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Jeffrey N. Weiser

Jeffrey N. Weiser, MD

Chair, Department of Microbiology

Jan T. Vilcek Professor of Molecular Pathogenesis, Department of Microbiology

microbiology, immunology, bacterial infection of the respiratory tract, bacterial-viral co-infections

Our lab investigates the molecular basis of host–pathogen interactions in the human respiratory tract. Most of our studies focus on the pathogenesis of Streptococcus pneumoniae because of its prominence as a cause of acute respiratory tract infection. Other pathogens under investigation in our laboratory include Haemophilus influenzae, Klebsiella pneumoniae, Staphylococcus aureus, and influenza A virus.

Many of our research projects focus on colonization of the upper airway mucosa, the initial step in the disease process, with particular interest in both host and pathogen factors affecting colonization. We employ bacterial genetics to examine the effects of specific microbial genes, along with mouse models of colonization to study infection in genetically modified hosts.

Ongoing projects in our lab include examinations of the following:

  • mechanisms by which colonizing microbes stimulate and evade innate and adaptive immune responses

  • mechanisms that facilitate interspecies competition within a host

  • factors affecting competition between co-colonizing pneumococci

  • effects of influenza co-infection on bacterial colonization

  • pneumococcal interaction with neutrophils and macrophages and evasion of clearance by professional phagocytes

  • the role of phosphorylcholine, a surface constituent of many respiratory tract inhabitants, in pathogenesis

  • host and bacterial factors affecting shedding and host-to-host transmission

  • the systemic effects of colonizing flora (microbiota) on innate immunity 



Academic office

430 East 29th Street, Alexandria – West Tower

5th Floor, Room 503

New York, NY 10016

Lab Website
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Jan T. Vilcek Professor of Molecular Pathogenesis, Department of Microbiology at NYU Grossman School of Medicine

Chair, Department of Microbiology

MD from Harvard University

Fellowship, Oxford University, Oxford, UK, Lab of E.R. Moxon

Fellowship, Rockefeller University, New York, NY, Lab of E.C. Gotschlich

Residency, University of Washington, Seattle, WA, Pediatrics

Binsker, Ulrike; Lees, John A; Hammond, Alexandria J; Weiser, Jeffrey N

Journal of clinical investigation. 2020 Feb 03; 130(2):927-941

Adams, Walter; Bhowmick, Rudra; Bou Ghanem, Elsa N; Wade, Kristin; Shchepetov, Mikhail; Weiser, Jeffrey N; McCormick, Beth A; Tweten, Rodney K; Leong, John M

Journal of immunology (1950). 2020 Jan 01; 204(1):101-111

Zafar, M Ammar; Hammond, Alexandria J; Hamaguchi, Shigeto; Wu, Weisheng; Kono, Masamitsu; Zhao, Lili; Weiser, Jeffrey N

MBio. 2019 06 18; 10(3):

Lees, John A; Ferwerda, Bart; Kremer, Philip H C; Wheeler, Nicole E; Serón, Mercedes Valls; Croucher, Nicholas J; Gladstone, Rebecca A; Bootsma, Hester J; Rots, Nynke Y; Wijmega-Monsuur, Alienke J; Sanders, Elisabeth A M; Trzciński, Krzysztof; Wyllie, Anne L; Zwinderman, Aeilko H; van den Berg, Leonard H; van Rheenen, Wouter; Veldink, Jan H; Harboe, Zitta B; Lundbo, Lene F; de Groot, Lisette C P G M; van Schoor, Natasja M; van der Velde, Nathalie; Ängquist, Lars H; Sørensen, Thorkild I A; Nohr, Ellen A; Mentzer, Alexander J; Mills, Tara C; Knight, Julian C; du Plessis, Mignon; Nzenze, Susan; Weiser, Jeffrey N; Parkhill, Julian; Madhi, Shabir; Benfield, Thomas; von Gottberg, Anne; van der Ende, Arie; Brouwer, Matthijs C; Barrett, Jeffrey C; Bentley, Stephen D; van de Beek, Diederik

Nature communications. 2019 05 15; 10(1):2176

Wang, Yan; Li, Yong; Zhang, Peggy; Baker, Sandy T; Wolfson, Marla R; Weiser, Jeffrey N; Tian, Ying; Shen, Hao

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 Apr 23; 116(17):8493-8498

Lees, John A; Harris, Simon R; Tonkin-Hill, Gerry; Gladstone, Rebecca A; Lo, Stephanie W; Weiser, Jeffrey N; Corander, Jukka; Bentley, Stephen D; Croucher, Nicholas J

Genome research. 2019 Feb; 29(2):304-316

Copin, Richard; Sause, William E; Fulmer, Yi; Balasubramanian, Divya; Dyzenhaus, Sophie; Ahmed, Jamil M; Kumar, Krishan; Lees, John; Stachel, Anna; Fisher, Jason C; Drlica, Karl; Phillips, Michael; Weiser, Jeffrey N; Planet, Paul J; Uhlemann, Anne-Catrin; Altman, Deena R; Sebra, Robert; van Bakel, Harm; Lighter, Jennifer; Torres, Victor J; Shopsin, Bo

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 Jan 29; 116(5):1745-1754

Shen, Pamela; Lees, John A; Bee, Gavyn Chern Wei; Brown, Sam P; Weiser, Jeffrey N

Nature microbiology. 2019 Jan; 4(1):198-208