Betty Bigio, PhD

My work utilizes integrative computational and bioinformatic approaches applied to preclinical models and clinical phenotypes of main mental diseases, including major depression and Alzheimer’s Disease. I used a broad range of multi-omics data types including epigenome, transcriptome and DNA variants to understand mechanisms underlying environmental and genetic risks of complex diseases and novel molecular targets and pathways involved in the complex responses to treatments.

I acquired a publication record of numerous high profile publications in journals such as Science, Nature, Neuron, and Nature Molecular Psychiatry in this research area. These approaches allow us to identify modifiable molecular targets and pathways in specific phenotypes informing diagnosis and individualized treatment strategies. In the long term, we hope that these approaches will afford the development of novel therapeutic strategies and treatment selection decisions for precision medicine.