Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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Associate Professor, Department of Pathology

Director, Center for Applied Bioinformatics

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Lazaris, Charalampos; Kelly, Stephen; Ntziachristos, Panagiotis; Aifantis, Iannis; Tsirigos, Aristotelis

BMC genomics. 2017 Jan 05; 18(1):22-22

Strikoudis, Alexandros; Lazaris, Charalampos; Trimarchi, Thomas; Galvao Neto, Antonio L; Yang, Yan; Ntziachristos, Panagiotis; Rothbart, Scott; Buckley, Shannon; Dolgalev, Igor; Stadtfeld, Matthias; Strahl, Brian D; Dynlacht, Brian D; Tsirigos, Aristotelis; Aifantis, Iannis

Nature cell biology. 2016 Nov; 18(11):1127-1138

Epigenetics of decidual inflammation [Meeting Abstract]

Erlebacher, A; Siewiera, J; Dolgalev, I; Tagliani, E; Clementi, C; Columbus, D; Manandhar, P; Tsirigos, A; Nancy, P

American journal of reproductive immunology (1989). 2016 November; Conference:(36th):26-27

Licciardi, F; Kramer, Y; Zhang, Y; Tsirigos, A; Lhakhang, T; Heguy, A

Human reproduction. 2016 July; Conference:(32nd):i53

Ntziachristos, Panagiotis; Tsirigos, Aristotelis; Welstead, G Grant; Trimarchi, Thomas; Bakogianni, Sofia; Xu, Luyao; Loizou, Evangelia; Holmfeldt, Linda; Strikoudis, Alexandros; King, Bryan; Mullanders, Jasper; Becksfort, Jared; Nedjic, Jelena; Paietta, Elisabeth; Tallman, Martin S; Rowe, Jacob M; Tonon, Giovanni; Satoh, Takashi; Kruidenier, Laurens; Prinjha, Rab; Akira, Shizuo; Van Vlierberghe, Pieter; Ferrando, Adolfo A; Jaenisch, Rudolf; Mullighan, Charles G; Aifantis, Iannis

Nature. 2014 Oct 23; 514(7523):513-517

Vidal, Simon E; Amlani, Bhishma; Chen, Taotao; Tsirigos, Aristotelis; Stadtfeld, Matthias

Stem cell reports. 2014 Oct 14; 3(4):574-584

Di Micco, Raffaella; Fontanals-Cirera, Barbara; Low, Vivien; Ntziachristos, Panagiotis; Yuen, Stephanie K; Lovell, Claudia D; Dolgalev, Igor; Yonekubo, Yoshiya; Zhang, Guangtao; Rusinova, Elena; Gerona-Navarro, Guillermo; Canamero, Marta; Ohlmeyer, Michael; Aifantis, Iannis; Zhou, Ming-Ming; Tsirigos, Aristotelis; Hernando, Eva

Cell reports. 2014 Oct 09; 9(1):234-247

Trimarchi, Thomas; Bilal, Erhan; Ntziachristos, Panagiotis; Fabbri, Giulia; Dalla-Favera, Riccardo; Tsirigos, Aristotelis; Aifantis, Iannis

Cell. 2014 Jul 31; 158(3):593-606