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Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
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Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

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Lab Website
Tsirigos Lab
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Positions

Associate Professor, Department of Pathology

Director, Center for Applied Bioinformatics

Director, Clinical Informatics, Molecular Pathology Lab

Graduate Education

PhD from New York University

Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression

Cimmino, Luisa; Dolgalev, Igor; Wang, Yubao; Yoshimi, Akihide; Martin, Gaelle H; Wang, Jingjing; Ng, Victor; Xia, Bo; Witkowski, Matthew T; Mitchell-Flack, Marisa; Grillo, Isabella; Bakogianni, Sofia; Ndiaye-Lobry, Delphine; Martin, Miguel Torres; Guillamot, Maria; Banh, Robert S; Xu, Mingjiang; Figueroa, Maria E; Dickins, Ross A; Abdel-Wahab, Omar; Park, Christopher Y; Tsirigos, Aristotelis; Neel, Benjamin G; Aifantis, Iannis

Cell. 2017 Aug 17; 170(6):1079-1095.e20

Bacteriophages as potential new mammalian pathogens

Tetz, George V; Ruggles, Kelly V; Zhou, Hua; Heguy, Adriana; Tsirigos, Aristotelis; Tetz, Victor

Scientific reports. 2017 Aug 01; 7(1):7043-7043

Predictive biomarkers of ipilimumab toxicity in metastatic melanoma [Meeting Abstract]

Gowen, M; Tchack, J; Zhou, H; Giles, K M; Paschke, S; Moran, U; Fenyo, D; Tsirigos, A; Pacold, M; Pavlick, A C; Krogsgaard, M; Osman, I

Journal of clinical oncology. 2017 Jun 20; Conference:(2017):

lncRNA-screen: an interactive platform for computationally screening long non-coding RNAs in large genomics datasets

Gong, Yixiao; Huang, Hsuan-Ting; Liang, Yu; Trimarchi, Thomas; Aifantis, Iannis; Tsirigos, Aristotelis

BMC genomics. 2017 Jun 05; 18(1):434-434

LOW-GRADE ASTROCYTOMA CORE MUTATIONS IN IDH1, P53 AND ATRX COOPERATE TO BLOCK DIFFERENTIATION OF HUMAN NEURAL STEM CELLS VIA EPIGENETIC REPRESSION OF SOX2 [Meeting Abstract]

Modrek, Aram; Golub, Danielle; Khan, Themasap; Prado, Jod; Bowman, Christopher; Deng, Jingjing; Zhang, Guoan; Rocha, Pedro; Raviram, Ramya; Lazaris, Harris; Kader, Michael; Dhaliwal, Joravar; Chi, Andrew; Golfinos, John; Tsirigos, Aristotelis; Zagzag, David; Snuderl, Matija; Skok, Jane; Neubert, Thomas; Placantonakis, Dimitris

Neuro-oncology. 2017 JUN; 19:35-35

N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration

Rigoutsos, Isidore; Lee, Sang Kil; Nam, Su Youn; Anfossi, Simone; Pasculli, Barbara; Pichler, Martin; Jing, Yi; Rodriguez-Aguayo, Cristian; Telonis, Aristeidis G; Rossi, Simona; Ivan, Cristina; Catela Ivkovic, Tina; Fabris, Linda; Clark, Peter M; Ling, Hui; Shimizu, Masayoshi; Redis, Roxana S; Shah, Maitri Y; Zhang, Xinna; Okugawa, Yoshinaga; Jung, Eun Jung; Tsirigos, Aristotelis; Huang, Li; Ferdin, Jana; Gafa, Roberta; Spizzo, Riccardo; Nicoloso, Milena S; Paranjape, Anurag N; Shariati, Maryam; Tiron, Aida; Yeh, Jen Jen; Teruel-Montoya, Raul; Xiao, Lianchun; Melo, Sonia A; Menter, David; Jiang, Zhi-Qin; Flores, Elsa R; Negrini, Massimo; Goel, Ajay; Bar-Eli, Menashe; Mani, Sendurai A; Liu, Chang Gong; Lopez-Berestein, Gabriel; Berindan-Neagoe, Ioana; Esteller, Manel; Kopetz, Scott; Lanza, Giovanni; Calin, George A

Genome biology. 2017 May 24; 18(1):98-98

Notch signaling regulates metabolic heterogeneity in glioblastoma stem cells

Bayin, N Sumru; Frenster, Joshua D; Sen, Rajeev; Si, Sheng; Modrek, Aram S; Galifianakis, Nataliya; Dolgalev, Igor; Ortenzi, Valerio; Illa-Bochaca, Irineu; Khahera, Anadjeet; Serrano, Jonathan; Chiriboga, Luis; Zagzag, David; Golfinos, John G; Doyle, Werner; Tsirigos, Aristotelis; Heguy, Adriana; Chesler, Mitch; Barcellos-Hoff, Mary Helen; Snuderl, Matija; Placantonakis, Dimitris G

Oncotarget. 2017 May 23; ?-?

Defining cellular quiescence as a multi-drug resistance mechanism in squamous cell carcinoma [Meeting Abstract]

Brown, J; Yonekubo, Y; Tsirigos, A

Journal of investigative dermatology. 2017 MAY; 137(5):S22-S22

See All Publications (29)