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Ian J. Mohr

Ian J. Mohr, PhD

Professor, Department of Microbiology

Keywords
translational control of gene expression in virus infected cells, cancer, genome integrity, immunology, microbiology, RNA biology
Summary

My laboratory utilizes virus infection models to investigate how gene expression is regulated post-transcriptionally by physiological stress. Besides ensuring swift spatially & temporally coordinated responses, post-transcriptional control of gene expression is exceptionally important in virus infection biology as virus are absolutely reliant on host protein synthetic functions for their replication and pathogenesis. Moreover, many cell intrinsic host anti-viral responses target mRNA decay and the regulation of protein synthesis. By leveraging virus infection models as powerful genetic and cell biological tools, we can tease apart fundamental cellular mechanisms regulating gene expression. Our research uses a variety different viruses, exploiting natural features of individual virus reproductive cycles to investigate specific aspects of gene expression control in infected cells. 

Ongoing research areas include:

i)  how RNA chemical modification impacts virus gene expression and host innate immune responses
ii) how ribosomes and ribosome biogenesis regulate infected cell gene expression
iii) differential regulation of virus vs host gene expression in infected cells 
iv) how virus latency in neurons is regulated by sustained activation of a neurotrophic signaling pathway that regulates protein synthesis together  with concurrent DNA damage response signaling.

Phone

212-263-0415

Academic office

430 East 29th Street, Alexandria - West Tower

5th floor, 510

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
represents one publication
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*Due to PubMed processing times, the most recent publications may not be reflected in the timeline.

PhD from State University of New York at Stony Brook

University of California, Berkeley, Molecular and Cell Biology

Thompson, Letitia; Depledge, Daniel P; Burgess, Hannah M; Mohr, Ian

Cell reports. 2022 05 03; 39(5):110767

Abebe, Jonathan S; Price, Alexander M; Hayer, Katharina E; Mohr, Ian; Weitzman, Matthew D; Wilson, Angus C; Depledge, Daniel P

Bioinformatics. 2022 Apr 15;

Ly, Michael; Burgess, Hannah M; Shah, Sahil B; Mohr, Ian; Glaunsinger, Britt A

PLoS pathogens. 2022 Feb 24; 18(2):e1010099

Burgess, Hannah M; Vink, Elizabeth I; Mohr, Ian

Genes & development. 2022 Feb 01; 36(3-4):108-132

Wilson, Angus C; Mohr, Ian

Advances in virus research. 2022 Jul; 112:87-114

Barrett, Tessa J; Bilaloglu, Seda; Cornwell, Macintosh; Burgess, Hannah M; Virginio, Vitor W; Drenkova, Kamelia; Ibrahim, Homam; Yuriditsky, Eugene; Aphinyanaphongs, Yin; Lifshitz, Mark; Xia Liang, Feng; Alejo, Julie; Smith, Grace; Pittaluga, Stefania; Rapkiewicz, Amy V; Wang, Jun; Iancu-Rubin, Camelia; Mohr, Ian; Ruggles, Kelly; Stapleford, Kenneth A; Hochman, Judith; Berger, Jeffrey S

Journal of thrombosis & haemostasis : JTH. 2021 Dec; 19(12):3139-3153

Hu, Hui-Lan; Srinivas, Kalanghad P; Wang, Shuoshuo; Chao, Moses V; Lionnet, Timothee; Mohr, Ian; Wilson, Angus C; Depledge, Daniel P; Huang, Tony T

EMBO reports. 2021 Nov 29; e53543

Vink, Elizabeth I; Andrews, John; Duffy, Carol; Mohr, Ian

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2021 11 09; 118(45):