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David Schoppik

David Schoppik, PhD

Neuroscience Institute

Assistant Professor, Department of Otolaryngology-Head and Neck Surgery

Assistant Professor, Department of Neuroscience and Physiology

Keywords
imaging, molecular, cellular, & translational neuroscience, systems, cognitive, & computational neuroscience, zebrafish, neurodegeneration
Summary

In our lab, we study balance. Our goals are to discover how reflexes that permit stable movements develop and function, and to understand how neurodegenerative disease compromises balance. To make progress, we leverage the transparency, rapid development, and genetic accessibility of the zebrafish, a small model vertebrate. We focus on three broad questions:

  • How do balance circuits develop? Balance circuits are made of sets of anatomically and functionally specialized neurons. We work to understand how these anatomical and functional properties are established and refined during development. Our focus is on the sets of neurons that together stabilize posture and gaze.
  • How does the nervous system balance the body? Physical forces continuously challenge animals’ balance. Animals sense these forces, compute appropriate responses, and biomechanically counter destabilization. We measure and model these phenomena. Our long-term goal is to define how specific neurons compute and implement solutions to permit stable movement.
  • How does progressive neurodegeneration give rise to such debilitating symptoms? Many molecular events associated with neurodegenerative disorders have been identified, but how these molecular changes lead to cellular dysfunction and attendant behavioral disturbances remains a mystery. In a new line of study, we are focusing on a class of neurodegenerative disorders that share a common molecular origin, the protein tau. Together with our collaborators, we study how balance and gaze problems emerge in a model of a tau-driven disorder, progressive supranuclear palsy.
Phone

646-501-4555

Fax

212-263-9170

Academic office

Science Building, 435 East 30th Street

11th Floor, Room 1103

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Assistant Professor, Department of Otolaryngology-Head and Neck Surgery

Assistant Professor, Department of Neuroscience and Physiology

PhD from University of California, San Francisco

Harvard University, Schier / Engert Laboratories

Bagnall, Martha W; Schoppik, David

Current opinion in neurobiology. 2018 Dec; 53:83-89

Jung, Heekyung; Baek, Myungin; D'Elia, Kristen P; Boisvert, Catherine; Currie, Peter D; Tay, Boon-Hui; Venkatesh, Byrappa; Brown, Stuart M; Heguy, Adriana; Schoppik, David; Dasen, Jeremy S

Cell. 2018 02 08; 172(4):667-682.e15

Ehrlich, David E; Schoppik, David

Current biology. CB. 2017 Feb 06; 27(3):334-344

Greaney, Marie R; Privorotskiy, Ann E; D'Elia, Kristen P; Schoppik, David

Journal of comparative neurology. 2017 01 01; 525(1):65-78

Schoppik, David; Bianco, Isaac H; Prober, David A; Douglass, Adam D; Robson, Drew N; Li, Jennifer M B; Greenwood, Joel S F; Soucy, Edward; Engert, Florian; Schier, Alexander F

Journal of neuroscience. 2017 11 22; 37(47):11353-11365

Ma 马漫修, Manxiu; Ramirez, Alexandro D; Wang 王彤, Tong; Roberts, Rachel L; Harmon, Katherine E; Schoppik, David; Sharma, Avirale; Kuang, Christopher; Goei, Stephanie L; Gagnon, James A; Zimmerman, Steve; Tsai, Shengdar Q; Reyon, Deepak; Joung, J Keith; Aksay, Emre R F; Schier, Alexander F; Pan 潘於勤, Y Albert

Journal of neuroscience. 2019 Nov 04;

Suver, Marie P; Matheson, Andrew M M; Sarkar, Sinekdha; Damiata, Matthew; Schoppik, David; Nagel, Katherine I

Neuron. 2019 May 22; 102(4):828-842.e7