Jessica E. Treisman

Jessica E. Treisman

Skirball Institute

Professor, Department of Cell Biology

Keywords
cancer, developmental genetics, molecular, cellular, & translational neuroscience, cell signaling, synapse formation
Summary

During development, cells signal to one another to communicate positional information that directs them to take on appropriate fates and form contacts with the correct partners. We study these processes using the visual system of the fruit fly Drosophila as our primary model. The repetitive yet exquisitely organized structure of the Drosophila eye and the power of unbiased genetic screens have enabled us to uncover general mechanisms by which cells communicate.

We have identified novel components of the Hedgehog, Wnt, Notch, and epidermal growth factor (EGF) receptor pathways that are important for patterning the fly eye and are misregulated in cancer and other human diseases.

We also study how cell–cell signals are translated into cell fate decisions through effects on specific transcriptional or post-transcriptional regulators of gene expression. Visual system assembly requires neurons to identify and form synapses with the correct partners, in order to form a functional neural circuit. We are investigating the molecular basis for synaptic partner selection, as well as the mechanisms that allow synapse size to grow in proportion to the size of the target. 

For further details on my research, please visit the Treisman Lab website .

Phone

212-263-1031

Fax

212-263-7760

Academic office

540-562 First Avenue, Skirball Institute

Fourth Floor, Lab 9

New York, NY 10016

Lab Website
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Professor, Department of Cell Biology

Coord Developmental Genetics Prog

Suisse, Annabelle; He, DanQing; Legent, Kevin; Treisman, Jessica E

Development. 2017 Jun 15; 144(14):2673-2682

Legent, Kevin; Liu, Hui Hua; Treisman, Jessica E

Development. 2015 Apr 15; 142(8):1480-1491

Malone, Colin D; Mestdagh, Claire; Akhtar, Junaid; Kreim, Nastasja; Deinhard, Pia; Sachidanandam, Ravi; Treisman, Jessica; Roignant, Jean-Yves

Genes & development. 2014 Aug 15; 28(16):1786-1799

Marr, Sharon K; Lis, John T; Treisman, Jessica E; Marr, Michael T 2nd

Molecular & cellular biology. 2014 Jul; 34(14):2710-2720

Steinhauer, Josefa; Liu, Hui Hua; Miller, Eli; Treisman, Jessica E

Journal of cell science. 2013 Oct 01; 126(Pt 19):4469-4478

Treisman, Jessica E

Wiley interdisciplinary reviews. Developmental biology. 2013 Jul; 2(4):545-557