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Dafna Bar-Sagi

Dafna Bar-Sagi, PhD

Saul J. Farber Professor of Biochemistry and Molecular Pharmacology, Department of Biochemistry and Molecular Pharmacology

Professor, Department of Medicine

Keywords
oncogene function in pancreatic cancer, signal transduction, ras function, inflammation, ras signaling
Summary

The transformation of normal cells to cancer cells is tightly linked to alterations in signaling cascades that control cell proliferation, differentiation and motility. The research in our laboratory focuses a signaling axis that is deregulated in more than 30% of human cancers due to the mutational activation of the GTP-binding protein Ras. We are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies. Ongoing projects in the laboratory include the development of cell- and animal-based models to study the role of inflammation in Ras-driven tumorigenesis, the characterization of feedback mechanisms that control the functional output of the Ras signaling axis and the use of chemical biology approaches to identify new modalities for therapeutic targeting.

Phone

212-263-2095

Fax

646-501-6721

Academic office

530 First Avenue, HCC

15, Executive Offices

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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PhD from State University of New York at Stony Brook

Qin, Rui; Kurz, Emma; Chen, Shuhui; Zeck, Briana; Chiribogas, Luis; Jackson, Dana; Herchen, Alex; Attia, Tyson; Carlock, Michael; Rapkiewicz, Amy; Bar-Sagi, Dafna; Ritchie, Bruce; Ross, Ted M; Mahal, Lara K

ACS infectious diseases. 2022 Nov 11; 8(11):2348-2361

Barriga, Francisco M; Tsanov, Kaloyan M; Ho, Yu-Jui; Sohail, Noor; Zhang, Amy; Baslan, Timour; Wuest, Alexandra N; Del Priore, Isabella; Meškauskaitė, Brigita; Livshits, Geulah; Alonso-Curbelo, Direna; Simon, Janelle; Chaves-Perez, Almudena; Bar-Sagi, Dafna; Iacobuzio-Donahue, Christine A; Notta, Faiyaz; Chaligne, Ronan; Sharma, Roshan; Pe'er, Dana; Lowe, Scott W

Nature cancer. 2022 Nov; 3(11):1367-1385

Kurz, Emma; Hirsch, Carolina Alcantara; Dalton, Tanner; Shadaloey, Sorin Alberto; Khodadadi-Jamayran, Alireza; Miller, George; Pareek, Sumedha; Rajaei, Hajar; Mohindroo, Chirayu; Baydogan, Seyda; Ngo-Huang, An; Parker, Nathan; Katz, Matthew H G; Petzel, Maria; Vucic, Emily; McAllister, Florencia; Schadler, Keri; Winograd, Rafael; Bar-Sagi, Dafna

Cancer cell. 2022 Jul 11; 40(7):720-737.e5

Garcia-Bermudez, Javier; Badgley, Michael A; Prasad, Sheela; Baudrier, Lou; Liu, Yuyang; La, Konnor; Soula, Mariluz; Williams, Robert T; Yamaguchi, Norihiro; Hwang, Rosa F; Taylor, Laura J; de Stanchina, Elisa; Rostandy, Bety; Alwaseem, Hanan; Molina, Henrik; Bar-Sagi, Dafna; Birsoy, Kıvanç

Nature metabolism. 2022 06; 4(6):724-738

LaRue, Madeleine M; Parker, Seth; Puccini, Joseph; Cammer, Michael; Kimmelman, Alec C; Bar-Sagi, Dafna

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2022 Apr 19; 119(16):e2119168119

Marzio, Antonio; Kurz, Emma; Sahni, Jennifer M; Di Feo, Giuseppe; Puccini, Joseph; Jiang, Shaowen; Hirsch, Carolina Alcantara; Arbini, Arnaldo A; Wu, Warren L; Pass, Harvey I; Bar-Sagi, Dafna; Papagiannakopoulos, Thales; Pagano, Michele

Cell. 2022 Jan 06; 185(1):169-183.e19

Puccini, Joseph; Badgley, Michael Alexander; Bar-Sagi, Dafna

Trends in cancer. 2022 Jan; 8(1):54-64

Siolas, Despina; Vucic, Emily; Kurz, Emma; Hajdu, Cristina; Bar-Sagi, Dafna

Cell reports. 2021 Aug 24; 36(8):109578