Assistant Professor, Department of Cell Biology
From atoms to cells to organisms, life is in constant motion. Every cell faces the challenge of transporting molecules from one location to another within the cell, a process that is essential for normal function. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. In our lab, we use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are spectacularly coordinated to facilitate transport in normal cells, and what goes wrong when they break.
We are interested in understanding how protein structure, function, and dynamics are coordinated in biological systems. We use structural biology techniques such as cryo-electron microscopy and X-ray crystallography, in combination with biochemistry, functional assays, and cell biology, to study complex macromolecular machines in cells. Our questions are centered on microbes and pathogens.
Fellowship, University of California, San Francisco, Ron Vale Lab
Nature communications. 2022 Apr 06; 13(1):1857
Journal of molecular biology. 2022 Jan 22; 167463
Nature communications. 2022 01 10; 13(1):17
Experientia supplementum (2012). 2022 Apr; 114:215-245
Cell chemical biology. 2021 Oct 21; 28(10):1460-1473.e15
Nature microbiology. 2021 Jun; 6(6):731-745
Nature communications. 2021 04 16; 12(1):2294