Helen E. Scharfman

Helen E. Scharfman, PhD

Professor, Department of Child and Adolescent Psychiatry

Professor, Department of Neuroscience and Physiology

Professor, Department of Psychiatry

Keywords
hippocampus and parahippocampal areas, their role in normal function and their contribution to neurological disorders and mental illness, neurotrophins (BDNF)and neuronal plasticity , neurogenesis in the dentate gyrus , mechanisms controlling neuronal excitability; seizures; epilepsy, neuronal modulation by reproductive steroids, brain and spinal cord injury; neuroprotection, imaging, molecular, cellular, & translational neuroscience, systems, cognitive, & computational neuroscience

Phone

845-398-5427

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Positions

Professor, Department of Child and Adolescent Psychiatry at NYU Grossman School of Medicine

Professor, Department of Neuroscience and Physiology at NYU Grossman School of Medicine

Professor, Department of Psychiatry at NYU Grossman School of Medicine

Field EPSPs of Dentate Gyrus Granule Cells Studied by Selective Optogenetic Activation of Hilar Mossy Cells in Hippocampal Slices

Bernstein, Hannah L; Lu, Yi-Ling; Botterill, Justin J; Duffy, Áine M; LaFrancois, John J; Scharfman, Helen E

Hippocampus. 2025 Jan; 35(1):e23652

Increasing adult-born neurons protects mice from epilepsy

Jain, Swati; LaFrancois, John J; Gerencer, Kasey; Botterill, Justin J; Kennedy, Meghan; Criscuolo, Chiara; Scharfman, Helen E

eLife. 2024 Oct 24; 12:

Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease

Chartampila, Elissavet; Elayouby, Karim S; Leary, Paige; LaFrancois, John J; Alcantara-Gonzalez, David; Jain, Swati; Gerencer, Kasey; Botterill, Justin J; Ginsberg, Stephen D; Scharfman, Helen E

eLife. 2024 Jun 21; 12:

Dentate Gyrus Granule Cells Show Stability of BDNF Protein Expression in Mossy Fiber Axons with Age, and Resistance to Alzheimer's Disease Neuropathology in a Mouse Model

Criscuolo, Chiara; Chartampila, Elissavet; Ginsberg, Stephen D; Scharfman, Helen E

eNeuro. 2024 Mar; 11(3):

High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer's Disease

Lisgaras, Christos Panagiotis; Scharfman, Helen E

bioRxiv.org : the preprint server for biology. 2023 Nov 02;

Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum

Lisgaras, Christos Panagiotis; Scharfman, Helen E

Neurobiology of disease. 2023 Oct 15; 187:106294

Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy

Whitebirch, Alexander C; Santoro, Bina; Barnett, Anastasia; Lisgaras, Christos Panagiotis; Scharfman, Helen E; Siegelbaum, Steven A

Journal of neuroscience. 2023 Oct 11; 43(41):6930-6949

Interictal Spikes in Alzheimer's Disease: Preclinical Evidence for Dominance of the Dentate Gyrus and Cholinergic Control by Medial Septum

Lisgaras, Christos Panagiotis; Scharfman, Helen E

bioRxiv.org : the preprint server for biology. 2023 Aug 16;

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