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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Associate Professor, Department of Pathology

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Li, Fei; Huang, Qingyuan; Luster, Troy A; Hu, Hai; Zhang, Hua; Ng, Wai-Lung; Khodadadi-Jamayran, Alireza; Wang, Wei; Chen, Ting; Deng, Jiehui; Ranieri, Michela; Fang, Zhaoyuan; Pyon, Val; Dowling, Catriona M; Bagdatlioglu, Ece; Almonte, Christina; Labbe, Kristen; Silver, Heather; Rabin, Alexandra R; Jani, Kandarp; Tsirigos, Aristotelis; Papagiannakopoulos, Thales; Hammerman, Peter S; Velcheti, Vamsidhar; Freeman, Gordon J; Qi, Jun; Miller, George; Wong, Kwok-Kin

Cancer discovery. 2020 Feb; 10(2):270-287

Hanniford, Douglas; Ulloa-Morales, Alejandro; Karz, Alcida; Berzoti-Coelho, Maria Gabriela; Moubarak, Rana S; Sánchez-Sendra, Beatriz; Kloetgen, Andreas; Davalos, Veronica; Imig, Jochen; Wu, Pamela; Vasudevaraja, Varshini; Argibay, Diana; Lilja, Karin; Tabaglio, Tommaso; Monteagudo, Carlos; Guccione, Ernesto; Tsirigos, Aristotelis; Osman, Iman; Aifantis, Iannis; Hernando, Eva

Cancer cell. 2020 Jan 13; 37(1):55-70.e15

Hatzioannou, Aikaterini; Banos, Aggelos; Sakelaropoulos, Theodore; Fedonidis, Constantinos; Vidali, Maria-Sophia; Köhne, Maren; Händler, Kristian; Boon, Louis; Henriques, Ana; Koliaraki, Vasiliki; Georgiadis, Panagiotis; Zoidakis, Jerome; Termentzi, Aikaterini; Beyer, Marc; Chavakis, Triantafyllos; Boumpas, Dimitrios; Tsirigos, Aristotelis; Verginis, Panayotis

Nature immunology. 2020 Jan; 21(1):75-85

Giro-Perafita, A; Luo, L; Khodadadi-Jamayran, A; Thompson, M; Akgol Oksuz, B; Tsirigos, A; Dynlacht, B D; Sánchez, I; Esteva, F J

NPJ breast cancer. 2020 Jan; 6:1

Halaby, Marie Jo; Hezaveh, Kebria; Lamorte, Sara; Ciudad, M Teresa; Kloetgen, Andreas; MacLeod, Bethany L; Guo, Mengdi; Chakravarthy, Ankur; Medina, Tiago Da Silva; Ugel, Stefano; Tsirigos, Aristotelis; Bronte, Vincenzo; Munn, David H; Pugh, Trevor J; De Carvalho, Daniel D; Butler, Marcus O; Ohashi, Pamela S; Brooks, David G; McGaha, Tracy L

Science immunology. 2019 Dec 13; 4(42):

Ostroff, Linnaea E; Santini, Emanuela; Sears, Robert; Deane, Zachary; Kanadia, Rahul N; LeDoux, Joseph E; Lhakhang, Tenzin; Tsirigos, Aristotelis; Heguy, Adriana; Klann, Eric

eLife. 2019 Dec 11; 8:

Sakellaropoulos, Theodore; Vougas, Konstantinos; Narang, Sonali; Koinis, Filippos; Kotsinas, Athanassios; Polyzos, Alexander; Moss, Tyler J; Piha-Paul, Sarina; Zhou, Hua; Kardala, Eleni; Damianidou, Eleni; Alexopoulos, Leonidas G; Aifantis, Iannis; Townsend, Paul A; Panayiotidis, Mihalis I; Sfikakis, Petros; Bartek, Jiri; Fitzgerald, Rebecca C; Thanos, Dimitris; Mills Shaw, Kenna R; Petty, Russell; Tsirigos, Aristotelis; Gorgoulis, Vassilis G

Cell reports. 2019 Dec 10; 29(11):3367-3373.e4

Bledea, Ramona; Vasudevaraja, Varshini; Patel, Seema; Stafford, James; Serrano, Jonathan; Esposito, Gianna; Tredwin, Lilian M; Goodman, Nina; Kloetgen, Andreas; Golfinos, John G; Zagzag, David; Weigelt, Britta; Iafrate, A John; Sulman, Erik P; Chi, Andrew S; Dogan, Snjezana; Reis-Filho, Jorge S; Chiang, Sarah; Placantonakis, Dimitris; Tsirigos, Aristotelis; Snuderl, Matija

Scientific reports. 2019 Nov 14; 9(1):16830