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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Khodadadi-Jamayran, Alireza; Tsirigos, Aristotelis

bioRxiv.org : the preprint server for biology. 2020 May 05;

Saint Fleur-Lominy, Shella; Evensen, Nikki A; Bhatla, Teena; Sethia, Gunjan; Narang, Sonali; Choi, Jun H; Ma, Xiaotu; Yang, Jun J; Kelly, Stephen; Raetz, Elizabeth; Harvey, Richard C; Willman, Cheryl; Loh, Mignon L; Hunger, Stephen P; Brown, Patrick A; Getz, Kylie M; Meydan, Cem; Mason, Christopher E; Tsirigos, Aristotelis; Carroll, William L

Cancer research. 2020 Oct 16;

Cui, Xin; Ma, Chao; Vasudevaraja, Varshini; Serrano, Jonathan; Tong, Jie; Peng, Yansong; Delorenzo, Michael; Shen, Guomiao; Frenster, Joshua; Morales, Renee-Tyler Tan; Qian, Weiyi; Tsirigos, Aristotelis; Chi, Andrew S; Jain, Rajan; Kurz, Sylvia C; Sulman, Erik P; Placantonakis, Dimitris G; Snuderl, Matija; Chen, Weiqiang

eLife. 2020 09 10; 9:

Vidal, Simon E; Polyzos, Alexander; Chatterjee, Kaushiki; Ee, Ly-Sha; Swanzey, Emily; Morales-Valencia, Jorge; Wang, Hongsu; Parikh, Chaitanya N; Amlani, Bhishma; Tu, Shengjiang; Gong, Yixiao; Snetkova, Valentina; Skok, Jane A; Tsirigos, Aristotelis; Kim, Sangyong; Apostolou, Effie; Stadtfeld, Matthias

Stem cell reports. 2020 Sep 07;

Zhou, Yalu; Han, Cuijuan; Wang, Eric; Lorch, Adam H; Serafin, Valentina; Cho, Byoung-Kyu; Guttierrez Diaz, Blanca T; Calvo, Julien; Fang, Celestia; Khodadadi-Jamayran, Alireza; Tabaglio, Tommaso; Marier, Christian; Kuchmiy, Anna; Sun, Limin; Yacu, George; Filip, Szymon K; Jin, Qi; Takahashi, Yoh-Hei; Amici, David R; Rendleman, Emily J; Rawat, Radhika; Bresolin, Silvia; Paganin, Maddalena; Zhang, Cheng; Li, Hu; Kandela, Irawati; Politanska, Yuliya; Abdala-Valencia, Hiam; Mendillo, Marc L; Zhu, Ping; Palhais, Bruno; Van Vlierberghe, Pieter; Taghon, Tom; Aifantis, Iannis; Goo, Young Ah; Guccione, Ernesto; Heguy, Adriana; Tsirigos, Aristotelis; Wee, Keng Boon; Mishra, Rama K; Pflumio, Francoise; Accordi, Benedetta; Basso, Giuseppe; Ntziachristos, Panagiotis

Cancer discovery. 2020 Sep; 10(9):1388-1409

Moro, Loredana; Simoneschi, Daniele; Kurz, Emma; Arbini, Arnaldo A; Jang, Shaowen; Guaragnella, Nicoletta; Giannattasio, Sergio; Wang, Wei; Chen, Yu-An; Pires, Geoffrey; Dang, Andrew; Hernandez, Elizabeth; Kapur, Payal; Mishra, Ankita; Tsirigos, Aristotelis; Miller, George; Hsieh, Jer-Tsong; Pagano, Michele

Nature cell biology. 2020 Sep; 22(9):1130-1142

Pierro, Joanna; Saliba, Jason; Narang, Sonali; Sethia, Gunjan; Saint Fleur-Lominy, Shella; Chowdhury, Ashfiyah; Qualls, Anita; Fay, Hannah; Kilberg, Harrison L; Moriyama, Takaya; Fuller, Tori J; Teachey, David T; Schmiegelow, Kjeld; Yang, Jun J; Loh, Mignon L; Brown, Patrick A; Zhang, Jinghui; Ma, Xiaotu; Tsirigos, Aristotelis; Evensen, Nikki A; Carroll, William L

Molecular cancer research. 2020 Aug; 18(8):1153-1165

Witkowski, Matthew T; Dolgalev, Igor; Evensen, Nikki A; Ma, Chao; Chambers, Tiffany; Roberts, Kathryn G; Sreeram, Sheetal; Dai, Yuling; Tikhonova, Anastasia N; Lasry, Audrey; Qu, Chunxu; Pei, Deqing; Cheng, Cheng; Robbins, Gabriel A; Pierro, Joanna; Selvaraj, Shanmugapriya; Mezzano, Valeria; Daves, Marla; Lupo, Philip J; Scheurer, Michael E; Loomis, Cynthia A; Mullighan, Charles G; Chen, Weiqiang; Rabin, Karen R; Tsirigos, Aristotelis; Carroll, William L; Aifantis, Iannis

Cancer cell. 2020 Jun 08; 37(6):867-882.e12