Skip to Main Content
Benjamin tenOever

Benjamin tenOever, PhD

Professor, Department of Microbiology

Professor, Department of Medicine

virology, SARS-CoV-2, COVID-19, influenza A virus, synthetic biology, innate immune signaling, spatial transcriptomics, single cell sequencing, virus-host interactions, tool building

We pursue biology through virology by uncovering fundamental aspects of the interplay between viruses and their hosts and use this knowledge to expand our molecular toolbox and enable new innovations.

The biology underlying the interplay between viruses and their hosts represent the products of evolutionary adaptations that are rooted in the origins of life itself. Both virus replication strategies and host defense mechanisms have materialized as a result of countless gene duplications and modifications to preexisting molecular tools that provide a selective advantage. Each successful new replication strategy or host defense then drives further adaptation in an endless evolutionary process.

The study of how life responds to virus infection has significantly advanced our fundamental understanding of molecular biology.  From basic transcriptional control to gene splicing, viruses have provided us an insight into the basic mechanics of all life. Moreover, the study of viral defense systems has provided us with restriction enzymes to cut and design DNA, RNA interference (RNAi) to silence mRNA, cytokines with immune-modulating properties, and most recently, CRISPR biology, which has enabled DNA editing with unprecedented specificity. Despite all of the knowledge and technology that has accrued from the study of virus-host interactions, there is undoubtedly much more to be discovered, a prospect that drives our work in the tenOever Lab.


Academic office

430 East 29th Street, Alexandria - West Tower

5th Floor, 540

New York, NY 10016

Lab Website
Is this your profile?
These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

PhD from McGill University

Harvard University, Molecular and Cellular Biology

Blanco-Melo, Daniel; Nilsson-Payant, Benjamin E; Liu, Wen-Chun; Uhl, Skyler; Hoagland, Daisy; Møller, Rasmus; Jordan, Tristan X; Oishi, Kohei; Panis, Maryline; Sachs, David; Wang, Taia T; Schwartz, Robert E; Lim, Jean K; Albrecht, Randy A; tenOever, Benjamin R

Cell. 2020 05 28; 181(5):1036-1045.e9

Hoagland, Daisy A; Møller, Rasmus; Uhl, Skyler A; Oishi, Kohei; Frere, Justin; Golynker, Ilona; Horiuchi, Shu; Panis, Maryline; Blanco-Melo, Daniel; Sachs, David; Arkun, Knarik; Lim, Jean K; tenOever, Benjamin R

Immunity. 2021 03 09; 54(3):557-570.e5

Aguado, Lauren C; Schmid, Sonja; May, Jared; Sabin, Leah R; Panis, Maryline; Blanco-Melo, Daniel; Shim, Jaehee V; Sachs, David; Cherry, Sara; Simon, Anne E; Levraud, Jean-Pierre; tenOever, Benjamin R

Nature. 2017 07 06; 547(7661):114-117

Yaron, Tomer M; Heaton, Brook E; Levy, Tyler M; Johnson, Jared L; Jordan, Tristan X; Cohen, Benjamin M; Kerelsky, Alexander; Lin, Ting-Yu; Liberatore, Katarina M; Bulaon, Danielle K; Van Nest, Samantha J; Koundouros, Nikos; Kastenhuber, Edward R; Mercadante, Marisa N; Shobana-Ganesh, Kripa; He, Long; Schwartz, Robert E; Chen, Shuibing; Weinstein, Harel; Elemento, Olivier; Piskounova, Elena; Nilsson-Payant, Benjamin E; Lee, Gina; Trimarco, Joseph D; Burke, Kaitlyn N; Hamele, Cait E; Chaparian, Ryan R; Harding, Alfred T; Tata, Aleksandra; Zhu, Xinyu; Tata, Purushothama Rao; Smith, Clare M; Possemato, Anthony P; Tkachev, Sasha L; Hornbeck, Peter V; Beausoleil, Sean A; Anand, Shankara K; Aguet, François; Getz, Gad; Davidson, Andrew D; Heesom, Kate; Kavanagh-Williamson, Maia; Matthews, David A; tenOever, Benjamin R; Cantley, Lewis C; Blenis, John; Heaton, Nicholas S

Science signaling. 2022 Oct 25; 15(757):eabm0808

Voloudakis, Georgios; Vicari, James M; Venkatesh, Sanan; Hoffman, Gabriel E; Dobrindt, Kristina; Zhang, Wen; Beckmann, Noam D; Higgins, Christina A; Argyriou, Stathis; Jiang, Shan; Hoagland, Daisy; Gao, Lina; Corvelo, André; Cho, Kelly; Lee, Kyung Min; Bian, Jiantao; Lee, Jennifer S; Iyengar, Sudha K; Luoh, Shiuh-Wen; Akbarian, Schahram; Striker, Robert; Assimes, Themistocles L; Schadt, Eric E; Lynch, Julie A; Merad, Miriam; tenOever, Benjamin R; Charney, Alexander W; Brennand, Kristen J; Fullard, John F; Roussos, Panos

NPJ genomic medicine. 2022 Sep 05; 7(1):52

Frere, Justin J; tenOever, Benjamin R

Nature reviews. Immunology. 2022 Jul; 22(7):399-400

Oishi, Kohei; Horiuchi, Shu; Frere, Justin; Schwartz, Robert E; tenOever, Benjamin R

Cell reports. 2022 Jun 28; 39(13):111002

Frere, Justin J; Serafini, Randal A; Pryce, Kerri D; Zazhytska, Marianna; Oishi, Kohei; Golynker, Ilona; Panis, Maryline; Zimering, Jeffrey; Horiuchi, Shu; Hoagland, Daisy A; Møller, Rasmus; Ruiz, Anne; Kodra, Albana; Overdevest, Jonathan B; Canoll, Peter D; Borczuk, Alain C; Chandar, Vasuretha; Bram, Yaron; Schwartz, Robert; Lomvardas, Stavros; Zachariou, Venetia; tenOever, Benjamin R

Science translational medicine. 2022 Jun 07; eabq3059