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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

Lab Website
Tsirigos Lab
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Positions

Associate Professor, Department of Pathology

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

Graduate Education

PhD from New York University

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

Chen, Xufeng; Glytsou, Christina; Zhou, Hua; Narang, Sonali; Reyna, Denis E; Lopez, Andrea; Sakellaropoulos, Theodore; Gong, Yixiao; Kloetgen, Andreas; Yap, Yoon Sing; Wang, Eric; Gavathiotis, Evripidis; Tsirigos, Aristotelis; Tibes, Raoul; Aifantis, Iannis

Cancer discovery. 2019 May 02;

The bone marrow microenvironment at single-cell resolution

Tikhonova, Anastasia N; Dolgalev, Igor; Hu, Hai; Sivaraj, Kishor K; Hoxha, Edlira; Cuesta-Domínguez, Álvaro; Pinho, Sandra; Akhmetzyanova, Ilseyar; Gao, Jie; Witkowski, Matthew; Guillamot, Maria; Gutkin, Michael C; Zhang, Yutong; Marier, Christian; Diefenbach, Catherine; Kousteni, Stavroula; Heguy, Adriana; Zhong, Hua; Fooksman, David R; Butler, Jason M; Economides, Aris; Frenette, Paul S; Adams, Ralf H; Satija, Rahul; Tsirigos, Aristotelis; Aifantis, Iannis

Nature. 2019 May; 569(7755):222-228

135 Defining the T cell landscape and neoantigens via T-cell receptor sequencing and gene expression profiling in cutaneous squamous cell carcinoma [Meeting Abstract]

Doudican, N A; Santana, A; Felsen, D; Khodadadi-Jamayran, A; Tsirigos, A; Carucci, J

Journal of investigative dermatology. 2019 May; Conference:(Society):S24

Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma

Spino, Marissa; Kurz, Sylvia C; Chiriboga, Luis; Serrano, Jonathan; Zeck, Briana; Sen, Namita; Patel, Seema; Shen, Guomiao; Vasudevaraja, Varshini; Tsirigos, Aristotelis; Suryadevara, Carter M; Frenster, Joshua D; Tateishi, Kensuke; Wakimoto, Hiroaki; Jain, Rajan; Riina, Howard A; Nicolaides, Theodore; Sulman, Erik P; Cahill, Daniel P; Golfinos, John G; Isse, Kumiko; Saunders, Laura R; Zagzag, David; Placantonakis, Dimitris G; Snuderl, Matija; Chi, Andrew S

Clinical cancer research. 2019 Feb 15; 25(4):1261-1271

Draft Genome Sequence of Streptococcus halitosis sp. nov., Isolated from the Dorsal Surface of the Tongue of a Patient with Halitosis

Tetz, George; Vikina, Daria; Brown, Stuart; Zappile, Paul; Dolgalev, Igor; Tsirigos, Aristotelis; Heguy, Adriana; Tetz, Victor

Microbiology resource announcements. 2019 Jan; 8(4):

KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer

Xiong, Xiaozhong; Schober, Markus; Tassone, Evelyne; Khodadadi-Jamayran, Alireza; Sastre-Perona, Ana; Zhou, Hua; Tsirigos, Aristotelis; Shen, Steven; Chang, Miao; Melamed, Jonathan; Ossowski, Liliana; Wilson, Elaine L

Cell reports. 2018 Dec 11; 25(11):3006-3020.e7

Airway Microbiota Is Associated with Up-Regulation of the PI3K Pathway in Lung Cancer

Tsay, Jun-Chieh J; Wu, Benjamin G; Badri, Michelle H; Clemente, Jose C; Shen, Nan; Meyn, Peter; Li, Yonghua; Yie, Ting-An; Lhakhang, Tenzin; Olsen, Evan; Murthy, Vivek; Michaud, Gaetane; Sulaiman, Imran; Tsirigos, Aristotelis; Heguy, Adriana; Pass, Harvey; Weiden, Michael D; Rom, William N; Sterman, Daniel H; Bonneau, Richard; Blaser, Martin J; Segal, Leopoldo N

American journal of respiratory & critical care medicine. 2018 Nov 01; 198(9):1188-1198

Identification of a whole blood signature for venous thromboembolism [Meeting Abstract]

Hogan, M; Zhou, H; Lhakhang, T; Barrett, T J; O'Reilly, D; Smilowitz, N; Heguy, A; Maldonado, T; Tsirigos, A; Berger, J

Blood. 2018 November; Conference:(60th):

See All Publications (63)