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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Positions

Associate Professor, Department of Pathology

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

Graduate Education

PhD from New York University

An intrinsic role of IL-33 in T<sub>reg</sub> cell-mediated tumor immunoevasion

Hatzioannou, Aikaterini; Banos, Aggelos; Sakelaropoulos, Theodore; Fedonidis, Constantinos; Vidali, Maria-Sophia; Köhne, Maren; Händler, Kristian; Boon, Louis; Henriques, Ana; Koliaraki, Vasiliki; Georgiadis, Panagiotis; Zoidakis, Jerome; Termentzi, Aikaterini; Beyer, Marc; Chavakis, Triantafyllos; Boumpas, Dimitrios; Tsirigos, Aristotelis; Verginis, Panayotis

Nature immunology. 2020 Jan; 21(1):75-85

LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancer

Giro-Perafita, A; Luo, L; Khodadadi-Jamayran, A; Thompson, M; Akgol Oksuz, B; Tsirigos, A; Dynlacht, BD; Sanchez, I; Esteva, FJ

NPJ breast cancer. 2020; 6(1):

GCN2 drives macrophage and MDSC function and immunosuppression in the tumor microenvironment

Halaby, Marie Jo; Hezaveh, Kebria; Lamorte, Sara; Ciudad, M Teresa; Kloetgen, Andreas; MacLeod, Bethany L; Guo, Mengdi; Chakravarthy, Ankur; Medina, Tiago Da Silva; Ugel, Stefano; Tsirigos, Aristotelis; Bronte, Vincenzo; Munn, David H; Pugh, Trevor J; De Carvalho, Daniel D; Butler, Marcus O; Ohashi, Pamela S; Brooks, David G; McGaha, Tracy L

Science immunology. 2019 Dec 13; 4(42):

Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amgydala

Ostroff, Linnaea E; Santini, Emanuela; Sears, Robert; Deane, Zachary; Kanadia, Rahul N; LeDoux, Joseph E; Lhakhang, Tenzin; Tsirigos, Aristotelis; Heguy, Adriana; Klann, Eric

eLife. 2019 Dec 11; 8:

A Deep Learning Framework for Predicting Response to Therapy in Cancer

Sakellaropoulos, Theodore; Vougas, Konstantinos; Narang, Sonali; Koinis, Filippos; Kotsinas, Athanassios; Polyzos, Alexander; Moss, Tyler J; Piha-Paul, Sarina; Zhou, Hua; Kardala, Eleni; Damianidou, Eleni; Alexopoulos, Leonidas G; Aifantis, Iannis; Townsend, Paul A; Panayiotidis, Mihalis I; Sfikakis, Petros; Bartek, Jiri; Fitzgerald, Rebecca C; Thanos, Dimitris; Mills Shaw, Kenna R; Petty, Russell; Tsirigos, Aristotelis; Gorgoulis, Vassilis G

Cell reports. 2019 Dec 10; 29(11):3367-3373.e4

In vivo epigenetic CRISPR screen identifies Asf1a as an immunotherapeutic target in Kras-mutant lung adenocarcinoma

Li, Fei; Huang, Qingyuan; Luster, Troy A; Hu, Hai; Zhang, Hua; Ng, Wai-Lung; Khodadadi-Jamayran, Alireza; Wang, Wei; Chen, Ting; Deng, Jiehui; Ranieri, Michela; Fang, Zhaoyuan; Pyon, Val; Dowling, Catriona M; Bagdatlioglu, Ece; Almonte, Christina; Labbe, Kristen; Silver, Heather; Rabin, Alexandra R; Jani, Kandarp; Tsirigos, Aristotelis; Papagiannakopoulos, Thales; Hammerman, Peter S; Velcheti, Vamsidhar; Freeman, Gordon J; Qi, Jun; Miller, George; Wong, Kwok-Kin

Cancer discovery. 2019 Nov 19;

Functional and topographic effects on DNA methylation in IDH1/2 mutant cancers

Bledea, Ramona; Vasudevaraja, Varshini; Patel, Seema; Stafford, James; Serrano, Jonathan; Esposito, Gianna; Tredwin, Lilian M; Goodman, Nina; Kloetgen, Andreas; Golfinos, John G; Zagzag, David; Weigelt, Britta; Iafrate, A John; Sulman, Erik P; Chi, Andrew S; Dogan, Snjezana; Reis-Filho, Jorge S; Chiang, Sarah; Placantonakis, Dimitris; Tsirigos, Aristotelis; Snuderl, Matija

Scientific reports. 2019 Nov 14; 9(1):16830

Histone 1 Mutations Drive Lymphomagenesis By Inducing Primitive Stem Cell Functions and Epigenetic Instructions through Profound 3D Re-Organization of the B-Cell Genome

Yusufova, Nevin; Teater, Matthew R; Soshnev, Alexey; Kloetgen, Andreas; Osunsade, Adewola; Conway, Joseph; Doane, Ashley; Skoultchi, Arthur; Tsirigos, Aristotelis; David, Yael; Allis, C David; Cesarman, Ethel; Melnick, Ari

Blood. 2019 Nov 13; 134(Supplement_1):23

See All Publications (60)

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