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Edward Ziff

Edward Ziff, PhD

Professor Emeritus of Biochemistry, Department of Biochemistry and Molecular Pharmacology

molecular mechanisms of synaptic regulation

Our lab studies the molecular mechanisms which regulate synaptic transmission at excitatory synapses. We focus on two ion channels, the AMPA and the NMDA type glutamate receptors. These receptors are multisubunited pores that admit cations into the postsynaptic cell when stimulated by glutamate. AMPA receptors function in fast excitatory transmission while NMDA receptors function in altering synaptic architecture and transmission strength. Both receptor types are composed of integral membrane protein subunits that project domains outside the cell and into the cytoplasm. The cytoplasmic domains associate with binding proteins that serve as attachment sites to the cytoskeleton or to regulatory proteins (such as kinase or phosphatases) that modify receptor activity. We have cloned proteins which associate with the cytoplasmic tail of the GluR2 AMPA type glutamate receptor subunit and are studying the role of these binding factors in receptor control. One protein that binds to GluR2 is the chaperone, NSF. A second protein is AMPA Receptor Binding Protein (ABP). ABP may form a cytoplasmic scaffold that binds receptors at the synapse. We are testing a model that NSF regulates the attachment of GluR2 to ABP and other cytoplasmic factors. We are studying the role of the NMDA receptor in the control of the AMPA receptor. Our goal is to obtain a molecular view of changes in synaptic signaling induced by neuron activity.



Academic office

455 First Avenue, Public Health Building

8, 835B

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Graduate Student Advisor

PhD from Princeton University

de Matos Balsalobre, Natália; Dos Santos, Elisangela; Mariano Dos Santos, Sidney; Arena, Arielle Cristina; Konkiewitz, Elisabete Castelon; Ziff, Edward Benjamin; Nazari Formagio, Anelise Samara; Leite Kassuya, Candida Aparecida

Journal of ethnopharmacology. 2022 Oct 09; 301:115785

Sathler, Matheus F; Khatri, Latika; Roberts, Jessica P; Schmidt, Isabella G; Zaytseva, Anastasiya; Kubrusly, Regina C C; Ziff, Edward B; Kim, Seonil

Journal of cell science. 2021 Sep 01; 134(17):

Dos Santos, Elisangela; Radai, Joyce Alencar Santos; do Nascimento, Kamilla Felipe; Formagio, Anelise Samara Nazari; de Matos Balsalobre, Natália; Ziff, Edward Benjamin; Castelon Konkiewitz, Elisabete; Kassuya, Candida Aparecida Leite

Nutritional neuroscience. 2020 Sep 11; 1-11

Cossenza, Marcelo; Socodato, Renato; Mejía-García, Telmo A; Domith, Ivan; Portugal, Camila C; Gladulich, Luis F H; Duarte-Silva, Aline T; Khatri, Latika; Antoine, Shannon; Hofmann, Franz; Ziff, Edward B; Paes-de-Carvalho, Roberto

Biochimica & biophysica acta. Molecular cell research. 2020 Apr 29; 118732

Pick, Joseph E; Ziff, Edward B

Molecular & cellular neurosciences. 2018 09; 91:3-9

Kim, Seonil; Shou, Jiayi; Abera, Sinedu; Ziff, Edward B

Neuropharmacology. 2018 03 01; 130:10-17

Castelon Konkiewitz, Elisabete; Ziff, Edward Benjamin

Frontiers of neurology & neuroscience. 2018 May; 43:196-220

Castelon Konkiewitz, Elisabete; Ziff, Edward B

Frontiers of neurology & neuroscience. 2018 Dec; 43:145-163