Aristotelis Tsirigos

Aristotelis Tsirigos, PhD

Associate Professor, Department of Pathology

Keywords
computational biology, genomics, Hi-C data analysis, pediatric acute lymphoblastic leukemia, cancer, bioinformatics, molecular pathology
Summary

Our lab has extensive experience in Cancer Genomics and Epigenomics involving designing computational methods and pipelines, analyzing data and interpreting the results in different biological contexts (e.g. leukemia, stem cells). We have developed GenomicTools, a free open-source computational platform for designing high-throughput analytics in genomics (Tsirigos et al. Bioinformatics 2011), and HiC-bench, a computational platform for comprehensive and reproducible Hi-C data analysis designed for parameter exploration and benchmarking. Our work was pivotal in the molecular understanding of epigenetic changes in pediatric acute lymphoblastic leukemia (Ntziachristos*, Tsirigos* et al. Nature Medicine 2012; Ntziachristos*, Tsirigos* et al. Nature 2014) as well as the discovery of novel long non-coding RNAs as biomarkers and potential therapeutic targets (Trimarchi et al. Cell 2014).

These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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Associate Professor, Department of Pathology

Director, Applied Bioinformatics Laboratories

Director, Clinical Informatics, Molecular Pathology Lab

PhD from New York University

Kourtis, Nikos; Lazaris, Charalampos; Hockemeyer, Kathryn; Balandrán, Juan Carlos; Jimenez, Alejandra R; Mullenders, Jasper; Gong, Yixiao; Trimarchi, Thomas; Bhatt, Kamala; Hu, Hai; Shrestha, Liza; Ambesi-Impiombato, Alberto; Kelliher, Michelle; Paietta, Elisabeth; Chiosis, Gabriela; Guzman, Monica L; Ferrando, Adolfo A; Tsirigos, Aristotelis; Aifantis, Iannis

Nature medicine. 2018 Aug 25; 24(8):1157-1166

Adeegbe, Dennis O; Liu, Shengwu; Hattersley, Maureen; Bowden, Michaela; Zhou, Chensheng W; Li, Shuai; Vlahos, Raven; Grondine, Michael; Dolgalev, Igor; Ivanova, Elena; Quinn, Max M; Gao, Peng; Hammerman, Peter S; Bradner, James E; Diehl, J Alan; Rustgi, Anil K; Bass, Adam J; Tsirigos, Aristotelis; Freeman, Gordon J; Chen, Huawei; Wong, Kwok-Kin

Cancer immunology research. 2018 Aug 07;

Smith-Raska, Matthew R; Arenzana, Teresita L; D'Cruz, Louise M; Khodadadi-Jamayran, Alireza; Tsirigos, Aristotelis; Goldrath, Ananda W; Reizis, Boris

Frontiers in immunology. 2018 Jul 04; 9:1482-1482

Shekhar, Akshay; Lin, Xianming; Lin, Bin; Liu, Fang-Yu; Zhang, Jie; Khodadadi-Jamayran, Alireza; Tsirigos, Aristotelis; Bu, Lei; Fishman, Glenn I; Park, David S

Scientific reports. 2018 Jul 02; 8(1):9944-9944

Kirkling, Margaret E; Cytlak, Urszula; Lau, Colleen M; Lewis, Kanako L; Resteu, Anastasia; Khodadadi-Jamayran, Alireza; Siebel, Christian W; Salmon, Hélène; Merad, Miriam; Tsirigos, Aristotelis; Collin, Matthew; Bigley, Venetia; Reizis, Boris

Cell reports. 2018 Jun 19; 23(12):3658-33672.e6

Shinde, Rahul; Hezaveh, Kebria; Halaby, Marie Jo; Kloetgen, Andreas; Chakravarthy, Ankur; da Silva Medina, Tiago; Deol, Reema; Manion, Kieran P; Baglaenko, Yuriy; Eldh, Maria; Lamorte, Sara; Wallace, Drew; Chodisetti, Sathi Babu; Ravishankar, Buvana; Liu, Haiyun; Chaudhary, Kapil; Munn, David H; Tsirigos, Aristotelis; Madaio, Michael; Gabrielsson, Susanne; Touma, Zahi; Wither, Joan; De Carvalho, Daniel D; McGaha, Tracy L

Nature immunology. 2018 Jun 16; 19(6):571-582

Tsay, Jun-Chieh J; Wu, Benjamin G; Badri, Michelle H; Clemente, Jose C; Shen, Nan; Meyn, Peter; Li, Yonghua; Yie, Ting-An; Lhakhang, Tenzin; Olsen, Evan; Murthy, Vivek; Michaud, Gaetane; Sulaiman, Imran; Tsirigos, Aristotelis; Heguy, Adriana; Pass, Harvey; Weiden, Michael D; Rom, William N; Sterman, Daniel H; Bonneau, Richard; Blaser, Martin J; Segal, Leopoldo N

American journal of respiratory & critical care medicine. 2018 Jun 04;

DNA methylation of circulating tumor educated leukocytes as a biomarker of IDH1/2 mutation in diffuse gliomas [Meeting Abstract]

Kloetgen, Andreas; Serrano, Jonathan; Patel, Seema; Bowman, Christopher; Shen, Guomiao; Zagzag, David; Karajannis, Matthias; Golfinos, John; Placantonakis, Dimitris; Tsirigos, Aristotelis; Chi, Andrew; Snuderl, Matija

Journal of neuropathology & experimental neurology. 2018 JUN; 77:482-482