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Angel G. Pellicer

Angel G. Pellicer, MD, PhD

Adjunct Professor, Department of Pathology

oncogenes and tumor suppressor genes , tumorigenesis

Our laboratory investigates the mechanisms of oncogene activation, tumor suppressor gene inactivation and the function that these genes have in malignant transformation and normal cellular processes. Specifically, we study the ras family genes, which are activated in a significant percentage of human tumors. Working with animal model systems, we have induced several types of tumors and analyzed them at the molecular level. To determine the exact role of the N-ras oncogene in these tumors, we constructed several lines of transgenic mice that develop different types of neoplasias, mimicking the phenotype of the tumors from where the oncogene was originally isolated. Moreover, with mutant mice lacking the N-ras gene (knockout) we are determining the cellular pathways in which this gene is specifically involved.

In addition, we are characterizing a new oncogene identified in the laboratory, rsc, that is a homologue of the activator for another member of the ras extended gene family, Ral, and we are continuing our studies on the mechanisms of inactivation of p15 in murine thymic lymphomas.

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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PhD from University of Valencia

MD from University of Valencia

LeÓn, J; Pellicer, A

The ras Superfamily of GTPases. p.3-36. (3330202)

Lynch, Stephen J; Snitkin, Harriet; Gumper, Iwona; Philips, Mark R; Sabatini, David; Pellicer, Angel

Journal of cellular physiology. 2015 Mar; 230(3):610-9

Lynch, Stephen J; Zavadil, Jiri; Pellicer, Angel

PLoS one. 2014 Aug; 8(6):e63193

Suzme, R; Tseng, J-C; Levin, B; Ibrahim, S; Meruelo, D; Pellicer, A

Cancer gene therapy. 2012 Nov; 19(11):757-66

Benet M; Dulman RY; Suzme R; de Miera EV; Vega ME; Nguyen T; Zavadil J; Pellicer A

Journal of cellular physiology. 2012 Jun; 227(6):2341-51

Osei-Sarfo, Kwame; Perez de Castro, Ignacio; Pellicer, Angel

Carcinogenesis. 2012 Mar; 33(3):708-13

Wei JJ; Wu X; Peng Y; Shi G; Olca B; Yang X; Daniels G; Osman I; Ouyang J; Hernando E; Pellicer A; Rhim J; Melamed J; Lee P

Clinical cancer research. 2011 Mar 15; 17(6):1297-305