Jeffrey N. Weiser

Jeffrey N. Weiser, MD

Chair, Department of Microbiology

Jan T. Vilcek Professor of Molecular Pathogenesis, Department of Microbiology

microbiology, immunology, bacterial infection of the respiratory tract, bacterial-viral co-infections

Our lab investigates the molecular basis of host–pathogen interactions in the human respiratory tract. Most of our studies focus on the pathogenesis of Streptococcus pneumoniae because of its prominence as a cause of acute respiratory tract infection. Other pathogens under investigation in our laboratory include Haemophilus influenzae, Klebsiella pneumoniae, Staphylococcus aureus, and influenza A virus.

Many of our research projects focus on colonization of the upper airway mucosa, the initial step in the disease process, with particular interest in both host and pathogen factors affecting colonization. We employ bacterial genetics to examine the effects of specific microbial genes, along with mouse models of colonization to study infection in genetically modified hosts.

Ongoing projects in our lab include examinations of the following:

  • mechanisms by which colonizing microbes stimulate and evade innate and adaptive immune responses

  • mechanisms that facilitate interspecies competition within a host

  • factors affecting competition between co-colonizing pneumococci

  • effects of influenza co-infection on bacterial colonization

  • pneumococcal interaction with neutrophils and macrophages and evasion of clearance by professional phagocytes

  • the role of phosphorylcholine, a surface constituent of many respiratory tract inhabitants, in pathogenesis

  • host and bacterial factors affecting shedding and host-to-host transmission

  • the systemic effects of colonizing flora (microbiota) on innate immunity 



Academic office

550 First Avenue

Medical Science Building, Room 256

New York, NY 10016

Lab Website
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Jan T. Vilcek Professor of Molecular Pathogenesis, Department of Microbiology

Chair, Department of Microbiology

MD from Harvard University

Fellowship, Oxford University, Oxford, UK, Lab of E.R. Moxon

Fellowship, Rockefeller University, New York, NY, Lab of E.C. Gotschlich

Residency, University of Washington, Seattle, WA, Pediatrics

Hamaguchi, Shigeto; Zafar, M Ammar; Cammer, Michael; Weiser, Jeffrey N

Infection & immunity. 2018 Jan 8; ?-?

Jochems, Simon P; Weiser, Jeffrey N; Malley, Richard; Ferreira, Daniela M

PLoS pathogens. 2017 Dec 21; 13(12):e1006665-e1006665

Zafar, M Ammar; Hamaguchi, Shigeto; Zangari, Tonia; Cammer, Michael; Weiser, Jeffrey N

MBio. 2017 Aug 22; 8(4):?-?

Zangari, Tonia; Wang, Yang; Weiser, Jeffrey N

MBio. 2017 Mar 14; 8(2):?-?

Zafar, M Ammar; Wang, Yang; Hamaguchi, Shigeto; Weiser, Jeffrey N

Cell host & microbe. 2017 Jan 11; 21(1):73-83

Microaspiration Murine Model With Non-Pathogenic S. Pneumoniae Results In "like Will To Like" Microbiota Phenomenon [Meeting Abstract]

Wu, BG; Li, Y; Wang, J; Clemente, J; Zangari, T; Weiser, JN; Segal, LN

American journal of respiratory & critical care medicine. 2017; 195:?-?

Mitsi, E; Roche, A M; Reine, J; Zangari, T; Owugha, J T; Pennington, S H; Gritzfeld, J F; Wright, A D; Collins, A M; van Selm, S; de Jonge, M I; Gordon, S B; Weiser, J N; Ferreira, D M

Mucosal immunology. 2016 Aug 31; 10(2):385-394

Hergott, Christopher B; Roche, Aoife M; Tamashiro, Edwin; Clarke, Thomas B; Bailey, Aubrey G; Laughlin, Alice; Bushman, Frederic D; Weiser, Jeffrey N

Blood. 2016 May 19; 127(20):2460-2471