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Gira Bhabha

Gira Bhabha, PhD

Skirball Institute

Assistant Professor, Department of Cell Biology

Keywords
protein dynamics, molecular machines, cellular motility, cryo electron microscopy, structural biology, structure-dynamics-function relationships, motor proteins, lipid trafficking
Summary

From atoms to cells to organisms, life is in constant motion. Every cell faces the challenge of transporting molecules from one location to another within the cell, a process that is essential for normal function. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. In our lab, we use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are spectacularly coordinated to facilitate transport in normal cells, and what goes wrong when they break.

We are interested in understanding how protein structure, function, and dynamics are coordinated in biological systems. We use structural biology techniques such as cryo-electron microscopy and X-ray crystallography, in combination with biochemistry, functional assays and cell biology, to study complex macromolecular machines in cells.

To learn more about our lab and the specific questions we are addressing, please visit  http://bhabhalab.org/

 

Academic office

540 First Avenue, Skirball Institute

Second Floor, Lab 14

New York, NY 10016

Lab Website
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Assistant Professor, Department of Cell Biology

Fellowship, University of California, San Francisco

Niekamp, Stefan; Sung, Jongmin; Huynh, Walter; Bhabha, Gira; Vale, Ronald D; Stuurman, Nico

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 Feb 15;

Ekiert, Damian C; Bhabha, Gira; Isom, Georgia L; Greenan, Garrett; Ovchinnikov, Sergey; Henderson, Ian R; Cox, Jeffery S; Vale, Ronald D

Cell. 2017 04 06; 169(2):273-285.e17

Architectures of Lipid Transport Systems for the Bacterial Outer Membrane [Meeting Abstract]

Bhabha, Gira; Ekiert, Damian C; Greenan, Garrett; Ovchinnikov, Sergey; Cox, Jeffery; Vale, Ronald D

Biophysical journal. 2017 FEB 3; 112(3):14A-14A

Bhabha, Gira; Johnson, Graham T; Schroeder, Courtney M; Vale, Ronald D

Trends in biochemical sciences. 2016 Jan; 41(1):94-105

Brunette, T J; Parmeggiani, Fabio; Huang, Po-Ssu; Bhabha, Gira; Ekiert, Damian C; Tsutakawa, Susan E; Hura, Greg L; Tainer, John A; Baker, David

Nature. 2015 Dec 24; 528(7583):580-4

Bhabha, Gira; Biel, Justin T; Fraser, James S

Accounts of chemical research. 2015 Feb 17; 48(2):423-30

Bhabha, Gira; Cheng, Hui-Chun; Zhang, Nan; Moeller, Arne; Liao, Maofu; Speir, Jeffrey A; Cheng, Yifan; Vale, Ronald D

Cell. 2014 Nov 06; 159(4):857-68

Liu, Yu; Zhang, Xin; Tan, Yun Lei; Bhabha, Gira; Ekiert, Damian C; Kipnis, Yakov; Bjelic, Sinisa; Baker, David; Kelly, Jeffery W

Journal of the American Chemical Society. 2014 Sep 24; 136(38):13102-5