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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

Lab Website
Tsirigos Lab
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Positions

Associate Professor, Department of Pathology

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

Graduate Education

PhD from New York University

KLF4, A Gene Regulating Prostate Stem Cell Homeostasis, Is a Barrier to Malignant Progression and Predictor of Good Prognosis in Prostate Cancer

Xiong, Xiaozhong; Schober, Markus; Tassone, Evelyne; Khodadadi-Jamayran, Alireza; Sastre-Perona, Ana; Zhou, Hua; Tsirigos, Aristotelis; Shen, Steven; Chang, Miao; Melamed, Jonathan; Ossowski, Liliana; Wilson, Elaine L

Cell reports. 2018 Dec 11; 25(11):3006-33020.e7

Cell surface Notch ligand DLL3 is a therapeutic target in isocitrate dehydrogenase mutant glioma

Spino, Marissa; Kurz, Sylvia C; Chiriboga, Luis; Serrano, Jonathan; Zeck, Briana; Sen, Namita; Patel, Seema; Shen, Guomiao; Vasudevaraja, Varshini; Tsirigos, Aristotelis; Suryadevara, Carter M; Frenster, Joshua D; Tateishi, Kensuke; Wakimoto, Hiroaki; Jain, Rajan; Riina, Howard A; Nicolaides, Theodore; Sulman, Erik P; Cahill, Daniel P; Golfinos, John G; Isse, Kumiko; Saunders, Laura R; Zagzag, David; Placantonakis, Dimitris G; Snuderl, Matija; Chi, Andrew S

Clinical cancer research. 2018 Nov 05;

Airway Microbiota Is Associated with Up-Regulation of the PI3K Pathway in Lung Cancer

Tsay, Jun-Chieh J; Wu, Benjamin G; Badri, Michelle H; Clemente, Jose C; Shen, Nan; Meyn, Peter; Li, Yonghua; Yie, Ting-An; Lhakhang, Tenzin; Olsen, Evan; Murthy, Vivek; Michaud, Gaetane; Sulaiman, Imran; Tsirigos, Aristotelis; Heguy, Adriana; Pass, Harvey; Weiden, Michael D; Rom, William N; Sterman, Daniel H; Bonneau, Richard; Blaser, Martin J; Segal, Leopoldo N

American journal of respiratory & critical care medicine. 2018 Nov 01; 198(9):1188-1198

Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning

Coudray, Nicolas; Ocampo, Paolo Santiago; Sakellaropoulos, Theodore; Narula, Navneet; Snuderl, Matija; Fenyö, David; Moreira, Andre L; Razavian, Narges; Tsirigos, Aristotelis

Nature medicine. 2018 Oct 19; 24(10):1559-1567

BET bromodomain inhibition cooperates with PD-1 blockade to facilitate antitumor response in Kras-mutant non-small cell lung cancer

Adeegbe, Dennis O; Liu, Shengwu; Hattersley, Maureen; Bowden, Michaela; Zhou, Chensheng W; Li, Shuai; Vlahos, Raven; Grondine, Michael; Dolgalev, Igor; Ivanova, Elena; Quinn, Max M; Gao, Peng; Hammerman, Peter S; Bradner, James E; Diehl, J Alan; Rustgi, Anil K; Bass, Adam J; Tsirigos, Aristotelis; Freeman, Gordon J; Chen, Huawei; Wong, Kwok-Kin

Cancer immunology research. 2018 Oct 09; 6(10):1234-1245

Human blastocysts of normal and abnormal karyotypes display distinct transcriptome profiles

Licciardi, Frederick; Lhakhang, Tenzin; Kramer, Yael G; Zhang, Yutong; Heguy, Adriana; Tsirigos, Aristotelis

Scientific reports. 2018 Oct 08; 8(1):14906-14906

Classification and Mutation Prediction from Non-Small Cell Lung Cancer Histopathology Images Using Deep Learning [Meeting Abstract]

Ocampo, P.; Moreira, A.; Coudray, N.; Sakellaropoulos, T.; Narula, N.; Snuderl, M.; Fenyo, D.; Razavian, N.; Tsirigos, A.

Journal of thoracic oncology. 2018 OCT; 13:S562-S562

MOSAIC BLASTOCYSTS DIAGNOSED WITH NEXT GENERATION SEQUENCING (NGS) HAVE UNIQUE TRANSCRIPTOMIC PROFILES DIFFERENT FROM THOSE OF EUPLOID OR ANEUPLOID EMBRYOS. [Meeting Abstract]

Maxwell, S. M.; Lhakhang, T.; Kramer, Y. G.; Zhang, Y.; Heguy, A.; Tsirigos, A.; Grifo, J. A.; Licciardi, F.

Fertility & sterility. 2018 SEP; 110:E80-E81

See All Publications (57)