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David Fenyo

David Fenyo, PhD

Institute for Systems Genetics

Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
biostatistics, cancer, computational biology, genomics, imaging, pharmacology, proteomics, systems biology
Summary

Our goal is detailed understanding of the dynamics of cellular processes, and we apply mathematical, statistical and computational methods to solve practical problems in experimental design optimization, quantitative data analysis, and in the modeling of biological systems for generating new hypotheses. The focus of our research is proteomic data analysis: we are developing computational methods and databases for protein identification, characterization and quantitation using mass spectrometry-based proteomics.

Phone

917-754-6066

Academic office

435 E 30th St

9th Floor, Room 907

New York, NY 10016

Lab Website
Fenyo Lab
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Positions

Professor, Department of Biochemistry and Molecular Pharmacology

Director, Biomedical Informatics Masters Training Program

Director, Systems and Computational Biomedicine PhD Training Program

Graduate Education

PhD from Uppsala University

Postdoctoral Training

Rockefeller University, Chait Lab

Regulated Phosphosignaling Associated with Breast Cancer Subtypes and Druggability

Huang, Kuan-Lin; Wu, Yige; Primeau, Tina; Wang, Yi-Ting; Gao, Yuqian; McMichael, Joshua F; Scott, Adam D; Cao, Song; Wendl, Michael C; Johnson, Kimberly J; Ruggles, Kelly; Held, Jason; Payne, Samuel H; Davies, Sherri R; Dar, Arvin; Kinsinger, Christopher R; Mesri, Mehdi; Rodriguez, Henry; Ellis, Matthew J; Townsend, R Reid; Chen, Feng; Fenyo, David; Li, Shunqiang; Liu, Tao; Carr, Steven A; Ding, Li

Molecular & cellular proteomics. 2019 Aug; 18(8):1630-1650

Quantitative mass spectrometry to interrogate proteomic heterogeneity in metastatic lung adenocarcinoma and validate a novel somatic mutation CDK12-G879V

Zhang, Xu; Nguyen, Khoa Dang; Rudnick, Paul; Roper, Nitin; Kawaler, Emily; Maity, Tapan K; Awasthi, Shivangi; Gao, Shaojian; Biswas, Romi; Venugopalan, Abhilash; Cultraro, Constance M; Fenyö, David; Guha, Udayan

Molecular & cellular proteomics. 2019 Apr; 18(4):622-641

Transcription shapes DNA replication initiation and termination in human cells

Chen, Yu-Hung; Keegan, Sarah; Kahli, Malik; Tonzi, Peter; Fenyö, David; Huang, Tony T; Smith, Duncan J

Nature structural & molecular biology. 2019 Jan; 26(1):67-77

Transposon insertion profiling by sequencing (TIPseq) for mapping LINE-1 insertions in the human genome

Steranka, Jared P; Tang, Zuojian; Grivainis, Mark; Huang, Cheng Ran Lisa; Payer, Lindsay M; Rego, Fernanda O R; Miller, Thiago Luiz Araujo; Galante, Pedro A F; Ramaswami, Sitharam; Heguy, Adriana; Fenyö, David; Boeke, Jef D; Burns, Kathleen H

Mobile DNA. 2019; 10:8

The ULK1-FBXW5-SEC23B nexus controls autophagy

Jeong, Yeon-Tae; Simoneschi, Daniele; Keegan, Sarah; Melville, David; Adler, Natalia S; Saraf, Anita; Florens, Laurence; Washburn, Michael P; Cavasotto, Claudio N; Fenyö, David; Cuervo, Ana Maria; Rossi, Mario; Pagano, Michele

eLife. 2018 12 31; 7:

Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells

Hadi, Tarik; Boytard, Ludovic; Silvestro, Michele; Alebrahim, Dornazsadat; Jacob, Samson; Feinstein, Jordyn; Barone, Krista; Spiro, Wes; Hutchison, Susan; Simon, Russell; Rateri, Debra; Pinet, Florence; Fenyo, David; Adelman, Mark; Moore, Kathryn J; Eltzschig, Holger K; Daugherty, Alan; Ramkhelawon, Bhama

Nature communications. 2018 11 27; 9(1):5022

Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning

Coudray, Nicolas; Ocampo, Paolo Santiago; Sakellaropoulos, Theodore; Narula, Navneet; Snuderl, Matija; Fenyö, David; Moreira, Andre L; Razavian, Narges; Tsirigos, Aristotelis

Nature medicine. 2018 Oct; 24(10):1559-1567

Spatiotemporal dynamics of homologous recombination repair at single collapsed replication forks

Whelan, Donna R; Lee, Wei Ting C; Yin, Yandong; Ofri, Dylan M; Bermudez-Hernandez, Keria; Keegan, Sarah; Fenyo, David; Rothenberg, Eli

Nature communications. 2018 09 24; 9(1):3882

See All Publications (159)