Associate Professor, Department of Cell Biology
From atoms to cells to organisms, life is in constant motion. Every cell faces the challenge of transporting molecules from one location to another within the cell, a process that is essential for normal function. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. In our lab, we use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are spectacularly coordinated to facilitate transport in normal cells, and what goes wrong when they break.
We are interested in understanding how protein structure, function, and dynamics are coordinated in biological systems. We use structural biology techniques such as cryo-electron microscopy and X-ray crystallography, in combination with biochemistry, functional assays, and cell biology, to study complex macromolecular machines in cells. Our questions are centered on microbes and pathogens.
540 First Avenue, Skirball Institute
Second Floor, Lab 14
New York, NY 10016
Associate Professor, Department of Cell Biology at NYU Grossman School of Medicine
Fellowship, University of California, San Francisco, Ron Vale Lab
Nature. 2023 Aug; 620(7973):445-452
eLife. 2023 Jun 01; 12:?-?
Journal of biological chemistry. 2023 Apr 24; 104744
Nature. 2023 Apr; 616(7957):581-589
Nature structural & molecular biology. 2022 Dec; 29(12):1266-1276
Annual review of cell & developmental biology. 2022 Oct 06; 38:125-153
Nature communications. 2022 Sep 26; 13(1):5653
Current opinion in structural biology. 2022 Aug 15; 76:102429