Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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Associate Professor, Department of Pathology

Director, Center for Applied Bioinformatics

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Nancy, Patrice; Siewiera, Johan; Rizzuto, Gabrielle; Tagliani, Elisa; Osokine, Ivan; Manandhar, Priyanka; Dolgalev, Igor; Clementi, Caterina; Tsirigos, Aristotelis; Erlebacher, Adrian

Journal of clinical investigation. 2018 Jan 02; 128(1):233-247

Brown, Jessie A; Yonekubo, Yoshiya; Hanson, Nicole; Sastre-Perona, Ana; Basin, Alice; Rytlewski, Julie A; Dolgalev, Igor; Meehan, Shane; Tsirigos, Aristotelis; Beronja, Slobodan; Schober, Markus

Cell stem cell. 2017 Nov 02; 21(5):650-664.e8

PERIPHERAL BLOOD DNA METHYLATION PROFILES IDENTIFY IDH1/2 MUTATION STATUS IN ADULTS WITH DIFFUSE GLIOMA [Meeting Abstract]

Kloetgen, Andreas; Serrano, Jonathan; Patel, Seema; Bowman, Christopher; Shen, Guomiao; Zagzag, David; Karajannis, Matthias; Golfinos, John; Placantonakis, Dimitris; Tsirigos, Aristotelis; Chi, Andrew S; Snuderl, Matija

Neuro-oncology. 2017 NOV; 19:92-92

CHARACTERIZATION OF GPR133 EXPRESSION IN GLIOMA SUBTYPES [Meeting Abstract]

Kader, Michael; Frenster, Joshua; Liechty, Benjamin; Modrek, Aram; Tsirigos, Aristotelis; Golfinos, John; Eisele, Sylvia; Jain, Rajan; Shepherd, Timothy; Fatterpekar, Girish; MacNeil, Douglas; Shohdy, Nadim; Huang, Xinyan; Chi, Andrew S; Snuderl, Matija; Zagzag, David; Placantonakis, Dimitris

Neuro-oncology. 2017 NOV; 19:36-36

Modrek, Aram S; Golub, Danielle; Khan, Themasap; Bready, Devin; Prado, Jod; Bowman, Christopher; Deng, Jingjing; Zhang, Guoan; Rocha, Pedro P; Raviram, Ramya; Lazaris, Charalampos; Stafford, James M; LeRoy, Gary; Kader, Michael; Dhaliwal, Joravar; Bayin, N Sumru; Frenster, Joshua D; Serrano, Jonathan; Chiriboga, Luis; Baitalmal, Rabaa; Nanjangud, Gouri; Chi, Andrew S; Golfinos, John G; Wang, Jing; Karajannis, Matthias A; Bonneau, Richard A; Reinberg, Danny; Tsirigos, Aristotelis; Zagzag, David; Snuderl, Matija; Skok, Jane A; Neubert, Thomas A; Placantonakis, Dimitris G

Cell reports. 2017 Oct 31; 21(5):1267-1280

Tetz, George; Vecherkovskaya, Maria; Zappile, Paul; Dolgalev, Igor; Tsirigos, Aristotelis; Heguy, Adriana; Tetz, Victor

Genome announcements. 2017 Oct 26; 5(43):?-?

COMPREHENSIVE TRANSCRIPTOME CHARACTERIZATION OF HUMAN BLASTOCYSTS FOR NORMALS AND EVERY KNOWN KARYOTYPE [Meeting Abstract]

Licciardi, F; Kramer, YG; Lhakhang, T; Zhang, Y; Tsirigos, A; Heguy, A

Fertility & sterility. 2017 SEP; 108(3):E106-E106

Cimmino, Luisa; Dolgalev, Igor; Wang, Yubao; Yoshimi, Akihide; Martin, Gaelle H; Wang, Jingjing; Ng, Victor; Xia, Bo; Witkowski, Matthew T; Mitchell-Flack, Marisa; Grillo, Isabella; Bakogianni, Sofia; Ndiaye-Lobry, Delphine; Martin, Miguel Torres; Guillamot, Maria; Banh, Robert S; Xu, Mingjiang; Figueroa, Maria E; Dickins, Ross A; Abdel-Wahab, Omar; Park, Christopher Y; Tsirigos, Aristotelis; Neel, Benjamin G; Aifantis, Iannis

Cell. 2017 Aug 17; 170(6):1079-1095.e20