Our laboratory investigates the mechanisms of oncogene activation, tumor suppressor gene inactivation and the function that these genes have in malignant transformation and normal cellular processes. Specifically, we study the ras family genes, which are activated in a significant percentage of human tumors. Working with animal model systems, we have induced several types of tumors and analyzed them at the molecular level. To determine the exact role of the N-ras oncogene in these tumors, we constructed several lines of transgenic mice that develop different types of neoplasias, mimicking the phenotype of the tumors from where the oncogene was originally isolated. Moreover, with mutant mice lacking the N-ras gene (knockout) we are determining the cellular pathways in which this gene is specifically involved.
In addition, we are characterizing a new oncogene identified in the laboratory, rsc, that is a homologue of the activator for another member of the ras extended gene family, Ral, and we are continuing our studies on the mechanisms of inactivation of p15 in murine thymic lymphomas.
Adjunct Professor, Department of Pathology
PhD from University of Valencia
MD from University of Valencia
The ras Superfamily of GTPases. p.3-36. (3330202)
Journal of cellular physiology. 2015 Mar; 230(3):610-619
PLoS one. 2014; 8(6):e63193-e63193
Cancer gene therapy. 2012 Nov; 19(11):757-766
Journal of cellular physiology. 2012 Jun; 227(6):2341-2351
Carcinogenesis. 2012 Mar; 33(3):708-713
Oncogene. 2011 Aug 25; 30(34):3661-3671
Clinical cancer research. 2011 Mar 15; 17(6):1297-1305