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Catherine G. Klein

Catherine G. Klein, PhD

Associate Professor, Department of Medicine

mechanisms of gene silencing, epigenetics, gene methylation, environmental toxicants, metals

With molecular biologic and molecular cytogenetic techniques, we study the mutagenic and epigenetic mechanisms that silence genes, including transgene expression in a unique set of mammalian cell lines. The G12 and G10 cell lines each contain a bacterial xanthine-guanine phosphoribosyl transferase (gpt) gene target that has been stably inserted into different chromosomal genome locations. These cell lines exhibit differing propensities for mutagenesis, deletions and epigenetic gene silencing by various oxidative carcinogens and clastogens, including x-rays, anticancer therapeutics, metals and traditionally nonmutagenic carcinogens such as diethylstilbestrol (DES). The assay offers the ability to analyze the epigenetic potential of other putative xenoestrogens or environmental toxicants, such as organic pesticides, environmental mixtures and nanoparticles. Using this assay system, the epigenetic silencing of the gpt transgene by DNA condensation, excess methylation and histone modifications were identified as important mechanisms for trangene silencing in carcinogenic nickel-induced G12 mutants. Epigenome arrays add complementary information about other genes and pathways that can be altered by a variety of environmental exposures.



Academic office

341 East 25Th St

Second Floor, 302A

New York, NY 10010

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Dir Environmental Health Science Graduate Pgm

PhD from New York University

Klein, Catherine B.; Costa, Max

Handbook on the Toxicology of Metals. [S.l.] : Elsevier Inc., 2021. 5th ed.. p.615-637. (5189482)

Avenbuan, Oyemwenosa N; Klein, Catherine B; Zelikoff, Judith T

Toxicological sciences. 2020 12 01; 178(2):213-214

Wang, Fei; Chen, Danqi; Wu, Peipei; Klein, Catherine; Jin, Chunyuan

Chemical research in toxicology. 2019 May 20; 32(5):820-830

Zelikoff, Judith T; Parmalee, Nancy; Corbett, Kevin; Gordon, Terry; Klein, Catherine B; Aschner, Michael

Toxicological sciences. 2018 03 01; 162(1):276-286

Lauterstein, Dana E; Tijerina, Pamella B; Corbett, Kevin; Akgol Oksuz, Betul; Shen, Steven S; Gordon, Terry; Klein, Catherine B; Zelikoff, Judith T

International journal of environmental research & public health. 2016 Apr 12; 13(4):417

Mauro, Maurizio; Caradonna, Fabio; Klein, Catherine B

Environmental & molecular mutagenesis. 2016 Mar; 57(2):137-50

Klein, Catherine; Costa, Max

Handbook on the toxicology of metals. Amsterdam : Academic Press, 2014. 4th ed.. p.1091-1111. (2061012)