Professor, Department of Medicine
Professor, Department of Pathology
Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).
Co- Director, Division of Precision Medicine
Director, Applied Bioinformatics Laboratories
Director, Clinical Informatics, Molecular Pathology Lab
PhD from New York University
JTO clinical & research reports. 2025 Aug; 6(8):100849
Cancer research communications. 2025 Jul 01; 5(7):1102-1118
Journal of leukocyte biology. 2025 Jun 04; 117(6):
Neurosurgery. 2025 Jun 01; 96(6):1227-1235
Journal of molecular diagnostics. 2025 May; 27(5):346-359
Journal of experimental medicine. 2025 Apr 07; 222(4):
Nature reviews. Clinical oncology. 2025 Apr; 22(4):239-240
Cell genomics. 2025 Mar 18; 100813