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Iannis Aifantis

Iannis Aifantis, PhD

Chair of the Department of Pathology

Hermann M. Biggs Professor of Pathology, Department of Pathology

Keywords
cancer, immunology, stem cell biology, epigenetic regulation, leukemia, tumor microenvironment
Summary

Our laboratory focuses on molecular mechanisms of differentiation and transformation of hematopoietic stem cells and progenitors. More specifically, we focus on mechanisms of both lymphoid (T-ALL, B-ALL) and myeloid (AML, CML, CMML) leukemia initiation and progression. Our work has identified and studied a number of novel oncogenes (including NOTCH1), tumor suppressors (including FBXW7, TET2, ASXL1, CYLD, EZH2, UTX, cohesins) and downstream oncogenic signaling pathways. We have used these pathways to design molecularly targeted therapeutic protocols that inhibit the induction or affect the maintenance of each malignancy.

Moreover, our laboratory is studying mechanisms of hematopoietic stem cell differentiation and self-renewal using both genomic and genetic approaches. Current areas of focus for our lab include the impact of DNA methylation in stem cell transformation, mapping of long non-coding RNAs in a number of human tumors, the discovery of RNA-binding proteins that can control transformation in leukemia, understanding the impact of the 3D chromosomal architecture in cancer, the role of stress responses in human malignancy, and in vivo mapping of the tumor microenvironment for acute leukemia.

Phone

212-263-9898

Academic office

550 First Avenue, Smilow Research Building

13th Floor, Room 1303

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Hermann M. Biggs Professor of Pathology, Department of Pathology at NYU Grossman School of Medicine

Chair of the Department of Pathology

PhD from University of Paris

Dana Farber Cancer Institute, Harvard Medical School, Immunology

Yeaton, Anna; Cayanan, Geraldine; Loghavi, Sanam; Dolgalev, Igor; Leddin, Emmett M; Loo, Christian E; Torabifard, Hedieh; Nicolet, Deedra; Wang, Jingjing; Corrigan, Kate; Paraskevopoulou, Varvara; Starczynowski, Daniel T; Wang, Eric; Abdel-Wahab, Omar; Viny, Aaron D; Stone, Richard M; Byrd, John C; Guryanova, Olga A; Kohli, Rahul M; Cisneros, G Andres; Tsirigos, Aristotelis; Eisfeld, Ann-Kathrin; Aifantis, Iannis; Guillamot, Maria

Cancer discovery. 2022 Oct 05; 12(10):2392-2413

Parlani, Maria; Boccalatte, Francesco; Yeaton, Anna; Wang, Feng; Zhang, Jianhua; Aifantis, Iannis; Dondossola, Eleonora

Journal of nuclear medicine. 2022 Oct; 63(10):1544-1550

Kedmi, Ranit; Najar, Tariq A; Mesa, Kailin R; Grayson, Allyssa; Kroehling, Lina; Hao, Yuhan; Hao, Stephanie; Pokrovskii, Maria; Xu, Mo; Talbot, Jhimmy; Wang, Jiaxi; Germino, Joe; Lareau, Caleb A; Satpathy, Ansuman T; Anderson, Mark S; Laufer, Terri M; Aifantis, Iannis; Bartleson, Juliet M; Allen, Paul M; Paidassi, Helena; Gardner, James M; Stoeckius, Marlon; Littman, Dan R

Nature. 2022 Oct; 610:737-743

Witkowski, Matthew T; Lee, Soobeom; Wang, Eric; Lee, Anna K; Talbot, Alexis; Ma, Chao; Tsopoulidis, Nikolaos; Brumbaugh, Justin; Zhao, Yaqi; Roberts, Kathryn G; Hogg, Simon J; Nomikou, Sofia; Ghebrechristos, Yohana E; Thandapani, Palaniraja; Mullighan, Charles G; Hochedlinger, Konrad; Chen, Weiqiang; Abdel-Wahab, Omar; Eyquem, Justin; Aifantis, Iannis

Nature immunology. 2022 Oct; 23(10):1424-1432

Kedmi, Ranit; Najar, Tariq A; Mesa, Kailin R; Grayson, Allyssa; Kroehling, Lina; Hao, Yuhan; Hao, Stephanie; Pokrovskii, Maria; Xu, Mo; Talbot, Jhimmy; Wang, Jiaxi; Germino, Joe; Lareau, Caleb A; Satpathy, Ansuman T; Anderson, Mark S; Laufer, Terri M; Aifantis, Iannis; Bartleson, Juliet M; Allen, Paul M; Paidassi, Helena; Gardner, James M; Stoeckius, Marlon; Littman, Dan R

Nature. 2022 Oct; 610(7931):E7

Bride, Karen L; Hu, Hai; Tikhonova, Anastasia; Fuller, Tori J; Vincent, Tiffaney L; Shraim, Rawan; Li, Marilyn M; Carroll, William L; Raetz, Elizabeth A; Aifantis, Iannis; Teachey, David T

Haematologica (Roma). 2022 Aug 01; 107(8):1746-1757

Kim, Randie H; Nomikou, Sofia; Coudray, Nicolas; Jour, George; Dawood, Zarmeena; Hong, Runyu; Esteva, Eduardo; Sakellaropoulos, Theodore; Donnelly, Douglas; Moran, Una; Hatzimemos, Aristides; Weber, Jeffrey S; Razavian, Narges; Aifantis, Iannis; Fenyo, David; Snuderl, Matija; Shapiro, Richard; Berman, Russell S; Osman, Iman; Tsirigos, Aristotelis

Journal of investigative dermatology. 2022 Jun; 142(6):1650-1658.e6

Lee, Anna K; Aifantis, Iannis; Thandapani, Palaniraja

Trends in immunology. 2022 Jun; 43(6):466-477