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Helen E. Scharfman

Helen E. Scharfman, PhD

Professor, Department of Child and Adolescent Psychiatry

Professor, Department of Neuroscience and Physiology

Professor, Department of Psychiatry

Keywords
hippocampus and parahippocampal areas, their role in normal function and their contribution to neurological disorders and mental illness, neurotrophins (BDNF)and neuronal plasticity , neurogenesis in the dentate gyrus , mechanisms controlling neuronal excitability; seizures; epilepsy, neuronal modulation by reproductive steroids, brain and spinal cord injury; neuroprotection, imaging, molecular, cellular, & translational neuroscience, systems, cognitive, & computational neuroscience

Phone

845-398-5427

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Positions

Professor, Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine

Professor, Department of Neuroscience and Physiology at NYU Grossman School of Medicine

Professor, Department of Psychiatry at NYU Grossman School of Medicine

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease

Chartampila, Elissavet; Elayouby, Karim S; Leary, Paige; LaFrancois, John J; Alcantara-Gonzalez, David; Jain, Swati; Gerencer, Kasey; Botterill, Justin J; Ginsberg, Stephen D; Scharfman, Helen E

eLife. 2024 Jun 21; 12:

Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum

Lisgaras, Christos Panagiotis; Scharfman, Helen E

Neurobiology of disease. 2023 Oct 15; 187:106294

Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy

Whitebirch, Alexander C; Santoro, Bina; Barnett, Anastasia; Lisgaras, Christos Panagiotis; Scharfman, Helen E; Siegelbaum, Steven A

Journal of neuroscience. 2023 Oct 11; 43(41):6930-6949

Assessments of dentate gyrus function: discoveries and debates

Borzello, Mia; Ramirez, Steve; Treves, Alessandro; Lee, Inah; Scharfman, Helen; Stark, Craig; Knierim, James J; Rangel, Lara M

Nature reviews. Neuroscience. 2023 Aug; 24(8):502-517

Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity

Rosenberg, Evan C; Chamberland, Simon; Bazelot, Michael; Nebet, Erica R; Wang, Xiaohan; McKenzie, Sam; Jain, Swati; Greenhill, Stuart; Wilson, Max; Marley, Nicole; Salah, Alejandro; Bailey, Shanice; Patra, Pabitra Hriday; Rose, Rebecca; Chenouard, Nicolas; Sun, Simón E D; Jones, Drew; Buzsáki, György; Devinsky, Orrin; Woodhall, Gavin; Scharfman, Helen E; Whalley, Benjamin J; Tsien, Richard W

Neuron. 2023 Apr 19; 111(8):1282-1300.e8

High Frequency Oscillations (250-500Hz) in Animal Models of Alzheimer's Disease and Two Animal Models of Epilepsy

Lisgaras, Christos Panagiotis; Scharfman, Helen E

Epilepsia. 2023 Jan; 64(1):231-246

Hippocampal mossy cells exhibit some of the earliest signs of increased excitability in the Tg2576 model of Alzheimer"™s disease neuropathology

Alcantara-Gonzalez, David; Criscuolo, Chiara; Botterill, Justin J.; Lisgaras, Christos; Kennedy, Meghan; Scharfman, Helen E.

Alzheimer's & dementia. 2022 Dec 01; 18(<prism:issueIdentifier>S4):?-?

Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy

Whitebirch, Alexander C; LaFrancois, John J; Jain, Swati; Leary, Paige; Santoro, Bina; Siegelbaum, Steven A; Scharfman, Helen E

Neuron. 2022 Oct 05; 110(19):3121-3138.e8

See All Publications (203)

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