Our research involves clinical studies of immune responses to malignant melanoma. We have developed a method of inducing cellular immune responses to metastatic melanoma that result in frequent durable complete regressions of disease.
We also are interested in immunological and virological aspects of human immunodeficiency virus (HIV) infection. We are investigating HIV-specific cellular immune responses in acute, primary HIV infection and in elite controllers who "spontaneously" control HIV without antiretroviral drugs. We have discovered that individuals treated very early in their HIV infection develop strong CD4 T cell memory responses to HIV antigens, similar but often of smaller magnitude to the memory responses observed in elite controllers. Many individuals treated for one year after the onset of their infection are subsequently able to control their blood levels of HIV for at least 1 to 2 years after stopping their anti-HIV drugs.
Research Professor, Department of Medicine
MD from Harvard Medical School
Fellowship, NYU School of Medicine, Infectious Diseases and Immunology
Residency, Harvard Medical Service Boston City Hospital, Internal Medicine
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2015 Aug 25; 112(34):E4762-E4771
Structural Characterization of Two Monoclonal Antibodies Targeting the Fourth Constant Domain in the Bridging Sheet of HIV-1 gp120 [Meeting Abstract]
AIDS research & human retroviruses. 2013 NOV 1; 29(11):A61-A62
Pediatric infectious disease journal. 2012 Jul; 31(7):732-735
Clinical infectious diseases. 2011 Sep; 53(5):490-496
Blood. 2010 Nov 11; 116(19):3839-3852
American journal of tropical medicine & hygiene. 2010 Sep; 83(3):565-570
Journal of infectious diseases. 2010 Mar 15; 201(6):843-854
Open AIDS journal. 2010 Mar 05; 4:76-83