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Ian M. Ahearn

Ian M. Ahearn, MD, PhD

Research Assistant Professor, Ronald O. Perelman Department of Dermatology

Positions

Research Assistant Professor, Ronald O. Perelman Department of Dermatology at NYU Grossman School of Medicine

Graduate Education

MD from New York University

PhD from New York University

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Palmitoylation and PDE6δ regulate membrane-compartment-specific substrate ubiquitylation and degradation

Liang, David; Jiang, Liping; Bhat, Sameer Ahmed; Missiroli, Sonia; Perrone, Mariasole; Lauriola, Angela; Adhikari, Ritika; Gudur, Anish; Vasi, Zahra; Ahearn, Ian; Guardavaccaro, Daniele; Giorgi, Carlotta; Philips, Mark; Kuchay, Shafi

Cell reports. 2023 Jan 31; 42(1):111999

NRAS is unique among RAS proteins in requiring ICMT for trafficking to the plasma membrane

Ahearn, Ian M; Court, Helen R; Siddiqui, Farid; Abankwa, Daniel; Philips, Mark R

Life science alliance. 2021 May; 4(5):

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

Deng, Jiehui; Thennavan, Aatish; Dolgalev, Igor; Chen, Ting; Li, Jie; Marzio, Antonio; Poirier, John T; Peng, David; Bulatovic, Mirna; Mukhopadhyay, Subhadip; Silver, Heather; Papadopoulos, Eleni; Pyon, Val; Thakurdin, Cassandra; Han, Han; Li, Fei; Li, Shuai; Ding, Hailin; Hu, Hai; Pan, Yuanwang; Weerasekara, Vajira; Jiang, Baishan; Wang, Eric S; Ahearn, Ian; Philips, Mark; Papagiannakopoulos, Thales; Tsirigos, Aristotelis; Rothenberg, Eli; Gainor, Justin; Freeman, Gordon J; Rudin, Charles M; Gray, Nathanael S; Hammerman, Peter S; Pagano, Michele; Heymach, John V; Perou, Charles M; Bardeesy, Nabeel; Wong, Kwok-Kin

Nature cancer. 2021 May; 2(5):503-514

A small-molecule ICMT inhibitor delays senescence of Hutchinson-Gilford progeria syndrome cells

Chen, Xue; Yao, Haidong; Kashif, Muhammad; Revêchon, Gwladys; Eriksson, Maria; Hu, Jianjiang; Wang, Ting; Liu, Yiran; Tüksammel, Elin; Strömblad, Staffan; Ahearn, Ian M; Philips, Mark R; Wiel, Clotilde; Ibrahim, Mohamed X; Bergo, Martin O

eLife. 2021 Feb 02; 10:

Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association

Zhou, Mo; Kuruvilla, Leena; Shi, Xiarong; Viviano, Stephen; Ahearn, Ian M; Amendola, Caroline R; Su, Wenjuan; Badri, Sana; Mahaffey, James; Fehrenbacher, Nicole; Skok, Jane; Schlessinger, Joseph; Turk, Benjamin E; Calderwood, David A; Philips, Mark R

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2020 Dec 15; 117(50):31914-31922

The structural features that distinguish PD-L2 from PD-L1 emerged in placental mammals

Philips, Elliot A; Garcia-España, Antonio; Tocheva, Anna S; Ahearn, Ian M; Adam, Kieran R; Pan, Ruimin; Mor, Adam; Kong, Xiang-Peng

Journal of biological chemistry. 2020 Apr 03; 295(14):4372-4380

KRAS4A directly regulates hexokinase 1

Amendola, Caroline R; Mahaffey, James P; Parker, Seth J; Ahearn, Ian M; Chen, Wei-Ching; Zhou, Mo; Court, Helen; Shi, Jie; Mendoza, Sebastian L; Morten, Michael J; Rothenberg, Eli; Gottlieb, Eyal; Wadghiri, Youssef Z; Possemato, Richard; Hubbard, Stevan R; Balmain, Allan; Kimmelman, Alec C; Philips, Mark R

Nature. 2019 Dec; 576(7787):482-486

Posttranslational Modifications of RAS Proteins

Ahearn, Ian; Zhou, Mo; Philips, Mark R

Cold Spring Harbor perspectives in medicine. 2018 11 01; 8(11):

See All Publications (25)