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Angelica Ortiz

Angelica Ortiz, PhD

Assistant Professor, Department of Medicine

Carcinogenesis, Metastasis, Inflammation, Extracellular Vesicles

My research focuses on extracellular vesicles as biomarkers and mediators of inflammatory diseases, carcinogenesis and metastasis. Extracellular vesicles are phospholipid bilayer vesicles containing lipids, proteins, and genetic material (DNA, mRNA, microRNA, etc) released by cells. These extracellular vesicles participate in homeostatic functions, but can be altered in number and content following cellular stress. Extracellular vesicles can be incorporated by cells, and therefore changes in cargo can be adopted by the host cells to alter protein composition and transcriptome. A current interest examines how exposure to toxic metals alters extracellular vesicle release and composition to mediate inflammatory response and contribute to cancer progression. Another area of interest is analysis of urine-derived extracellular vesicles to examine changes in kidney function and elucidate possible systemic vascular dysfunction.



Academic office

341 East 25th Street, Rm 212

2nd Floor, 212

New York, NY 10010

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PhD from University of Texas

University of Pennsylvania, School of Veterinary Medicine, Serge Y. Fuch Laboratory

Liu, Shan; Ortiz, Angelica; Stavrou, Aikaterini; Talusan, Angela R; Costa, Max

International journal of molecular sciences. 2022 Dec 17; 23(24):

Stavrou, Aikaterini; Ortiz, Angelica

Cancers. 2022 Sep 14; 14(18):

Zhang, Hongru; Yu, Pengfei; Tomar, Vivek S; Chen, Xiangjie; Atherton, Matthew J; Lu, Zhen; Zhang, Hong-Guang; Li, Shifeng; Ortiz, Angelica; Gui, Jun; Leu, N Adrian; Yan, Fangxue; Blanco, Andres; Meyer-Ficca, Mirella L; Meyer, Ralph G; Beiting, Daniel P; Li, Jinyang; Nunez-Cruz, Selene; O'Connor, Roddy S; Johnson, Lexus R; Minn, Andy J; George, Subin S; Koumenis, Constantinos; Diehl, J Alan; Milone, Michael C; Zheng, Hui; Fuchs, Serge Y

Nature cancer. 2022 07; 3(7):808-820

De Palma, Giuseppe; Ortiz, Angelica; Apostoli, Pietro

Handbook on the Toxicology of Metals. [S.l.] : Elsevier, 2021. 5th ed. p.565-592. (5317142)

Liu, Shan; Costa, Max; Ortiz, Angelica

Handbook on the Toxicology of Metals. [S.l.] : Elsevier, 2021. 5th ed. p.279-298. (5317152)

Ortiz, Angelica

Seminars in cancer biology. 2021 Nov; 76:139-142

Lu, Zhen; Ortiz, Angelica; Verginadis, Ioannis I; Peck, Amy R; Zahedi, Farima; Cho, Christina; Yu, Pengfei; DeRita, Rachel M; Zhang, Hongru; Kubanoff, Ryan; Sun, Yunguang; Yaspan, Andrew T; Krespan, Elise; Beiting, Daniel P; Radaelli, Enrico; Ryeom, Sandra W; Diehl, J Alan; Rui, Hallgeir; Koumenis, Constantinos; Fuchs, Serge Y

Journal of clinical investigation. 2021 May 17; 131(10):