Emily R. Stern

Emily R. Stern, PhD

Associate Professor, Department of Psychiatry

Keywords
obsessive-compulsive disorder, tourette's disorder, functional neuroimaging, anxiety
Summary

My research uses a multi-method approach to identify and target behavioral and neural mechanisms in psychiatric disorders, focusing on heterogeneity in obsessive-compulsive disorder (OCD) and transdiagnostic features shared with other disorders. The lab’s work seeks to understand the fundamental problem of variability of treatment efficacy among patients with the same diagnosis by employing a program of research to: 1) identify behavioral and neural mechanisms underlying core processes contributing to within-disorder heterogeneity and 2) target those mechanisms using techniques to manipulate neural circuit functioning. Primarily focusing on the clinically impairing but understudied sensory processing abnormalities in OCD, research in my lab has linked sensory symptoms to hyper-functioning of an insula-sensorimotor circuit and is testing the use of pharmacotherapeutic (e.g., the 5-HT3 antagonist ondansetron) and neuromodulatory (e.g., TMS) methods to modulate this circuitry in order to alter behavior and, ultimately, clinical symptoms. The overall aim of this work is to use mechanistic findings to develop and refine treatments targeting individual patient characteristics within the framework of a personalized medicine approach.

Academic office

One Park Avenue

8th Floor

New York, NY

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Positions

Associate Professor, Department of Psychiatry at NYU Grossman School of Medicine

Graduate Education

PhD from Columbia University

Postdoctoral Training

University of Michigan, Psychiatry Department

Heterogeneity in OCD and Depression

See All Studies (1)

High-dose ondansetron reduces activation of interoceptive and sensorimotor brain regions

Stern, Emily R; Shahab, Rebbia; Grimaldi, Stephanie J; Leibu, Evan; Murrough, James W; Fleysher, Lazar; Parides, Michael K; Coffey, Barbara J; Burdick, Katherine E; Goodman, Wayne K

Neuropsychopharmacology. 2019 01; 44(2):390-398

Cognitive Neuroscience of Obsessive-Compulsive Disorder

Bragdon, Laura B; Eng, Goi Khia; Recchia, Nicolette; Collins, Katherine A; Stern, Emily R

Psychiatric clinics of North America. 2023 Mar; 46(1):53-67

Imbalance between default mode and sensorimotor connectivity is associated with perseverative thinking in obsessive-compulsive disorder

Stern, Emily R; Eng, Goi Khia; De Nadai, Alessandro S; Iosifescu, Dan V; Tobe, Russell H; Collins, Katherine A

Translational psychiatry. 2022 Jan 12; 12(1):19

The buildup of an urge in obsessive-compulsive disorder: Behavioral and neuroimaging correlates

Stern, Emily R; Brown, Carina; Ludlow, Molly; Shahab, Rebbia; Collins, Katherine; Lieval, Alexis; Tobe, Russell H; Iosifescu, Dan V; Burdick, Katherine E; Fleysher, Lazar

Human brain mapping. 2020 Apr 15; 41(6):1611-1625

Identifying subgroups of urge suppression in Obsessive-Compulsive Disorder using machine learning

Eng, Goi Khia; De Nadai, Alessandro S; Collins, Katherine A; Recchia, Nicolette; Tobe, Russell H; Bragdon, Laura B; Stern, Emily R

Journal of psychiatric research. 2024 Sep; 177:129-139

Functional neural mechanisms of sensory phenomena in obsessive-compulsive disorder

Brown, Carina; Shahab, Rebbia; Collins, Katherine; Fleysher, Lazar; Goodman, Wayne K; Burdick, Katherine E; Stern, Emily R

Journal of psychiatric research. 2019 Feb; 109:68-75

Negative valence in Obsessive-Compulsive Disorder: A worldwide mega-analysis of task-based functional neuroimaging data of the ENIGMA-OCD consortium

Dzinalija, Nadza; Vriend, Chris; Waller, Lea; Simpson, H Blair; Ivanov, Iliyan; Agarwal, Sri Mahavir; Alonso, Pino; Backhausen, Lea L; Balachander, Srinivas; Broekhuizen, Aniek; Castelo-Branco, Miguel; Costa, Ana Daniela; Cui, Hailun; Denys, Damiaan; Duarte, Isabel Catarina; Eng, Goi Khia; Erk, Susanne; Fitzsimmons, Sophie M D D; Ipser, Jonathan; Jaspers-Fayer, Fern; de Joode, Niels T; Kim, Minah; Koch, Kathrin; Kwon, Jun Soo; van Leeuwen, Wieke; Lochner, Christine; van Marle, Hein J F; Martinez-Zalacain, Ignacio; Menchon, Jose M; Morgado, Pedro; Narayanaswamy, Janardhanan C; Olivier, Ian S; Picó-Pérez, Maria; Postma, Tjardo S; Rodriguez-Manrique, Daniela; Roessner, Veit; Rus-Oswald, Oana Georgiana; Shivakumar, Venkataram; Soriano-Mas, Carles; Stern, Emily R; Stewart, S Evelyn; van der Straten, Anouk L; Sun, Bomin; Thomopoulos, Sophia I; Veltman, Dick J; Vetter, Nora C; Visser, Henny; Voon, Valerie; Walter, Henrik; van der Werf, Ysbrand D; van Wingen, Guido; ,; Stein, Dan J; Thompson, Paul M; Veer, Ilya M; van den Heuvel, Odile A

Biological psychiatry. 2024 Dec 24;

White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group

Kim, Bo-Gyeom; Kim, Gakyung; Abe, Yoshinari; Alonso, Pino; Ameis, Stephanie; Anticevic, Alan; Arnold, Paul D; Balachander, Srinivas; Banaj, Nerisa; Bargalló, Nuria; Batistuzzo, Marcelo C; Benedetti, Francesco; Bertolín, Sara; Beucke, Jan Carl; Bollettini, Irene; Brem, Silvia; Brennan, Brian P; Buitelaar, Jan K; Calvo, Rosa; Castelo-Branco, Miguel; Cheng, Yuqi; Chhatkuli, Ritu Bhusal; Ciullo, Valentina; Coelho, Ana; Couto, Beatriz; Dallaspezia, Sara; Ely, Benjamin A; Ferreira, Sónia; Fontaine, Martine; Fouche, Jean-Paul; Grazioplene, Rachael; Gruner, Patricia; Hagen, Kristen; Hansen, Bjarne; Hanna, Gregory L; Hirano, Yoshiyuki; Höxter, Marcelo Q; Hough, Morgan; Hu, Hao; Huyser, Chaim; Ikuta, Toshikazu; Jahanshad, Neda; James, Anthony; Jaspers-Fayer, Fern; Kasprzak, Selina; Kathmann, Norbert; Kaufmann, Christian; Kim, Minah; Koch, Kathrin; Kvale, Gerd; Kwon, Jun Soo; Lazaro, Luisa; Lee, Junhee; Lochner, Christine; Lu, Jin; Manrique, Daniela Rodriguez; Martínez-Zalacaín, Ignacio; Masuda, Yoshitada; Matsumoto, Koji; Maziero, Maria Paula; Menchón, Jose M; Minuzzi, Luciano; Moreira, Pedro Silva; Morgado, Pedro; Narayanaswamy, Janardhanan C; Narumoto, Jin; Ortiz, Ana E; Ota, Junko; Pariente, Jose C; Perriello, Chris; Picó-Pérez, Maria; Pittenger, Christopher; Poletti, Sara; Real, Eva; Reddy, Y C Janardhan; van Rooij, Daan; Sakai, Yuki; Sato, João Ricardo; Segalas, Cinto; Shavitt, Roseli G; Shen, Zonglin; Shimizu, Eiji; Shivakumar, Venkataram; Soriano-Mas, Carles; Sousa, Nuno; Sousa, Mafalda Machado; Spalletta, Gianfranco; Stern, Emily R; Stewart, S Evelyn; Szeszko, Philip R; Thomas, Rajat; Thomopoulos, Sophia I; Vecchio, Daniela; Venkatasubramanian, Ganesan; Vriend, Chris; Walitza, Susanne; Wang, Zhen; Watanabe, Anri; Wolters, Lidewij; Xu, Jian; Yamada, Kei; Yun, Je-Yeon; Zarei, Mojtaba; Zhao, Qing; Zhu, Xi; ,; Thompson, Paul M; Bruin, Willem B; van Wingen, Guido A; Piras, Federica; Piras, Fabrizio; Stein, Dan J; van den Heuvel, Odile A; Simpson, Helen Blair; Marsh, Rachel; Cha, Jiook

Molecular psychiatry. 2024 Apr; 29(4):1063-1074

See All Publications (90)