Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).
Associate Professor, Department of Pathology
Director, Center for Applied Bioinformatics
Director, Clinical Informatics, Molecular Pathology Lab
PhD from New York University
Journal of clinical investigation. 2018 Jan 02; 128(1):233-247
Cell stem cell. 2017 Nov 02; 21(5):650-664.e8
PERIPHERAL BLOOD DNA METHYLATION PROFILES IDENTIFY IDH1/2 MUTATION STATUS IN ADULTS WITH DIFFUSE GLIOMA [Meeting Abstract]
Neuro-oncology. 2017 NOV; 19:92-92
CHARACTERIZATION OF GPR133 EXPRESSION IN GLIOMA SUBTYPES [Meeting Abstract]
Neuro-oncology. 2017 NOV; 19:36-36
Cell reports. 2017 Oct 31; 21(5):1267-1280
Genome announcements. 2017 Oct 26; 5(43):?-?
COMPREHENSIVE TRANSCRIPTOME CHARACTERIZATION OF HUMAN BLASTOCYSTS FOR NORMALS AND EVERY KNOWN KARYOTYPE [Meeting Abstract]
Fertility & sterility. 2017 SEP; 108(3):E106-E106
Cell. 2017 Aug 17; 170(6):1079-1095.e20