Fred T. Valentine, MD

Research Professor, Department of Medicine

Keywords
malignant melanoma, induction of effective immune responses against metastatic melanoma, pathogenesis of HIV disease, immune responses to HIV, cellular immunology, vaccine design
Summary

Our research involves clinical studies of immune responses to malignant melanoma. We have developed a method of inducing cellular immune responses to metastatic melanoma that result in frequent durable complete regressions of disease.

We also are interested in immunological and virological aspects of human immunodeficiency virus (HIV) infection. We are investigating HIV-specific cellular immune responses in acute, primary HIV infection and in elite controllers who "spontaneously" control HIV without antiretroviral drugs. We have discovered that individuals treated very early in their HIV infection develop strong CD4 T cell memory responses to HIV antigens, similar but often of smaller magnitude to the memory responses observed in elite controllers. Many individuals treated for one year after the onset of their infection are subsequently able to control their blood levels of HIV for at least 1 to 2 years after stopping their anti-HIV drugs.

Phone

212-263-6401

Academic office

550 First Avenue, Bellevue C&D

5th Floor, Room 517

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Research Professor, Department of Medicine

MD from Harvard Medical School

Fellowship, NYU School of Medicine, Infectious Diseases and Immunology

Residency, Harvard Medical Service Boston City Hospital, Internal Medicine

Gornalusse, German G; Mummidi, Srinivas; Gaitan, Alvaro A; Jimenez, Fabio; Ramsuran, Veron; Picton, Anabela; Rogers, Kristen; Manoharan, Muthu Saravanan; Avadhanam, Nymisha; Murthy, Krishna K; Martinez, Hernan; Molano Murillo, Angela; Chykarenko, Zoya A; Hutt, Richard; Daskalakis, Demetre; Shostakovich-Koretskaya, Ludmila; Abdool Karim, Salim; Martin, Jeffrey N; Deeks, Steven G; Hecht, Frederick; Sinclair, Elizabeth; Clark, Robert A; Okulicz, Jason; Valentine, Fred T; Martinson, Neil; Tiemessen, Caroline Tanya; Ndung'u, Thumbi; Hunt, Peter W; He, Weijing; Ahuja, Sunil K

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Aug 25; 112(34):E4762-E4771

Structural Characterization of Two Monoclonal Antibodies Targeting the Fourth Constant Domain in the Bridging Sheet of HIV-1 gp120 [Meeting Abstract]

Pan, R. ; Chen, Y. ; Vaine, M. ; Wang, S. ; Kelker, H. C. ; Itri, V. R. ; Valentine, F. T. ; Lu, S. ; Kong, X.

AIDS research & human retroviruses. 2013 NOV 1; 29(11):A61-A62

Sivapalasingam, Sumathi; Ahmed, Aabid; Mendillo, Megan; Holzman, Robert; Marshed, Fatuma; Mwamzuka, Musa; Khamadi, Samuel; Mwau, Matilu; Laverty, Maura; Valentine, Fred

Pediatric infectious disease journal. 2012 Jul; 31(7):732-735

Mehta, Sapna A; Ahmed, Aabid; Laverty, Maura; Holzman, Robert S; Valentine, Fred; Sivapalasingam, Sumathi

Clinical infectious diseases. 2011 Sep; 53(5):490-496

Sabado, Rachel Lubong; O'Brien, Meagan; Subedi, Abhignya; Qin, Li; Hu, Nan; Taylor, Elizabeth; Dibben, Oliver; Stacey, Andrea; Fellay, Jacques; Shianna, Kevin V; Siegal, Frederick; Shodell, Michael; Shah, Kokila; Larsson, Marie; Lifson, Jeffrey; Nadas, Arthur; Marmor, Michael; Hutt, Richard; Margolis, David; Garmon, Donald; Markowitz, Martin; Valentine, Fred; Borrow, Persephone; Bhardwaj, Nina

Blood. 2010 Nov 11; 116(19):3839-3852

Mehta, Sapna A; Ahmed, Aabid; Kariuki, Beatrice W; Said, Swaleh; Omasete, Fanuel; Mendillo, Megan; Laverty, Maura; Holzman, Robert; Valentine, Fred; Sivapalasingam, Sumathi

American journal of tropical medicine & hygiene. 2010 Sep; 83(3):565-570

El Hed, Aimee; Khaitan, Alka; Kozhaya, Lina; Manel, Nicolas; Daskalakis, Demetre; Borkowsky, William; Valentine, Fred; Littman, Dan R; Unutmaz, Derya

Journal of infectious diseases. 2010 Mar 15; 201(6):843-854

Silvera, Richard; Stein, Dylan; Hutt, Richard; Hagerty, Robert; Daskalakis, Demetre; Valentine, Fred; Marmor, Michael

Open AIDS journal. 2010 Mar 05; 4:76-83