Adjunct Professor, Department of Pathology
Our laboratory investigates the mechanisms of oncogene activation, tumor suppressor gene inactivation and the function that these genes have in malignant transformation and normal cellular processes. Specifically, we study the ras family genes, which are activated in a significant percentage of human tumors. Working with animal model systems, we have induced several types of tumors and analyzed them at the molecular level. To determine the exact role of the N-ras oncogene in these tumors, we constructed several lines of transgenic mice that develop different types of neoplasias, mimicking the phenotype of the tumors from where the oncogene was originally isolated. Moreover, with mutant mice lacking the N-ras gene (knockout) we are determining the cellular pathways in which this gene is specifically involved.
In addition, we are characterizing a new oncogene identified in the laboratory, rsc, that is a homologue of the activator for another member of the ras extended gene family, Ral, and we are continuing our studies on the mechanisms of inactivation of p15 in murine thymic lymphomas.
PhD from University of Valencia
MD from University of Valencia
The ras Superfamily of GTPases. p.3-36. (3330202)
Journal of cellular physiology. 2015 Mar; 230(3):610-9
PLoS one. 2014 Aug; 8(6):e63193
Cancer gene therapy. 2012 Nov; 19(11):757-66
Journal of cellular physiology. 2012 Jun; 227(6):2341-51
Carcinogenesis. 2012 Mar; 33(3):708-13
Oncogene. 2011 Aug 25; 30(34):3661-71
Clinical cancer research. 2011 Mar 15; 17(6):1297-305