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Jeffrey N. Weiser

Jeffrey N. Weiser, MD

Chair, Department of Microbiology

Jan T. Vilcek Professor of Molecular Pathogenesis, Department of Microbiology

Keywords
microbiology, immunology, bacterial infection of the respiratory tract, bacterial-viral co-infections
Summary

Our lab investigates the molecular basis of host–pathogen interactions in the human respiratory tract. Most of our studies focus on the pathogenesis of Streptococcus pneumoniae because of its prominence as a cause of acute respiratory tract infection. Other pathogens under investigation in our laboratory include Haemophilus influenzae, Klebsiella pneumoniae, Staphylococcus aureus, and influenza A virus.

Many of our research projects focus on colonization of the upper airway mucosa, the initial step in the disease process, with particular interest in both host and pathogen factors affecting colonization. We employ bacterial genetics to examine the effects of specific microbial genes, along with mouse models of colonization to study infection in genetically modified hosts.

Ongoing projects in our lab include examinations of the following:

  • mechanisms by which colonizing microbes stimulate and evade innate and adaptive immune responses

  • mechanisms that facilitate interspecies competition within a host

  • factors affecting competition between co-colonizing pneumococci

  • effects of influenza co-infection on bacterial colonization

  • pneumococcal interaction with neutrophils and macrophages and evasion of clearance by professional phagocytes

  • the role of phosphorylcholine, a surface constituent of many respiratory tract inhabitants, in pathogenesis

  • host and bacterial factors affecting shedding and host-to-host transmission

  • the systemic effects of colonizing flora (microbiota) on innate immunity 

Phone

212-263-1080

Academic office

430 East 29th Street, Alexandria – West Tower

5th Floor, Room 503

New York, NY 10016

Lab Website
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Jan T. Vilcek Professor of Molecular Pathogenesis, Department of Microbiology

Chair, Department of Microbiology

MD from Harvard University

Fellowship, Oxford University, Oxford, UK, Lab of E.R. Moxon

Fellowship, Rockefeller University, New York, NY, Lab of E.C. Gotschlich

Residency, University of Washington, Seattle, WA, Pediatrics

Copin, Richard; Sause, William E; Fulmer, Yi; Balasubramanian, Divya; Dyzenhaus, Sophie; Ahmed, Jamil M; Kumar, Krishan; Lees, John; Stachel, Anna; Fisher, Jason C; Drlica, Karl; Phillips, Michael; Weiser, Jeffrey N; Planet, Paul J; Uhlemann, Anne-Catrin; Altman, Deena R; Sebra, Robert; van Bakel, Harm; Lighter, Jennifer; Torres, Victor J; Shopsin, Bo

Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2019 Jan 11;

Shen, Pamela; Lees, John A; Bee, Gavyn Chern Wei; Brown, Sam P; Weiser, Jeffrey N

Nature microbiology. 2019 Jan; 4(1):198-208

Lees, John A; Galardini, Marco; Bentley, Stephen D; Weiser, Jeffrey N; Corander, Jukka

Bioinformatics. 2018 Dec 15; 34(24):4310-4312

Kuipers, Kirsten; Lokken, Kristen L; Zangari, Tonia; Boyer, Mark A; Shin, Sunny; Weiser, Jeffrey N

PLoS pathogens. 2018 Oct; 14(10):e1007396-e1007396

Weiser, Jeffrey N; Ferreira, Daniela M; Paton, James C

Nature reviews. Microbiology. 2018 Jun; 16(6):355-367

Renz, Harald; Adkins, Becky D; Bartfeld, Sina; Blumberg, Richard S; Farber, Donna L; Garssen, Johan; Ghazal, Peter; Hackam, David J; Marsland, Benjamin J; McCoy, Kathy D; Penders, John; Prinz, Immo; Verhasselt, Valerie; von Mutius, Erika; Weiser, Jeffrey N; Wesemann, Duane R; Hornef, Mathias W

Journal of allergy & clinical immunology. 2018 Apr; 141(4):1212-1214

Hamaguchi, Shigeto; Zafar, M Ammar; Cammer, Michael; Weiser, Jeffrey N

Infection & immunity. 2018 Jan 08;