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Iannis Aifantis

Iannis Aifantis, PhD

Chair, Department of Pathology

Hermann M. Biggs Professor of Pathology, Department of Pathology

cancer, immunology, stem cell biology, epigenetic regulation, leukemia, tumor microenvironment

Our laboratory focuses on molecular mechanisms of differentiation and transformation of hematopoietic stem cells and progenitors. More specifically, we focus on mechanisms of both lymphoid (T-ALL, B-ALL) and myeloid (AML, CML, CMML) leukemia initiation and progression. Our work has identified and studied a number of novel oncogenes (including NOTCH1), tumor suppressors (including FBXW7, TET2, ASXL1, CYLD, EZH2, UTX, cohesins) and downstream oncogenic signaling pathways. We have used these pathways to design molecularly targeted therapeutic protocols that inhibit the induction or affect the maintenance of each malignancy.

Moreover, our laboratory is studying mechanisms of hematopoietic stem cell differentiation and self-renewal using both genomic and genetic approaches. Current areas of focus for our lab include the impact of DNA methylation in stem cell transformation, mapping of long non-coding RNAs in a number of human tumors, the discovery of RNA-binding proteins that can control transformation in leukemia, understanding the impact of the 3D chromosomal architecture in cancer, the role of stress responses in human malignancy, and in vivo mapping of the tumor microenvironment for acute leukemia.



Academic office

550 First Avenue, Smilow Research Building

13th Floor, Room 1303

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Hermann M. Biggs Professor of Pathology, Department of Pathology at NYU Grossman School of Medicine

Chair, Department of Pathology

PhD from University of Paris

Dana Farber Cancer Institute, Harvard Medical School, Immunology

Wang, Jun; Lu, Qiao; Chen, Xufeng; Aifantis, Iannis

Trends in immunology. 2024 Mar; 45(3):177-187

Chen, Xufeng; Lu, Qiao; Zhou, Hua; Liu, Jia; Nadorp, Bettina; Lasry, Audrey; Sun, Zhengxi; Lai, Baoling; Rona, Gergely; Zhang, Jiangyan; Cammer, Michael; Wang, Kun; Al-Santli, Wafa; Ciantra, Zoe; Guo, Qianjin; You, Jia; Sengupta, Debrup; Boukhris, Ahmad; Zhang, Hongbing; Liu, Cheng; Cresswell, Peter; Dahia, Patricia L M; Pagano, Michele; Aifantis, Iannis; Wang, Jun

Cell. 2023 Aug 31; 186(18):3903-3920.e21

Contreras Yametti, Gloria Paz; Evensen, Nikki A; Schloss, Jennifer; Aldebert, Clemence; Duan, Emily; Zhang, Yan; Hu, Jiyuan; Chambers, Tiffany M; Scheurer, Michael E; Teachey, David T; Rabin, Karen R; Raetz, Elizabeth A; Aifantis, Iannis; Carroll, William L; Witkowski, Matthew T

Blood advances. 2023 Aug 08; 7(15):3928-3931

Tan, Jimin; Shenker-Tauris, Nina; Rodriguez-Hernaez, Javier; Wang, Eric; Sakellaropoulos, Theodore; Boccalatte, Francesco; Thandapani, Palaniraja; Skok, Jane; Aifantis, Iannis; Fenyö, David; Xia, Bo; Tsirigos, Aristotelis

Nature biotechnology. 2023 Aug; 41(8):1140-1150

Glytsou, Christina; Chen, Xufeng; Zacharioudakis, Emmanouil; Al-Santli, Wafa; Zhou, Hua; Nadorp, Bettina; Lee, Soobeom; Lasry, Audrey; Sun, Zhengxi; Papaioannou, Dimitrios; Cammer, Michael; Wang, Kun; Zal, Tomasz; Zal, Malgorzata Anna; Carter, Bing Z; Ishizawa, Jo; Tibes, Raoul; Tsirigos, Aristotelis; Andreeff, Michael; Gavathiotis, Evripidis; Aifantis, Iannis

Cancer discovery. 2023 Jul 07; 13(7):1656-1677

Balandrán, Juan Carlos; Lasry, Audrey; Aifantis, Iannis

Blood cancer discovery. 2023 Jul 05; 4(4):254-266

Shamloo, Sama; Kloetgen, Andreas; Petroulia, Stavroula; Hockemeyer, Kathryn; Sievers, Sonja; Tsirigos, Aristotelis; Aifantis, Ioannis; Imig, Jochen

Biomedicines. 2023 Jul 01; 11(<prism:issueIdentifier>7):?-?

Battistello, Elena; Hixon, Kimberlee A; Comstock, Dawn E; Collings, Clayton K; Chen, Xufeng; Rodriguez Hernaez, Javier; Lee, Soobeom; Cervantes, Kasey S; Hinkley, Madeline M; Ntatsoulis, Konstantinos; Cesarano, Annamaria; Hockemeyer, Kathryn; Haining, W Nicholas; Witkowski, Matthew T; Qi, Jun; Tsirigos, Aristotelis; Perna, Fabiana; Aifantis, Iannis; Kadoch, Cigall

Molecular cell. 2023 Apr 20; 83(8):1216-1236.e12