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Benjamin G. Neel

Benjamin G. Neel, MD, PhD

Laura and Isaac Perlmutter Director of the Laura and Isaac Perlmutter Cancer Center

Professor, Department of Medicine

As the director of Perlmutter Cancer Center, I lead a rigorous academic community of clinician–scientists and basic scientists, as well as a team of compassionate physicians who are dedicated to our patients. Through our clinical trials, we give patients unprecedented access to novel therapies and experimental treatments. I also oversee the advancement of our translational programs in immunotherapy, cancer genetics, targeted therapies, and epigenetics, as well as imaging, community outreach, and supportive oncology.

One of my goals as director is to foster collaboration between physicians and researchers. I create new opportunities for them to meaningfully engage with one another and form multidisciplinary partnerships. We have the best chance at dramatically impacting patient survival when we work together to understand the essence of cancer and its vulnerabilities, as well as the progress that has been made in cancer biology.

We’re at a historic time in the field — we finally understand a range of factors that cause cancer, from one’s environment to molecular defects in cancer cells. When I was a graduate student, we didn’t know a single gene mutation that causes cancer, nor did we understand cancer’s molecular basis. Now we know that different cancers are caused by different agents, and we have identified between 500 and 1,000 gene mutations that, in various combinations, can lead to cancer. With this knowledge, we have created a bevy of treatments that we can use against the disease, such as epigenetic therapy and immunotherapy.

My own research focuses on cell signaling in cancer and developmental disease, as well as the biology of breast and ovarian cancer. In addition to authoring more than 200 original papers, 25 reviews, and 2 books, I have received multiple grants from the National Institutes of Health and National Cancer Institute, as well as private foundations. I was the inaugural recipient of the Gertrude Elion Award of the American Association for Cancer Research, have held multiple named lectureships, and serve on editorial board of several journals, including Cancer Cell, Molecular Cell, and Cancer Discovery, among others. I am an elected member of the Association of American Physicians, a former member of the board of directors of the American Association for Cancer Research, and co-founder of Northern Biologics, a biotechnology company developing new therapies for cancer and fibrosis.





Academic office

522 First Avenue, Smilow Building

Twelfth Floor, Suite 1201

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Laura and Isaac Perlmutter Director of the Laura and Isaac Perlmutter Cancer Center

MD from Cornell University

PhD from Rockefeller University

Hattori, Takamitsu; Maso, Lorenzo; Araki, Kiyomi Y; Koide, Akiko; Hayman, James; Akkapeddi, Padma; Bang, Injin; Neel, Benjamin G; Koide, Shohei

Cancer discovery. 2023 Jan 09; 13(1):132-145

Punekar, Salman R; Velcheti, Vamsidhar; Neel, Benjamin G; Wong, Kwok-Kin

Nature reviews. Clinical oncology. 2022 Oct; 19(10):637-655

Bhardwaj, Abhishek; Banh, Robert S; Zhang, Wei; Sidhu, Sachdev S; Neel, Benjamin G

Life science alliance. 2022 May; 5(5):

Chang, Chewei Anderson; Jen, Jayu; Jiang, Shaowen; Sayad, Azin; Mer, Arvind Singh; Brown, Kevin R; Nixon, Allison M L; Dhabaria, Avantika; Tang, Kwan Ho; Venet, David; Sotiriou, Christos; Deng, Jiehui; Wong, Kwok-Kin; Adams, Sylvia; Meyn, Peter; Heguy, Adriana; Skok, Jane A; Tsirigos, Aristotelis; Ueberheide, Beatrix; Moffat, Jason; Singh, Abhyudai; Haibe-Kains, Benjamin; Khodadadi-Jamayran, Alireza; Neel, Benjamin G

Cancer discovery. 2022 Apr 01; 12(4):1022-1045

Tang, Kwan Ho; Li, Shuai; Khodadadi-Jamayran, Alireza; Jen, Jayu; Han, Han; Guidry, Kayla; Chen, Ting; Hao, Yuan; Fedele, Carmine; Zebala, John A; Maeda, Dean Y; Christensen, James G; Olson, Peter; Athanas, Argus; Loomis, Cynthia A; Tsirigos, Aristotelis; Wong, Kwok-Kin; Neel, Benjamin G

Cancer discovery. 2022 Jan; 12(1):47-61

Chirgadze, Yuri N; Battaile, Kevin P; Likhachev, Ilya V; Balabaev, Nikolay K; Gordon, Roni D; Romanov, Vladimir; Lin, Andres; Karisch, Robert; Lam, Robert; Ruzanov, Max; Brazhnikov, Evgeniy V; Pai, Emil F; Neel, Benjamin G; Chirgadze, Nickolay Y

Journal of biomolecular structure & dynamics. 2021 Oct 27; 1-10

Brkic, Sime; Stivala, Simona; Santopolo, Alice; Szybinski, Jakub; Jungius, Sarah; Passweg, Jakob R; Tsakiris, Dimitrios; Dirnhofer, Stefan; Hutter, Gregor; Leonards, Katharina; Lischer, Heidi E L; Dettmer, Matthias S; Neel, Benjamin G; Levine, Ross L; Meyer, Sara C

Leukemia. 2021 Oct; 35(10):2875-2884

Gu, Shengqing; Lheureux, Stephanie; Sayad, Azin; Cybulska, Paulina; Hogen, Liat; Vyarvelska, Iryna; Tu, Dongsheng; Parulekar, Wendy R; Nankivell, Matthew; Kehoe, Sean; Chi, Dennis S; Levine, Douglas A; Bernardini, Marcus Q; Rosen, Barry; Oza, Amit; Brown, Myles; Neel, Benjamin G

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2021 Jun 22; 118(25):