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Harvey I. Pass

Harvey I. Pass, MD

Stephen E. Banner Professor of Thoracic Oncology, Department of Cardiothoracic Surgery

Professor, Department of Surgery

osteopontin, fibulin 3, lung cancer, microRNA, proteomics, mesothelioma, asbestos, screening, early detection, thoracic oncology

The Thoracic Oncology laboratory investigates biomarker signatures for lung cancer and mesothelioma both in tissue and in the blood for discovery and validation. This work is supported by the National Cancer Institute Early Detection Research Network since 2005. Specifically our interests include the use of plasma osteopontin for the early detection and diagnosis of lung cancer, and studies of the role of osteopontin isoforms in order to increase specificity. Osteopontin is also being investigated for the prognosis of early lung cancer and mesothelioma, and we have demonstrated that plasma osteopontin can stratify resected Stage I lung cancers by their disease free survival. In mesothelioma, modeling of clinical parameters with plasma osteopontin can predict which patients will have long term survival. Other mesothelioma biomarkers include Fibulin 3 which to date has the highest sensitivity and specificty published for the diagnosis of mesothelioma using blood based biomarkers. Fibulin 3 levels in blood as well as in pleural effusions can differentiate mesothelioma from individuals with benign effusions, from others with non mesothelioma malignant effusions, and from patients exposed to asbestos but who do not have mesothelioma. A large validation study using an asbestos exposed cohort of individuals in Santiago Chile funded by the NCI will commence in the third quarter of 2015.  MicroRNA studies, using NanoString are also the subject of an NCI awarded RO1 to Drs. Pass and Carlo Croce for the differential diagnosis of the solitary pulmonary nodule, and these studies are ongoing. The Thoracic Oncology Laboratory collaborates with Industry for the discovery and validation of biomarkers. Biomarker profiles for lung cancer and mesothelioma using  Slow Off Rate Modified Aptamers (SOMAmers) in collaboration with Somalogic, Boulder CO, have been published and are in final validation phases. Other proteomic based plasma biomarker studies for lung cancer have been reported in collaboration with Integrated Diagnostics.





Academic office

530 First Avenue

Skirball 9V

New York, NY 10016

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Vice Chair of Research, Department of Cardiothoracic Surgery

MD from Duke University

Altorki, Nasser; Wang, Xiaofei; Kozono, David; Watt, Colleen; Landrenau, Rodney; Wigle, Dennis; Port, Jeffrey; Jones, David R; Conti, Massimo; Ashrafi, Ahmad S; Liberman, Moishe; Yasufuku, Kazuhiro; Yang, Stephen; Mitchell, John D; Pass, Harvey; Keenan, Robert; Bauer, Thomas; Miller, Daniel; Kohman, Leslie J; Stinchcombe, Thomas E; Vokes, Everett

New England journal of medicine. 2023 Feb 09; 388(6):489-498

Kwok, Benjamin; Wu, Benjamin G; Kocak, Ibrahim F; Sulaiman, Imran; Schluger, Rosemary; Li, Yonghua; Anwer, Raheel; Goparaju, Chandra; Ryan, Daniel J; Sagatelian, Marla; Dreier, Matthew S; Murthy, Vivek; Rafeq, Samaan; Michaud, Gaetane C; Sterman, Daniel H; Bessich, Jamie L; Pass, Harvey I; Segal, Leopoldo N; Tsay, Jun-Chieh J

Scientific reports. 2023 Feb 08; 13(1):2229

Peters, Brandilyn A; Pass, Harvey I; Burk, Robert D; Xue, Xiaonan; Goparaju, Chandra; Sollecito, Christopher C; Grassi, Evan; Segal, Leopoldo N; Tsay, Jun-Chieh J; Hayes, Richard B; Ahn, Jiyoung

Genome medicine. 2022 10 27; 14(1):121

Guidry, Kayla; Vasudevaraja, Varshini; Labbe, Kristen; Mohamed, Hussein; Serrano, Jonathan; Guidry, Brett W; DeLorenzo, Michael; Zhang, Hua; Deng, Jiehui; Sahu, Soumyadip; Almonte, Christina; Moreira, Andre L; Tsirigos, Aristotelis; Papagiannakopoulos, Thales; Pass, Harvey; Snuderl, Matija; Wong, Kwok-Kin

Clinical cancer research. 2022 Sep 01; 28(17):3824-3835

Carbone, Michele; Pass, Harvey I; Ak, Guntulu; Alexander, H Richard; Baas, Paul; Baumann, Francine; Blakely, Andrew M; Bueno, Raphael; Bzura, Aleksandra; Cardillo, Giuseppe; Churpek, Jane E; Dianzani, Irma; De Rienzo, Assunta; Emi, Mitsuru; Emri, Salih; Felley-Bosco, Emanuela; Fennell, Dean A; Flores, Raja M; Grosso, Federica; Hayward, Nicholas K; Hesdorffer, Mary; Hoang, Chuong D; Johansson, Peter A; Kindler, Hedy L; Kittaneh, Muaiad; Krausz, Thomas; Mansfield, Aaron; Metintas, Muzaffer; Minaai, Michael; Mutti, Luciano; Nielsen, Maartje; O'Byrne, Kenneth; Opitz, Isabelle; Pastorino, Sandra; Pentimalli, Francesca; de Perrot, Marc; Pritchard, Antonia; Ripley, Robert Taylor; Robinson, Bruce; Rusch, Valerie; Taioli, Emanuela; Takinishi, Yasutaka; Tanji, Mika; Tsao, Anne S; Tuncer, A Murat; Walpole, Sebastian; Wolf, Andrea; Yang, Haining; Yoshikawa, Yoshie; Zolodnick, Alicia; Schrump, David S; Hassan, Raffit

Journal of thoracic oncology. 2022 Jul; 17(7):873-889

Chen, Stacey; Malas, Jad; Latson, Larry A; Narula, Navneet; Rapkiewicz, Amy V; Williams, David M; Pass, Harvey I; Galloway, Aubrey C; Smith, Deane E

Aorta. 2022 Jun; 10(3):104-113

Zhou, Fang; Villalba, Julian A; Sayo, Treah May S; Narula, Navneet; Pass, Harvey; Mino-Kenudson, Mari; Moreira, Andre L

Modern pathology. 2022 Feb; 35(2):210-217

Marzio, Antonio; Kurz, Emma; Sahni, Jennifer M; Di Feo, Giuseppe; Puccini, Joseph; Jiang, Shaowen; Hirsch, Carolina Alcantara; Arbini, Arnaldo A; Wu, Warren L; Pass, Harvey I; Bar-Sagi, Dafna; Papagiannakopoulos, Thales; Pagano, Michele

Cell. 2022 Jan 06; 185(1):169-183.e19