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Emily R. Stern, PhD

Associate Professor, Department of Psychiatry

Keywords
obsessive-compulsive disorder, tourette's disorder, functional neuroimaging, anxiety
Summary

My research uses a multi-method approach to identify and target behavioral and neural mechanisms in psychiatric disorders, focusing on heterogeneity in obsessive-compulsive disorder (OCD) and transdiagnostic features shared with other disorders. The lab’s work seeks to understand the fundamental problem of variability of treatment efficacy among patients with the same diagnosis by employing a program of research to: 1) identify behavioral and neural mechanisms underlying core processes contributing to within-disorder heterogeneity and 2) target those mechanisms using techniques to manipulate neural circuit functioning. Primarily focusing on the clinically impairing but understudied sensory processing abnormalities in OCD, research in my lab has linked sensory symptoms to hyper-functioning of an insula-sensorimotor circuit and is testing the use of pharmacotherapeutic (e.g., the 5-HT3 antagonist ondansetron) and neuromodulatory (e.g., TMS) methods to modulate this circuitry in order to alter behavior and, ultimately, clinical symptoms. The overall aim of this work is to use mechanistic findings to develop and refine treatments targeting individual patient characteristics within the framework of a personalized medicine approach.

Academic office

One Park Avenue

8th Floor

New York, NY

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PhD from Columbia University

University of Michigan, Psychiatry Department

Stern, Emily R; Shahab, Rebbia; Grimaldi, Stephanie J; Leibu, Evan; Murrough, James W; Fleysher, Lazar; Parides, Michael K; Coffey, Barbara J; Burdick, Katherine E; Goodman, Wayne K

Neuropsychopharmacology. 2019 01; 44(2):390-398

Bragdon, Laura B; Eng, Goi Khia; Recchia, Nicolette; Collins, Katherine A; Stern, Emily R

Psychiatric clinics of North America. 2023 Mar; 46(1):53-67

Eng, Goi Khia; Collins, Katherine A; Brown, Carina; Ludlow, Molly; Tobe, Russell H; Iosifescu, Dan V; Stern, Emily R

Cerebral cortex. 2022 Nov 21; 32(23):5285-5300

Stern, Emily R; Brown, Carina; Ludlow, Molly; Shahab, Rebbia; Collins, Katherine; Lieval, Alexis; Tobe, Russell H; Iosifescu, Dan V; Burdick, Katherine E; Fleysher, Lazar

Human brain mapping. 2020 Apr 15; 41(6):1611-1625

Eng, Goi Khia; Collins, Katherine A; Brown, Carina; Ludlow, Molly; Tobe, Russell H; Iosifescu, Dan V; Stern, Emily R

Journal of obsessive-compulsive & related disorders. 2020 Oct; 27:

Brown, Carina; Shahab, Rebbia; Collins, Katherine; Fleysher, Lazar; Goodman, Wayne K; Burdick, Katherine E; Stern, Emily R

Journal of psychiatric research. 2019 Feb; 109:68-75

Eng, Goi Khia; De Nadai, Alessandro S; Collins, Katherine A; Recchia, Nicolette; Tobe, Russell H; Bragdon, Laura B; Stern, Emily R

Journal of psychiatric research. 2024 Sep; 177:129-139

Kim, Bo-Gyeom; Kim, Gakyung; Abe, Yoshinari; Alonso, Pino; Ameis, Stephanie; Anticevic, Alan; Arnold, Paul D; Balachander, Srinivas; Banaj, Nerisa; Bargalló, Nuria; Batistuzzo, Marcelo C; Benedetti, Francesco; Bertolín, Sara; Beucke, Jan Carl; Bollettini, Irene; Brem, Silvia; Brennan, Brian P; Buitelaar, Jan K; Calvo, Rosa; Castelo-Branco, Miguel; Cheng, Yuqi; Chhatkuli, Ritu Bhusal; Ciullo, Valentina; Coelho, Ana; Couto, Beatriz; Dallaspezia, Sara; Ely, Benjamin A; Ferreira, Sónia; Fontaine, Martine; Fouche, Jean-Paul; Grazioplene, Rachael; Gruner, Patricia; Hagen, Kristen; Hansen, Bjarne; Hanna, Gregory L; Hirano, Yoshiyuki; Höxter, Marcelo Q; Hough, Morgan; Hu, Hao; Huyser, Chaim; Ikuta, Toshikazu; Jahanshad, Neda; James, Anthony; Jaspers-Fayer, Fern; Kasprzak, Selina; Kathmann, Norbert; Kaufmann, Christian; Kim, Minah; Koch, Kathrin; Kvale, Gerd; Kwon, Jun Soo; Lazaro, Luisa; Lee, Junhee; Lochner, Christine; Lu, Jin; Manrique, Daniela Rodriguez; Martínez-Zalacaín, Ignacio; Masuda, Yoshitada; Matsumoto, Koji; Maziero, Maria Paula; Menchón, Jose M; Minuzzi, Luciano; Moreira, Pedro Silva; Morgado, Pedro; Narayanaswamy, Janardhanan C; Narumoto, Jin; Ortiz, Ana E; Ota, Junko; Pariente, Jose C; Perriello, Chris; Picó-Pérez, Maria; Pittenger, Christopher; Poletti, Sara; Real, Eva; Reddy, Y C Janardhan; van Rooij, Daan; Sakai, Yuki; Sato, João Ricardo; Segalas, Cinto; Shavitt, Roseli G; Shen, Zonglin; Shimizu, Eiji; Shivakumar, Venkataram; Soreni, Noam; Soriano-Mas, Carles; Sousa, Nuno; Sousa, Mafalda Machado; Spalletta, Gianfranco; Stern, Emily R; Stewart, S Evelyn; Szeszko, Philip R; Thomas, Rajat; Thomopoulos, Sophia I; Vecchio, Daniela; Venkatasubramanian, Ganesan; Vriend, Chris; Walitza, Susanne; Wang, Zhen; Watanabe, Anri; Wolters, Lidewij; Xu, Jian; Yamada, Kei; Yun, Je-Yeon; Zarei, Mojtaba; Zhao, Qing; Zhu, Xi; ,; Thompson, Paul M; Bruin, Willem B; van Wingen, Guido A; Piras, Federica; Piras, Fabrizio; Stein, Dan J; van den Heuvel, Odile A; Simpson, Helen Blair; Marsh, Rachel; Cha, Jiook

Molecular psychiatry. 2024 Apr; 29(4):1216