Ivan I. Gusarov, PhD

Research Assistant Professor, Department of Biochemistry and Molecular Pharmacology

Summary

Nitric Oxide synthesis in bacteria. We discovered that Gram-positive bacteria has enzyme highly homologues to eukaryotic NO-synthases. We demonstrated that this enzyme produce NO under physiological conditions and this NO protect bacteria against oxidative stress. Currently we studying the role of NO in interaction between bacteria (Staphylococci and Bacilli) and C. elegance. Studies are on the way to demonstrate that bacterial NO is important for nematode colonization.

Phone

212-263-5461

Academic office

450 East 29th Street, Alexandria Bldg. West

3

New York, NY 10016

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Positions

Research Assistant Professor, Department of Biochemistry and Molecular Pharmacology at NYU Grossman School of Medicine

Graduate Education

PhD from Inst for Genetics, Moscow

Unraveling cysteine deficiency-associated rapid weight loss

Varghese, Alan; Gusarov, Ivan; Gamallo-Lana, Begoña; Dolgonos, Daria; Mankan, Yatin; Shamovsky, Ilya; Phan, Mydia; Jones, Rebecca; Gomez-Jenkins, Maria; White, Eileen; Wang, Rui; Jones, Drew; Papagiannakopoulos, Thales; Pacold, Michael E; Mar, Adam C; Littman, Dan R; Nudler, Evgeny

bioRxiv.org : the preprint server for biology. 2024 Jul 31;

Publisher Correction: Dietary thiols accelerate aging of C. elegans

Gusarov, Ivan; Shamovsky, Ilya; Pani, Bibhusita; Gautier, Laurent; Eremina, Svetlana; Katkova-Zhukotskaya, Olga; Mironov, Alexander; Makarov, Alexander А; Nudler, Evgeny

Nature communications. 2021 Dec 06; 12(1):7220

Dietary thiols accelerate aging of C. elegans

Gusarov, Ivan; Shamovsky, Ilya; Pani, Bibhusita; Gautier, Laurent; Eremina, Svetlana; Katkova-Zhukotskaya, Olga; Mironov, Alexander; Makarov, Alexander А; Nudler, Evgeny

Nature communications. 2021 07 15; 12(1):4336

Glycogen at the Crossroad of Stress Resistance, Energy Maintenance, and Pathophysiology of Aging

Gusarov, Ivan; Nudler, Evgeny

Bioessays. 2018 Sep; 40(9):e1800033

Protein S-Nitrosylation: Enzymatically Controlled, but Intrinsically Unstable, Post-translational Modification

Gusarov, Ivan; Nudler, Evgeny

Molecular cell. 2018 02 01; 69(3):351-353

Mechanism of biofilm-mediated stress resistance and lifespan extension in C. elegans

Smolentseva, Olga; Gusarov, Ivan; Gautier, Laurent; Shamovsky, Ilya; DeFrancesco, Alicia S; Losick, Richard; Nudler, Evgeny

Scientific reports. 2017 Aug 02; 7(1):7137

Glycogen controls Caenorhabditis elegans lifespan and resistance to oxidative stress

Gusarov, Ivan; Pani, Bibhusita; Gautier, Laurent; Smolentseva, Olga; Eremina, Svetlana; Shamovsky, Ilya; Katkova-Zhukotskaya, Olga; Mironov, Alexander; Nudler, Evgeny

Nature communications. 2017 06 19; 8:15868

Methicillin-resistant Staphylococcus aureus Bacterial Nitric-oxide Synthase Affects Antibiotic Sensitivity and Skin Abscess Development

van Sorge, Nina M; Beasley, Federico C; Gusarov, Ivan; Gonzalez, David J; von Kockritz-Blickwede, Maren; Anik, Sabina; Borkowski, Andrew W; Dorrestein, Pieter C; Nudler, Evgeny; Nizet, Victor

Journal of biological chemistry. 2013 Mar 01; 288(9):6417-26

See All Publications (23)