Hong Sun

Hong Sun, PhD

Assistant Professor, Department of Medicine

Keywords
Carcinogenesis, Epigenetics, Metal toxicity, Genome integrity, Stem cell, Muscle regeneration
Summary

My research primarily focuses on the epigenetic regulation of cell proliferation, differentiation, and malignant transformation by environmental toxic metals, as well as their impact on human diseases. Our studies have demonstrated that hexavalent chromium, a group I human carcinogen, can modulate epigenetic programming by targeting histone modification enzymes. This targeting leads to the silencing of crucial tumor suppressor genes, thereby promoting cell transformation and carcinogenesis. Our ongoing research employs in vitro cultured cells, 3D tissue organoids, and genetically modified mouse models to investigate the mechanisms of metal-induced lung carcinogenesis. 

Recently, we initiated a new study to explore the effects of hexavalent chromium exposure on skeletal muscle development, health, and regeneration. This area is relatively new and largely understudied. Our recent findings showed that chromium exposure inhibited myogenic differentiation in both C2C12 myoblasts (in vitro) and freshly isolated satellite cells (ex vivo). Future studies will integrate multiple levels of analysis to investigate the impact of chromium exposure on embryonic myogenesis and adult muscle regeneration in vivo, as well as the potential involvement of epigenetic mechanisms.

Phone

646-754-9459

Academic office

341 East 25th St.

Second Floor, 217

New York, NY 10010

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PhD from Shanghai University

Mount Sinai School of Medicine, Molecular, Cellular, and Developmental Biology

Li, Ling-Bing; Yang, Ling-Xiao; Liu, Lei; Liu, Fan-Rong; Li, Alex H; Zhu, Yi-Lin; Wen, Hao; Xue, Xia; Tian, Zhong-Xian; Sun, Hong; Li, Pei-Chao; Zhao, Xiao-Gang

Acta pharmacologica Sinica. 2024 May; 45(5):1060-1076

Li, Peichao; Yang, Lingxiao; Park, Sun Young; Liu, Fanrong; Li, Alex H; Zhu, Yilin; Sui, Huacong; Gao, Fengyuan; Li, Lingbing; Ye, Lan; Zou, Yongxin; Tian, Zhongxian; Zhao, Yunpeng; Costa, Max; Sun, Hong; Zhao, Xiaogang

Oncogene. 2024 Mar; 43(12):899-917

Li, Alex H; Park, Sun Young; Li, Peiwei; Zhou, Chaoting; Kluz, Thomas; Li, Jingxia; Costa, Max; Sun, Hong

International journal of molecular sciences. 2024 Feb 01; 25(3):

Ortiz, Angelica; Sun, Hong; Kluz, Thomas; Matsui, Mary S; Carle, Tiffany; Gan, David; Gordon, Terry; Gildea, Lucy; Costa, Max

International journal of cosmetic science. 2023 Dec; 45(6):791-801

Park, Sun Young; Liu, Shan; Carbajal, Edgar Perez; Wosczyna, Michael; Costa, Max; Sun, Hong

Toxicology & applied pharmacology. 2023 Oct 15; 477:116693

Luo, Junwen; Tian, Zhongxian; Zhou, Yongjia; Xiao, Zhaohua; Park, Sun Young; Sun, Hong; Zhuang, Ting; Wang, Yongjie; Li, Peiwei; Zhao, Xiaogang

Cancer science. 2023 Jul; 114(7):2835-2847

Park, Sun Young; Karantenislis, Georgia; Rosen, Hannah T; Sun, Hong

Scientific reports. 2023 May 25; 13(1):8481

Park, Sung-Hyun; Lu, Yuting; Shao, Yongzhao; Prophete, Colette; Horton, Lori; Sisco, Maureen; Lee, Hyun-Wook; Kluz, Thomas; Sun, Hong; Costa, Max; Zelikoff, Judith; Chen, Lung-Chi; Gorr, Matthew W; Wold, Loren E; Cohen, Mitchell D

International journal of environmental research & public health. 2022 Jan 14; 19(2):