances. 2021 Mar; 7(13):

Steele, Maria M; Lund, Amanda W

Journal of immunology (1950). 2021 Jan 15; 206(2):264-272

Lund, Amanda W; Soengas, Maria S

Cancer cell. 2020 Oct 12; 38(4):446-448

Leachman, Sancy A; Hornyak, Thomas J; Barsh, Greg; Bastian, Boris C; Brash, Douglas E; Cleaver, James E; Cooper, Cynthia D; D'Orazio, John A; Fujita, Mayumi; Holmen, Sheri L; Indra, Arup K; Kramer, Kenneth H; Le Poole, I Caroline; Lo, Roger S; Lund, Amanda W; Manga, Prashiela; Pavan, William J; Setaluri, Vijayasaradhi; Stemwedel, Clara E; Kulesz-Martin, Molly F

Journal of investigative dermatology. 2020 Feb; 140(2):269-274

O'Melia, Meghan J; Lund, Amanda W; Thomas, Susan N

iScience. 2019 Nov 06; 22:28-43