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Itai Yanai

Itai Yanai, PhD

Scientific Director, Bioinformatics Core

Professor, Department of Biochemistry and Molecular Pharmacology

cancer, computational biology, developmental genetics, genomics, microbiome, systems biology, single-cell transcriptomics, gene expression atlas construction, genome evolution

Our lab uses the tractable C. elegans embryo as an experimental system. One of our goals is to make a comprehensive determination of gene expression in every cell in this nematode. We are computationally analyzing this complete atlas to infer gene regulatory pathways. One future goal is to compare gene expression patterns across disparate metazoan phyla, searching for how the various signaling pathways and transcription factor (TF) modules are differentially expressed in patterning distinct body plans. In addition to embryonic development, we aim to reveal the spatial and conditional aspects of gene regulatory pathways by studying an organ (the human pancreas), tumorigenesis (zebrafish melanoma), and host-pathogen interaction (human Salmonella), through a collaborative approach that will also include the development of novel methods for spatial transcriptomics. We will also extend our analysis to regulatory pathways involving—in addition to mRNA—small RNA such as miRNAs and piRNAs, as well as lincRNAs. By providing insight into the structure, function, and plasticity of gene regulatory networks, this research will impact the fields of developmental, ecological, and evolutionary biology. 



Academic office

@ItaiYanai, 435 East 30th Street

8th Floor, Room 817

New York, NY 10016

Lab Website
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These focus areas and their associated publications are derived from medical subject headings from PubMed.
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Scientific Director, Bioinformatics Core

PhD from Boston University

Avital, Gal; Kuperwaser, Felicia; Pountain, Andrew W; Lacey, Keenan A; Zwack, Erin E; Podkowik, Magdalena; Shopsin, Bo; Torres, Victor J; Yanai, Itai

Cell reports. 2022 10 11; 41(2):111477

Barkley, Dalia; Moncada, Reuben; Pour, Maayan; Liberman, Deborah A; Dryg, Ian; Werba, Gregor; Wang, Wei; Baron, Maayan; Rao, Anjali; Xia, Bo; França, Gustavo S; Weil, Alejandro; Delair, Deborah F; Hajdu, Cristina; Lund, Amanda W; Osman, Iman; Yanai, Itai

Nature genetics. 2022 Aug; 54(8):1192-1201

Yanai, Itai

Nature reviews. Genetics. 2022 Apr; 23(4):196-197

Cable, Jennifer; Elowitz, Michael B; Domingos, Ana I; Habib, Naomi; Itzkovitz, Shalev; Hamidzada, Homaira; Balzer, Michael S; Yanai, Itai; Liberali, Prisca; Whited, Jessica; Streets, Aaron; Cai, Long; Stergachis, Andrew B; Hong, Clarice Kit Yee; Keren, Leeat; Guilliams, Martin; Alon, Uri; Shalek, Alex K; Hamel, Regan; Pfau, Sarah J; Raj, Arjun; Quake, Stephen R; Zhang, Nancy R; Fan, Jean; Trapnell, Cole; Wang, Bo; Greenwald, Noah F; Vento-Tormo, Roser; Santos, Silvia D M; Spencer, Sabrina L; Garcia, Hernan G; Arekatla, Geethika; Gaiti, Federico; Arbel-Goren, Rinat; Rulands, Steffen; Junker, Jan Philipp; Klein, Allon M; Morris, Samantha A; Murray, John I; Galloway, Kate E; Ratz, Michael; Romeike, Merrit

Annals of the New York Academy of Sciences. 2021 Dec; 1506(1):74-97

Hunter, Miranda V; Moncada, Reuben; Weiss, Joshua M; Yanai, Itai; White, Richard M

Nature communications. 2021 Nov 01; 12(1):6278