Jeremy F. Nance

Jeremy F. Nance, PhD

Skirball Institute

Associate Professor, Department of Cell Biology

Keywords
C. elegans, embryogenesis, cell polarity, gastrulation, organogenesis, epithelial cells, germ cells, cancer, developmental genetics, stem cell biology
Summary

Our lab uses the C. elegans embryo as a simple model to understand how cell interactions and movements shape the developing body plan.  As in many organisms, cells in the early embryo polarize in response to cell-cell contacts.  Polarity in early C. elegans cells provides a foundation for subsequent cytoskeletal asymmetries that direct the cell movements of gastrulation. Projects in the lab include:

  1. Understanding how cell contacts induce polarity in early embryonic cells.  We have identified a signaling pathway that translates cell contact cues into cell polarity by regulating the spatial activity of RhoGTPases.
  2. Learning how gastrulation movements are triggered in specific cells.   We have found that primordial germ cells utilize a unique hitchhiking mechanism, regulated by E-cadherin, which allows them to be pulled into the embryo during gastrulation. 
  3. Uncovering how the various cell types of an organ assemble together.  We have examined assembly of the primordial gonad as a simple model for organogenesis.  The primordial gonad contains two germ cells and two somatic gonad cells, which undergo an elaborate assembly process that includes migration, stopping, pseudopod extension, and wrapping. 
  4. Investigating how epithelial cells and tubes form during organogenesis.   We have identified different roles for PAR-3 and PAR-6 in epithelial cell polarization and junction assembly, respectively, and have shown that PAR proteins cooperate with the vesicle tethering exocyst complex to regulate lumen formation in a single-celled tube. 
Phone

212-263-3156

Academic office

540-562 First Avenue

Fourth Floor, Lab 17

New York, NY 10016

Lab Website
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Associate Professor, Department of Cell Biology

PhD from University of Arizona

Abdu, Yusuff; Maniscalco, Chelsea; Heddleston, John M; Chew, Teng-Leong; Nance, Jeremy

Nature cell biology. 2016 Dec; 18(12):1302-1310

Koorman, Thijs; Klompstra, Diana; van der Voet, Monique; Lemmens, Irma; Ramalho, Joao J; Nieuwenhuize, Susan; van den Heuvel, Sander; Tavernier, Jan; Nance, Jeremy; Boxem, Mike

Nature cell biology. 2016 Mar; 18(3):337-346

Mainpal, Rana; Nance, Jeremy; Yanowitz, Judith L

Development. 2015 Oct 15; 142(20):3571-3582

Klompstra, Diana; Anderson, Dorian C; Yeh, Justin Y; Zilberman, Yuliya; Nance, Jeremy

Nature cell biology. 2015 Jun; 17(6):726-735

Armenti, Stephen T; Lohmer, Lauren L; Sherwood, David R; Nance, Jeremy

Development. 2014 Dec; 141(23):4640-4647

Armenti, Stephen T; Chan, Emily; Nance, Jeremy

Developmental biology (Orlando). 2014 Oct 01; 394(1):110-121

Nance, Jeremy

Journal of cell biology. 2014 Sep 29; 206(7):823-832

Rohrschneider, Monica R; Nance, Jeremy

Developmental biology (Orlando). 2013 Jul 15; 379(2):139-151