Aristotelis Tsirigos, PhD
Associate Professor, Department of Pathology
Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).
Associate Professor, Department of Pathology
Director, Center for Applied Bioinformatics
Director, Clinical Informatics, Molecular Pathology Lab
PhD from New York University
Scientific reports. 2017 Aug 01; 7(1):7043-7043
Predictive biomarkers of ipilimumab toxicity in metastatic melanoma [Meeting Abstract]
Journal of clinical oncology. 2017 Jun 20; Conference:(2017):
BMC genomics. 2017 Jun 05; 18(1):434-434
LOW-GRADE ASTROCYTOMA CORE MUTATIONS IN IDH1, P53 AND ATRX COOPERATE TO BLOCK DIFFERENTIATION OF HUMAN NEURAL STEM CELLS VIA EPIGENETIC REPRESSION OF SOX2 [Meeting Abstract]
Neuro-oncology. 2017 JUN; 19:35-35
Genome biology. 2017 May 24; 18(1):98-98
Oncotarget. 2017 May 23; ?-?
Defining cellular quiescence as a multi-drug resistance mechanism in squamous cell carcinoma [Meeting Abstract]
Journal of investigative dermatology. 2017 MAY; 137(5):S22-S22
BMC genomics. 2017 Jan 05; 18(1):22-22