Iman Osman

Iman Osman, MD

Rudolf L. Baer Professor of Dermatology, Ronald O. Perelman Department of Dermatology

Professor, Department of Medicine

Professor, Department of Urology

Keywords
melanoma, biomarkers, cancer immunology, machine learning
Summary

Melanoma remains the deadliest form of skin cancer. A hallmark of Melanoma is its propensity to invade and spread to distant organs when the tumor is a few mm in thickness. My research focuses on understanding the biologic processes driving this aggressive clinical behavior, identifying new molecular targets of treatments, and better understanding the relationship between response and toxicity to treatment. I rely on studying melanoma patients’ specimens linked to clinical information to prioritize targets for functional studies. My team and I are also interested in using cutting edge technology to develop simple tools and assays that can be used in clinics. We are also interested in machine learning to create predictive models from multi-dimensional data.

Phone

212-263-9076

Fax

212-263-5819

Academic office

522 First Avenue

4th Floor, , Lab 407; Office 405

New York, NY 10016

Lab Website
Osman Lab
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Positions

Rudolf L. Baer Professor of Dermatology, Ronald O. Perelman Department of Dermatology at NYU Grossman School of Medicine

Professor, Department of Medicine at NYU Grossman School of Medicine

Professor, Department of Urology at NYU Grossman School of Medicine

Associate Dean, Clinical Research Strategy

Director, Interdisciplinary Melanoma Cooperative Group

Graduate Education

MD from National Cancer Institute

MD from Cairo University

Residency And Fellowship Training

Fellowship, Memorial Sloan-Kettering Cancer Center , Molecular Pathology

Fellowship, Memorial Sloan-Kettering Cancer Center , Medical Oncology

NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma

Ibrahim, Milad; Illa-Bochaca, Irineu; Jour, George; Vega-Saenz de Miera, Eleazar; Fracasso, Joseph; Ruggles, Kelly; Osman, Iman; Schober, Markus

Cancer research. 2025 Jun 10;

Inherited mitochondrial genetics as a predictor of immune checkpoint inhibition efficacy in melanoma

Monson, Kelsey R; Ferguson, Robert; Handzlik, Joanna E; Morales, Leah; Xiong, Jiahan; Chat, Vylyny; Dagayev, Sasha; Khodadadi-Jamayran, Alireza; Simpson, Danny; Kazlow, Esther; Bunis, Anabelle; Sreenivasaiah, Chaitra; Ibrahim, Milad; Voloshyna, Iryna; Ouwerkerk, Wouter; Luiten, Rosalie M; Capone, Mariaelena; Madonna, Gabriele; Lu, Yuting; Shao, Yongzhao; Pavlick, Anna; Krogsgaard, Michelle; Mehnert, Janice; Tang, Hao; Dolfi, Sonia; Tenney, Daniel; Haanen, John B A G; Gajewski, Thomas F; Hodi, F Stephen; Flaherty, Keith T; Couts, Kasey; Robinson, William; Puzanov, Igor; Ernstoff, Marc S; Rahma, Osama; Postow, Michael; Sullivan, Ryan J; Luke, Jason J; Ascierto, Paolo A; ,; Osman, Iman; Kirchhoff, Tomas

Nature medicine. 2025 Jun 05;

Characterizing Chronic Cutaneous Immune-Related Adverse Events Following Immune Checkpoint Inhibitors

Fletcher, Kylie A; Goodman, Rachel S; Lawless, Aleigha; Woodford, Rachel; Fa'ak, Faisal; Tipirneni, Asha; Patrinely, J Randall; Yeoh, Hui Ling; Rapisuwon, Suthee; Haydon, Andrew; Osman, Iman; Mehnert, Janice M; Long, Georgina V; Sullivan, Ryan J; Carlino, Matteo S; Menzies, Alexander M; Dewan, Anna K; Johnson, Douglas B

JAMA dermatology. 2025 Mar 12;

DNA Methylation Classes of Stage II and III Primary Melanomas and Their Clinical and Prognostic Significance

Conway, Kathleen; Edmiston, Sharon N; Vondras, Amanda; Reiner, Allison; Corcoran, David L; Shen, Ronglai; Parrish, Eloise A; Hao, Honglin; Lin, Lan; Kenney, Jessica M; Ilelaboye, Gbemisola; Kostrzewa, Caroline E; Kuan, Pei Fen; Busam, Klaus J; Lezcano, Cecilia; Lee, Tim K; Hernando, Eva; Googe, Paul B; Ollila, David W; Moschos, Stergios; Gorlov, Ivan; Amos, Christopher I; Ernstoff, Marc S; Cust, Anne E; Wilmott, James S; Scolyer, Richard A; Mann, Graham J; Vergara, Ismael A; Ko, Jennifer; Rees, Judy R; Yan, Shaofeng; Nagore, Eduardo; Bosenberg, Marcus; Rothberg, Bonnie Gould; Osman, Iman; Lee, Jeffrey E; Saenger, Yvonne; Bogner, Paul; Thompson, Cheryl L; Gerstenblith, Meg; Holmen, Sheri L; Funchain, Pauline; Brunsgaard, Elise; Depcik-Smith, Natalie D; Luo, Li; Boyce, Tawny; Orlow, Irene; Begg, Colin B; Berwick, Marianne; Thomas, Nancy E; ,

JCO precision oncology. 2024 Nov; 8:e2400375

Tyrosine Protein Kinase SYK-Related Gene Signature in Baseline Immune Cells Associated with Adjuvant Immunotherapy-Induced Immune-Related Adverse Events in Melanoma

Monson, Kelsey R; Ferguson, Robert; Handzlik, Joanna E; Xiong, Jiahan; Dagayev, Sasha; Morales, Leah; Chat, Vylyny; Bunis, Anabelle; Sreenivasaiah, Chaitra; Dolfi, Sonia; Tenney, Daniel J; Shao, Yongzhao; Osman, Iman; Weber, Jeffrey S; Kirchhoff, Tomas

Clinical cancer research. 2024 Oct 01; 30(19):4412-4423

The stress response regulator HSF1 modulates natural killer cell anti-tumour immunity

Hockemeyer, Kathryn; Sakellaropoulos, Theodore; Chen, Xufeng; Ivashkiv, Olha; Sirenko, Maria; Zhou, Hua; Gambi, Giovanni; Battistello, Elena; Avrampou, Kleopatra; Sun, Zhengxi; Guillamot, Maria; Chiriboga, Luis; Jour, George; Dolgalev, Igor; Corrigan, Kate; Bhatt, Kamala; Osman, Iman; Tsirigos, Aristotelis; Kourtis, Nikos; Aifantis, Iannis

Nature cell biology. 2024 Oct; 26(10):1734-1744

MicroRNA-615-3p decreases apo B expression in human liver cells

Ansari, Abulaish; Yadav, Pradeep Kumar; Valmiki, Swati; Laine, Antoine; Rimbert, Antoine; Islam, Shahidul; Osman, Iman; Najafi-Shoustari, S Hani; Hussain, M Mahmood

Journal of lipid research. 2024 Sep 25; 100659

Tumor-Intrinsic Galectin-3 Suppresses Melanoma Metastasis

Mohammed, Norhan B B; Lau, Lee Seng; Souchak, Joseph; Qiu, Shi; Ahluwalia, Manmeet S; Osman, Iman; Dimitroff, Charles J

Journal of investigative dermatology. 2024 Sep; 144(9):2039-2051.e9

See All Publications (363)

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