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Dafna Bar-Sagi, PhD

Senior Vice President and Vice Dean for Science, Chief Scientific Officer

Saul J. Farber Professor of Biochemistry and Molecular Pharmacology, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Medicine

Dafna Bar-Sagi
oncogene function in pancreatic cancer, signal transduction, ras function, inflammation, ras signaling

The transformation of normal cells to cancer cells is tightly linked to alterations in signaling cascades that control cell proliferation, differentiation and motility. The research in our laboratory focuses a signaling axis that is deregulated in more than 30% of human cancers due to the mutational activation of the GTP-binding protein Ras. We are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies. Ongoing projects in the laboratory include the development of cell- and animal-based models to study the role of inflammation in Ras-driven tumorigenesis, the characterization of feedback mechanisms that control the functional output of the Ras signaling axis and the use of chemical biology approaches to identify new modalities for therapeutic targeting.





Academic office

530 First Avenue, HCC

15, Executive Offices

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Senior Vice President and Vice Dean for Science, Chief Scientific Officer

PhD from State University of New York at Stony Brook

Daley, Donnele; Zambirinis, Constantinos Pantelis; Seifert, Lena; Akkad, Neha; Mohan, Navyatha; Werba, Gregor; Barilla, Rocky; Torres-Hernandez, Alejandro; Hundeyin, Mautin; Kumar Mani, Vishnu Raj; Avanzi, Antonina; Tippens, Daniel; Narayanan, Rajkishen; Jang, Jung-Eun; Newman, Elliot; Pillarisetty, Venu Gopal; Dustin, Michael Loran; Bar-Sagi, Dafna; Hajdu, Cristina; Miller, George

Cell. 2020 Nov 12; 183(4):1134-1136

Yoo, Daniel Y; Barros, Stephanie A; Brown, Gordon C; Rabot, Christian; Bar-Sagi, Dafna; Arora, Paramjit S

Journal of the American Chemical Society. 2020 Aug 26; 142(34):14461-14471

Parker, Seth J; Amendola, Caroline R; Hollinshead, Kate E R; Yu, Qijia; Yamamoto, Keisuke; Encarnacion-Rosado, Joel; Rose, Rebecca E; LaRue, Madeleine M; Sohn, Albert S W; Biancur, Doug E; Paulo, Joao A; Gygi, Steven P; Jones, Drew R; Wang, Huamin; Philips, Mark R; Bar-Sagi, Dafna; Mancias, Joseph D; Kimmelman, Alec C

Cancer discovery. 2020 Jul; 10(7):1018-1037

Yoo, Daniel Y; Hauser, Andrew D; Joy, Stephen T; Bar-Sagi, Dafna; Arora, Paramjit S

ACS chemical biology. 2020 Jun 19; 15(6):1604-1612

Das, Shipra; Shapiro, Beny; Vucic, Emily A; Vogt, Sandra; Bar-Sagi, Dafna

Cancer research. 2020 Mar 01; 80(5):1088-1101

Ramirez, Craig; Hauser, Andrew D; Vucic, Emily A; Bar-Sagi, Dafna

Nature. 2019 Dec; 576(7787):477-481

Wang, Lidong; Yang, Huibin; Zamperone, Andrea; Diolaiti, Daniel; Palmbos, Phillip L; Abel, Ethan V; Purohit, Vinee; Dolgalev, Igor; Rhim, Andrew D; Ljungman, Mats; Hadju, Christina H; Halbrook, Christopher J; Bar-Sagi, Dafna; di Magliano, Marina Pasca; Crawford, Howard C; Simeone, Diane M

Genes & development. 2019 Jun 01; 33(11-12):641-655