Itai Yanai is the Director of the Institute for Computational Medicine and Professor of Biochemistry and Molecular Pharmacology.
Our lab uses the tractable C. elegans embryo as an experimental system. One of our goals is to make a comprehensive determination of gene expression in every cell in this nematode. We are computationally analyzing this complete atlas to infer gene regulatory pathways. One future goal is to compare gene expression patterns across disparate metazoan phyla, searching for how the various signaling pathways and transcription factor (TF) modules are differentially expressed in patterning distinct body plans. In addition to embryonic development, we aim to reveal the spatial and conditional aspects of gene regulatory pathways by studying an organ (the human pancreas), tumorigenesis (zebrafish melanoma), and host-pathogen interaction (human Salmonella), through a collaborative approach that will also include the development of novel methods for spatial transcriptomics. We will also extend our analysis to regulatory pathways involving—in addition to mRNA—small RNA such as miRNAs and piRNAs, as well as lincRNAs. By providing insight into the structure, function, and plasticity of gene regulatory networks, this research will impact the fields of developmental, ecological, and evolutionary biology.
Professor, Department of Biochemistry and Molecular Pharmacology
Director, Institute for Computational Medicine
PhD from Boston University
Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2018 Apr 24; 115(17):4459-4464
Molecular biology & evolution. 2017 Dec 11;
Genome biology. 2017 Nov 23; 18(1):223-223
Cell. 2017 Nov 16; 171(5):1221-1223
Genome biology. 2017 Oct 27; 18(1):200-200
Trends in genetics. 2017 Oct 20; 34(1):11-20
Genome biology. 2017 Aug 24; 18(1):159-159