Chair, Department of Pathology
Hermann M. Biggs Professor of Pathology, Department of Pathology
Our laboratory focuses on molecular mechanisms of differentiation and transformation of hematopoietic stem cells and progenitors. More specifically, we focus on mechanisms of both lymphoid (T-ALL, B-ALL) and myeloid (AML, CML, CMML) leukemia initiation and progression. Our work has identified and studied a number of novel oncogenes (including NOTCH1), tumor suppressors (including FBXW7, TET2, ASXL1, CYLD, EZH2, UTX, cohesins) and downstream oncogenic signaling pathways. We have used these pathways to design molecularly targeted therapeutic protocols that inhibit the induction or affect the maintenance of each malignancy.
Moreover, our laboratory is studying mechanisms of hematopoietic stem cell differentiation and self-renewal using both genomic and genetic approaches. Current areas of focus for our lab include the impact of DNA methylation in stem cell transformation, mapping of long non-coding RNAs in a number of human tumors, the discovery of RNA-binding proteins that can control transformation in leukemia, understanding the impact of the 3D chromosomal architecture in cancer, the role of stress responses in human malignancy, and in vivo mapping of the tumor microenvironment for acute leukemia.
212-263-9898
550 First Avenue, Smilow Research Building
13th Floor, Room 1303
New York, NY 10016
Hermann M. Biggs Professor of Pathology, Department of Pathology at NYU Grossman School of Medicine
Chair, Department of Pathology
PhD from University of Paris
Dana Farber Cancer Institute, Harvard Medical School, Immunology
Cell. 2023 Aug 31; 186(18):3903-3920.e21
Blood advances. 2023 Aug 08; 7(15):3928-3931
Nature biotechnology. 2023 Aug; 41(8):1140-1150
Cancer discovery. 2023 Jul 07; 13(7):1656-1677
Blood cancer discovery. 2023 Jul 05; 4(4):254-266
Molecular cell. 2023 Apr 20; 83(8):1216-1236.e12
Nature communications. 2023 Apr 14; 14(1):2155
Nature cancer. 2023 Jan; 4(1):27-42