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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Positions

Associate Professor, Department of Pathology

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

Graduate Education

PhD from New York University

Author Correction: The bone marrow microenvironment at single-cell resolution

Tikhonova, Anastasia N; Dolgalev, Igor; Hu, Hai; Sivaraj, Kishor K; Hoxha, Edlira; Cuesta-Domínguez, Álvaro; Pinho, Sandra; Akhmetzyanova, Ilseyar; Gao, Jie; Witkowski, Matthew; Guillamot, Maria; Gutkin, Michael C; Zhang, Yutong; Marier, Christian; Diefenbach, Catherine; Kousteni, Stavroula; Heguy, Adriana; Zhong, Hua; Fooksman, David R; Butler, Jason M; Economides, Aris; Frenette, Paul S; Adams, Ralf H; Satija, Rahul; Tsirigos, Aristotelis; Aifantis, Iannis

Nature. 2019 Aug; 572(7767):E6

Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining

Vougas, Konstantinos; Sakelaropoulos, Theodore; Kotsinas, Athanassios; Foukas, George-Romanos P; Ntargaras, Andreas; Koinis, Filippos; Polyzos, Alexander; Myrianthopoulos, Vassilis; Zhou, Hua; Narang, Sonali; Georgoulias, Vassilis; Alexopoulos, Leonidas; Aifantis, Iannis; Townsend, Paul A; Sfikakis, Petros; Fitzgerald, Rebecca; Thanos, Dimitris; Bartek, Jiri; Petty, Russell; Tsirigos, Aristotelis; Gorgoulis, Vassilis G

Pharmacology & therapeutics. 2019 Jul 30; 107395

Molecular and metabolic pathways mediating curative treatment of a non-Hodgkin B cell lymphoma by Sindbis viral vectors and anti-4-1BB monoclonal antibody

Yu, Minjun; Scherwitzl, Iris; Opp, Silvana; Tsirigos, Aristotelis; Meruelo, Daniel

Journal for immunotherapy of cancer. 2019 Jul 15; 7(1):185

Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1

Lignitto, Luca; LeBoeuf, Sarah E; Homer, Harrison; Jiang, Shaowen; Askenazi, Manor; Karakousi, Triantafyllia R; Pass, Harvey I; Bhutkar, Arjun J; Tsirigos, Aristotelis; Ueberheide, Beatrix; Sayin, Volkan I; Papagiannakopoulos, Thales; Pagano, Michele

Cell. 2019 Jul 11; 178(2):316-329.e18

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

Chen, Xufeng; Glytsou, Christina; Zhou, Hua; Narang, Sonali; Reyna, Denis E; Lopez, Andrea; Sakellaropoulos, Theodore; Gong, Yixiao; Kloetgen, Andreas; Yap, Yoon Sing; Wang, Eric; Gavathiotis, Evripidis; Tsirigos, Aristotelis; Tibes, Raoul; Aifantis, Iannis

Cancer discovery. 2019 Jul; 9(7):890-909

The bone marrow microenvironment at single-cell resolution

Tikhonova, Anastasia N; Dolgalev, Igor; Hu, Hai; Sivaraj, Kishor K; Hoxha, Edlira; Cuesta-Domínguez, Álvaro; Pinho, Sandra; Akhmetzyanova, Ilseyar; Gao, Jie; Witkowski, Matthew; Guillamot, Maria; Gutkin, Michael C; Zhang, Yutong; Marier, Christian; Diefenbach, Catherine; Kousteni, Stavroula; Heguy, Adriana; Zhong, Hua; Fooksman, David R; Butler, Jason M; Economides, Aris; Frenette, Paul S; Adams, Ralf H; Satija, Rahul; Tsirigos, Aristotelis; Aifantis, Iannis

Nature. 2019 May; 569(7755):222-228

Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma

Spino, Marissa; Kurz, Sylvia C; Chiriboga, Luis; Serrano, Jonathan; Zeck, Briana; Sen, Namita; Patel, Seema; Shen, Guomiao; Vasudevaraja, Varshini; Tsirigos, Aristotelis; Suryadevara, Carter M; Frenster, Joshua D; Tateishi, Kensuke; Wakimoto, Hiroaki; Jain, Rajan; Riina, Howard A; Nicolaides, Theodore; Sulman, Erik P; Cahill, Daniel P; Golfinos, John G; Isse, Kumiko; Saunders, Laura R; Zagzag, David; Placantonakis, Dimitris G; Snuderl, Matija; Chi, Andrew S

Clinical cancer research. 2019 Feb 15; 25(4):1261-1271

Draft Genome Sequence of Streptococcus halitosis sp. nov., Isolated from the Dorsal Surface of the Tongue of a Patient with Halitosis

Tetz, George; Vikina, Daria; Brown, Stuart; Zappile, Paul; Dolgalev, Igor; Tsirigos, Aristotelis; Heguy, Adriana; Tetz, Victor

Microbiology resource announcements. 2019 Jan; 8(4):

See All Publications (46)

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