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Gira Bhabha

Gira Bhabha, PhD

Associate Professor, Department of Cell Biology

protein dynamics, molecular machines, cellular motility, cryo electron microscopy, structural biology, structure-dynamics-function relationships, motor proteins, lipid trafficking, host-parasite interactions, microbes, parasites, multi-scale imaging, pathogens

From atoms to cells to organisms, life is in constant motion. Every cell faces the challenge of transporting molecules from one location to another within the cell, a process that is essential for normal function. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. In our lab, we use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are spectacularly coordinated to facilitate transport in normal cells, and what goes wrong when they break.

We are interested in understanding how protein structure, function, and dynamics are coordinated in biological systems. We use structural biology techniques such as cryo-electron microscopy and X-ray crystallography, in combination with biochemistry, functional assays, and cell biology, to study complex macromolecular machines in cells. Our questions are centered on microbes and pathogens.

Academic office

540 First Avenue, Skirball Institute

Second Floor, Lab 14

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

Fellowship, University of California, San Francisco, Ron Vale Lab

Chen, James; Fruhauf, Alice; Fan, Catherine; Ponce, Jackeline; Ueberheide, Beatrix; Bhabha, Gira; Ekiert, Damian C

Nature. 2023 Aug; 620(7973):445-452

Chang, Ray; Davydov, Ari; Jaroenlak, Pattana; Budaitis, Breane; Ekiert, Damian C.; Bhabha, Gira; Prakash, Manu

eLife. 2023 Jun 01; 12:?-?

MacRae, Mark R; Puvanendran, Dhenesh; Haase, Max A B; Coudray, Nicolas; Kolich, Ljuvica; Lam, Cherry; Baek, Minkyung; Bhabha, Gira; Ekiert, Damian C

Journal of biological chemistry. 2023 Apr 24; 104744

Wu, Kejia; Bai, Hua; Chang, Ya-Ting; Redler, Rachel; McNally, Kerrie E; Sheffler, William; Brunette, T J; Hicks, Derrick R; Morgan, Tomos E; Stevens, Tim J; Broerman, Adam; Goreshnik, Inna; DeWitt, Michelle; Chow, Cameron M; Shen, Yihang; Stewart, Lance; Derivery, Emmanuel; Silva, Daniel Adriano; Bhabha, Gira; Ekiert, Damian C; Baker, David

Nature. 2023 Apr; 616(7957):581-589

Bermeo, Sherry; Favor, Andrew; Chang, Ya-Ting; Norris, Andrew; Boyken, Scott E; Hsia, Yang; Haddox, Hugh K; Xu, Chunfu; Brunette, T J; Wysocki, Vicki H; Bhabha, Gira; Ekiert, Damian C; Baker, David

Nature structural & molecular biology. 2022 Dec; 29(12):1266-1276

Giacometti, Sabrina I; MacRae, Mark R; Dancel-Manning, Kristen; Bhabha, Gira; Ekiert, Damian C

Annual review of cell & developmental biology. 2022 Oct 06; 38:125-153

Murareanu, Brandon M; Antao, Noelle V; Zhao, Winnie; Dubuffet, Aurore; El Alaoui, Hicham; Knox, Jessica; Ekiert, Damian C; Bhabha, Gira; Roy, Peter J; Reinke, Aaron W

Nature communications. 2022 Sep 26; 13(1):5653

Ekiert, Damian C; Coudray, Nicolas; Bhabha, Gira

Current opinion in structural biology. 2022 Aug 15; 76:102429