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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Institute for Computational Medicine

Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Co-Director, Division of Precision Medicine

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Aronson, Boaz E; Scourzic, Laurianne; Shah, Veevek; Swanzey, Emily; Kloetgen, Andreas; Polyzos, Alexander; Sinha, Abhishek; Azziz, Annabel; Caspi, Inbal; Li, Jiexi; Pelham-Webb, Bobbie; Glenn, Rachel A; Vierbuchen, Thomas; Wichterle, Hynek; Tsirigos, Aristotelis; Dawlaty, Meelad M; Stadtfeld, Matthias; Apostolou, Effie

Developmental cell. 2021 Nov 22; 56(22):3052-3065.e5

Zampetidis, Christos P; Galanos, Panagiotis; Angelopoulou, Andriani; Zhu, Yajie; Polyzou, Aikaterini; Karamitros, Timokratis; Kotsinas, Athanassios; Lagopati, Nefeli; Mourkioti, Ioanna; Mirzazadeh, Reza; Polyzos, Alexandros; Garnerone, Silvano; Mizi, Athanasia; Gusmao, Eduardo G; Sofiadis, Konstantinos; Gál, Zita; Larsen, Dorthe H; Pefani, Dafni-Eleftheria; Demaria, Marco; Tsirigos, Aristotelis; Crosetto, Nicola; Maya-Mendoza, Apolinar; Papaspyropoulos, Angelos; Evangelou, Konstantinos; Bartek, Jiri; Papantonis, Argyris; Gorgoulis, Vassilis G

Molecular cell. 2021 Nov 12;

Kim, Randie H; Nomikou, Sofia; Coudray, Nicolas; Jour, George; Dawood, Zarmeena; Hong, Runyu; Esteva, Eduardo; Sakellaropoulos, Theodore; Donnelly, Douglas; Moran, Una; Hatzimemos, Aristides; Weber, Jeffrey S; Razavian, Narges; Aifantis, Iannis; Fenyo, David; Snuderl, Matija; Shapiro, Richard; Berman, Russell S; Osman, Iman; Tsirigos, Aristotelis

Journal of investigative dermatology. 2021 Oct 29;

Tang, Kwan Ho; Li, Shuai; Khodadadi-Jamayran, Alireza; Jen, Jayu; Han, Han; Guidry, Kayla; Chen, Ting; Hao, Yuan; Fedele, Carmine; Zebala, John A; Maeda, Dean Y; Christensen, James G; Olson, Peter; Athanas, Argus; Loomis, Cynthia A; Tsirigos, Aristotelis; Wong, Kwok-Kin; Neel, Benjamin G

Cancer discovery. 2021 Aug 05;

Grigoriou, Maria; Banos, Aggelos; Hatzioannou, Aikaterini; Kloetgen, Andreas; Kouzis, Panagiotis; Aggouraki, Despoina; Zakopoulou, Roubini; Bamias, Giorgos; Kassi, Eva; Mavroudis, Dimitris; Bamias, Aristotelis; Boumpas, Dimitrios T; Tsirigos, Aristotelis; Gogas, Helen J; Alissafi, Themis; Verginis, Panagiotis

Cancer immunology research. 2021 Jul; 9(7):726-734

Wang, Yanan; Coudray, Nicolas; Zhao, Yun; Li, Fuyi; Hu, Changyuan; Zhang, Yao-Zhong; Imoto, Seiya; Tsirigos, Aristotelis; Webb, Geoffrey I; Daly, Roger J; Song, Jiangning

Bioinformatics. 2021 May 19;

Hartl, Johannes; Serpas, Lee; Wang, Yueyang; Rashidfarrokhi, Ali; Perez, Oriana A; Sally, Benjamin; Sisirak, Vanja; Soni, Chetna; Khodadadi-Jamayran, Alireza; Tsirigos, Aristotelis; Caiello, Ivan; Bracaglia, Claudia; Volpi, Stefano; Ghiggeri, Gian Marco; Chida, Asiya Seema; Sanz, Ignacio; Kim, Mimi Y; Belmont, H Michael; Silverman, Gregg J; Clancy, Robert M; Izmirly, Peter M; Buyon, Jill P; Reizis, Boris

Journal of experimental medicine. 2021 05 03; 218(5):

Deng, Jiehui; Thennavan, Aatish; Dolgalev, Igor; Chen, Ting; Li, Jie; Marzio, Antonio; Poirier, John T; Peng, David; Bulatovic, Mirna; Mukhopadhyay, Subhadip; Silver, Heather; Papadopoulos, Eleni; Pyon, Val; Thakurdin, Cassandra; Han, Han; Li, Fei; Li, Shuai; Ding, Hailin; Hu, Hai; Pan, Yuanwang; Weerasekara, Vajira; Jiang, Baishan; Wang, Eric S; Ahearn, Ian; Philips, Mark; Papagiannakopoulos, Thales; Tsirigos, Aristotelis; Rothenberg, Eli; Gainor, Justin; Freeman, Gordon J; Rudin, Charles M; Gray, Nathanael S; Hammerman, Peter S; Pagano, Michele; Heymach, John V; Perou, Charles M; Bardeesy, Nabeel; Wong, Kwok-Kin

Nature cancer. 2021 May; 2(5):503-514