Edward Ziff

Edward Ziff, PhD

Professor, Department of Biochemistry and Molecular Pharmacology

molecular mechanisms of synaptic regulation

Our lab studies the molecular mechanisms which regulate synaptic transmission at excitatory synapses. We focus on two ion channels, the AMPA and the NMDA type glutamate receptors. These receptors are multisubunited pores that admit cations into the postsynaptic cell when stimulated by glutamate. AMPA receptors function in fast excitatory transmission while NMDA receptors function in altering synaptic architecture and transmission strength. Both receptor types are composed of integral membrane protein subunits that project domains outside the cell and into the cytoplasm. The cytoplasmic domains associate with binding proteins that serve as attachment sites to the cytoskeleton or to regulatory proteins (such as kinase or phosphatases) that modify receptor activity. We have cloned proteins which associate with the cytoplasmic tail of the GluR2 AMPA type glutamate receptor subunit and are studying the role of these binding factors in receptor control. One protein that binds to GluR2 is the chaperone, NSF. A second protein is AMPA Receptor Binding Protein (ABP). ABP may form a cytoplasmic scaffold that binds receptors at the synapse. We are testing a model that NSF regulates the attachment of GluR2 to ABP and other cytoplasmic factors. We are studying the role of the NMDA receptor in the control of the AMPA receptor. Our goal is to obtain a molecular view of changes in synaptic signaling induced by neuron activity.



Academic office

540 First Avenue, Skirball Institute

5, 1

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication

Professor, Department of Biochemistry and Molecular Pharmacology

Graduate Student Advisor

PhD from Princeton University

Castelon Konkiewitz, Elisabete; Ziff, Edward B

Frontiers of neurology & neuroscience. 2018 Nov 13; 43:145-163

Castelon Konkiewitz, Elisabete; Ziff, Edward Benjamin

Frontiers of neurology & neuroscience. 2018 Oct 20; 43:196-220

Pick, Joseph E; Ziff, Edward B

Molecular & cellular neurosciences. 2018 Sep 17; 91:3-9

Kim, Seonil; Shou, Jiayi; Abera, Sinedu; Ziff, Edward B

Neuropharmacology. 2018 Mar 01; 130:10-17

Farooq, Mobeen; Kim, Seonil; Patel, Sunny; Khatri, Latika; Hikima, Takuya; Rice, Margaret E; Ziff, Edward B

Neuropharmacology. 2017 Feb; 113(Pt A):426-433

Piccinelli, Ana Claudia; Morato, Priscila Neder; Dos Santos Barbosa, Marcelo; Croda, Julio; Sampson, Jared; Kong, Xiangpeng; Konkiewitza, Elisabete Castelon; Ziff, Edward B; Amaya-Farfan, Jaime; Kassuya, Candida Aparecida Leite

Life sciences. 2016 Nov 22; 174:28-34

Pick, Joseph E; Khatri, Latika; Sathler, Matheus F; Ziff, Edward B

EMBO journal. 2016 Nov 17; 36(2):232-244

Kim, Seonil; Pick, Joseph E; Abera, Sinedu; Khatri, Latika; Ferreira, Danielle D P; Sathler, Matheus F; Morison, Sage L; Hofmann, Franz; Ziff, Edward B

Learning & memory. 2016 Aug; 23(8):435-441

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