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Einar M. Sigurdsson

Einar M. Sigurdsson

Professor, Department of Neuroscience and Physiology

Professor, Department of Psychiatry

pathogenesis , Alzheimer's disease, prion diseases, type-2 diabetes, immunology, molecular, cellular, & translational neuroscience, systems, cognitive, & computational neuroscience, diagnosis, therapy, Parkinson's disease, Neurodegeneration, Neurodegenerative diseases, Protein conformational disorders, imaging, synuclein, tau, amyloid-beta, amyloids

My current research focuses on pathogenesis, treatment, and diagnosis of age-related degenerative diseases—in particular Alzheimer’s disease and, more recently, Parkinson’s disease and related synucleinopathies.

In these protein conformational disorders, a normal protein is converted to a pathological form with high beta-sheet content. The main theme of my work involves clarifying this pathological process, its consequences at the molecular and functional levels, and how best to diagnose and prevent it.



Academic office

Science Building, 435 East 30th Street

11th Floor, Room 1115

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.
Jiang, Yixiang; Lin, Yan; Krishnaswamy, Senthilkumar; Pan, Ruimin; Wu, Qian; Sandusky-Beltran, Leslie A; Liu, Mengyu; Kuo, Min-Hao; Kong, Xiang-Peng; Congdon, Erin E; Sigurdsson, Einar M

Science advances. 2023 May 10; 9(19):eadf3775

Congdon, Erin E; Pan, Ruimin; Jiang, Yixiang; Sandusky-Beltran, Leslie A; Dodge, Andie; Lin, Yan; Liu, Mengyu; Kuo, Min-Hao; Kong, Xiang-Peng; Sigurdsson, Einar M

EBioMedicine. 2022 Sep 10; 84:104249

Congdon, Erin E; Jiang, Yixiang; Sigurdsson, Einar M

Seminars in cell & developmental biology. 2022 Jun; 126:125-137

Wu, Qian; Bai, Yang; Li, Wei; Congdon, Erin E; Liu, Wenke; Lin, Yan; Ji, Changyi; Gan, Wen-Biao; Sigurdsson, Einar M

Neurobiology of disease. 2021 Jan; 147:105165

Congdon, Erin E; Chukwu, Jessica E; Shamir, Dov B; Deng, Jingjing; Ujla, Devyani; Sait, Hameetha B R; Neubert, Thomas A; Kong, Xiang-Peng; Sigurdsson, Einar M

EBioMedicine. 2019 Apr; 42:157-173

Wu, Qian; Lin, Yan; Gu, Jiaping; Sigurdsson, Einar M

EBioMedicine. 2018 Sep; 35:270-278

Krishnaswamy, S; Huang, H-W; Marchal, I S; Ryoo, H D; Sigurdsson, E M

Neurobiology of disease. 2020 Jan 23; 104770

Congdon, Erin E; Ji, Changyi; Tetlow, Amber M; Jiang, Yixiang; Sigurdsson, Einar M

Nature reviews. Neurology. 2023 Dec; 19(12):715-736