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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Associate Professor, Department of Pathology

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Di Giammartino, Dafne Campigli; Kloetgen, Andreas; Polyzos, Alexander; Liu, Yiyuan; Kim, Daleum; Murphy, Dylan; Abuhashem, Abderhman; Cavaliere, Paola; Aronson, Boaz; Shah, Veevek; Dephoure, Noah; Stadtfeld, Matthias; Tsirigos, Aristotelis; Apostolou, Effie

Nature cell biology. 2019 Oct; 21(10):1179-1190

Saldaña-Meyer, Ricardo; Rodriguez-Hernaez, Javier; Escobar, Thelma; Nishana, Mayilaadumveettil; Jácome-López, Karina; Nora, Elphege P; Bruneau, Benoit G; Tsirigos, Aristotelis; Furlan-Magaril, Mayra; Skok, Jane; Reinberg, Danny

Molecular cell. 2019 Sep 05;

Guillamot, Maria; Ouazia, Dahmane; Dolgalev, Igor; Yeung, Stephen T; Kourtis, Nikos; Dai, Yuling; Corrigan, Kate; Zea-Redondo, Luna; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Tikhonova, Anastasia N; Malumbres, Marina; Gong, Yixiao; Tsirigos, Aristotelis; Park, Christopher; Barbieri, Christopher; Khanna, Kamal M; Busino, Luca; Aifantis, Iannis

Nature immunology. 2019 Sep; 20(9):1196-1207

Kloetgen, Andreas; Thandapani, Palaniraja; Tsirigos, Aristotelis; Aifantis, Iannis

Trends in immunology. 2019 Sep; 40(9):809-824

Tikhonova, Anastasia N; Dolgalev, Igor; Hu, Hai; Sivaraj, Kishor K; Hoxha, Edlira; Cuesta-Domínguez, Álvaro; Pinho, Sandra; Akhmetzyanova, Ilseyar; Gao, Jie; Witkowski, Matthew; Guillamot, Maria; Gutkin, Michael C; Zhang, Yutong; Marier, Christian; Diefenbach, Catherine; Kousteni, Stavroula; Heguy, Adriana; Zhong, Hua; Fooksman, David R; Butler, Jason M; Economides, Aris; Frenette, Paul S; Adams, Ralf H; Satija, Rahul; Tsirigos, Aristotelis; Aifantis, Iannis

Nature. 2019 Aug; 572(7767):E6

Vougas, Konstantinos; Sakelaropoulos, Theodore; Kotsinas, Athanassios; Foukas, George-Romanos P; Ntargaras, Andreas; Koinis, Filippos; Polyzos, Alexander; Myrianthopoulos, Vassilis; Zhou, Hua; Narang, Sonali; Georgoulias, Vassilis; Alexopoulos, Leonidas; Aifantis, Iannis; Townsend, Paul A; Sfikakis, Petros; Fitzgerald, Rebecca; Thanos, Dimitris; Bartek, Jiri; Petty, Russell; Tsirigos, Aristotelis; Gorgoulis, Vassilis G

Pharmacology & therapeutics. 2019 Jul 30; 107395

Yu, Minjun; Scherwitzl, Iris; Opp, Silvana; Tsirigos, Aristotelis; Meruelo, Daniel

Journal for immunotherapy of cancer. 2019 Jul 15; 7(1):185

Lignitto, Luca; LeBoeuf, Sarah E; Homer, Harrison; Jiang, Shaowen; Askenazi, Manor; Karakousi, Triantafyllia R; Pass, Harvey I; Bhutkar, Arjun J; Tsirigos, Aristotelis; Ueberheide, Beatrix; Sayin, Volkan I; Papagiannakopoulos, Thales; Pagano, Michele

Cell. 2019 Jul 11; 178(2):316-329.e18