Helen E. Scharfman

My Research

Keywords

hippocampus and parahippocampal areas, their role in normal function and their contribution to neurological disorders and mental illness, neurotrophins (BDNF)and neuronal plasticity , neurogenesis in the dentate gyrus , mechanisms controlling neuronal excitability; seizures; epilepsy, neuronal modulation by reproductive steroids, brain and spinal cord injury; neuroprotection, imaging, molecular, cellular, & translational neuroscience, systems, cognitive, & computational neuroscience

Contact

Phone

845-398-5427

Helen.Scharfman@nyulangone.org

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Positions & Education

Positions

Professor, Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine

Professor, Department of Neuroscience at NYU Grossman School of Medicine

Professor, Department of Psychiatry at NYU Grossman School of Medicine

Selected Publications

Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer's disease. Opens in a new tab

Alcantara-Gonzalez, David; Kennedy, Meghan; Criscuolo, Chiara; Botterill, Justin; Scharfman, Helen E

Alzheimer's research & therapy. 2025 May 15; 17(1):105

Adenosine Makes a Scene. Opens in a new tab

Scharfman, Helen E

Epilepsy currents. 2025 Apr 16; 15357597251323126

Field EPSPs of Dentate Gyrus Granule Cells Studied by Selective Optogenetic Activation of Hilar Mossy Cells in Hippocampal Slices. Opens in a new tab

Bernstein, Hannah L; Lu, Yi-Ling; Botterill, Justin J; Duffy, Áine M; LaFrancois, John J; Scharfman, Helen E

Hippocampus. 2025 Jan; 35(1):e23652

Increasing adult-born neurons protects mice from epilepsy. Opens in a new tab

Jain, Swati; LaFrancois, John J; Gerencer, Kasey; Botterill, Justin J; Kennedy, Meghan; Criscuolo, Chiara; Scharfman, Helen E

eLife. 2024 Oct 24; 12:

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease. Opens in a new tab

Chartampila, Elissavet; Elayouby, Karim S; Leary, Paige; LaFrancois, John J; Alcantara-Gonzalez, David; Jain, Swati; Gerencer, Kasey; Botterill, Justin J; Ginsberg, Stephen D; Scharfman, Helen E

eLife. 2024 Jun 21; 12:

Dentate Gyrus Granule Cells Show Stability of BDNF Protein Expression in Mossy Fiber Axons with Age, and Resistance to Alzheimer's Disease Neuropathology in a Mouse Model. Opens in a new tab

Criscuolo, Chiara; Chartampila, Elissavet; Ginsberg, Stephen D; Scharfman, Helen E

eNeuro. 2024 Mar; 11(3):

High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer's Disease. Opens in a new tab

Lisgaras, Christos Panagiotis; Scharfman, Helen E

bioRxiv.org : the preprint server for biology. 2023 Nov 02;

Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum. Opens in a new tab