Assistant Professor, Department of Medicine
My research primarily focuses on the epigenetic regulation of cell proliferation, differentiation, and malignant transformation by environmental toxic metals, as well as their impact on human diseases. Our studies have demonstrated that hexavalent chromium, a group I human carcinogen, can modulate epigenetic programming by targeting histone modification enzymes. This targeting leads to the silencing of crucial tumor suppressor genes, thereby promoting cell transformation and carcinogenesis. Our ongoing research employs in vitro cultured cells, 3D tissue organoids, and genetically modified mouse models to investigate the mechanisms of metal-induced lung carcinogenesis.
Recently, we initiated a new study to explore the effects of hexavalent chromium exposure on skeletal muscle development, health, and regeneration. This area is relatively new and largely understudied. Our recent findings showed that chromium exposure inhibited myogenic differentiation in both C2C12 myoblasts (in vitro) and freshly isolated satellite cells (ex vivo). Future studies will integrate multiple levels of analysis to investigate the impact of chromium exposure on embryonic myogenesis and adult muscle regeneration in vivo, as well as the potential involvement of epigenetic mechanisms.
646-754-9459
341 East 25th St.
Second Floor, 217
New York, NY 10010
Assistant Professor, Department of Medicine at NYU Grossman School of Medicine
PhD from Shanghai University
Mount Sinai School of Medicine, Molecular, Cellular, and Developmental Biology
Acta pharmacologica Sinica. 2024 May; 45(5):1060-1076
International journal of molecular sciences. 2024 Feb 01; 25(3):
International journal of cosmetic science. 2023 Dec; 45(6):791-801
Toxicology & applied pharmacology. 2023 Oct 15; 477:116693
Cancer science. 2023 Jul; 114(7):2835-2847
Scientific reports. 2023 May 25; 13(1):8481
International journal of environmental research & public health. 2022 Jan 14; 19(2):