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David L. Stokes

David L. Stokes, PhD

Skirball Institute

Professor, Department of Cell Biology

cryo-electron microscopy, X-Ray crystallography, ion transport, biophysics, channels and transporters

Our laboratory is interested primarily in the molecular mechanisms of membrane transport. We use a variety of methods to study active transporters that directly use ATP as an energy source as well as secondary transporters that couple transport to the electrochemical gradient. Current transporters under study include the KdpFABC complex from bacteria that is responsible for active import of potassium, the YiiP transporter, also from bacteria, that uses the proton motive force to export zinc and the Bor1p transporter from yeast that imports borate. We have solved structures of each transporter using either X-ray crystallography or Cryo-EM and have used activity assays to characterize the functional parameters of transport. We are currently exploring a variety of experimental and computational approaches to characterize the conformational changes that accompany transport, with the goal of ultimately developing a comprehensive understanding of the transport cycle from both structural and energetic perspectives.



Academic office

540 First Avenue

Skirball Institute, Lab 3-13

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

PhD from Brandeis University

Pedersen, Bjørn P; Stokes, David L; Apell, Hans-Jürgen

Molecular membrane biology. 2019 Jul 01; 1-34

Kim, Seung Joong; Fernandez-Martinez, Javier; Nudelman, Ilona; Shi, Yi; Zhang, Wenzhu; Raveh, Barak; Herricks, Thurston; Slaughter, Brian D; Hogan, Joanna A; Upla, Paula; Chemmama, Ilan E; Pellarin, Riccardo; Echeverria, Ignacia; Shivaraju, Manjunatha; Chaudhury, Azraa S; Wang, Junjie; Williams, Rosemary; Unruh, Jay R; Greenberg, Charles H; Jacobs, Erica Y; Yu, Zhiheng; de la Cruz, M Jason; Mironska, Roxana; Stokes, David L; Aitchison, John D; Jarrold, Martin F; Gerton, Jennifer L; Ludtke, Steven J; Akey, Christopher W; Chait, Brian T; Sali, Andrej; Rout, Michael P

Nature. 2018 03 22; 555(7697):475-482

Lopez-Redondo, Maria Luisa; Coudray, Nicolas; Zhang, Zhening; Alexopoulos, John; Stokes, David L

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2018 03 20; 115(12):3042-3047

Beilin, Chiara; Choudhuri, Kaushik; Bouma, Gerben; Malinova, Dessislava; Llodra, Jaime; Stokes, David L; Shimaoka, Motumu; Springer, Timothy A; Dustin, Michael L; Thrasher, Adrian J; Burns, Siobhan O

Wellcome open research. 2018; 3:84

Saadipour, Khalil; MacLean, Michael; Pirkle, Sean; Ali, Solav; Lopez-Redondo, Maria Luisa; Stokes, David L; Chao, Moses V

Journal of biological chemistry. 2017 10 06; 292(40):16594-16604

Fai, Thomas G; Leo-Macias, Alejandra; Stokes, David L; Peskin, Charles S

PLoS computational biology. 2017 Oct; 13(10):e1005790

Huang, Ching-Shin; Pedersen, Bjorn Panyella; Stokes, David L

Nature. 2017 06 29; 546(7660):681-685

Upla, Paula; Kim, Seung Joong; Sampathkumar, Parthasarathy; Dutta, Kaushik; Cahill, Sean M; Chemmama, Ilan E; Williams, Rosemary; Bonanno, Jeffrey B; Rice, William J; Stokes, David L; Cowburn, David; Almo, Steven C; Sali, Andrej; Rout, Michael P; Fernandez-Martinez, Javier

Structure. 2017 03 07; 25(3):434-445