Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Professor, Department of Medicine

Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

Lab Website
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Co- Director, Division of Precision Medicine

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Tsay, Jun-Chieh J; Velez, Antonio; Collazo, Destiny; Laniado, Isaac; Bessich, Jamie; Murthy, Vivek; DeMaio, Andrew; Rafeq, Samaan; Kwok, Benjamin; Darawshy, Fares; Pillai, Ray; Wong, Kendrew; Li, Yonghua; Schluger, Rosemary; Lukovnikova, Alena; Roldan, Sofia; Blaisdell, Matt; Paz, Fernanda; Krolikowski, Kelsey; Gershner, Katherine; Liu, Yong; Gong, Judy; Borghi, Sara; Zhou, Fang; Tsirigos, Aristotelis; Pass, Harvey; Segal, Leopoldo N; Sterman, Daniel H

JTO clinical & research reports. 2025 Aug; 6(8):100849

Petroulia, Stavroula; Hockemeyer, Kathryn; Tiwari, Shashank; Berico, Pietro; Shamloo, Sama; Banijamali, Seyedeh Elnaz; Vega-Saenz de Miera, Eleazar; Gong, Yixiao; Thandapani, Palaniraja; Wang, Eric; Schloßhauer, Jeffrey L; Tsirigos, Aristotelis; Osman, Iman; Aifantis, Ioannis; Imig, Jochen

Cancer research communications. 2025 Jul 01; 5(7):1102-1118

Tetz, Victor; Kardava, Kristina; Vecherkovskaya, Maria; Khodadadi-Jamayran, Alireza; Tsirigos, Aristotelis; Tetz, George

Journal of leukocyte biology. 2025 Jun 04; 117(6):

Alyakin, Anton; Kurland, David; Alber, Daniel Alexander; Sangwon, Karl L; Li, Danxun; Tsirigos, Aristotelis; Leuthardt, Eric; Kondziolka, Douglas; Oermann, Eric Karl

Neurosurgery. 2025 Jun 01; 96(6):1227-1235

Galbraith, Kristyn; Wu, Jamin; Sikkink, Kristin; Mohamed, Hussein; Reid, Derek; Perez-Arreola, Michelle; Belton, Jon-Matthew; Nomikou, Sofia; Melnyk, Shadi; Yang, Yiying; Liechty, Benjamin L; Jour, George; Tsirigos, Aristotelis; Hermel, David J; Beck, Alyssa; Sigal, Darren; Dahl, Nathan A; Vibhakar, Rajeev; Schmitt, Anthony; Snuderl, Matija

Journal of molecular diagnostics. 2025 May; 27(5):346-359

Wang, Qing; Boccalatte, Francesco; Xu, Jason; Gambi, Giovanni; Nadorp, Bettina; Akter, Fatema; Mullin, Carea; Melnick, Ashley F; Choe, Elizabeth; McCarter, Anna C; Jerome, Nicole A; Chen, Siyi; Lin, Karena; Khan, Sarah; Kodgule, Rohan; Sussman, Jonathan H; Pölönen, Petri; Rodriguez-Hernaez, Javier; Narang, Sonali; Avrampou, Kleopatra; King, Bryan; Tsirigos, Aristotelis; Ryan, Russell J H; Mullighan, Charles G; Teachey, David T; Tan, Kai; Aifantis, Iannis; Chiang, Mark Y

Journal of experimental medicine. 2025 Apr 07; 222(4):

Le, Hortense; Tsirigos, Aristotelis

Nature reviews. Clinical oncology. 2025 Apr; 22(4):239-240

Do, Catherine; Jiang, Guimei; Cova, Giulia; Katsifis, Christos C; Narducci, Domenic N; Sakellaropoulos, Theodore; Vidal, Raphael; Lhoumaud, Priscillia; Tsirigos, Aristotelis; Regis, Faye Fara D; Kakabadze, Nata; Nora, Elphege P; Noyes, Marcus; Hansen, Anders S; Skok, Jane A

Cell genomics. 2025 Mar 18; 100813