Daniel P. Depledge, PhD

Research in my lab is focused on several broad themes including: characterizing the roles of diverse base modifications (including m⁶A) on host and viral RNAs during productive infections; investigating the functions of herpesviral latency-associated transcripts and other non-coding RNAs (including miRNAs) during both lytic and latent infections; and, characterizing the transcriptional complexity of diverse viruses (herpesviruses, adenoviruses, coronaviruses) in distinct cell types, such as epithelial cells and neurons.

This is primarily achieved through the integration of computational biology with a variety of high-throughput molecular techniques to study multiple aspects of virus-host interactions at a genome-wide scale. Specific targets of interest are subsequently followed up using classical molecular biology approaches.