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Professor, Department of Medicine
Professor, Department of Pathology
Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).
Co- Director, Division of Precision Medicine
Director, Applied Bioinformatics Laboratories
Director, Clinical Informatics, Molecular Pathology Lab
PhD from New York University
The Journal of molecular diagnostics : JMD. 2025 May; 27(5):346-359
Cell genomics. 2025 Mar 18; 100813
Nature communications. 2025 Mar 08; 16(1):2328
Nature biomedical engineering. 2025 Mar; 9(3):405-419
Experimental hematology & oncology. 2025 Feb 26; 14(1):22
bioRxiv : the preprint server for biology. 2025 Feb 18;
NPJ digital medicine. 2025 Feb 15; 8(1):105
Nature reviews. Clinical oncology. 2025 Feb 10;
