Irma Sanchez

Irma Sanchez, PhD

Perlmutter Cancer Center

Assistant Professor, Department of Pathology

Summary

I am interested in studying the subcellular mechanisms through which MAPKs transduce environmental extracellular signals. My previous work focused on the identification and characterization of SEK1/MKK4/JNKK the first known activator for the SAPK/JNK enzyme. I have now turned our attention towards studying the ERK3/MAPK6 enzyme. ERK3 was first identified in 1991 and is highly enriched in the developing nervous system. Interestingly,unlike other members of the MAPK family, ERK3 appears to be restricted to vertebrates as there are no known homologs in yeast or in Drosophila and C. elegans. Using a combination of biochemical, cell biological, and molecular biological approaches we hope to uncover the regulatory controls and cellular role of this very interesting enzyme.

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Assistant Professor, Department of Pathology

PhD from University of California at Berkeley

Malonis, Ryan J; Fu, Wenxiang; Jelcic, Mark J; Thompson, Marae; Canter, Brian S; Tsikitis, Mary; Esteva, Francisco J; Sanchez, Irma

Journal of biological chemistry. 2017 Mar 14; 292(18):7435-7451

Sanchez, Irma; Dynlacht, Brian David

Nature cell biology. 2016 Jun 28; 18(7):711-717

Wang, Lei; Lee, Kwanwoo; Malonis, Ryan; Sanchez, Irma; Dynlacht, Brian D

eLife. 2016 May 5; 5:?-?

Sanchez, Irma; Dynlacht, Brian D

Nature. 2014 Jun 05; 510(7503):40-42

Tsikitis, Mary; Acosta-Alvear, Diego; Blais, Alexandre; Campos, Eric I; Lane, William S; Sanchez, Irma; Dynlacht, Brian D

EMBO reports. 2010 Dec; 11(12):969-976

Tsang, William Y; Spektor, Alexander; Vijayakumar, Sangeetha; Bista, Bigyan R; Li, Ji; Sanchez, Irma; Duensing, Stefan; Dynlacht, Brian D

Developmental cell. 2009 May; 16(5):649-660

Tsang, William Y; Wang, Leyu; Chen, Zhihong; Sanchez, Irma; Dynlacht, Brian David

Journal of cell biology. 2007 Aug 13; 178(4):621-633

Tsang, William Y; Spektor, Alexander; Luciano, Daniel J; Indjeian, Vahan B; Chen, Zhihong; Salisbury, Jeffery L; Sanchez, Irma; Dynlacht, Brian David

Molecular biology of the cell. 2006 Aug; 17(8):3423-3434