Hakhamanesh Mostafavi

Hakhamanesh Mostafavi, PhD

Center for Human Genetics & Genomics

Assistant Professor, Department of Population Health

Keywords
Complex Traits and Diseases, Population and Statistical Genetics, Functional Genomics, Phenotypic Prediction
Summary

My group uses and develops computational and theoretical approaches to address fundamental questions about the biology of human traits and diseases.

How does genetic variation lead to phenotypic variation? Which genes underlie specific traits, and why? What cellular and molecular processes mediate the genetic effects? How can functional knowledge inform disease prediction and prevention?

To address these fundamental questions, our work integrates molecular and cellular perspectives with insights from evolutionary and population genetics.

Phone

212-263-0865

Academic office

550 First Avenue, Medical Science Building

3rd Floor, Room 116

New York, NY 10016

Lab Website
Mostafavi Lab
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Positions

Assistant Professor, Department of Population Health at NYU Grossman School of Medicine

Center for Human Genetics & Genomics

Graduate Education

PhD from Columbia University

Postdoctoral Training

Stanford University, Genetics

Systematic differences in discovery of genetic effects on gene expression and complex traits

Mostafavi, Hakhamanesh; Spence, Jeffrey P; Naqvi, Sahin; Pritchard, Jonathan K

Nature genetics. 2023 Nov; 55(11):1866-1875

Variable prediction accuracy of polygenic scores within an ancestry group

Mostafavi, Hakhamanesh; Harpak, Arbel; Agarwal, Ipsita; Conley, Dalton; Pritchard, Jonathan K; Przeworski, Molly

eLife. 2020 Jan 30; 9:

Identifying genetic variants that affect viability in large cohorts

Mostafavi, Hakhamanesh; Berisa, Tomaz; Day, Felix R; Perry, John R B; Przeworski, Molly; Pickrell, Joseph K

PLoS biology. 2017 Sep; 15(9):e2002458

Bayesian estimation of gene constraint from an evolutionary model with gene features

Zeng, Tony; Spence, Jeffrey P; Mostafavi, Hakhamanesh; Pritchard, Jonathan K

Nature genetics. 2024 Aug; 56(8):1632-1643

Measuring intolerance to mutation in human genetics

Fuller, Zachary L; Berg, Jeremy J; Mostafavi, Hakhamanesh; Sella, Guy; Przeworski, Molly

Nature genetics. 2019 May; 51(5):772-776

Genetic interactions drive heterogeneity in causal variant effect sizes for gene expression and complex traits

Patel, Roshni A; Musharoff, Shaila A; Spence, Jeffrey P; Pimentel, Harold; Tcheandjieu, Catherine; Mostafavi, Hakhamanesh; Sinnott-Armstrong, Nasa; Clarke, Shoa L; Smith, Courtney J; Durda, Peter P; Taylor, Kent D; Tracy, Russell; Liu, Yongmei; Johnson, W Craig; Aguet, Francois; Ardlie, Kristin G; Gabriel, Stacey; Smith, Josh; Nickerson, Deborah A; Rich, Stephen S; Rotter, Jerome I; Tsao, Philip S; Assimes, Themistocles L; Pritchard, Jonathan K

American journal of human genetics. 2022 Jul 07; 109(7):1286-1297

Bayesian model comparison for rare-variant association studies

Venkataraman, Guhan Ram; DeBoever, Christopher; Tanigawa, Yosuke; Aguirre, Matthew; Ioannidis, Alexander G; Mostafavi, Hakhamanesh; Spencer, Chris C A; Poterba, Timothy; Bustamante, Carlos D; Daly, Mark J; Pirinen, Matti; Rivas, Manuel A

American journal of human genetics. 2021 Dec 02; 108(12):2354-2367

A Litmus Test for Confounding in Polygenic Scores

Smith, Samuel Pattillo; Smith, Olivia S; Mostafavi, Hakhamanesh; Peng, Dandan; Berg, Jeremy J; Edge, Michael D; Harpak, Arbel

bioRxiv.org : the preprint server for biology. 2025 Feb 04;

See All Publications (16)