Itai Yanai

Itai Yanai, PhD

Director, Institute for Computational Medicine

Professor, Department of Biochemistry and Molecular Pharmacology

Keywords
cancer, computational biology, developmental genetics, genomics, microbiome, systems biology, single-cell transcriptomics, gene expression atlas construction, genome evolution
Summary

Itai Yanai is the Director of the Institute for Computational Medicine and Professor of Biochemistry and Molecular Pharmacology.

Our lab uses the tractable C. elegans embryo as an experimental system. One of our goals is to make a comprehensive determination of gene expression in every cell in this nematode. We are computationally analyzing this complete atlas to infer gene regulatory pathways. One future goal is to compare gene expression patterns across disparate metazoan phyla, searching for how the various signaling pathways and transcription factor (TF) modules are differentially expressed in patterning distinct body plans. In addition to embryonic development, we aim to reveal the spatial and conditional aspects of gene regulatory pathways by studying an organ (the human pancreas), tumorigenesis (zebrafish melanoma), and host-pathogen interaction (human Salmonella), through a collaborative approach that will also include the development of novel methods for spatial transcriptomics. We will also extend our analysis to regulatory pathways involving—in addition to mRNA—small RNA such as miRNAs and piRNAs, as well as lincRNAs. By providing insight into the structure, function, and plasticity of gene regulatory networks, this research will impact the fields of developmental, ecological, and evolutionary biology. 

Phone

646-501-4603

Academic office

430 East 29th Street, Alexandria Building West

5th Floor, Room 513

New York, NY 10016

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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Professor, Department of Biochemistry and Molecular Pharmacology

Director, Institute for Computational Medicine

PhD from Boston University

Baron, Maayan; Yanai, Itai

Genome biology. 2017 Aug 24; 18(1):159-159

Zalts, Harel; Yanai, Itai

Nature ecology & evolution. 2017 Mar 27; 1(5):113-113

Baron, Maayan; Yanai, Itai

Genome biology. 2017 Feb 16; 18(1):30-30

Baron, Maayan; Veres, Adrian; Wolock, Samuel L; Faust, Aubrey L; Gaujoux, Renaud; Vetere, Amedeo; Ryu, Jennifer Hyoje; Wagner, Bridget K; Shen-Orr, Shai S; Klein, Allon M; Melton, Douglas A; Yanai, Itai

Cell systems. 2016 Oct 26; 3(4):346-360.e4

Singer, Meromit; Wang, Chao; Cong, Le; Marjanovic, Nemanja D; Kowalczyk, Monika S; Zhang, Huiyuan; Nyman, Jackson; Sakuishi, Kaori; Kurtulus, Sema; Gennert, David; Xia, Junrong; Kwon, John Y H; Nevin, James; Herbst, Rebecca H; Yanai, Itai; Rozenblatt-Rosen, Orit; Kuchroo, Vijay K; Regev, Aviv; Anderson, Ana C

Cell. 2016 Sep 08; 166(6):1500-1511.e9

Hashimshony, Tamar; Senderovich, Naftalie; Avital, Gal; Klochendler, Agnes; de Leeuw, Yaron; Anavy, Leon; Gennert, Dave; Li, Shuqiang; Livak, Kenneth J; Rozenblatt-Rosen, Orit; Dor, Yuval; Regev, Aviv; Yanai, Itai

Genome biology. 2016 Apr 28; 17:77-77

Levin, Michal; Anavy, Leon; Cole, Alison G; Winter, Eitan; Mostov, Natalia; Khair, Sally; Senderovich, Naftalie; Kovalev, Ekaterina; Silver, David H; Feder, Martin; Fernandez-Valverde, Selene L; Nakanishi, Nagayasu; Simmons, David; Simakov, Oleg; Larsson, Tomas; Liu, Shang-Yun; Jerafi-Vider, Ayelet; Yaniv, Karina; Ryan, Joseph F; Martindale, Mark Q; Rink, Jochen C; Arendt, Detlev; Degnan, Sandie M; Degnan, Bernard M; Hashimshony, Tamar; Yanai, Itai

Nature. 2016 Mar 31; 531(7596):637-641

Yanai, Itai; Lercher, Martin J

Genome biology. 2016 Mar 02; 17(1):39-39