Irma Sanchez

Irma Sanchez, PhD

Perlmutter Cancer Center

Associate Professor, Department of Pathology

Summary

I am interested in studying the subcellular mechanisms through which MAPKs transduce environmental extracellular signals. My previous work focused on the identification and characterization of SEK1/MKK4/JNKK the first known activator for the SAPK/JNK enzyme. I have now turned our attention towards studying the ERK3/MAPK6 enzyme. ERK3 was first identified in 1991 and is highly enriched in the developing nervous system. Interestingly,unlike other members of the MAPK family, ERK3 appears to be restricted to vertebrates as there are no known homologs in yeast or in Drosophila and C. elegans. Using a combination of biochemical, cell biological, and molecular biological approaches we hope to uncover the regulatory controls and cellular role of this very interesting enzyme.

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Positions

Associate Professor, Department of Pathology at NYU Grossman School of Medicine

Graduate Education

PhD from University of California at Berkeley

Whole-genome screen identifies diverse pathways that negatively regulate ciliogenesis

Failler, Marion; Giro-Perafita, Ariadna; Owa, Mikito; Srivastava, Shalini; Yun, Chi; Kahler, David J; Unutmaz, Derya; Esteva, Francisco J; Sánchez, Irma; Dynlacht, Brian D

Molecular biology of the cell. 2020 Nov 18; mbcE20020111

LncRNA RP11-19E11 is an E2F1 target required for proliferation and survival of basal breast cancer

Giro-Perafita, A; Luo, L; Khodadadi-Jamayran, A; Thompson, M; Akgol Oksuz, B; Tsirigos, A; Dynlacht, B D; Sánchez, I; Esteva, F J

NPJ breast cancer. 2020 Jan; 6:1

Prognostic role of elevated mir-24-3p in breast cancer and its association with the metastatic process

Khodadadi-Jamayran, Alireza; Akgol-Oksuz, Betul; Afanasyeva, Yelena; Heguy, Adriana; Thompson, Marae; Ray, Karina; Giro-Perafita, Ariadna; Sánchez, Irma; Wu, Xifeng; Tripathy, Debu; Zeleniuch-Jacquotte, Anne; Tsirigos, Aristotelis; Esteva, Francisco J

Oncotarget. 2018 Feb 27; 9(16):12868-12878

Gating Ciliary Transport

Sanchez, Irma; Dynlacht, Brian D

Developmental cell. 2017 07 10; 42(1):5-6

Rnf11 sequestration of Smurf2 on membranes antagonizes Smad7 down-regulation of TGFbeta signaling

Malonis, Ryan J; Fu, Wenxiang; Jelcic, Mark J; Thompson, Marae; Canter, Brian S; Tsikitis, Mary; Esteva, Francisco J; Sanchez, Irma

Journal of biological chemistry. 2017 05 05; 292(18):7435-7451

Cilium assembly and disassembly

Sanchez, Irma; Dynlacht, Brian David

Nature cell biology. 2016 06 28; 18(7):711-7

Tethering of an E3 ligase by PCM1 regulates the abundance of centrosomal KIAA0586/Talpid3 and promotes ciliogenesis

Wang, Lei; Lee, Kwanwoo; Malonis, Ryan; Sanchez, Irma; Dynlacht, Brian D

eLife. 2016 May 05; 5:

Traf7, a MyoD1 transcriptional target, regulates nuclear factor-kappaB activity during myogenesis

Tsikitis, Mary; Acosta-Alvear, Diego; Blais, Alexandre; Campos, Eric I; Lane, William S; Sanchez, Irma; Dynlacht, Brian D

EMBO reports. 2010 Dec; 11(12):969-76

See All Publications (21)