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Gira Bhabha

Gira Bhabha, PhD

Assistant Professor, Department of Cell Biology

Keywords
protein dynamics, molecular machines, cellular motility, cryo electron microscopy, structural biology, structure-dynamics-function relationships, motor proteins, lipid trafficking, host-parasite interactions, microbes, parasites, multi-scale imaging, pathogens
Summary

From atoms to cells to organisms, life is in constant motion. Every cell faces the challenge of transporting molecules from one location to another within the cell, a process that is essential for normal function. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. In our lab, we use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are spectacularly coordinated to facilitate transport in normal cells, and what goes wrong when they break.

We are interested in understanding how protein structure, function, and dynamics are coordinated in biological systems. We use structural biology techniques such as cryo-electron microscopy and X-ray crystallography, in combination with biochemistry, functional assays, and cell biology, to study complex macromolecular machines in cells. Our questions are centered on microbes and pathogens.

Academic office

540 First Avenue, Skirball Institute

Second Floor, Lab 14

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Fellowship, University of California, San Francisco, Ron Vale Lab

Kelley, Kotaro; Raczkowski, Ashleigh M; Klykov, Oleg; Jaroenlak, Pattana; Bobe, Daija; Kopylov, Mykhailo; Eng, Edward T; Bhabha, Gira; Potter, Clinton S; Carragher, Bridget; Noble, Alex J

Nature communications. 2022 Apr 06; 13(1):1857

Vieni, Casey; Coudray, Nicolas; Isom, Georgia L; Bhabha, Gira; Ekiert, Damian C

Journal of molecular biology. 2022 Jan 22; 167463

Lažetić, Vladimir; Wu, Fengting; Cohen, Lianne B; Reddy, Kirthi C; Chang, Ya-Ting; Gang, Spencer S; Bhabha, Gira; Troemel, Emily R

Nature communications. 2022 01 10; 13(1):17

Jaroenlak, Pattana; Usmani, Mahrukh; Ekiert, Damian C; Bhabha, Gira

Experientia supplementum (2012). 2022 Apr; 114:215-245

Santarossa, Cristina C; Mickolajczyk, Keith J; Steinman, Jonathan B; Urnavicius, Linas; Chen, Nan; Hirata, Yasuhiro; Fukase, Yoshiyuki; Coudray, Nicolas; Ekiert, Damian C; Bhabha, Gira; Kapoor, Tarun M

Cell chemical biology. 2021 Oct 21; 28(10):1460-1473.e15

Perelman, Sofya S; James, David B A; Boguslawski, Kristina M; Nelson, Chase W; Ilmain, Juliana K; Zwack, Erin E; Prescott, Rachel A; Mohamed, Adil; Tam, Kayan; Chan, Rita; Narechania, Apurva; Pawline, Miranda B; Vozhilla, Nikollaq; Moustafa, Ahmed M; Kim, Sang Y; Dittmann, Meike; Ekiert, Damian C; Bhabha, Gira; Shopsin, Bo; Planet, Paul J; Koralov, Sergei B; Torres, Victor J

Nature microbiology. 2021 Jun; 6(6):731-745

Hsia, Yang; Mout, Rubul; Sheffler, William; Edman, Natasha I; Vulovic, Ivan; Park, Young-Jun; Redler, Rachel L; Bick, Matthew J; Bera, Asim K; Courbet, Alexis; Kang, Alex; Brunette, T J; Nattermann, Una; Tsai, Evelyn; Saleem, Ayesha; Chow, Cameron M; Ekiert, Damian; Bhabha, Gira; Veesler, David; Baker, David

Nature communications. 2021 04 16; 12(1):2294

Daniloski, Zharko; Jordan, Tristan X; Ilmain, Juliana K; Guo, Xinyi; Bhabha, Gira; tenOever, Benjamin R; Sanjana, Neville E

eLife. 2021 02 11; 10: