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Amanda W. Lund, PhD

Member of the Faculty, Ronald O. Perelman Department of Dermatology

Member of the Faculty, Department of Pathology

Keywords
Lymphatic Vessels, Cutaneous Immunity, Melanoma, T cell Trafficking, Lymph Nodes
Summary

The lymphatic vasculature is the critical interface between peripheral tissues and secondary lymphoid organs where adaptive immune responses are initiated. Though the immune response and the lymphatic vasculature are anatomically and functionally related, the contribution of these vessels to anti-tumor immunity remains underappreciated and unexplored. Our group tests the hypothesis that the lymphatic vasculature is an active regulator of cutaneous and tumor immunity both serving as the requisite route for immune priming and directly contributing to multiple mechanisms of immune resolution and tumor immune escape. We apply novel tools to track and quantify lymphatic biology in vivo, including three-dimensional and high-content imaging, in situ photoconversion, bulk and single-cell transcriptomics, and cell-specific proteomics strategies. By elucidating novel mechanisms of lymphatic vessel-mediated immune control, we are working towards the long-term goal of identifying novel targets and strategies to use the lymphatic vasculature to tune immune function to enhance cancer immunotherapy. 

Phone

347-266-7243

Academic office

522 First Ave.

4th Floor, Lab 406; Office 410

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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PhD from Rensselaer Polytechnic Institute

Ecole Polytechnique Federale de Lausanne, Melody A. Swartz, PhD

Leachman, Sancy A; Hornyak, Thomas J; Barsh, Greg; Bastian, Boris C; Brash, Douglas E; Cleaver, James E; Cooper, Cynthia D; D'Orazio, John A; Fujita, Mayumi; Holmen, Sheri L; Indra, Arup K; Kramer, Kenneth H; Le Poole, I Caroline; Lo, Roger S; Lund, Amanda W; Manga, Prashiela; Pavan, William J; Setaluri, Vijayasaradhi; Stemwedel, Clara E; Kulesz-Martin, Molly F

Journal of investigative dermatology. 2020 Feb; 140(2):269-274

O'Melia, Meghan J; Lund, Amanda W; Thomas, Susan N

iScience. 2019 Nov 06; 22:28-43

Steele, Maria M; Churchill, Madeline J; Breazeale, Alec P; Lane, Ryan S; Nelson, Nicholas A; Lund, Amanda W

Journal of visualized experiments : JoVE. 2019 01 07; (143):

Lane, Ryan S; Femel, Julia; Breazeale, Alec P; Loo, Christopher P; Thibault, Guillaume; Kaempf, Andy; Mori, Motomi; Tsujikawa, Takahiro; Chang, Young Hwan; Lund, Amanda W

Journal of experimental medicine. 2018 12 03; 215(12):3057-3074

Goodman, James R; Adham, Zachariah O; Woltjer, Randall L; Lund, Amanda W; Iliff, Jeffrey J

Brain, behavior & immunity. 2018 10; 73:34-40

Rambow, Florian; Rogiers, Aljosja; Marin-Bejar, Oskar; Aibar, Sara; Femel, Julia; Dewaele, Michael; Karras, Panagiotis; Brown, Daniel; Chang, Young Hwan; Debiec-Rychter, Maria; Adriaens, Carmen; Radaelli, Enrico; Wolter, Pascal; Bechter, Oliver; Dummer, Reinhard; Levesque, Mitchell; Piris, Adriano; Frederick, Dennie T; Boland, Genevieve; Flaherty, Keith T; van den Oord, Joost; Voet, Thierry; Aerts, Stein; Lund, Amanda W; Marine, Jean-Christophe

Cell. 2018 08 09; 174(4):843-855.e19

Loo, Christopher P; Nelson, Nicholas A; Lane, Ryan S; Booth, Jamie L; Loprinzi Hardin, Sofia C; Thomas, Archana; Slifka, Mark K; Nolz, Jeffrey C; Lund, Amanda W

Cell reports. 2017 Sep 26; 20(13):3176-3187