Professor, Department of Neuroscience and Physiology
Professor, Department of Psychiatry
My current research focuses on pathogenesis, treatment, and diagnosis of age-related degenerative diseases—in particular Alzheimer’s disease and, more recently, Parkinson’s disease and related synucleinopathies.
In these protein conformational disorders, a normal protein is converted to a pathological form with high beta-sheet content. The main theme of my work involves clarifying this pathological process, its consequences at the molecular and functional levels, and how best to diagnose and prevent it.
212-263-3913
Science Building, 435 East 30th Street
11th Floor, Room 1115
New York, NY 10016
New York University , Frangione Lab
Science advances. 2023 May 10; 9(19):eadf3775
EBioMedicine. 2022 Sep 10; 84:104249
Seminars in cell & developmental biology. 2022 Jun; 126:125-137
Neurobiology of disease. 2021 Jan; 147:105165
EBioMedicine. 2019 Apr; 42:157-173
EBioMedicine. 2018 Sep; 35:270-278
Neurobiology of disease. 2020 Jan 23; 104770
Nature reviews. Neurology. 2018 Jul; 14(7):399-415