George Lipkin

George Lipkin, MD

Professor, Ronald O. Perelman Department of Dermatology

Keywords
reversing malignant melanoma-restoring host control
Summary

Current treatment of malignancy is hindered by tumor cell heterogeneity and progressive clonal evolution. Reversion of the malignant phenotype by differentiation agents could favorably alter the tumor/host relationship by stabilizing phenotypes and reducing heterogeneity. We have identified a unique endogenous inhibitor in a revertant melanoma line, which restores normal growth control--density-, anchorage-, and serum-dependence--to melanoma cells. It induces early Gl growth arrest, differentiation antigens, and decreased susceptibility to natural killer cells with increased vulnerability to cytotoxic T cells and with increased class I MHC expression. Effects are nontoxic, reversible, and transcend species and tissue barriers. Treated melanoma and hepatoma cells exhibited striking cytoskeletal reorganization, including changes in an actin-binding substrate for phosphorylation by the EGF receptor. In situ treatment of lethal hamster melanoma transplants with liposome-entrapped partially purified inhibitor for 30 days led to complete tumor regression and 100% survival. In situ administration of inhibitor in an aqueous suspension to C57BL/6J mice with established subcutaneous Lewis lung carcinomas led to regression of 75% of tumors (no survivors in control mice). This new inhibitor appears to favorably alter the biologic balance between tumor and host by reducing heterogeneity, restoring sensitivity to normal environmental signals governing growth, and inducing surface markers which alert and facilitate host response. We have partially purified this inhibitor and distinguished it from other known tumor inhibitors. Our laboratory's focus is on completing purification, well under way, and developing a new, powerful, nontoxic, biologically rational, and more effective therapy for currently incurable cancers.

Phone

212-263-6653

Academic office

530 First Avenue

Suite 7C

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Professor, Ronald O. Perelman Department of Dermatology

MD from State University of New York Downstate Medical Center

Mundi, Jyoti P; Rose, Amy E; Boyd, Kevin P; Patel, Rishi R; Lipkin, George

Dermatology online journal. 2013 Dec 16; 19(12):20722-20722

Gonzalez, Mercedes E; Votava, Henry J; Lipkin, George; Sanchez, Miguel

Dermatology online journal. 2009 Aug 15; 15(8):17-17

Lipkin, George

Journal of investigative dermatology. 2008 Sep; 128(9):2152-2155

Acral dermatoses

Lipkin G

Current dermatologic diagnosis & treatment. Philadelphia : Lippincott Williams & Wilkins, 2001. p.6-7. (3668)

Lipkin G

Archives of dermatology (1960). 2000 Jan; 136(1):67-67

Baer RL; Bystryn JC; Cohen D; Curwin J; Freedberg IM; Kopf AW; Lipkin G; Podwal M; Shupack J

American journal of dermatopathology. 1994 Feb; 16(1):89-96

MODULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ACCOMPANIES REVERSION OF MALIGNANT-MELANOMA PHENOTYPE BY CONTACT INHIBITORY FACTOR [Meeting Abstract]

LIPKIN, G; MERUELO, D

Clinical research. 1992 Apr; 40(2):A528-A528

MODULATION OF MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGENS ACCOMPANIES REVERSION OF MALIGNANT-MELANOMA PHENOTYPE BY CONTACT INHIBITORY FACTOR [Meeting Abstract]

LIPKIN, G; MERUELO, D

Journal of investigative dermatology. 1992 Apr; 98(4):643-643