Gabriele Grunig

Gabriele Grunig, DVM

Research Professor, Department of Environmental Medicine

Research Professor, Department of Medicine

Keywords
lung diseases associated with environmental pollutants: asthma, chronic inflammation, airway and arterial remodeling, interactions between the immune system and environmental pollutants, Soluble mediators (cytokines such as IL-13, IL-10 family cytokines)
Summary

Exposure to airborne pollutants and cigarette smoke are major causes of chronic inflammation in the lungs. The lungs also become more susceptible to infection with viruses or bacteria. The result is the dysfunction of the bronchi that transport air to and from the alveoli, and to the blood vessels that circulate the blood through the lungs. The major focus point of research in the laboratory is to define the role of secreted proteins by which immune cells communicate with the cells that make up the structure of the lungs. This research has identified one of these mediators, called Interleukin-13 (IL-13), to directly initiate the processes that induce the cardinal signs of asthma: bronchial constriction, inflammation and increased mucus production. At the present time, we have a grant from the National Institute of Health that has the goal to help to develop a drug that inhibits Interleukin-13 and a few other key mediators of asthma. We have most recently begun to investigate the blood vessels in the lungs. We have shown for the first time experimentally that the immune response can induce severe wall-thickening of arteries (structure stained in brown by labeling with a smooth muscle specific antibody) in the lungs. In addition, the studies showed that Interleukin-13 (IL-13) is a critical, indirect communicator in the process that leads to the severe thickening of the pulmonary arterial walls. This thickening of the pulmonary arterial walls has been described in patients who have pulmonary hypertension, a debilitating disease that frequently accompanies chronic lung disease caused by smoking. This research might aid in developing new methods to follow disease progression and tailor treatment strategies in patients with pulmonary hypertension.

Phone

845-731-3669

Academic office

57 Old Forge Rd.

First Floor

Tuxedo, NY 10987

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Research Professor, Department of Environmental Medicine

Research Professor, Department of Medicine

DVM from University of Zurich

Genetic Background (mouse Strain) As Determinant Of The Role Of Resistin Like Molecule In The Response To Pulmonary Exposure With Antigen And Urban Fine Dust [Meeting Abstract]

Grunig, G; Park, S-H; Durmus, N

American journal of respiratory & critical care medicine. 2017; 195:?-?

Jian, Jinlong; Tian, Qing-Yun; Hettinghouse, Aubryanna; Zhao, Shuai; Liu, Helen; Wei, Jianlu; Grunig, Gabriele; Zhang, Wujuan; Setchell, Kenneth D R; Sun, Ying; Overkleeft, Herman S; Chan, Gerald L; Liu, Chuan-Ju

EBioMedicine. 2016 Nov; 13:212-224

Olschewski, A; Berghausen, E M; Eichstaedt, C A; Fleischmann, B K; Grunig, E; Grunig, G; Hansmann, G; Harbaum, L; Hennigs, J K; Jonigk, D; Kubler, W M; Kwapiszewska, G; Pullamsetti, S S; Stacher, E; Weissmann, N; Wenzel, D; Schermuly, R T

Deutsche medizinische Wochenschrift (1946). 2016 Oct; 141(S 01):S4-S9

Jian, Jinlong; Zhao, Shuai; Tian, Qing-Yun; Liu, Helen; Zhao, Yunpeng; Chen, Wen-Chi; Grunig, Gabriele; Torres, Paola A; Wang, Betty C; Zeng, Bai; Pastores, Gregory; Tang, Wei; Sun, Ying; Grabowski, Gregory A; Kong, Max Xiangtian; Wang, Guilin; Chen, Ying; Liang, Fengxia; Overkleeft, Herman S; Saunders-Pullman, Rachel; Chan, Gerald L; Liu, Chuan-Ju

EBioMedicine. 2016 Sep; 11:127-137

Paths To Acos: Evaluation Of Persistent Airflow Limitation In An Urban Population With Asthma [Meeting Abstract]

Doo, K; Xu, N; Shao, Y; Liu, M; Fernandez-Beros, M-E; Schattner, G; Garafano, S; Rogers, L; Grunig, G; Bleck, B; Reibman, J

American journal of respiratory & critical care medicine. 2016; 193:?-?

Effect Of Voluntary Exercise On Inflammation, Vascular And Airway Remodeling In A Mouse Model Of Pulmonary Hypertension Induced By Exposure To Antigen And Urban Particulate Matter [Meeting Abstract]

Durmus, N; Bleck, B; Reibman, J; Grunig, G

American journal of respiratory & critical care medicine. 2016; 193:?-?

Grunig, Gabriele; Durmus, Nedim

American journal of respiratory & critical care medicine. 2015 Oct 15; 192(8):913-915