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Iannis Aifantis

Iannis Aifantis, PhD

Chair, Department of Pathology

Hermann M. Biggs Professor of Pathology, Department of Pathology

Keywords
cancer, immunology, stem cell biology, epigenetic regulation , leukemia, tumor microenvironment
Summary

Our laboratory focuses on molecular mechanisms of differentiation and transformation of hematopoietic stem cells and progenitors. More specifically, we focus on mechanisms of both lymphoid (T-ALL, B-ALL) and myeloid (AML, CML, CMML) leukemia initiation and progression. Our work has identified and studied a number of novel oncogenes (including NOTCH1), tumor suppressors (including FBXW7, TET2, ASXL1, CYLD, EZH2, UTX, cohesins) and downstream oncogenic signaling pathways. We have used these pathways to design molecularly targeted therapeutic protocols that inhibit the induction or affect the maintenance of each malignancy. Moreover, our laboratory is studying mechanisms of hematopoietic stem cell differentiation and self-renewal using both genomic and genetic approaches. Current areas of focus for our lab include the impact of DNA methylation in stem cell transformation, the mapping of long non-coding RNAs in a number of human tumors, the discovery of RNA-binding proteins that can control transformation in leukemia, the understanding of the impact of the 3D chromosomal architecture in cancer, the role of stress responses in human malignancy and the in vivo mapping of the tumor microenvironment for acute leukemia.

Phone

212-263-9898

Academic office

550 First Avenue, Smilow Research Building

13th Floor, Room 1303

New York, NY 10016

Lab Website
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Hermann M. Biggs Professor of Pathology, Department of Pathology at NYU Grossman School of Medicine

Chair, Department of Pathology

PhD from University of Paris

Dana Farber Cancer Institute, Harvard Medical School, Immunology

Wang, Eric; Aifantis, Iannis

Trends in cancer. 2020 Aug; 6(8):631-644

Bohin, Natacha; Keeley, Theresa M; Carulli, Alexis J; Walker, Emily M; Carlson, Elizabeth A; Gao, Jie; Aifantis, Iannis; Siebel, Christian W; Rajala, Michael W; Myers, Martin G; Jones, Jennifer C; Brindley, Constance D; Dempsey, Peter J; Samuelson, Linda C

Stem cell reports. 2020 Jul 14; 15(1):156-170

Tikhonova, Anastasia N; Lasry, Audrey; Austin, Rebecca; Aifantis, Iannis

Cell stem cell. 2020 Jul 02; 27(1):19-34

Witkowski, Matthew T; Dolgalev, Igor; Evensen, Nikki A; Ma, Chao; Chambers, Tiffany; Roberts, Kathryn G; Sreeram, Sheetal; Dai, Yuling; Tikhonova, Anastasia N; Lasry, Audrey; Qu, Chunxu; Pei, Deqing; Cheng, Cheng; Robbins, Gabriel A; Pierro, Joanna; Selvaraj, Shanmugapriya; Mezzano, Valeria; Daves, Marla; Lupo, Philip J; Scheurer, Michael E; Loomis, Cynthia A; Mullighan, Charles G; Chen, Weiqiang; Rabin, Karen R; Tsirigos, Aristotelis; Carroll, William L; Aifantis, Iannis

Cancer cell. 2020 Jun 08; 37(6):867-882.e12

Zhou, Yalu; Han, Cuijuan; Wang, Eric; Lorch, Adam H; Serafin, Valentina; Cho, Byoung-Kyu; Guttierrez Diaz, Blanca T; Calvo, Julien; Fang, Celestia; Khodadadi-Jamayran, Alireza; Tabaglio, Tommaso; Marier, Christian; Kuchmiy, Anna; Sun, Limin; Yacu, George; Filip, Szymon K; Jin, Qi; Takahashi, Yoh-Hei; Amici, David R; Rendleman, Emily J; Rawat, Radhika; Bresolin, Silvia; Paganin, Maddalena; Zhang, Cheng; Li, Hu; Kandela, Irawati; Politanska, Yuliya; Abdala-Valencia, Hiam; Mendillo, Marc L; Zhu, Ping; Palhais, Bruno; Van Vlierberghe, Pieter; Taghon, Tom; Aifantis, Iannis; Goo, Young Ah; Guccione, Ernesto; Heguy, Adriana; Tsirigos, Aristotelis; Wee, Keng Boon; Mishra, Rama K; Pflumio, Francoise; Accordi, Benedetta; Basso, Giuseppe; Ntziachristos, Panagiotis

Cancer discovery. 2020 May 22;

Rodriguez, Sonia; Abundis, Christina; Boccalatte, Francesco; Mehrotra, Purvi; Chiang, Mark Y; Yui, Mary A; Wang, Lin; Zhang, Huajia; Zollman, Amy; Bonfim-Silva, Ricardo; Kloetgen, Andreas; Palmer, Joycelynne; Sandusky, George; Wunderlich, Mark; Kaplan, Mark H; Mulloy, James C; Marcucci, Guido; Aifantis, Iannis; Cardoso, Angelo A; Carlesso, Nadia

Leukemia. 2020 May; 34(5):1241-1252

Koscsó, Balázs; Kurapati, Sravya; Rodrigues, Richard R; Nedjic, Jelena; Gowda, Kavitha; Shin, Changsik; Soni, Chetna; Ashraf, Azree Zaffran; Purushothaman, Indira; Palisoc, Maryknoll; Xu, Sulei; Sun, Haoyu; Chodisetti, Sathi Babu; Lin, Eugene; Mack, Matthias; Kawasawa, Yuka Imamura; He, Pingnian; Rahman, Ziaur S M; Aifantis, Iannis; Shulzhenko, Natalia; Morgun, Andrey; Bogunovic, Milena

Science immunology. 2020 04 10; 5(46):

Kloetgen, Andreas; Thandapani, Palaniraja; Ntziachristos, Panagiotis; Ghebrechristos, Yohana; Nomikou, Sofia; Lazaris, Charalampos; Chen, Xufeng; Hu, Hai; Bakogianni, Sofia; Wang, Jingjing; Fu, Yi; Boccalatte, Francesco; Zhong, Hua; Paietta, Elisabeth; Trimarchi, Thomas; Zhu, Yixing; Van Vlierberghe, Pieter; Inghirami, Giorgio G; Lionnet, Timothee; Aifantis, Iannis; Tsirigos, Aristotelis

Nature genetics. 2020 Apr; 52(4):388-400