Institute for Computational Medicine
Professor, Department of Medicine
Professor, Department of Pathology
Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).
Co-Director, Division of Precision Medicine
Director, Applied Bioinformatics Laboratories
PhD from New York University
Science advances. 2022 Dec 09; 8(49):eabq8437
Cell reports. Medicine. 2022 Dec 06; 100868
Cancer discovery. 2022 Oct 05; 12(10):2392-2413
Clinical cancer research. 2022 Sep 01; 28(17):3824-3835
PLoS biology. 2022 Sep; 20(9):e3001754
Nature communications. 2022 Jul 29; 13(1):4410
Science. 2022 07 08; 377(6602):eabg9302