Einar M. Sigurdsson

Einar M. Sigurdsson, PhD

Professor, Department of Neuroscience

Professor, Department of Psychiatry

Keywords
pathogenesis , Alzheimer's disease, prion diseases, type-2 diabetes, immunology, molecular, cellular, & translational neuroscience, systems, cognitive, & computational neuroscience, diagnosis, therapy, Parkinson's disease, Neurodegeneration, Neurodegenerative diseases, Protein conformational disorders, imaging, synuclein, tau, amyloid-beta, amyloids
Summary

My current research focuses on pathogenesis, treatment, and diagnosis of age-related degenerative diseases—in particular Alzheimer’s disease and, more recently, Parkinson’s disease and related synucleinopathies.

In these protein conformational disorders, a normal protein is converted to a pathological form with high beta-sheet content. The main theme of my work involves clarifying this pathological process, its consequences at the molecular and functional levels, and how best to diagnose and prevent it.

Phone

212-263-3913

Academic office

Science Building, 435 East 30th Street

11th Floor, Room 1115

New York, NY 10016

Lab Website
Sigurdsson Lab
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Positions

Professor, Department of Neuroscience at NYU Grossman School of Medicine

Professor, Department of Psychiatry at NYU Grossman School of Medicine

Graduate Education

PhD from Loyola University Chicago

PhD from Loyola University Chicago

Postdoctoral Training

New York University , Frangione Lab

Clearing truncated tau protein restores neuronal function and prevents microglia activation in tauopathy mice

Martín-Ávila, Alejandro; Modak, Swananda R; Rajamohamedsait, Hameetha B; Dodge, Andie; Shamir, Dov B; Krishnaswamy, Senthilkumar; Sandusky-Beltran, Leslie A; Walker, Marilyn; Lin, Yan; Congdon, Erin E; Sigurdsson, Einar M

Cell reports. 2025 Sep 16; 44(10):116291

Single-domain antibody-based protein degrader for synucleinopathies

Jiang, Yixiang; Lin, Yan; Tetlow, Amber M; Pan, Ruimin; Ji, Changyi; Kong, Xiang-Peng; Congdon, Erin E; Sigurdsson, Einar M

Molecular neurodegeneration. 2024 May 31; 19(1):44

Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy

Ji, Changyi; Yang, Xiaofeng; Eleish, Mohamed; Jiang, Yixiang; Tetlow, Amber M; Song, Soomin C; Martín-Ávila, Alejandro; Wu, Qian; Zhou, Yanmei; Gan, Wenbiao; Lin, Yan; Sigurdsson, Einar M

Alzheimer's & dementia. 2024 Nov; 20(11):7954-7970

Anti-tau single domain antibodies clear pathological tau and attenuate its toxicity and related functional defects

Nair, Sudershana; Jiang, Yixiang; Marchal, Isabella S; Chernobelsky, Elizabeth; Huang, Huai-Wei; Suh, Sarah; Pan, Ruimin; Kong, Xiang-Peng; Ryoo, Hyung Don; Sigurdsson, Einar M

Cell death & disease. 2024 Jul 30; 15(7):543

Single-domain antibody-based noninvasive in vivo imaging of α-synuclein or tau pathology

Jiang, Yixiang; Lin, Yan; Krishnaswamy, Senthilkumar; Pan, Ruimin; Wu, Qian; Sandusky-Beltran, Leslie A; Liu, Mengyu; Kuo, Min-Hao; Kong, Xiang-Peng; Congdon, Erin E; Sigurdsson, Einar M

Science advances. 2023 May 10; 9(19):eadf3775

Single domain antibodies targeting pathological tau protein: Influence of four IgG subclasses on efficacy and toxicity

Congdon, Erin E; Pan, Ruimin; Jiang, Yixiang; Sandusky-Beltran, Leslie A; Dodge, Andie; Lin, Yan; Liu, Mengyu; Kuo, Min-Hao; Kong, Xiang-Peng; Sigurdsson, Einar M

EBioMedicine. 2022 Sep 10; 84:104249

Increased neuronal activity in motor cortex reveals prominent calcium dyshomeostasis in tauopathy mice

Wu, Qian; Bai, Yang; Li, Wei; Congdon, Erin E; Liu, Wenke; Lin, Yan; Ji, Changyi; Gan, Wen-Biao; Sigurdsson, Einar M

Neurobiology of disease. 2021 Jan; 147:105165

Tau-targeting therapies for Alzheimer disease: current status and future directions

Congdon, Erin E; Ji, Changyi; Tetlow, Amber M; Jiang, Yixiang; Sigurdsson, Einar M

Nature reviews. Neurology. 2023 Dec; 19(12):715-736

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