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Isaac I. Wirgin

Isaac I. Wirgin, PhD

Associate Professor, Department of Environmental Medicine

Keywords
molecular mechanisms of carcinogenesis in Hudson River tomcod
Summary

The Atlantic tomcod, Microgadus tomcod, from the Hudson River provides a unique opportunity to study the molecular aspects of genetic susceptibility to neoplasia in an outbred model organism that 1) exhibits an unusually high prevalence of hepatocellular carcinomas (more than 90% in 2-yr-old fish), 2) is exposed to high levels of environmentally borne chemical carcinogens, and 3) can be used to investigate the effects of controlled laboratory model-chemical exposures on sensitive early-life stages.

We examined the effects of the interactions of genetic variation and exposure to high levels of Hudson River-borne xenobiotics on the structure and expression of carcinogenically relevant genes, such as K-ras, aromatic hydrocarbonreceptor (Ahr) and cytochrome P4501A (CYP1A1). We found activated K-ras in a high percentage of tomcod liver-tumor DNAs, a transcribed genetic polymorphism in the 3' untranslated region of CYP1A1 in Hudson River tomcod that is not observed in cancer-free populations of tomcod.

Currently, we study the functional significance of genetic variation in this model relevant to: 1) the role of K-ras oncogene activation in early neoplastic events and hepatocarcinogenesis progression in tomcod livers, 2) the effects of environmentally relevant polychlorobiphenyl (PCB) promotion on clonal expansion of initiated cells, and 3) the molecular mechanisms of CYP1A1 gene regulation in environmentally exposed tomcod from the Hudson River. We also explore the effects of inter-specific and inter-individual differences in Ahr gene expression levels on CYP1A1 gene expression and transcription inhibition in halogenated aromatic hydrocarbon-exposed fish.

 

 

Phone

646-754-9449

Academic office

341 East 25th Street

Second Floor, 202

New York, NY 10010

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PhD from City College

NYU School of Medicine, Environmental Carcinogenesis

Harris, Sheila C.; Cope, W. Robert; Wirgin, Isaac; Hallerman, Eric M.

Fishes. 2020 Sep 01; 5(<prism:issueIdentifier>3):1-24

Wirgin, Isaac; Maceda, Lorraine; Tozer, Matt; Stabile, Joseph; Waldman, John

Fisheries research. 2020 Jun 01; 226:?-?

Lilly, Jessie; McLean, Montana F.; Dadswell, Michael J.; Wirgin, Isaac; Comolli, Perry; Stokesbury, Michael J.W.

Animal biotelemetry. 2020 May 14; 8(<prism:issueIdentifier>1):?-?

Waldman, John; Alter, S. Elizabeth; Peterson, Douglas; Maceda, Lorraine; Roy, Nirmal; Wirgin, Isaac

Conservation genetics. 2019 APR; 20:167-184

Fox, Adam G.; Wirgin, Isaac I.; Peterson, Douglas L.

Marine & coastal fisheries : dynamics, management , & ecosystem science. 2018 DEC; 10:606-618

Roy, Nirmal K; DellaTorre, Melissa; Candelmo, Allison; Chambers, R Christopher; Habeck, Ehren; Wirgin, Isaac

Aquatic toxicology. 2018 Dec; 205:25-35

Wirgin, Isaac; Roy, Nirmal K.; Maceda, Lorraine; Mattson, Mark T.

Fisheries research. 2018 NOV; 207:165-170

Roy, Nirmal K; Candelmo, Allison; DellaTorre, Melissa; Chambers, R Christopher; Nádas, Arthur; Wirgin, Isaac

Aquatic toxicology. 2018 Apr; 197:19-31