Professor, Department of Microbiology
Our lab studies two different parasites: Plasmodium species, which causes malaria; and Trypanosoma cruzi, which causes Chagas disease.
Malaria is a devastating disease that causes about 400,000 deaths per year, mainly among children in Africa. There is an urgent need for new strategies to control malaria. However, details of the basic biological processes underlying Plasmodium infection are not well understood. Deeper knowledge would enable faster development of antimalarial drugs and vaccines.
A main focus in our laboratory is malaria-induced inflammatory response and its implications in the pathology of disease, including cerebral malaria and severe anemia.
We also intend to develop effective drugs against Chagas disease. In collaboration with GlaxoSmithKline, we have performed high-throughput screenings of intracellular T. cruzi, to find compounds with antitrypanosomal activity. Selected compounds are being developed in the pre-clinical phase with the aim of finding candidates for clinical trials in chronically-infected patients.
Co-Director, Anopheles Insectary
PhD from Autonomous University of Madrid
Fellowship, Institute Curie, Paris, France, Cell Biology/Immunology
Fellowship, Yale University School of Medicine, Cell Biology/Parasitology
Cell host & microbe. 2016 Feb 10; 19(2):194-203
Journal of clinical investigation. 2016 10 03; 126(10):4016-4029
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2017 12 05; 114(49):E10568-E10577
Nature communications. 2017 11 03; 8(1):1282
PLoS pathogens. 2008 Mar 07; 4(3):e1000013
Journal of experimental medicine. 2003 Jan 20; 197(2):143-51
Nature medicine. 2002 Nov; 8(11):1318-22
Science. 2001 Jan 05; 291(5501):141-4