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Ana M. Rodriguez Fernandez

Ana M. Rodriguez Fernandez, PhD

Professor, Department of Microbiology

Keywords
malaria, inflammation, Plasmodium, cerebral malaria, severe anemia, immunology, microbiology
Summary

Our lab studies two different parasites: Plasmodium species, which causes malaria; and Trypanosoma cruzi, which causes Chagas disease.

Malaria is a devastating disease that causes about 400,000 deaths per year, mainly among children in Africa. There is an urgent need for new strategies to control malaria. However, details of the basic biological processes underlying Plasmodium infection are not well understood. Deeper knowledge would enable faster development of antimalarial drugs and vaccines.

A main focus in our laboratory is malaria-induced inflammatory response and its implications in the pathology of disease, including cerebral malaria and severe anemia.

We also intend to develop effective drugs against Chagas disease. In collaboration with GlaxoSmithKline, we have performed high-throughput screenings of intracellular T. cruzi, to find compounds with antitrypanosomal activity. Selected compounds are being developed in the pre-clinical phase with the aim of finding candidates for clinical trials in chronically-infected patients.

Phone

646-501-6997

Academic office

430 E. 29th st, Alexandria Center West Tower

room 511, lab 524

New York, NY 10010

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Professor, Department of Microbiology

Co-Director, Anopheles Insectary

PhD from Autonomous University of Madrid

Fellowship, Institute Curie, Paris, France, Cell Biology/Immunology

Fellowship, Yale University School of Medicine, Cell Biology/Parasitology

Fernandez-Arias, Cristina; Rivera-Correa, Juan; Gallego-Delgado, Julio; Rudlaff, Rachel; Fernandez, Clemente; Roussel, Camille; Gotz, Anton; Gonzalez, Sandra; Mohanty, Akshaya; Mohanty, Sanjib; Wassmer, Samuel; Buffet, Pierre; Ndour, Papa Alioune; Rodriguez, Ana

Cell host & microbe. 2016 Feb 10; 19(2):194-203

Gallego-Delgado, Julio; Basu-Roy, Upal; Ty, Maureen; Alique, Matilde; Fernandez-Arias, Cristina; Movila, Alexandru; Gomes, Pollyanna; Weinstock, Ada; Xu, Wenyue; Edagha, Innocent; Wassmer, Samuel C; Walther, Thomas; Ruiz-Ortega, Marta; Rodriguez, Ana

Journal of clinical investigation. 2016 10 03; 126(10):4016-4029

Gotz, Anton; Tang, Mei San; Ty, Maureen C; Arama, Charles; Ongoiba, Aissata; Doumtabe, Didier; Traore, Boubacar; Crompton, Peter D; Loke, P'ng; Rodriguez, Ana

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2017 12 05; 114(49):E10568-E10577

Rivera-Correa, J; Guthmiller, J J; Vijay, R; Fernandez-Arias, C; Pardo-Ruge, M A; Gonzalez, S; Butler, N S; Rodriguez, A

Nature communications. 2017 11 03; 8(1):1282

Orengo, Jamie M; Evans, James E; Bettiol, Esther; Leliwa-Sytek, Aleksandra; Day, Karen; Rodriguez, Ana

PLoS pathogens. 2008 Mar 07; 4(3):e1000013

Ocana-Morgner, Carlos; Mota, Maria M; Rodriguez, Ana

Journal of experimental medicine. 2003 Jan 20; 197(2):143-51

Mota, Maria M; Hafalla, Julius C R; Rodriguez, Ana

Nature medicine. 2002 Nov; 8(11):1318-22

Mota MM; Pradel G; Vanderberg JP; Hafalla JC; Frevert U; Nussenzweig RS; Nussenzweig V; Rodriguez A

Science. 2001 Jan 05; 291(5501):141-4