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Gira Bhabha

Gira Bhabha, PhD

Associate Professor, Department of Cell Biology

Keywords
protein dynamics, molecular machines, cellular motility, cryo electron microscopy, structural biology, structure-dynamics-function relationships, motor proteins, lipid trafficking, host-parasite interactions, microbes, parasites, multi-scale imaging, pathogens
Summary

From atoms to cells to organisms, life is in constant motion. Every cell faces the challenge of transporting molecules from one location to another within the cell, a process that is essential for normal function. Proteins that are responsible for proper transport range from simple globular proteins to large multi-protein complexes. In our lab, we use a hybrid approach to study the structural mechanisms of how macromolecular protein machines are spectacularly coordinated to facilitate transport in normal cells, and what goes wrong when they break.

We are interested in understanding how protein structure, function, and dynamics are coordinated in biological systems. We use structural biology techniques such as cryo-electron microscopy and X-ray crystallography, in combination with biochemistry, functional assays, and cell biology, to study complex macromolecular machines in cells. Our questions are centered on microbes and pathogens.

Academic office

540 First Avenue, Skirball Institute

Second Floor, Lab 14

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Fellowship, University of California, San Francisco, Ron Vale Lab

Chang, Ray; Davydov, Ari; Jaroenlak, Pattana; Budaitis, Breane; Ekiert, Damian C; Bhabha, Gira; Prakash, Manu

eLife. 2024 Feb 21; 12:

Ilmain, Juliana K; Perelman, Sofya S; Panepinto, Maria C; Irnov, Irnov; Coudray, Nicolas; Samhadaneh, Nora; Pironti, Alejandro; Ueberheide, Beatrix; Ekiert, Damian C; Bhabha, Gira; Torres, Victor J

Journal of biological chemistry. 2023 Dec; 299(12):105321

Alexander, Leila T; Durairaj, Janani; Kryshtafovych, Andriy; Abriata, Luciano A; Bayo, Yusupha; Bhabha, Gira; Breyton, Cécile; Caulton, Simon G; Chen, James; Degroux, Séraphine; Ekiert, Damian C; Erlandsen, Benedikte S; Freddolino, Peter L; Gilzer, Dominic; Greening, Chris; Grimes, Jonathan M; Grinter, Rhys; Gurusaran, Manickam; Hartmann, Marcus D; Hitchman, Charlie J; Keown, Jeremy R; Kropp, Ashleigh; Kursula, Petri; Lovering, Andrew L; Lemaitre, Bruno; Lia, Andrea; Liu, Shiheng; Logotheti, Maria; Lu, Shuze; Markússon, Sigurbjörn; Miller, Mitchell D; Minasov, George; Niemann, Hartmut H; Opazo, Felipe; Phillips, George N; Davies, Owen R; Rommelaere, Samuel; Rosas-Lemus, Monica; Roversi, Pietro; Satchell, Karla; Smith, Nathan; Wilson, Mark A; Wu, Kuan-Lin; Xia, Xian; Xiao, Han; Zhang, Wenhua; Zhou, Z Hong; Fidelis, Krzysztof; Topf, Maya; Moult, John; Schwede, Torsten

Proteins. 2023 Dec; 91(12):1571-1599

Antao, Noelle V; Lam, Cherry; Davydov, Ari; Riggi, Margot; Sall, Joseph; Petzold, Christopher; Liang, Feng-Xia; Iwasa, Janet H; Ekiert, Damian C; Bhabha, Gira

Nature communications. 2023 Nov 23; 14(1):7662

Chen, James; Fruhauf, Alice; Fan, Catherine; Ponce, Jackeline; Ueberheide, Beatrix; Bhabha, Gira; Ekiert, Damian C

Nature. 2023 Aug; 620(7973):445-452

Chang, Ray; Davydov, Ari; Jaroenlak, Pattana; Budaitis, Breane; Ekiert, Damian C.; Bhabha, Gira; Prakash, Manu

eLife. 2023 Jun 01; 12:?-?

MacRae, Mark R; Puvanendran, Dhenesh; Haase, Max A B; Coudray, Nicolas; Kolich, Ljuvica; Lam, Cherry; Baek, Minkyung; Bhabha, Gira; Ekiert, Damian C

Journal of biological chemistry. 2023 Apr 24; 104744

Wu, Kejia; Bai, Hua; Chang, Ya-Ting; Redler, Rachel; McNally, Kerrie E; Sheffler, William; Brunette, T J; Hicks, Derrick R; Morgan, Tomos E; Stevens, Tim J; Broerman, Adam; Goreshnik, Inna; DeWitt, Michelle; Chow, Cameron M; Shen, Yihang; Stewart, Lance; Derivery, Emmanuel; Silva, Daniel Adriano; Bhabha, Gira; Ekiert, Damian C; Baker, David

Nature. 2023 Apr; 616(7957):581-589